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Hao Z., Wu Q., Li Y., Li Z., Li T.*, Hu R*. Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders. Cell Research 2019 Accepted. IF. 17.84.
Lu Y., Qiu Y., Chen P., Chang H., Guo L., Zhang F., Ma L., Zhang L., Zheng X., Xiao J., Zhong R., Han L., Xu X., Zhang Y., Li D., Zhong G., Boyton R., Huang Y., He Y., Hu R*., Wei B*, Wang H*. The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology. 2019 Accepted IF:14.30
Liu Z, Li H, Hong C, Chen M3, Yue T, Chen C, Wang Z, You Q, Li C, Weng Q, Xie H, Hu R*. ALS (Amyotrophic lateral sclerosis)-associated mutation in Optineurin promotes inflammation and causes neuronal cell death. Front Immunol. 2018 14;9:2647. doi: 10.3389/fimmu.2018.02647. IF: 5.511
Shen J, Li P, Shao X, Yang Y, Liu X, Feng M, Yu Q, Hu R*, Wang Z*. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival. Cancer Res. 2018 Jan 15;78(2):359-371. doi: 10.1158/0008-5472.CAN-17-1805. IF: 9.130
Yang J, Peng H, Xu Y,Xie X, Hu R*. SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination. Autophagy. 2018 Jun 14:0. doi: 10.1080/15548627.2017.1332566. IF:11.10
Xingxing Xu, Chuanyin Li, Xiaobo Gao, Kun Xia, Hui Guo, Yali Li, Zijian Hao, Lei Zhang, Huatai Xu, Ling Mei, Kangcheng Ruan, Ronggui Hu*. Excessive UBE3A Dosage Impairs Retinoic Acid Signaling and Synaptic Plasticity in Autism Spectrum Disorders. Cell Research, 2018, 28(1):48-68. IF:15.393
Xiangpeng Sheng#, Qing You#, Hongnian Zhu, ZeNan Chang4, Qingrun Li, Haifeng Wang, Chen Wang, Hongyan Wang, Lijian Hui, Chongtao Du, Xiaoduo Xie, Rong Zeng, Anning Lin, Dongfang Shi, Kangcheng Ruan, Jinghua Yan, George Fu Gao, Feng Shao, Ronggui Hu*. Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLOS Pathogens. 2017. https://doi.org/10.1371/journal. ppat.1006534 July 28, 2017, 1-28. IF:6.158
Hong Peng#, Jiao Yang#, Guangyi Li, Qing You, Wen Han, Byung-Hoon Lee, Juan Du, Jian Hou, Tao Zhang, Hai Rao, Ying Huang, Qinrun Li, Rong Zeng, Qin Xia, Xuemin Zhang, Yongning He, Masaaki Komatsu, Ivan Dikic, Daniel Finley, Ronggui Hu*. Ubiquitylation of p62/Sequestosome1 Activates Its Autophagy Receptor Function and Controls Selective Autophagy Upon Ubiquitin Stress. Cell Res. 2017.27(5): 657-74. IF:15.393
Feng Wang, Xing Fu, Peng Chen, Ping Wu5, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C L Wong, Ronggui Hu*, Jingyi Hui*. SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. Cell Res. 2017. 27:540–58. IF:15.393
Ronggui Hu, Mark Hochstrasser. Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling. Cell Res. 2016 26:389-390. IF:15.393
Xingxing Xu*, Yonghui Tao*, Xiaobo Gao*, Lei Zhang, Xufang Li, Weiguo Zou, Kangcheng Ruan, Feng Wang, Guo-liang Xu, Ronggui Hu*. A CRISPR-based approach for targeted DNA demethylation. Cell Discovery. 2016. 2: 16009; doi:10.1038/celldisc.2016.9. IF:4.462
Yu-Jiao Liu, Chao Liu, ZeNan Chang, Brandon Wadas, Christopher S. Brower, Zhen-Hua Song, Zhi-Liang Xu, Yong-Liang Shang, Wei-Xiao Liu, Li-Na Wang, Wen Dong, Alexander Varshavsky, Rong-Gui Hu* and Wei Li*. Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway. J Biol Chem. 2016(4), 291:7426-38. IF:4.010
Tao Zhang,Haojie Lu,Weijun Li,,Ronggui Hu*,Zi Chen*. Identification of Arsenic Direct-Binding Proteins in Acute Promyelocytic Leukaemia Cells. Int J Mol Sci. 2015 Nov 10;16(11):26871-9 . IF:3.687
Shen J., Sheng X., Chang Z., Wu Q., Wang S., Xuan Z., Wu Y., Shang Y., Kong X., Yu L., Li L., Ruan K., Hu H., Huang Y., Wang F., Hu R* The heme-p53 interaction: linking iron metabolism to p53 signaling and tumorigenesis. Molecular & Cellular Oncology. 2014. DOI:10.4161/23723548.2014.965642 (Invited review)
Liu Z, Chen P, Gao H, Gu Y, Yang J, Pen H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zou J, Ruan K, Komatsu M, White E, Ji H, Finley D, Hu R*. (2014) Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell. 26: 106-120. (Highlighted in “Science Signaling”.)
Yu T, Tao Y, Yang M, Chen P, Gao X, Zhang Y, Zhang T, Chen Z, Hou J, Zhang Y, Ruan K, Wang H, Hu R.G*. (2014) Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Research doi:10.1038/cr.2014.122 (In press)
Shen J, Sheng X, Chang Z, Wu Q, Wang S, Xuan Z, Wu Y, Shang Y, Kong X, Yu L, Li L, Ruan K, Hu H, Huang Y, Wang F, Hu R.G*. (2014) Iron Metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 function, stability and localization. Cell Reports. 7:1-14. (Highlighted in “Faculty of 1000”, “Chemistry & Biology”, “Global Medical Discoveries”)
Xu X, Tao Y, Fu X, Yu T, Li Y, Chen K, Ding X, Ruan K, Jing N, Hu R.G*. (2014) ZIPseq: genome-wide mapping of DNA repeats at single base resolution. Journal of Molecular and Cell Biology. 6:93-6.
Shen J, Song G, An M, Li X, Wu N, Ruan K, Hu J, Hu R.G*. (2014) The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non small cell lung cancer therapy. Biomaterials. 35(1):316-26.
Song G., Li C., Hu J., Zou R., Xu K., Han L., Yang J., Chen Z., Qin Z., Ruan K., Hu R.G*. (2012) A simple transformation from silica core–shell–shell to yolk–shellnanostructures: a useful platform for effective cell imaging and drug delivery. J. Mater. Chem. 22: 17011-18