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个人简介

朴海龙博士2003年和2009年于韩国国立庆尚大学分别获理学硕士和博士学位,2009.9-2014.1在美国M.D.安德森癌症中心从事博士后研究。2014年2月全职回国到大连化学物理研究所转化医学科学研究中心工作。2015年5月聘任为生物技术部转化医学科学研究中心研究员。2020年7月聘任为生物分子功能与机制研究组组长。

研究领域

重点以细胞分子生物学、化学生物学、生物信息学及组学等多学科交叉为研究基础,开展生物分子调控的代谢重编程及分子机制,生物大小分子相互作用及药物作用靶点功能与机制,多维生物分子网络的癌症系统生物学的研究。

近期论文

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Wang W, Liu X, Chen H, Ling T, Xia T, Liu X, Liu J, Otkur W, Shi X, Qi H, Chen D, Piao HL#. Cholesterol as a functional metabolite cooperates with metadherin in cancer cells. Chinese Chemical Letters 31(2020)1831–1834. Zhang XX, Qi H, Lu MH, Yang SQ, Li P, Piao HL#, Han KL#. Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise. Research. 2020 Mar 18;2020:7043124. (#Corresponding Author) Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL#, Liu H#. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 2020; 10(9):4150-4167. (#Corresponding Author) Yu Z, Li J, Ren Z, Sun R, Zhou Y, Zhang Q, Wang Q, Cui G, Li J, Li A, Duan Z, Xu Y, Wang Z, Yin P, Piao HL, Lv J, Liu X, Wang Y, Fang M, Zhuang Z, Xu G, Kan Q. Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure. Adv Sci (Weinh). 2020 Feb 13;7(7):1902996. Wang Z, Chen D, Piao HL#, Hua X#.PTEN-deficient cells prefer glutamine for metabolic synthesis. Acta Biochimica et Biophysica Sinica, 52, 3, 2020, 251–258, (#Corresponding Author) Chen D, Zhao X, Sui1 Z, Niu H, Chen L, Hu C, Xuan Q, Hou X, Zhang R, Zhou L, Li Y, Yuan H, Zhang Y, Wu J, Zhang L#, Wu R#, Piao HL#, Xu G#, Jia W#. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. Theranostics. 2020 Jan; 10(5): 2029-2046. (#Corresponding Author) Chen D, Ning Z, Chen H, Lu C, Liu X, Xia T, Qi H, Wang W, Ling T, Guo X, Tekcham DS, Liu X, Liu J, Wang A, Yan Q, Liu JW#, Tan G#, Piao HL#. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. Oncogene. 2020 Jan;39 (3):587-602. (#Corresponding Author) Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC#. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism. 2019 Sep 3;3 0(3):508-524. Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL#. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. iScience. 2019 Jun 28;16:177-191. Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC#. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research. 2019 Jun;29 (6):460-473. Yan M, Qi H, Xia T, Zhao X, Wang W, Wang Z, Lu C, Ning Z, Chen H, Li T, Tekcham DS, Liu X, Liu J, Chen D, Liu X, Xu G#, Piao HL#. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα. Metabolism. 2019 Feb;91:18-29. (#Corresponding Author) Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L#. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 Dec; 50(12):1705-1715. Wang J, Qi H, Zhang X, Si W, Xu F, Hou T, Zhou H, Wang A, Li G, Liu Y, Fang Y, Piao HL#, Liang X#. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling. Biomed Pharmacother. 2018 Sep 21;108:724-733. (#Corresponding Author) Sang LJ, Ju HQ, Liu GP, Tian T, Ma GL, Lu YX, Liu ZX, Pan RL, Li RH, Piao HL, Marks JR, Yang LJ, Yan Q, Wang W, Shao J, Zhou Y, Zhou T, Lin A# LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling. Mol Cell. 2018 Oct 4;72(1):71-83. Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG#, Lin SC#. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017 Aug 3; 548 (7665):112-116. (#Corresponding Author) Wang W, Tekcham DS, Yan M, Wang Z, Qi H, Liu X, Piao HL#. Biochemical reactions in metabolite-protein interaction. Chinese Chemical Letters, 13 October 2017. Piao HL, Yuan Y, Wang M, Sun Y, Liang H, Ma L. α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling. Nat Cell Biol. 2014 Mar;16 (3):245-54. Lin A#, Piao HL#, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway. Cancer Res. 2014 Mar 15;74 (6):1682-93. (#Contributed equally to this work)

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