卜鹏程 - 中国科学院大学

个人简介

招生专业 071009-细胞生物学招生方向非编码RNA与疾病，肿瘤代谢教育背景 2004-09--2007-07 中科院生物物理研究所博士 2001-09--2004-07 大连理工大学硕士 1997-09--2001-07 大连工业大学学士工作简历 2008-2010 美国加州大学伯克利分校，博士后 2010-2015 美国康奈尔大学，研究助理 2015-2016 美国杜克大学，资深科学家 2016.09-至今中科院生物物理研究所，研究员专利与奖励中组部“青年****”，国家级， 2017 中科院率先行动“****” B类，院级， 2016 北京市科学技术奖一等奖 (7/13)，省级， 2014 中科院院长优秀奖，院级， 2007 中科院优秀毕业生，院级，2007

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1.Bu P#, Kaiyuan Chen,..., Shen X#. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metabolism. 2018 27 (1-14). #, Corresponding author. 2.Chen KY, Srinivasan T, Tung KL,…, Bu P#, Shen X#. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol. 2017 13(4):927. #, Corresponding author. 3.Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation. Cell Stem Cell. 2016 18(2):189-202. #, Corresponding author. Highlighted in Cancer Discovery and AAAS 4.Wang L*, Bu P*, Ai Y, et al. A large non-coding RNA regulates colon cancer stem cell asymmetric division. Elife. *, Co-first author. 2016; 10.7554/eLife.14620. 5.Chen HJ,…,Bu P,…et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016, doi: 10.1038/nbt.3586 6.Srinivasan T, Walters J, Bu P,… et al. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells. Cancer Res. 2016; DOI: 10.1158/0008-5472.CAN-15-3198. Srinivasan T, Than EB, Bu P et al. Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. Sci Rep. 2016 16;6:26069. doi: 10.1038/srep26069 7.Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF-b. Nat commun. 2015 6:6879. #, Corresponding author. 8.Sun S, …, Bu P…, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015, 17(12):1546-55 9.Li J, Ai Y, Wang L, Bu P,… et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2015 Oct 21;76:52-65 10.Chen, H, …, Bu, P, …, et al. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nat Biotechnol. 2015, 33(6):656-60. 11.Okada N, …, Bu P…, et al. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014 28: 438-450 12.Bu P, Chen K-Y, Chen JH et al. A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. 2013, 12(5):602-625. Highlighted in Cell Stem Cell and Biotechniques. 13.Bu P, Chen K-Y, Lipkin SM, Shen X. Asymmetric division: a marker for cancer stem cells in early stage tumors? Oncotarget. 2013, 4(7):950-951. 14.Chen JH Edwards R, Tucci S, Bu P, et al. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis. J Clin Invest. 2012, 122(9):3184-96 15. Choi YJ, …, Bu P, …, et al. miR-34a miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011, 13(11):1353-60. 16.Bu P, Zhuang J, Feng J, et al. Visualization of CD146 dimerization and its regulation in living cells. BBA-Mol Cell Res. 2007, 1773(4):513-20.1. 17.Bu P, Gao L, Zhuang J, et al. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation. Mol Caner Ther. 2006, 5(11): 2872-2878