张敏 - 重庆大学 - 药学院(创新药物研究中心)

个人简介

1999.9-2003.7, Sichuan University, majored in Pharmacy, B.S. (Supervisor: Prof. Yong Qin) 2003.9-2009.7, Sichuan University, majored in Medicinal Chemistry, Ph. D. (Supervisor: Prof. Yong Qin) 2009.9-2013.8, University of Wisconsin, Madison, Pharmaceutical Sciences, Postdoctoral Fellow (Supervisor: Prof. Weiping Tang) 2013.7-present, Chongqing University, Professor Awards and Grants Class AII of the Chongqing Talents (2021) Class III of the High-Level Talents of Chongqing (2020) First Prize of Outstanding Paper Awards of the 1st Sichuan-Chongqing Science&Technology Conference (2020) NSF Excellent Young Scientists Fund (2019) Asian Core Program Lectureship Award (Hongkong, 2019) Chongqing Excellent Doctoral Dissertation Award (Supervisor, 2019) First Prize of the Natural Science Award of Ministry of Education (with Qin, 2017) Nomination Prize of the National Excellent 100 Doctoral Dissertations (2012).

研究领域

The Zhang Research Group focuses on developing new methods and strategies to assemble simple chemical feedstocks into natural products with important bioactivities, and on developing therapeutics for the treatment of various human illnesses such as cancer, infectious diseases, and metabolic diseases. Organic Synthesis; Drug Discovery; Medicinal Chemistry; Chemical Biology.

近期论文

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Zhou, W.; Zhou, T.; Tian, M.; Jiang, Y.; Yang, J.; Lei, S.; Wang, Q.; Zhang, C.; Qiu, H.; He, L; Wang, Z.; Deng, J. Zhang, M.* Asymmetric Total Syntheses of Schizozygane Alkaloids. J. Am. Chem. Soc. 2021, 143, 19975–19982. Yang, Z.; Tan, Q.; Jiang, Y.; Yang, J.; Su, X.; Qiao, Z.; Zhou, W.; He, L.; Qiu, H.; Zhang, M.* Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids. Angew. Chem. Int. Ed. 2021, 60, 13105–13111. Zhang, Q.; Yang, Z.; Wang, Q.; Liu, S.; Zhou, T.; Zhao, Y.; Zhang, M.* Asymmetric Total Synthesis of Hetidine-Type C20-Diterpenoid Alkaloids: (+)-Talassimidine and (+)-Talassamine. J. Am. Chem. Soc. 2021, 143, 7088–7095. Xi, S.; Dong, J.; Chen, H.; Dong, Q.; Yang, J.; Tan, Q.; Zhang, C.; Lan, Y.*; Zhang, M.* Lewis acid-catalyzed domino generation/[2,3]-sigmatropic rearrangement of ammonium ylides to access chiral azabicycles. Science Advances, 2021, 7, eabd5290. Tan, Q.; Yang, Z.; Jiang, D.; Cheng, Y.; Yang, J.; Xi, S.; Zhang, M.* Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (-)-Suaveoline. Angew. Chem. Int. Ed. 2019, 58, 6420–6424. Xiong, Y.; Du, Z.; Chen, H.; Yang, Z.; Tan, Q.; Zhang, C.; Zhu, L.; Lan, Y.*; Zhang, M.* Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacry-lonitrile: A Combined Experimental and Theoretical Study. J. Am. Chem. Soc. 2019, 141, 961–971. Zhang, Q.; Zhang, Z.; Huang, Z.; Zhang, C.; Xi, S.; Zhang, M.* Stereoselective Total Synthesis of Hetisine-type C20-Diterpenoid Alkaloids: Spirasine IV and XI. Angew. Chem. Int. Ed. 2018, 57, 937–941. Tan, Q.; Wang, X.; Xiong, Y.; Zhao, Z.; Li, L.; Tang, P.; Zhang, M.* Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers. Angew. Chem. Int. Ed. 2017, 56, 4829–4833.