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个人简介

王钊教授是文革后恢复高考的第一批大学生,于1977年考入河南中医药大学临床医学院学习并于1982年12月获医学学士学位。之后于1984年在北京中医药大学基础医学院、1993年在日本国立冈山大学药学院和1996年在日本国立冈山大学研究生院分别获得医学硕士学位、药学硕士学位和药学博士学位。1996年至1998年受聘于日本国立冈山大学医学院药理学系任职助理教授。1998年作为引进人才从海外回国受聘到清华大学生命科学与工程研究院/生物科学与技术系(现生命科学学院)工作,2003年调入新成立的清华大学医学院工作,2015年转入新成立的清华大学药学院工作至今。期间在美国西奈山医学院小儿免疫学系做访问教授,并与俄勒冈健康与科学大学国家灵长类研究中心进行合作研究。 王钊教授曾任清华大学科研院院长助理。兼任清华大学天津高端装备研究院生物与医药装备研究所所长。

研究领域

王钊教授实验室一直致力于衰老生物学及相关药理学的研究。目前实验室的主要研究方向聚焦在: 分子细胞药理毒理学:药物尤其是天然药物的药理与毒理、神经药理、衰老药理、骨代谢与药物干预等; 衰老机制及药物干预的研究:尤其是脑衰老、骨衰老及药物对神经退行性疾病(老年痴呆、骨质疏松)等衰老相关疾病的研究; 天然药物与功能保健品的研究与开发。

近期论文

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Cong Cheng, Weiguang Li, Zheng Zhang, Shohei Yoshimura, Qinyu Hao, Chi Zhang and Zhao Wang*. MicroRNA-144 Is Regulated by Activator Protein-1 (AP-1) and Decreases Expression of Alzheimer’s Disease-related A Disintegrin And Metalloprotease 10 (ADAM10). J Biol Chem. In pr ess Lang Zhang, Qingyang Ding, Pan Wang, Zhao Wang*. An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene. Biochem Bioph Res Co. 430(1): 26-31 (2013) Lang Zhang, Qingyang Ding, Zhao Wang*.Nuclear Respiratory Factor 1 Mediates the Transcription Initiation of Insulin-Degrading Enzyme in a TATA Box-Binding Protein-Independent Manner. PLoS ONE. 7(8):e42035 (2012) Xueping Wu, Yongsheng Cheng, Tian Li, Zhao Wang, and Jin-Yuan Liu*. In vitro identification of DNA-binding motif for the new zinc finger protein AtYY1. Acta Biochim Biophys Sin (Shanghai). 44(6):483-9. (2012) Junwei Guo, Fangli Ren, Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, Hongxiu Ning, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu, Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. J Bone Miner Res.27 (7): 1607-18 (2012) Jiyong Zhang, Qiuying Luan, Yanze Liu, David Y-W Lee, Zhao Wang*. A Comparison of the Diastereoisomers, Silybin A and Silybin B, on the Induction of Apoptosis in K562 cells. Natural Product Communications. 6 (11) 1653-1656 (2011) Hui Zhu, Cong Cheng, Chi Zhang, Zhao Wang*. Echinacoside suppresses cellular senescence of human fibroblastic cells by down-regulation of p53. Journal of Chinese Pharmaceutical Sciences. 20 (5): 523-528 (2011) Xiaoyan Wang, Kenichi Harimoto, Sijie Xie, Hao Cheng, Jing Liu, Stephen Hinshaw, Zhijie Chang, Zhao Wang*. Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. J Bone Miner Res.26 (8): 1964-73 (2011) Xiaoyan WANG, Shangfeng LIU, Zhao WANG*. Pinctada fucata mantle gene 5 (PFMG5) from pearl oyster mantle inhibits osteoblast differentiation. Biosci Biotech Bioch. 75 (5): 991-993 (2011) Xiaoyan Wang, Shangfeng Liu, Liping Xie, Rongqing Zhang, Zhao Wang*. Pinctada fucata mantle gene 3 (PFMG3) promotes differentiation in mouse osteoblasts (MC3T3-E1).Comp Biochem Phys B. 158(2): 173-180 (2011) Huaqiang Cao*, Lu Zhang, He Zheng, and Zhao Wang*. Hydroxyapatite Nanocrystals for Biomedical Applications. J. Phys. Chem. C. 114: 18352–18357 (2010) Xiaoyan WANG, Kenichi HARIMOTO, Sijia XIE, Hao CHENG, Jing LIU, Zhao WANG*. Matrix Protein Biglycan Induces Osteoblast Differentiation through Extracellular Signal-Regulated Kinase and Smad Pathways. Biol. Pharm. Bull., 33(11): 1891-1897 (2010) Jing Du, Lang Zhang, Shubo Liu, Zhao Wang*. Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. Die Pharmazie. 65 (3): 231-232 (2010) Hong Xie, Hui Zhu, Cong Cheng, Yu Liang, Zhao Wang*. Echinacoside retards cellular senescence of human fibroblastic cells MRC-5. Die Pharmazie. 64 (11): 752-754 (2009) Jing Du, Lang Zhang, Zhao Wang*. Testosterone inhibits the activity of PPARg in a transcriptional transaction assay. Die Pharmazie. 64 (10): 692-693 (2009) Jianbin Yan, Chi Zhang, Min Gu, Zhiyan Bai, Weiguo Zhang, Tiancong Qi, Zhiwei Cheng, Wen Peng, Haibin Luo, Fajun Nan*, Zhao Wang*, and Daoxin Xie*. The Arabidopsis Coronatine Insensitive 1 Protein is a Jasmonate Receptor. Plant Cell. 21(8): 2220-2236 (2009) Jing Du, Junlei Chang, Songxi Guo, Qing Zhang, Zhao Wang*. ApoE4 Reduces the Expression of Ab degrading enzyme IDE by Activating the NMDA Receptor in Hippocampal Neurons. Neuroscience Letters.464 (2): 140-145 (2009) Jing Du, Zhao Wang*. Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease. Medical Hypotheses. 73 (5): 662-663 (2009) Hao Gao, Feng Zhao, Guo-Dong Chen, Shao-Dan Chen, Yang Yu, Zhi-Hong Yao, Brad W.C. Lau, Zhao Wang, Jin Li, Xin-Sheng Yao*. Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation. Phytochemistry. 70: 795-806 (2009) Jing Du, Bing Sun, Kui Chen, Li Fan, Zhao Wang*. Antagonist of Peroxisome Proliferator-activated Receptor Induces Cerebellar Amyloid- Levels and Motor Dysfunction in APP/PS1 Transgenic Mice. Biochem Bioph Res Co. 384 (3): 357-361 (2009)

学术兼职

中国药学会 高级会员 中国老年学学会衰老与抗衰老科学委员会 委员 中华中医药学会中成药分会 常务委员 中国药理学会 会员 中国癌症基金会鲜药学术委员会 副主任委员 《Pharmazie》 编委 《亚太传统医药》 编委 国家财政部科研项目预算 审评专家 国家自然科学基金委员会 评议专家 教育部留学回国基金 评审专家 国家食品药品监督管理局 药品(中药)/保健食品审评专家 《Journal of Pharmacological Sciences》 编委 《Food Science and Human Wellness》 编委

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