李伯良 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1994年被批准为博导，1993年特聘为研究员，1989年被破格晋升为副研究员，1983年在中科院原上海生化所研究生毕业并获硕士学位，1979年毕业于北京大学生物系生化专业。曾在美国Dartmouth医学院先1年、后多次短期合作研究(Visiting Scientist，1993-1994、1998、2000、2002)和美国New Jersey-UMDNJ从事研究2年(Research Associate, 1986-1988)。 2000年至今在中科院上海生科院生化与细胞所、现为中科院上海生化与细胞所从事研究，首任所长(2000-2003)、研究组长、博导、研究员、学位委员(2000-2014)和学术委员。曾在中科院原上海生化所从事研究(1983-2000)，任所长(1997-2000)、常务副所长(1995-1997，法人代表主持工作)、学术委员会主任(1995-2000)、研究组长(1991-2000)、博导(1994-2000)、研究员(1993-2000)、学术委员(1992-2000)、学位委员(1992-2000)、副研究员(1989-1993)。兼任：国家基金委生命科学部第七-六届咨询委员会委员(2014-2020)，国家基金委2个重大研究计划专家组(细胞器专家组成员2017-2025、RNA专家组副组长2014-2022)，中国生化与分子生物学会脂蛋白专业委员会的副主任(2009-)、常务委员(2006-)，Acta Biochim Biophys Sin，主编(2006-)、副主编(2002-2006)、常务编委(1996-)，《中国生物化学与分子生物学报》副主编(2011-)、常务编委(2011-)、编委(2004-2010)，《生命的化学》副主编(2002-)、常务编委(2002-)、编委(1998-2002)。曾兼任：中国生化与分子生物学会基因专业委员会主任(2005-2015)，中国生化与分子生物学会第10届常务理事(2009-2014)、第8届副理事长兼秘书长(2001-2005)、第7届副理事长(1997-2001)，上海市生化与分子生物学会连续3届理事(1992-2003)，中国生物工程学会第4届理事(2005-2009)、第3届常务理事(2001-2005)、第2届理事(1997-2001)，上海市生物工程学会第3届常务理事(2002-2006)、第2届理事(1999-2002)，中科院生命科学/微观生物学(1997-2003)、生物技术(1996-2003)和国际合作(1996-2003)的3个专家委员会委员，《Cell Research》编委(2002-2006)，《科学通报》特邀编委(2001-2008)，中科院上海生科院的党委书记（2002-2004）和学术委员会常务委员(1999-2006)，上海交通大学教授(1997-2000)，1998年被聘中国医科院医学生物学研究所教授，1994年被聘浙江大学教授

研究领域

实验室一直从事生化、分子生物学等方面工作，研究方向先为基因的表达功能、后聚焦于固醇代谢平衡•生理病理调控•靶标系统创建，主要围绕胆固醇代谢关键酶表达功能和固醇转运调控，长期与美国Dartmouth医学院TY Chang教授合作，着重研究细胞胆固醇代谢平衡关键酶--酰基辅酶A:胆固醇酰基转移酶(ACAT)的表达功能，探索ACAT的基因结构、转录剪接、翻译修饰、表达调控、功能模式及其与胆固醇代谢平衡的生理功能、病理变化等关系，包括与细胞质膜游离胆固醇的动态平衡、细胞胆固醇及其代谢物固醇的载运特异脂蛋白分泌外排和转运调控、动脉粥样硬化(AS)病(如冠心病、中风)、神经退行性疾病(如老年痴呆症，AD)、癌症(如肝癌，HCC)等关系，深入ACAT靶标系统创建及新药研发等

近期论文

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Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong, Shu-Yuan Guo, Huiyong Yin, Xu Lin, Qin Li, Catherine CY Chang, Ta-Yuan Chang, Bo-Liang Li* and Bao-Liang Song*. Cholesterol and fatty acid regulate cysteine ubiquitination on ACAT2 via competitive oxidation. Nat Cell Biol, 2017, 19: 808-819 Dong-Qing Guo, Xiao-Wei Zhang, Qin Li, Lei Qian, Jia-Jia Xu, Ming Lu, Xi-Han Hu, Zhu Ming, Catherine C. Y. Chang, Bao-Liang Song, Ta-Yuan Chang, Ying Xiong and Bo-Liang Li*. The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters. Acta Biochim Biophys Sin, 2016, 48: 990-997 Dong-Qing Guo, Ming Lu, Xi-Han Hu, Jia-Jia Xu, Guang-Jing Hu, Ming Zhu, Xiao-Wei Zhang, Qin Li, Catherine CY Chang, Ta-Yuan Chang, Bao-Liang Song, Ying Xiong and Bo-Liang Li*. Low-level expression of human ACAT2 gene in monocytic cells is regulated by C/EBP transcription factors. Acta Biochim Biophys Sin, 2016, 48: 980-989 Wei Yang, Yibing Bai, Ying Xiong, Jin Zhang, Shuokai Chen, Xiaojun Zheng, Xiangbo Meng, Lunyi Li, Jing Wang, Chenguang Xu, Chengsong Yan, Lijuan Wang, Catharine C. Y. Chang, Ta-Yuan Chang, Ti Zhang, Penghui Zhou, Bao-Liang Song, Wanli Liu, Shao-cong Sun, Xiaolong Liu, Bo-liang Li* and Chenqi Xu*. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature, 2016, 531: 651-655 Yang Zhan, Xiao-Wei Zhang, Ying Xiong, Bo-Liang Li* and Fa-Jun Nan*. Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2). Org Biomol Chem, 2016, 14: 747-751 Ming Zhu, Xiao-Nan Zhao, Jia Chen, Jia-Jia Xu, Guang-Jing Hu, Dong-Qing Guo, Qin Li, Xiao-Wei Zhang, Catherine CY Chang, Bao-Liang Song, Ying Xiong*, Ta-Yuan Chang*, and Bo-Liang Li*. ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-alpha-processing alternation. Acta Biochim Biophys Sin, 2015, 47: 951-959 Ming Zhu, Lei Lei, Zhen-Hua Zhu, Qin Li, Dong-Qing Guo, Jia-Jia Xu, Jia Chen, Hui-Fang Sha, Xiao-Wei Zhang, Xin-Ying Yang, Bao-Liang Song, Bo-Liang Li*, Yan Yan* and Ying Xiong*. Excess TNF-alpha in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells. Acta Biochim Biophys Sin, 2015, 47:899-907 Ming Lu, Xi-Han Hu, Qin Li, Ying Xiong, Guang-Jing Hu, Jia-Jia Xu, Xiao-Nan Zhao, Xi-Xiao Wei, Catherine C. Y. Chang, Yin-Kin Liu, Fa-Jun Nan, Jia Li, Ta-Yuan Chang, Bao-Liang Song* and Bo-Liang Li*. A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth. J Mol Cell Biol, 2013, 5: 404-415 Jia-Jia Xu, Huang-Jing Hu, Ming Lu, Ying Xiong, Qin Li,Catherine C. Y. Chang, Bao-Liang Song, Ta-Yuan Chang and Bo-Liang Li*. MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation. Acta Biochim Biophys Sin, 2013, 45: 953-962 Guang-Jing Hu, Jia Chen, Xiao-Nan Zhao, Jia-Jia Xu, Dong-Qing Guo, Ming Lu, Ming Zhu, Ying Xiong, Qin Li, Catherine C. Y. Chang, Bao-Liang Song, Ta-Yuan Chang and Bo-Liang Li*. Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene. Cell Res, 2013, 23: 1007-1024 Tong-Fei Liu, Jing-Jie Tang, Pei-Shan Li, Yang Shen, Jia-Gui Li, Hong-Hua Miao, Bo-Liang Li* and Bao-Liang Song*. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metab, 2012, 16: 213-225 Chang Xie, Zhang-Sen Zhou, Na Li, Yan Bian, Yong-Jian Wang, Li-Juan Wang, Bo-Liang Li* and Bao-Liang Song*. Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res, 2012, 53: 2092-2101 Lei Lei, Ying Xiong, Jia Chen, Jin-Bo Yang, Yi Wang, Xin-Ying Yang, Catherine C. Y. Chang,, Bao-Liang Song, Ta-Yuan Chang, and Bo-Liang Li*. TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation. J Lipid Res. 2009, 50: 1057-1067 Xiao-Nan Zhao, Jia Chen, Lei Lei, Guang-Jing Hu, Ying Xiong, Jia-Jia Xu, Qin Li, Xin-Ying Yang, Catherine Chang, Bao-Liang Song, Ta-Yuan Chang and Bo-Liang Li*. The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay. Acta Biochim Biophys Sin, 2009, 41: 30-41 Jia Chen, Xiao-Nan Zhao, Li Yang, Guang-Jing Hu, Ming Lu, Ying Xiong, Xin-Ying Yang, Catherine C. Y. Chang, Bao-Liang Song, Ta Yuan Chang and Bo-Liang Li*. The RNA secondary structures located at the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kD isoform. Cell Res, 2008, 18: 921-936 Jian Cao, Jiang Wang, Wei Qi, Hong-Hua Miao, Jing Wang, Liang Ge, Russell A.DeBose Boyd, Jingjie Tang, Bo-Liang Li* and Bao-Liang Song*. Ufd1 Is a Cofactor of gp78 and Plays a Key Role in Cholesterol Metabolism by Regulating the Stability of HMG-CoA Reductase. Cell Metab, 2007, 6: 115-128 Bao-Liang Song, Can-Hua Wang, Xiao-Min Yao, Li Yang, Wen-Jing Zhang, Zhen-Zhen Wang, Xiao-Nan Zhao, Jin-Bo Yang, Wei Qi, Xin-Ying Yang, Kenji Inoue, Zhi-Xin Lin, Hui-Zhan Zhang, Tatsuhiko Kodama, Catherine C.Y. Chang, Yin-Kun Liu, Ta-Yuan Chang* and Bo-Liang Li*. Human Acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Biochem J, 2006, 394: 617-626 Xiao-Min Yao, Can-Hua Wang, Bao-Liang Song, Xin-Ying Yang, Zhen-Zhen Wang, Wei Qi, Zhi-Xin Lin, Catherine C.Y. Chang, Ta-Yuan Chang and Bo-Liang Li*. Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes. Acta Biochim Biophys Sin, 2005, 37: 797-806 Li Yang, Oneil Lee, Jia Chen, Jiang Chen, Catherine C.Y. Chang, Pei Zhou, Zhen-Zhen Wang, Han-Hui Ma, Hui-Fang Sha, Jiu-Xian Feng, Yi Wang, Xin-Ying Yang, Li Wang, Rohong Dong, Kim Ornvold, Bo-Liang Li* and Ta-Yuan Chang*. Human acyl-coenzyme A:cholesterol acyltransferase 1 (Acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. J Biol Chem, 2004, 279: 46253-46262 Li Yang, Jin-Bo Yang, Jia Chen, Guang-Yao Yu, Pei Zhou, Lei Lei, Zhen-Zhen Wang, Catherine C.Y. Chang, Xin-Ying Yang, Ta-Yuan Chang* and Bo-Liang Li*. Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. Cell Res, 2004, 14: 315-323