张耀阳 - 中国科学院上海有机化学研究所 -

个人简介

2000-2006 北京理工大学学士和硕士 2006-2010 德国慕尼黑-路德维希-马克西米利安大学博士 2006-2010 德国马克斯普朗克精神病研究所博士生 2011-2013.9 美国斯克里普斯研究所研究助理 2013.9-至今中国科学院生物与化学交叉研究中心研究员、课题组长

研究领域

质谱和蛋白质组实验室利用生物质谱技术来研究蛋白质在生物体系中的多种特性。其研究方向主要包括： 1.质谱蛋白质组学新技术和新方法的研究 2.神经退行性疾病和衰老过程的相关蛋白质组学研究 3.质谱蛋白质组学技术在生物学问题中的广泛应用

近期论文

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1.Zhang, Y., Fonslow, B. R., Shan, B., Baek, M.-C. & Yates III, J. R. Protein Analysis by Shotgun/Bottom-up Proteomics. Chemical reviews(2013). 2.Webhofer, C.*, Zhang, Y.*, Brusis, J., Reckow, S., Landgraf, R., Maccarrone, G., Turck, C. W. & Filiou, M. D. < sup> 15 N metabolic labeling: Evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times. Journal of proteomics (2012). (equal contribution) 3.Zhang, Y., Reckow, S., Webhofer, C., Boehme, M., Gormanns, P., Egge-Jacobsen, W. M. & Turck, C. W. Proteome Scale Turnover Analysis in Live Animals Using Stable Isotope Metabolic Labeling. Analytical chemistry (2011). 4.Zhang, Y., Filiou, M. D., Reckow, S., Gormanns, P., Maccarrone, G., Kessler, M. S., Frank, E., Hambsch, B., Holsboer, F. & Landgraf, R. Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Molecular & Cellular Proteomics (2011). 5.Zhang, Y., Webhofer, C., Reckow, S., Filiou, M. D., Maccarrone, G. & Turck, C. W. A MS data search method for improved 15N‐labeled protein identification. Proteomics 9, 4265-4270 (2009). 6.Filiou, M. D., Webhofer, C., Gormanns, P., Zhang, Y., Reckow, S., Bisle, B., Teplytska, L., Frank, E., Kessler, M. S. & Maccarrone, G. The 15N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model. Proteomics 12, 2421-2427 (2012). 7.Filiou, M. D., Zhang, Y., Teplytska, L., Reckow, S., Gormanns, P., Maccarrone, G., Frank, E., Kessler, M. S., Hambsch, B. & Nussbaumer, M. Proteomics and Metabolomics Analysis of a Trait Anxiety Mouse Model Reveals Divergent Mitochondrial Pathways. Biological psychiatry (2011). 8.Haegler, K., Mueller, N. S., Maccarrone, G., Hunyadi-Gulyas, E., Webhofer, C., Filiou, M. D., Zhang, Y. & Turck, C. W. QuantiSpec--Quantitative mass spectrometry data analysis of 15N-metabolically labeled proteins. Journal of proteomics 71, 601-608 (2009). 9.Frank, E., Kessler, M. S., Filiou, M. D., Zhang, Y., Maccarrone, G., Reckow, S., Bunck, M., Heumann, H., Turck, C. W. & Landgraf, R. Stable Isotope Metabolic Labeling with a Novel 15N-Enriched Bacteria Diet for Improved Proteomic Analyses of Mouse Models for Psychopathologies. PloS one 4, e7821 (2009)