研究领域
肿瘤及代谢性疾病在表观遗传(组)学的变化及天然产物的干预，同时也进行药动-药效学在临床前和临床的研究。
近年来参与或主持课题：
1.姜黄素表观调控抗肿瘤研究机理（扬州大学高层次人才科研启动基金137011474，主持）
2.参加以下NIH研究项目：
1)EpigeneticmodificationsbydietaryPEITCinprostatecancer(R01-CA118947)fundedbyNationalCancerInstitute(NCI),2006-2016已结题(http://www.rdatlas.com/portal/portal.cfm?page=grants&applicationid=8841323),over3M
2)Prostatecancerpreventionbytocopherols(R01-CA152826)fundedbyNCI,(https://projectreporter.nih.gov/project_info_description.cfm?aid=8848785&icde=0)$320,637for5years,2011-2017已结题
3)PreventionofskincancerbyphytochemicalsviaNrf2andepigenetics(R01-CA200129)fundedbyNCI,(https://projectreporter.nih.gov/project_info_description.cfm?aid=9207083&icde=0)$354,563for5years,2016-2020未结题
4)Epigeneticmechanismsofindole-3-carbinol/diindolylemthaneandtriterpenoidsinpreventionofprostateinflammationandrelateddisease(R01-AT009152)fundedbytheNationalCenterforComplementaryandIntegrativeHealth(NCCIH)(http://www.rdatlas.com/portal/portal.cfm?page=grants&applicationid=9120455),$666,025for5years,2015-2019未结题
5)CurcumaLonga:epigeneticeffectsinprostateandcoloncancer(R01-AT007065)fromNCCIH(https://projectreporter.nih.gov/project_info_description.cfm?aid=9122322&icde=0),$463,811for5years，2012-2018未结题
3.口服姜黄素的健康人群药物代谢动力学及药效学（Rutgers大学及附属医院的联合临床药学研究课题,联合主持，2016-2018，排名第三）
4.饮茶与高血压流行病学研究(新加坡中医学院STCM2013-1，2013-2014主持)
5.筛选及评价当地中药提取物抗氧化活性（马来西亚MSU启动资金SG-090-1111-HS，2011-2013主持)
6.使用面向实验设计法(DOE)优化筛选当地草药提取物的降糖最优组合(马来西亚MSU启动资金SG-141-1112-HS,2011-2013,主持)
近期论文
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1.DavidCheng#,WenjiLi#,LujingWang#,TiffanyLin,GeorgePoianid,AndrewWassef,RasikaHudlikara,PatriciaOndare,LuigiBrunettia,andAh-NgKong,*Pharmacokinetics,pharmacodynamicsandPKPDmodelingofcurcumininregulatingantioxidantandepigeneticgeneexpressioninhumanhealthyvolunteers(#,equalcontribution.MolecularPharmaceutics.2019Mar12.doi:10.1021/acs.molpharmaceut.8b01246.[Epubaheadofprint])
2.NasserAlhajj,ZablizaZakaria,IdanawatiNaharudin,FakhrulAhsan,WenjiLi*,TinWuiWong*.Criticalphysicochemicalattributesofchitosannanoparticlesadmixedlactose-PEG3000microparticlesinpulmonaryinhalation.(*,correspondingauthor.AsianJournalofPharmaceuticalSciences(2019,accepted)).
3.RuomingFang,RenyiWu,QianZuo,RanYin,ChengyueZhang,ChaoWang,YueGuo,AnneYuqingYang,WenjiLi,LizhuLinandAh-NgKong.SophoraflavescensContaining-QYJDFormulaActivatesNrf2Anti-OxidantResponse,BlocksCellularTransformationandProtectsAgainstDSS-InducedColitisinMouseModel.(TheAmericanJournalofChineseMedicineVol.46,No.07,pp.1609-1623(2018))
4.WenjiLi#,HillyYang#,BrianBuckley,LujingwangandAh-NgKong.ANovelTripleStageIonTrapMSmethodvalidatedforcurcuminpharmacokineticsapplication:acomparisonsummaryofthelatestvalidatedcurcuminLC/MSmethods.(#,equalcontribution,JournalofPharmaceuticalandBiomedicalAnalysisVolume156,2018July15;156:116-124.doi:10.1016/j.jpba.2018.04.022.Epub2018Apr17.PMID:29702389DOI:10.1016/j.jpba.2018.04.022)
5.YueGuo,RenyiWu,JohnM.Gaspar,DavitSargsyan,Zheng-YuanSu,ChengyueZhang,LinboGao,DavidCheng,WenjiLi,ChaoWang,RanYin,MingzhuFang,MichaelP.Verzi,RonaldP.Hart,andAh-NgKong.DNAMethylomeandTranscriptomeAlterationsandCancerPreventionbyCurcumininColitis-acceleratedColonCancerinMice.(Carcinogenesis.2018May3;39(5):669-680.doi:10.1093/carcin/bgy043)
6.LinboGao,DavidCheng,JieYang,RenyiWu,WenjiLi,Ah-NgKong.SulforaphaneepigeneticallydemethylatestheCpGsitesofthemiR-9-3promoterandreactivatesmiR-9-3expressioninhumanlungcancerA549cells.(TheJournalofNutritionalBiochemistry.2018Jun;56:109-115.doi:10.1016/j.jnutbio.2018.01.015.Epub2018Feb9.)
7.ChaoWang,LiminShu,ChengyueZhang,WenjiLi,RenyiWu,YueGuo,YuqingYang,Ah-NgKong.HistoneMethyltransferaseSetd7RegulatesNrf2SignalingPathwaybyPhenethylIsothiocyanateandUrsolicAcidinHumanProstateCancerCells.(MolecularNutrition&FoodResearch.2018Sep;62(18):e1700840.doi:10.1002/mnfr.201700840.Epub2018Mar6.)
8.WenjiLi#,YingHuang#,DavitSargsyan,TinOoKhor,YueGuo,LiminShu,AnneYuqingYang,ChengyueZhang,XimenaParedes-Gonzalez,MichaelVerzi,RonaldPHart,andAh-NgKong.EpigeneticalterationsinTRAMPmice:genomicDNAmethylationprofilingusingMeDIP-seq.(#,equalcontribution,Cell&Bioscience2018Jan12;8:3.doi:10.1186/s13578-018-0201-y.eCollection2018.)
9.WenjiLi,Zheng-YuanSu,YueGuo,ChengyueZhang,RenyiWu,LinboGao,XiZheng,Zhi-YunDu,KunZhang,andAh-NgTonyKong.CurcuminDerivativeEpigeneticallyReactivatesNrf2AntioxidativeStressSignalinginMouseProstateCancerTRAMPC1Cells.(ChemicalResearchinToxicology2018Feb19;31(2):88-96.doi:10.1021/acs.chemrestox.7b00248.Epub2018Jan8.)
10.ChengyueZhang,ChaoWang,WenjiLi,RenyiWu,YueGuo,DavidCheng,YuqingYang,Ioannis,AndroulakisAndAh-NgKong.Pharmacokineticsandpharmacodynamicsofthetriterpenoidursolicacidinregulatingtheanti-oxidant,anti-inflammatoryandepigeneticgeneresponsesinratleukocytes.(MolecularPharmaceutics,2017Nov6;14(11):3709-3717.doi:10.1021/acs.molpharmaceut.7b00469.Epub2017Oct25.)
11.ChristinaN.Ramirez#,WenjiLi#,ChengyueZhang,RenyiWu,ShanSu,ChaoWang,LinboGao,andAh-NgKong.Invitro-invivodoseresponseofursolicacid,sulforaphane,PEITC,andcurcuminincancerprevention.(#,equalcontribution,AAPSJ.2017Dec20;20(1):19.doi:10.1208/s12248-017-0177-2.)
12.JieYang,RenyiWu,WenjiLi,LinboGao,YuqingYang,PingLi,Ah-NgKong.ThetriterpenoidcorosolicacidblockstransformationandepigeneticallyreactivatesNrf2inTRAMP-C1prostatecells.(MolecularCarcinogenesis2018Apr;57(4):512-521.doi:10.1002/mc.22776.Epub2018Jan11.)
13.HaixueKuang,ZhenqiuTang,ChengyueZhang,ZhibinWang,WenjiLi,ChunjuanYang,QiuhongWang,BingyouYangandAh-NgKong.TaxifolinActivatestheNrf2Anti-OxidativeStressPathwayinMouseSkinEpidermalJB6P+CellsthroughEpigeneticModifications.(InternalJournalofMolecularSciences2017,18(7),1546;doi:10.3390/ijms18071546)
14.WenjiLi,YueGuo,ChengyueZhang,RenyiWu,AnneYuqingYang,JohnGaspar,andAh-NgTonyKong.Dietaryphytochemicalsandcancerchemoprevention:Aperspectiveonoxidativestress,inflammationandepigenetics.(ChemicalResearchinToxicology.2016Dec19;29(12):2071-2095.DOI:10.1021/acs.chemrestox.6b00413)
15.YuqingYang,FranciscoFuentes,LiminShu,ChaoWang,DougPung,WenjiLi,ChengyueZhang,YueGuo,Ah-NgKong.EpigeneticCpGMethylationofthePromoterandReactivationoftheExpressionofGSTP1byAstaxanthininHumanProstateLNCaPCells(AAPSJournal.2017Mar;19(2):421-430.doi:10.1208/s12248-016-0016-x.Epub2016Dec2.)
16.SarandeepS.S.Boyanapalli#,WenjiLi#,FranciscoFuentes,YueGuo,ChristinaN.Ramirez,Ximena-ParadesGonzalez,DouglasPung,Ah-NgTonyKong.EpigeneticreactivationofRASSF1Abyphenethylisothiocyanate(PEITC)andpromotionofapoptosisinLNCaPcells.(#,equalcontribution,PharmacologicalResearch.2016Dec;114:175-184.doi:10.1016/j.phrs.2016.10.021.Epub2016Nov3)
17.YueGuo,YueLiu,ChengyueZhang,Zheng-YuanSu,WenjiLi,Mou-TuanHuang,andAh-NgTonyKong.Theepigeneticeffectsofaspirin:themodificationofhistoneH3lysine27acetylationinthepreventionofcoloncarcinogenesisinazoxymethane-anddextransulfatesodium-treatedCF-1mice.(Carcinogenesis.2016Jun;37(6):616-24.doi:10.1093/carcin/bgw042.Epub2016Apr9.)
18.WenjiLi#,DougPung#,Zheng-YuanSu,YueGuo,ChengyueZhang,AnneYuqingYang,XiZheng,Zhi-YunDu,KunZhang,andAh-NgKong.EpigeneticsReactivationofNrf2inProstateTRAMPC1CellsbyCurcuminAnalogueFN1.(#,equalcontribution,ChemicalResearchinToxicology.2016Apr18;29(4):694-703.doi:10.1021/acs.chemrestox.6b00016.Epub2016Mar29)
19.AnneYuqingYang,HyuckKim,WenjiLi,andAh-NgTonyKong.Naturalcompound-derivedepigeneticregulatorstargetingepigeneticreaders,writersanderasers.(CurrentTopicsinMedicinalChemistry.2016;16(7):697-713.)
20.ChengyueZhang,LiminShu,HyuckKim,TinOoKhor,RenyiWu,WenjiLi,andAh-NgTonyKong.Phenethylisothiocyanate(PEITC)suppressesprostatecancercellinvasionepigeneticallythroughregulatingmicroRNA-194.(MolecularNutrition&FoodResearch.2016Jun;60(6):1427-36.doi:10.1002/mnfr.201500918.Epub2016May17.)
21.WenjiLi*,JiaYang,XiaoshuZhu,Shu-chuenLiandPaulC.Ho.CorrelationbetweenteaconsumptionandprevalenceofhypertensionamongSingaporeanChineseresidentsaged⩾40years.(JournalofHumanHypertension.2016Jan;30(1):11-7.DOI:10.1038/jhh.2015.45.Epub2015May28.*,correspondingauthor)
22.YingHuang#,WenjiLi#,Zheng-yuanSu,Ah-NgTonyKong.ThecomplexityoftheNrf2pathway:Beyondtheantioxidantresponse.(#,equalcontribution,JournalofNutritionalBiochemistry,2015Dec;26(12):1401-13.doi:10.1016/j.jnutbio.2015.08.001.Epub2015Aug8.)
23.YueGuo,JongHunLee,LiminShu,YingHuang,WenjiLi,ChengyueZhang,AnneYuQingYang,SarandeepS.S.Boyanapalli,AnsuPerekatt,RonaldPHart,MichaelVerziandAh-NgTonyKong.AssociationofaberrantDNAmethylationinApcmin/+micewiththeepithelial-mesenchymaltransitionandWnt/beta-cateninpathways:genome-wideanalysisusingMeDIP-seq.(Cell&Bioscience2015May27;5:24.doi:10.1186/s13578-015-0013-2.)
24.WenjiLi,Ka-yunNg,PaulWSHeng.DevelopmentandEvaluationOfOptimizedSucroseEsterStabilizedNanosuspensionsOfOleanolicAcidViaWetBallMillingByDesignOfExperiments(DOE).(Biological&Pharmaceuticalbulletin,2014;37(6):926-37.)
25.WenjiLi,SurajitDas,Ka-yunNg,PaulWSHeng.Formulation,BiologicalAndPharmacokineticStudyOfASucroseEsterStabilizedNnanosuspensionsOfOleanolicAcid.(PharmaceuticalResearch2011Aug;28(8):2020-33.doi:10.1007/s11095-011-0428-3.Epub2011Apr9.)
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