严景华 - 中国科学院微生物研究所 -

个人简介

学习经历 2001年-2004年：军事医学科学院生物工程研究所遗传学专业，博士 1999年：德国汉诺威大学（Hanover University）进修 1986年-1989年：南京农业大学生物化学专业，硕士 1982年-1986年：安徽师范大学生物系，学士工作经历 2012年至今中国科学院微生物研究所研究员 2004年-2012年中国科学院微生物研究所副研究员 1989年-2001年：安徽农业大学生物化学教研室讲师、副教授

研究领域

结构为基础的新型疫苗及抗体工程改造

近期论文

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1. Wang Q, Ma T, Wu Y, Chen Z, Zeng H, Tong Z, Gao F, Qi J, Zhao Z, Chai Y, Yang H, Wong G, Bi Y, Wu L, Shi R, Yang M, Song J, Jiang H, An Z, Wang J, Yilma TD, Shi Y, Liu WJ, Liang M, Qin C, Gao GF*, Yan J*. Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nature Microbiology. 2019 Jul;4(7):1231-1241 2. Liu H, Guo L, Zhang J, Zhou Y, Zhou J, Yao J, Wu H, Yao S, Chen B, Chai Y, Qi J, Gao GF, Tan S, Feng H, Yan J. Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. MAbs. 2019 May/Jun;11(4):681-690. 3. Tan S, Zhang H, Chai Y, Song H, Tong Z, Wang Q, Qi J, Wong G, Zhu X, Liu WJ, Gao S, Wang Z, Shi Y, Yang F, Gao GF*, Yan J* . An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nature Communications. 2017, 8:14369.. 4. Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, Wong G, Peng R, Liu S, Li J, Li S, Song J, Liu J, He J, Yuan H, Xiong Y, Liao Y, Li J, Yang J, Tong Z, Griffin BD, Bi Y, Liang M, Xu X, Qin C, Cheng G, Zhang X, Wang P, Qiu X, Kobinger G, Shi Y, Yan J *, Gao GF *. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. Science Translational Medicine. 2016, 8(369):369ra179. 5. Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Zhang B, Yuen KY, Perlman S, Gao GF*, Yan J *. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Cell Research. 2015 , 25(11):1237-49 6. Lu G, Zhang N, Qi J, Li Y, Chen Z, Zheng C, Gao GF, Yan J *. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. Journal of Virology. 2014 ,88(23):13678-88. 7. Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013, 500(7461): 227-31.. 8. Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y, Yan J, Gao GF. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science. 2013, 342(6155):243-7. 9. Liu J., Qian X., Chen Z., Xu X., Gao F., Zhang S., Zhang R., Qi J., Gao GF., and Yan J *. Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. Journal of Immunology. 2012, 188(11):5511-20 10. Zhang N*, Yan J﹡, Lu G*, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications.. 2011, 2:577. 11. Liu J, Dai L, Qi J, Gao F, Feng Y, Liu W, Yan J*, Gao GF. 2011. Diverse peptide presentation of rhesus macaque MHC class I Mamu-A*02 revealed by two peptide-complex structures and insights into SIV immune escape. Journal of Virology. 2011. 85(14):7372-83. 12. Lu G, Qi J, Chen Z, Xu X, Gao F, Lin D, Qian W, Liu H, Jiang H, Yan J *, Gao GF*. Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrate, and anti-HFMD drug design. Journal of Virology 2011, 85(19):10319-31.