个人简介

郭炜，男，1972年出生于山西省长治市，2002年毕业于南开大学化学系并获博士学位，现为山西大学化学化工学院院长，二级教授，博士生导师。主要从事荧光染料及探针的开发及生物传感研究工作，在J.Am.Chem.Soc.、Angew.Chem.Int.Ed.、Chem.Sci.、Biomaterials、ACSAppl.Mater.Interfaces等国际权威学术期刊发表学术论文60余篇，他引2000余次。入选教育部新世纪优秀人才、山西省高等学校中青年拔尖人才、山西省高等学校优秀青年学术带头人、山西省学术技术带头人、山西省131领军人才。研究项目“荧光探针的构建及生物传感研究”获2015年度山西省科学技术（自然科学类）二等奖。 教育经历： 1991-1995山西大学化学系本科 1995-1998山西大学化学系硕士研究生 1999-2002南开大学化学系博士研究生 工作经历： 1998至今山西大学化学化工学院 讲授课程： 基础有机化学；物理有机化学；高等有机化学

研究领域

分子发光与生物传感

科研项目： 1．环二肽催化的不对称Baylis-Hillman反应研究，山西省青年科学基金，2004-2006，3.5万元。 2．新型有机负氢转移试剂，N1,N2-二取代的咪唑啉啶在有机合成中的应用研究，国家青年科学基金，2006-2008，26万元。 3．新型Tripodal氧杂、氮杂醚类化合物的构建以及对阳离子的选择性识别研究，国家自然科学基金，2008-2010，28万元。 4．山西省高校青年科技带头人，山西省教育厅，2009，10万元。 5．咪达那新的新工艺开发研究，太原市科技局项目，2010-2011，10万元。 6．罗丹明传感器的设计、合成及在离子传感、生物细胞中离子成像方面的应用，国家自然科学基金，2011-2011，12万元。 7．新型罗丹明传感器的设计、合成及在离子传感、细胞成像方面的应用，教育部博士点基金，2011-2013，6万元。 8．山西大学英才计划，山西大学，2011，8万元。 9．新世纪优秀人才支持计划，教育部，2011，50万元。 10．通键能量转移（TBET）近红外荧光功能分子的构建及化学传感研究，国家自然科学基金，2012-2015，65万元。 11.一氧化氮其下游产物过氧亚硝基新型有机荧光探针的构建及生物传感研究，国家自然科学基金，2016.01-2019.12，70万元。 12.“分子发光与生物传感”基础研究提升计划，山西省教育厅1331工程重点学科建设计划-2017年度一般性重点，2017.

近期论文

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62.YingyingHuo,JunfengMiao,LingjunHan,YapingLi,ZheLi,YaweiShi,andWeiGuo*;SelectiveandSensitiveVisualizationofEndogenousNitricOxideinLivingCellsandAnimalsbyaSi-RhodamineDeoxylactam-BasedNear-InfraredFluorescentProbe;Chem.Sci.,2017,DOI:10.1039/c7sc02608k. 61.HongxingZhang,JingLiu,ChenluLiu,PengchengYu,MinjiaSun,XiaohanYan,Jian-PingGuo,WeiGuo*;ImaginglysosomalhighlyreactiveoxygenspeciesandlightingupcancercellsandtumorsenabledbyaSi-rhodamine-basednear-infraredfluorescentprobe;Biomaterials,2017,133,60-69. 60.YunZhao*,YuanyuanXue,HaoyangLi,RuitaoZhuYuehongRen,QinghuaShi,SongWang,WeiGuo*;Anexcitedstateintramolecularprotontransferdyebasedfluorescenceturn-onprobeforfastdetectionofthiolsanditsapplicationsinbioimaging;Spectrochim.Acta,PartA,2017,175,215-221. 59.YueWang,XinLv*,WeiGuo**;Areaction-basedandhighlyselectivefluorescentprobeforhydrogensulfide;DyesandPigments,2017,139,482-486. 58.YingyingHuo,JunfengMiao,YapingLi,YaweiShi,HepingShiandWeiGuo*;Aromaticprimarymonoamine-basedfast-responseandhighlyspecificfluorescentprobesforimagingthebiologicalsignalingmoleculenitricoxideinlivingcellsandorganisms;J.Mater.Chem.B,2017,5,2483-2490. 57.JunfengMiao,YingyingHuo,QianLiu,ZheLi,HepingShi,YaweiShi,andWeiGuo*;Anewclassoffast-responseandhighlyselectivefluorescentprobesforvisualizingperoxynitriteinlivecells,subcellularorganelles,andkidneytissueofdiabeticrats;Biomaterials,2016,107,33-43. 56.JunfengMiao,YingyingHuo,XinLv,ZheLi,HualiangCao,HepingShi,YaweiShi,andWeiGuo*;Fast-responseandhighlyselectivefluorescentprobesforbiologicalsignalingmoleculeNObasedonN-nitrosationofelectron-richaromaticsecondaryamines;Biomaterials,2016,78,11. 55.JingLiu,Yuan-QiangSun,HongxingZhang,HepingShi,YaweiShi,andWeiGuo*;Sulfone-Rhodamines:ANewClassofNear-InfraredFluorescentDyesforBioimaging;ACSAppliedMaterials&Interfaces.2016,8,22953. 54.JianZhang,YapingLi,JingjingZhao,andWeiGuo*;Anarylboronate-basedfluorescentprobeforselectiveandsensitivedetectionofperoxynitriteanditsapplicationsforfluorescenceimaginginlivingcells;SensorsandActuatorsB,2016,237,67–74. 53.YueWangAuthorVitae,YaweiLiuAuthorVitae,JunfengMiao,MinghaoRen,WeiGuoAuthorVitae,XinLv*;AnovelBodipy-basedfluorescentprobeforAu3+ionswithhighselectivityanditsapplicationtobioimaging;SensorsandActuatorsB,2016,226,364–369. 52.YunZhao,YuehongRen,HaoyangLi,TaiheHan,HuanhuanChen,WeiGuo*;Anewfar-rednaphthorhodaminedye:Synthesis,fluorescentprobeandbioimagingapplications;DyesandPigments,2016,132,255-261. 51.YaweiLiu,XinLv,MinHou,YaweiShi,andWeiGuo*;SelectiveFluorescenceDetectionofCysoverHcyandGSHBasedonaCys-TriggeredDualMichaelAddition/Retro-aza-aldolCascadeReaction;Anal.Chem.,2015,87,11475. 50.YaweiLiu,XinLv,JingLiu,Yuan-QiangSun,andWeiGuo*;ConstructionofaSelectiveFluorescentProbeforGSHBasedonaChloro-functionalizedCoumarin-enoneDyePlatform;Chem.Eur.J.,2015,21,4747. 49.HongxingZhang,JingLiuYuan-QiangSun,YingyingHuo,YaohuaLi,WeizhiLiu,XiaoWu,NishuZhu,YaweiShi,andWeiGuo*;AMitochondria-TargetableFluorescentProbeforPeroxynitrite:FastResponseandHighSelectivity;Chem.Commun.,2015,51,2721. 48.XinLv,YueWang,SongZhang,YaweiLiu,JianZhangandWeiGuo*;AspecificfluorescentprobeforNObasedonanewNO-bindinggroup;Chem.Commun.,2014,50,7499. 47.Yuan-QiangSun,§JingLiu,HongxingZhang,YingyingHuo,XinLv,YaweiShi,andWeiGuo*;AMitochondria-TargetableFluorescentProbeforDual-ChannelNOImagingAssistedbyIntracellularCysteineandGlutathione;J.Am.Chem.Soc.,2014,136,12520. 46.YaweiLiu,SongZhang,XinLv,Yuan-QiangSun,JingLiu,andWeiGuo*;Constructingfluorescentprobeforspecificdetectionofcysteineoverhomocysteineandglutathionebasedonanovelcysteine-bindinggroupbut-3-yn-2-one;Analyst,2014,139,4081. 45.JingLiu,Yuan-QiangSun,YingyingHuo,HongxingZhang,LinfangWang,PeiZhang,YaweiShi,andWeiGuo*;SimultaneousFluorescenceSensingofCysandGSHfromDifferentEmissionChannels;J.Am.Chem.Soc.,2014,136,574. 44.JingLiu,Yuan-QiangSun,HongxingZhang,YingyingHuo,YaweiShi,HepingShi,andWeiGuo*;ACarboxylicacid-FunctionalizedCoumarin-HemicyanineFluorescentDyeandItsApplicationtoConstructaFluorescentProbeforSelectiveDetectionofCysteineoverHomocysteineandGlutathione;RSCAdv.,2014,4,64542. 43.JingLiu,Yuan-QiangSun,HongxingZhang,YingyingHuo,YaweiShi,andWeiGuo*;SimultaneousFluorescentImagingofCys/HcyandGSHfromDifferentEmissionChannels;Chem.Sci.,2014,5,3183. 42.JingyuZhangandWeiGuo*;AnewfluorescentprobeforgasotransmitterH2S:highsensitivityandselectivity,andasignificantfluorescenceoff–onresponse;Chem.Commun.,2014,50,4214. 41.JingyuZhang,Yuan-QiangSun,JingLiu,YaweiShiandWeiGuo*;AfluorescentprobeforthebiologicalsignalingmoleculeH2SbasedonaspecificH2Strapgroup;Chem.Commun.,2013,49,11305. 40.JingLiu,Yuan-QiangSun,PiWang,JingyuZhangandWeiGuo*;ConstructionofNIRandRatiometricFluorescentProbeforHg2+BasedonaRhodamine-InspiredDyePlatform;Analyst,2013,138,2654. 39.JingLiu,Yuan-QiangSun,JingyuZhang,TingYang,JianbinCao,LishenZhang,andWeiGuo*;ARatiometricFluorescentProbeforBiologicalSignalingMoleculeH2S:FastResponseandHighSelectivity;Chem.Eur.J.,2013,19,4717. 38.Yuan-QiangSun,zaJingLiu,zaJingyuZhang,aTingYangbandWeiGuo*;FluorescentprobeforbiologicalgasSO2derivativesbisulfiteandsulfite;Chem.Commun.,2013,49,2637. 37.JingLiu,Yuan-QiangSun,XinLv,andWeiGuo*;Fluorescentdetectionofbiothiolsbasedonanovelcascadereaction;Anal.Methods,2013,5,3642. 36.Yuan-QiangSun,PiWang,JingLiu,JingyuZhangandWeiGuo*;Afluorescentturn-onprobeforbisulfitebasedonhydrogenbond-inhibitedC=Nisomerizationmechanism;Analyst,2012,137,3430. 35.Yuan-QiangSun,JingLiu,PiWang,JingyuZhang,andWeiGuo*;D-LuciferinAnalogues:aMulticolorToolboxforBioluminescenceImaging;Angew.Chem.Int.Ed.,2012,51,8428. 34.Yuan-QiangSun,JingLiu,XinLv,YunlongLiu,YunZhao,andWeiGuo*;Rhodamine-InspiredFar-RedtoNear-InfraredDyesandTheirApplicationasFluorescenceProbes;Angew.Chem.Int.Ed.2012,51,7634. 33.YunZhao,XinLv,YunlongLiu,JingLiu,YanZhang,HepingShi,andWeiGuo*;TheemissionenhancementoftheNIRdistyrylBodipydyesbytheindirectedS0→S2excitationanditsapplicationtowardsHg2+probe;J.Mater.Chem.2012,22,11475. 32.XianshuZhou,XinLv,JunshengHao,DianshengLiu,WeiGuo*;Coumarin-indanedioneconjugateasadoublyactivatedMichaeladditiontypeprobeforthecolorimetricandratiometricfluorescentdetectionofcyanide;DyesandPigments2012,95,168. 31.XianshuZhou,HengquanYang,JunshengHao,CaixiaYin,DianshengLiu,*andWeiGuo*;AFluorescenceTurn-onSensorforCN￣BasedonExciplexSignalingMechanism;Chem.Lett.2012,41,518. 30.PiWang,JingLiu,XinLv,YunlongLiu,YunZhao,andWeiGuo*;ANaphthalimide-basedGlyoxalHydrazoneforSelectiveFluorescenceTurn-onSensingofCysandHcy;Org.Lett.2012,14,520. 29.YunlongLiu,XinLv,YunZhao,MaliangChen,JingLiu,PiWangandWeiGuo*;Anaphthalimide-rhodamineratiometricfluorescentprobeforHg2+basedonfluorescenceresonanceenergytransfer;DyesandPigments2012,92,909. 28.YunlongLiu,XinLv,YunZhao,JingLiu,Yuan-QiangSun,PiWangandWeiGuo*;ACu(II)-basedchemosensingensemblebearingrhodamineBfluorophoreforfluorescenceturn-ondetectionofcyanide;J.Mater.Chem.2011,22,1747. 27.XinLv,JingLiu,YunlongLiu,YunZhao,Yuan-QiangSun,PiWangandWeiGuo*;Ratiometricfluorescentdetectionofcyanidebasedahybridcoumarin-hemicyaninedye:thelargeemissionshiftandthehighselectivity;Chem.Commun.2011,47,12843. 26.Yuan-QiangSun,MaliangChen,JingLiu,XinLv,Jun-feiLiandWeiGuo*;Nitroolefin-basedcoumarinasacolorimetricandfluorescentdualprobeforbiothiols;Chem.Commun.2011,47,11029. 25.YunZhao,YanZhang,XinLv,YunlongLiu,MaliangChen,PiWang,JingLiuandWeiGuo*;Through-bondenergytransfercassettesbasedoncoumarin-bodipy/distyrylbodipysdyadswithefficientenergyefficiencesandlargepseudo-Stokes’shift;J.Mater.Chem.2011,21,13168. 24.XinLv,JingLiu,YunlongLiu,YunZhao,MaliangChen,PiWangandWeiGuo*;Rhodafluor-basedChromo-andFluorogenicProbeforCyanideAnion;SensorsandActuatorsB2011,158,405. 23.XinLv,JingLiu,YunlongLiu,YunZhao,MaliangChen,PiWangandWeiGuo*;ARatiometricFluorescentProbeforCyanideBasedonFRET;Org.Biomol.Chem.2011,9,4954. 22.MaliangChen,XinLv,YunlongLiu,YunZhao,JingLiu,PiWangandWeiGuo*;An2-(2'-aminophenyl)benzoxazole-basedOFF-ONfluorescentchemosensorforZn2+inaqueoussolution;Org.Biomol.Chem2011,9,2345. 21.YunlongLiu,YueSun,JunDu,XinLv,YunZhao,MaliangChen,PiWang,andWeiGuo*;HighlySensitiveandSelectiveTurn-onFluorescentandChromogenicProbeforCu2+andClOˉBasedonaN-PicolinylRhodamineB-HydrazideDerivative;Org.Biomol.Chem.2011,9,432. 20.YunZhao,YueSun,XinLv,YunlongLiu,MaliangChen,andWeiGuo*;Rhodamine-basedchemosensorforHg2+inaqueoussolutionwithabroadpHrangeanditsapplicationinlivecellimaging;Org.Biomol.Chem.2010,8,4143. 19.YueSun,YunlongLiu,MaliangChenandWeiGuo*;Anovelfluorescentandchromogenicprobeforcyanidedetectioninwaterbasedonthenucleophilicadditionofcyanidetoiminegroup;Talanta2009,80,996. 18.YueSun,YunlongLiuandWeiGuo*;Fluorescentandchromogenicprobesbearingsalicylaldehydehydrazonefunctionalityforcyanidedetectioninaqueoussolution;SensorsandActuatorsB2009,143,171. 17.YongbinZhang,GuofuZhou,DonghongLi,WeiGuo*;TetrahydropyrimidineDerivativesasEfficientOrganicReductantsforTransferHydrogenation;Heterocycles,2009,78,1541. 16.YueSun,Guofeng,Wang,WeiGuo*;ColorimetricDetectionofCyanidewithN-NitrophenylBenzamideDerivatives;Tetrahedron,2009,65,3480. 15.DonghongLi,YongbinZhang,GuofuZhou,WeiGuo*;1-Acetyl-2,3-Dimethylimidazolidine:anNovelOrganicReductantforTransferHydrogenation;Synlett,2008,2,225. 14.YongbinZhang,DonghongLi,GuofuZhou,ChizhongXia,WeiGuo*;SynthesisofFunctionalizedb-EnaminoCompoundsbyCarbon-FragmentTransferReactionofC(2)-SubstitutedImidazolidineswithAmines;Heterocycles,2008,75,1123. 13.ZhengangWu,GuofuZhou,JieyuZhou,WeiGuo*;Aza-Baylis-HillmanReactionofN-TosylatedImineswithAcrylamideorN-Arylacrylamide;Synthetic.Commun.2006,36,2491. 12.YongbinZhang,DonghongLi,ChizhongXia,WeiGuo*;1-(3-Nitro-Benzenesulfonyl)-3,4-DimethylimidazoliniumIodide:AMoreActiveTetrahydrofolateCoenzymeModel;Heterocycles2005,65,2893. 11.DonghongLi,YongbinZhang,ChizhongXia,WeiGuo*;AConvenientPreparationofaSeriesof2-Aryl-SubstitutedImidazolidinesThroughDiamineTransferReaction;Heterocycles2005,65,1829. 10.DonghongLi,YongbinZhang,WeiGuo*;SynthesisofFunctionalizedTetrahydro-β-carbolineDerivativesbyModifiedPictet-SpenglerReaction;Heterocycles2005,65,1063. 9.WeiGuo,XuelingMi,JingWang,Jiaqi,He,andJin-PeiCheng*;C–H···OHydrogenBondingAssistedSelf-assemblyofBiphenyl-bridged,AminoAcid-basedMacrocycles;ChemicalJournalofChineseUniversity，2005,26,1086. 8.WeiGuo*,WeiweiWu,NingjuanFan,ZhengangWu,ChizhongXia;Synthesisofa-SubstitutedN-ArylAcryamideDerivativesthroughBaylis-HillmanReaction;SyntheticCommun.2005,35,1239. 7.WeiGuo*,JunfeiLi,NingjuanFan,PeiwenZhou,andChizhongXia;ASimpleandEffectiveMethodforChemoselectiveEsterificationofPhenolicAcids;SyntheticCommun.2005,35,145. 6.DonghongLi,JunshengHao,BingDeng,WeiGuo,FangjunHuo,YongbingZhang,ChizhongXia*;AConvenientSynthesisof1-Tosyl-3,4-DimethylImidazoliumSaltandN,N,N1-TrisubstitutedEthylendiamineDerivatives;SyntheticCommun.2004,34,3535. 5.DonghongLi,JunshengHao,WeiGuo*;AGeneralandEfficientMethodforSynthesisofFunctionalizedEthylenediamineDerivatives;Heterocycles2004,63,2515. 4.WeiGuo,JingWang,JiaqiHe,ZuchengLi,andJin-PeiCheng*;Polymethylene-bridgedCystine-glycine-containingCyclopeptidesasHydrogen-bondingElectroneutralAnionReceptor:Design,Synthesis,andHalideIonRecognitionResearch;Supramol.Chem.2004,16,171. 3.WeiGuo,JiaqiHe,ZuchengLi,Jin-PeiCheng*;Chain-likeassemblyofthreonine-basedcyclophanesthroughp-pinteractionandC-H×××Ohydrogenbond;TetrahedronLett.,2004,45,5763. 2.WeiGuo,JingWang,JiaqiHe,ChizhongXia,andJin-PeiCheng*;NicotinoylDisubstitutedPseudo-Cyclopeptide:SynthesisandCoordinationBehaviorwithCu(II)”;ChemicalJournalofChineseUniversity，2003,24,837. 1.WeiGuo,Jingwang,ChunWang,JiaqiHe,XiwenHe,andJin-PeiCheng*;Design,synthesis,andenantiomericrecognitionofdicyclodipeptide-bearingcalix[4]arenas:apromisingfamilyforchiralgassensorcoatings;TetrahedronLett.,2002,43,5665.