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Vitamin A PromotesLeydig Cell Differentiation via Alcohol Dehydrogenase 1 .Yan Yang， Jiao Luo，Dan Yu，Tiantian Zhang，Qilian Lin， Quan Li，Xupeng Wu， Zhijian Su， Qihao Zhang，Qi Xiang，Yadong Huang*, Frontiers inEndocrinology, 2018.10.29, 9: 644-644
Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRHandtestosterone in aging male mice. Jiao Luo, Yan Yang, Tiantian Zhang , Zhijian Su, Dan Yu, Qilian Lin, Haolin Chen, Qihao Zhang,Qi Xiang , Wei Xue, Renshan Ge, Yadong Huang*. EBioMedicine ，2018, 35: 295-306
Tat-haFGF14–154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1a/XBP1 Pathway.Tian Meng, Qin Cao, Peng Lei,Ashley I. Bush, Qi Xiang, Zhijian Su, Xiang He, Jack T. Rogers,Ing-Ming Chiu, Qihao Zhang, and Yadong Huang*.Molecular Therapy: Nucleic Acids,Vol. 7 June 2017,439-452
Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors.Yang Y, Li Z, Wu X, Chen H, Xu W, Xiang Q, Zhang Q, Chen J, Ge RS, Su Z, Huang Y*. Stem Cell Reports. 2016 Dec 20. pii: S2213-6711(16)30272-7. doi: 10.1016/j.stemcr.2016.11.010.
Intranasal TAT-haFGF Improves Cognition and Amyloid-β Pathology in an APP/PS1 Mouse Model of Alzheimer's Disease.Lou G, Zhang Q, Xiao F, Xiang Q, Su Z, Huang Y*.J Alzheimers Dis. 2016 Feb 10.
The 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against the insulin resistance and hepatic steatosis in db/db mice. Xiaohuan Yuan, Hongzhi Li, He Bai, Xiaojin Zhao, Chunlei Zhang, Haifeng Liu, Yufei Zhang,Binghai Zhao, Yan Wu, Jieting Liu, Qi Xiang, Biao Feng, Yanhui Chu,*,Yadong Huang*. Eur J Pharmacol. 2016 May 27. pii: S0014-2999(16)30349-1. doi: 10.1016/j.ejphar.2016.05.034
Prevention of gastrointestinal lead poisoning using recombinant Lactococcus lactis expressing human metallothionein-I fusion protein. Xue Xiao, Changbin Zhang, Dajun Liu, Weibin Bai, Qihao Zhang2, Qi Xiang2, Yadong Huang*， Zhijian Su*..Sci Rep. 2016 Apr 5;6:23716. doi: 10.1038/srep23716.
Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals.Ji X, Li Z, Chen H, Li J, Tian H, Li Z, Gao X, Xiang Q, Su Z, Huang Y*, Zhang Q*.Toxicology. 2015 Aug 6;334:22-32.
Directed mouse embryonic stem cells into leydig-like cells rescue testosterone-deficient male rats in vivo.Yang Y, Su Z, Xu W, Luo J, Liang R, Xiang Q, Zhang Q, Ge RS, Huang Y*.Stem Cells Dev. 2015 Feb 15;24(4):459-70.
Basic fibroblast growth factor promotes stem Leydig cell development and inhibits LH-stimulated androgen production by regulating microRNA expression. Liu H, Yang Y, Zhang L, Liang R, Ge RS, Zhang Y, Zhang Q, Xiang Q, Huang Y*, Su Z*.J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:483-91.
Jinmei Xu ,# Qi Xiang,# Junhui Su, Penghui Yang, Qihao Zhang, Zhijian Su,Fei Xiao and Yadong Huang*,Evaluation of the Safety and Brain-Related Tissues Distribution Characteristics of TAT-HaFGF via Intranasal Administration. Biol. Pharm. Bull.2014, 37(7) 1149–1157
Hao Hu , Qi Xiang, Hui Liu , Hongyan Qu, Xin Tang, Xue Xiao, Qihao Zhang , Zhijian Su, Yadong Huang*. Expression, purification, and biological activity of the recombinant pramlintide precursor. Appl Microbiol Biotechnol , 2014, 98:7837–7844
Hongxia Chen, Shuhua Li, Tian Meng, Lei Zhang, Taoli Dai, Qi Xiang, Zhijian Su, Qihao Zhang*, Yadong Huang*. HSP27 as a biomarker for predicting skin irritation in human skin andreconstructed organotypic skin model. Toxicology Letters ,2014,226: 124–131
Xiaohuan Yuan, Hongzhi Li, He Bai, Zhijian Su, Qi Xiang, Chaonan Wang,Binghai Zhao, Yufei Zhang, Qihao Zhang, Yanhui Chu*, Yadong Huang*, Synthesis of novel curcumin analogues for inhibition of 11-b-hydroxysteroid dehydrogenase type 1 with anti-diabetic Properties. European Journal of Medicinal Chemistry , 2014,77: 223-230
Intranasal administration of TAT-haFGF14-154 attenuates disease progression in a mouse model of Alzheimer's disease.Guofeng Lou, Qihao Zhangb, Qi Xiang, Zhijian Su, Hua Xu, Qing Zheng, Yinyu Li, Yan Yang, Yangyang Zhang, Yadong Huang* Neuroscience. 2012, 223: 225-237 .
NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration. Zhang L, Wang H, Yang Y, Liu H, Zhang Q, Xiang Q, Ge R, Su Z, Huang Y. Biochem Biophys Res Commun. 2013,436(2):300-305.
Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study. Zhang M, Qiu Z, Li Y, Yang Y, Zhang Q, Xiang Q, Su Z, Huang Y. Appl Microbiol Biotechnol. 2013 ,97(9):3913-3923.
Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli .Zhang MJ ,Jiang XB, Su ZJ, Lin JC,Xiang Q, Yang Z, Huang YD .Appl Microbiol Biotechnol. 2012, 93(2): 613-621 .
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