侯百东 - 中国科学院生物物理研究所 -

个人简介

1989-1994: 北京医科大学（现北京大学医学部），临床医学，本科；1994-1997: 北京协和医院，住院医师；1997-2001: 北京协和医科大学，博士研究生；2001-2003: 范德比尔特大学，博士后；2003-2009: 加州大学旧金山分校，博士后；2009-2011: 加州大学旧金山分校，助理研究员；2011年至今：中国科学院生物物理所，研究员

研究领域

抗病毒抗体反应；自身抗体反应；B细胞分化的调控；新型疫苗及免疫治疗

近期论文

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Hong S, Zhang Zhimin, Liu H, Tian M, Zhu X, Zhang Zhuqiang, Wang W, Zhu B, Zhou X, Zhang F, Ge Q, Tang H*, Hua Z*, Hou B*. B cells are the dominant antigen-presenting cells that activate naive CD4+ T cells upon immunization with a virus-derived nanoparticle antigen. Immunity, 2018, Sep 21. pii: S1074-7613(18)30353-4. doi: 10.1016/j.immuni.2018.08.012. [Epub ahead of print] Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL and Hou B*. B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle. J Immunol. 2018 February 1. 200 (3) 937-948. PMID: 29282308 Liao W, Hua Z, Liu C, Lin L, Chen R, Hou B*. Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle. J Immunol. 2017 May 15. PMID:28416599 Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B*, DeFranco AL*. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 1;192(3):875-85. PMID: 24379120 Hua Z, Hou B*. TLR signaling in B cell development and activation. Cell. Mol. Immunol., Vol.10, 103-106, 2013. PMID: 23241902 DeFranco AL, Rookhuizen D, Hou B. Contribution of TLR signaling to germinal center antibody responses. Immunological reviews. 2012 May;247(1):64-72. PMID: 22500832. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, Defranco AL, Yarovinsky F. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity. 2012 Feb 24;36(2):228-38. PMID: 22306056. Hou B*, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee L, Coffman R, Bachmann M, DeFranco AL*. Selective utilization of TLR/MyD88 signaling in B cells for enhancement of the anti-viral germinal center response. Immunity 2011 Mar 25;34(3):375-84. PMID: 21353603. Hou B*, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F*. Critical coordination of innate immune defense to Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci USA. 2011 Jan 4;108(1):278-83. PMID: 21173242. Hou B, Reizis B, DeFranco AL. Toll-like receptor-mediated dendritic cell-dependent and –independent stimulation of innate and adaptive immunity. Immunity 2008 Aug; 29(2): 272-82. PMID: 18656388.