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个人简介

1996.09--2000.07河南师范大学生命科学学院,获理学学士学位,生物学专业。 2000.09--2005.09中国科学院遗传与发育生物学研究所发育生物学中心,硕博连读,从事植物遗传与发育研究,获理学博士学位,发育生物学专业。 2005.10--2008.02美国UniversityofCaliforniaSanFrancisco,DepartmentofMicrobiology&Immunology,博士后,从事蛋白质降解的机制研究。 2008.03--至今中国科学院成都生物研究所天然产物中心,从事化学生物学研究,副研究员(2008),研究员(2013),副主任(2014)。 2018.02--至今中国人民政治协商会议成都市第十五届委员会常务委员

研究领域

采用化学生物学的原理与方法,发现调控干扰素激活的JAK/STAT信号通路,雌激素的生物合成和代谢,RNAi信号通路和蛋白质泛素降解信号通路的天然产物化学小分子,研究其构效关系,以活性小分子为探针研究其作用机制,以期发现新的信号调控机制以及具有诊疗作用的药物前体; 探索新型蛋白质标记体系,实时动态的研究细胞膜受体在天然配体和化学小分子作用下的变化,以发现细胞膜受体的新的作用机制; 以骨质疏松为模型,研究中药治疗骨质疏松的物质基础和作用机制。

承担科研项目情况 分别主持: 《化学小分子调节RNAi信号途径》中科院成都生物所领域前沿项目; 《雌激素诱导的细胞膜表面结合的雌激素受体α的动态变化和信号终止机制研究》国家自然科学基金; 《调控干扰素信号途径的化学小分子的筛选和功能鉴定》中国科学院院长特别奖获得者项目启动基金和教育部留学回国人员启动基金; 《女贞子的综合利用与开发》中国科学院“西部之光”重点项目。 《蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究》国家自然科学基金面上项目 《基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用》中科院“西部之光”联合学者项目 作为项目主要研究人员,参与包括科技部973计划,国家自然科学基金重点项目和重大研究计划“基于化学小分子探针的信号转导过程研究”,中科院知识创新重点项目等国家级课题的研究。

近期论文

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1.JunliZhou,FeiWang,WenshiMa,YanshengZhang,BinHan,YongbiaoXue.StructuralandtranscriptionalanalysisofS-locusF-boxgenesinAntirrhinum.SexualPlantReproduction2003,16:165-177. 2.HongQiao*,FeiWang*,LanZhao*,JunliZhou,ZhaoLai,YanshengZhang,TimothyP.Robbins,andYongbiaoXue,TheF-boxproteinAhSLF-S2controlsthepollenfunctionofS-RNase-basedself-incompatibility,PlantCell,2004,16:2307-2322.(*equalcontribution) 3.杨笛笑,李麒麟,张国林,王飞,齐墩果醇-龙胆三糖苷雌激素样作用及其对肝癌HepG2细胞增殖的影响,天然产物研究与开发,2010,22:697-700 4.王玉梅,陈前锋,杨莉娟,王飞,女贞子对大鼠成骨细胞增殖与分化的影响,天然产物研究与开发,2011,23(2):232-235 5.LijuanYang,QianfengChen,FeiWang*,GuolinZhang*,AntiosteoporoticcompoundsfromseedsofCuscutachinensis,JournalofEthnopharmacology,2011,135:553-560.(*co-correspondingauthor) 6.WenchenPu,FeiWang,ChunWang,Bioactivitiesandsyntheticmethodsof2-arylbenzo[b]furans,ChineseJournalofOrganicChemistry,2011,31:155-165 7.XingWang,GuangyinLv,LijuanYang,FeiWang,ChunWang,Synthesisandselectiveestrogenreceptorbindingaffinityof7-hydroxylisoflavones,ChineseJournalofOrganicChemistry,2011,31:1245-1251. 8.ZhengfuTai,GuolinZhang,FeiWang*.IdentificationofsmallmoleculeactivatorsoftheJanuskinase/signaltransducerandactivatoroftranscriptionpathwayusingacell-basedscreening.Biological&PharmaceuticalBulletin,2012,35:65-71. 9.DanfengLu,LijuanYang,QilinLi,XiaopingGao,FeiWang*,GuolinZhang*.EgonolgentiobiosideandegonolgentiotriosidefromStyraxperkinsiaepromotethebiosynthesisofestrogenbyaromatase.EuropeanJournalofPharmacology,2012,691:275-282. 10.Dan-fengLu,Li-juanYang,FeiWang*,GuolinZhang*.Inhibitoryeffectofluteolinonestrogenbiosynthesisinhumanovariangranulosacellsbysuppressionofaromatase(CYP19).JournalofAgriculturalandFoodChemistry,2012,60:8411-8418. 11.QianfengChen,LijuanYang,GuolinZhang*,FeiWang*.Bioactivity-guidedisolationofantiosteoporoticcompoundsfromLigustrumlucidum.PhytotherapyResearch,2012,DOI:10.1002/ptr.4820. 12.LeiHua,YaLi,FeiWang,Dan-fengLu,KunGao.BiologicallyactivesteroidsfromtheaerialpartsofVernomiaanthelminticaWild.Fitoterapia,2012,83:1036-1041. 13.LijuanYang,DanfengLu,JiajiaGuo,XianliMeng,GuolinZhang*,FeiWang*.IcariinfromEpimediumbrevicornumMaximpromotesthebiosynthesisofestrogenbyaromatase(CYP19).JournalofEthopharmacology,2012.DOI:10.1016/j.jep.2012.11.031. 14.Han-weiLiu,Xiu-zhuYu,DanielePadula,GennaroPescitelli,Zhi-weiLin,FeiWang,KaiDing,MingLei,Jin-mingGao.LignansfromSchisandrasphenatheraRehd.etWils.andsemisyntheticschisantherinAanalogues:Absoluteconfiguration,andtheirestrogenicandanti-proliferativeactivity.EuropeanJournalofMedicinalChemistry,2013,59:265-273. 15.Pu-zhaoZhang,FeiWang,Li-juanYang,Guo-linZhang.PregnanealkaloidsfromSarcococcahookerianavar.digyna.Fitoterapia,2013,89:143-148. 16.YuanLin,FeiWang,Li-juanYang,ZeChun,Jin-kuBao,GuolinZhang*.Anti-inflammatoryphenanthrenederivativesfromstemsofDendrobiumdenneanum.Phytochemistry2013,95:242-251. 17.郭加加,黄君梅,王飞*。冰乙酸水解法提高女贞子提取物中红景天苷含量。《应用与环境生物学报》2013,19:723-726. 18.鲁丹枫,AzimovaBahtigulJovliqizi,张国林,王飞*。采用磁微粒酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型。《天然产物研究与开发》2013,25:27-30. 19.Jin-BaoXu,YuanLin,Shi-HuiDong,FeiWang,Jian-MinYue*.TrichinenlidesA-T,Mexcicanolide-TypeLimonoidsfromTrichiliasinensis.JournalofNaturalProducts2013,76:1872-1880. 20.ZhengfuTai,YuanLin,YujiaoHe,JunmeiHuang,JiajiaGuo,LijuanYang,GuolinZhang*,FeiWang*.LuteolinSensitizestheAntiproliferativeEffectofInterferonα/βbyActivationofJanusKinase/SignalTransducerandActivatorofTranscriptionPathwaySignalingthroughProteinKinaseA-MediatedInhibitionofProteinTyrosinePhosphataseSHP-2inCancerCells.CellularSignalling2013,DOI:10.1016/j.cellsig.2013.11.039. 21.BoyangHu,HaiZhang,XianliMeng,FeiWang*,PingWang*.Aloe-emodinfromrhubarb(Rheumrhabarbarum)inhibitslipopolysaccharide-inducedinflammatoryresponsesinRAW264.7macrophages.JournalofEthnopharmacology2014,153:846-853. 22.ChunyanYang,FuLi,BaowenDu,FeiWang*,MingkuiWang*.Isolationandcharacterizationofnewphenoliccompoundswithestrogenbiosynthesis-inhibitingandantioxidationactivitiesfromBroussonetiapapyriferaleaves.PLoSONE.2014.9:e94198. 23.JiajiaGuo,YunYuan,DanfengLu,BaowenDu,LiangXiong,JiangongShi,WanliLiu,LijuanYang,XiaohongYuan,GuolinZhang*,FeiWang*.Twonaturalproducts,trans-phytoland(22E)-ergosta-6,9,22-triene-3β,5α,8α-triol,inhibitthebiosynthesisofestrogeninhumanovariangranulosacellsbyaromatase(CYP19).ToxicologyandAppliedPharmacology.2014.DOI:10.1016/j.taap.2014.05.008. 24.LilingXu,GenLi,JingWang,YilinFan,ZhengpengWan,ShaosenZhang,SaminaShaheen,JingLi,LiWang,CaiYue,YanZhao,FeiWang,JosephBrzostowski,Ying-HuaChen,WenjieZheng,WanliLiu.ThroughanITIM-independentmechanismtheFcγRIIBblocksBcellactivationbydisruptingthecolocalizedmicroclusteringoftheBcellreceptorandCD19.JournalofImmunology2014,192:5179-5191. 25.袁韵,林之蔚,郭加加,王飞,袁小红。细胞膜结合的雌激素受体的特异性标记。《应用与环境生物学报》2014,20:227-232. 26.NilubonSornkaew,YuanLin,FeiWang,GuolinZhang,RatchanapornChokchaisiri,AilianZhang,KanjanaWongkrajang,ParichartSuebsakwong,PawineePiyachaturawat,ApichartSuksamrarn.DiarylheptanoidsofCurcumacomosawithInhibitoryEffectsonNitricOxideProductioninMacrophageRAW264.7Cells.NaturalProductCommunications2015,10:89-93. 27.YingyueZeng,JunyangYi,ZhengpengWan,KaiLiu,PingSong,AliciaChau,FeiWang,ZaiChang,WeidangHan,WenjieZheng,Ying-HuaChen,ChunyangXiong,WanliLiu.SubstratestiffnessregulatesB-cellactivation,proliferation,classswitch,andT-cell-independentantibodyresponsesinvivo.EuropeanJournalofImmunology2015,45:1621-1634. 28.CeLiu,XingWangZhao,LiLingXu,JunYangYi,SaminaShaheen,WeidongHan,FeiWang,WenjieZheng,ChenqiXu,WanliLiu.Anegative-feedbackfunctionofPKCintheformationandaccumulationofsignaling-activeBcellreceptormicroclusterswithinBcellimmunologicalsynapse.JournalofLeukocyteBiology2015,97:887-900. 29.ZhengpengWan,XiangjunChen,HaodongChen,QinghuaJi,YingjiaChen,JingWang,YiyunCao,FeiWang,JizhongLou,ZhuoTang,WanliLiu.TheactivationofIgM-orisotype-switchedIgG-andIgE-BCRexhibitsdistinctmechanicalforcesensitivityandthreshold.eLife2015,4:e06925. 30.邓腾,杨莉娟,罗国勇,李晟,杜宝文,王飞*。蛋白酪氨酸磷酸酶SHP2抑制剂体外筛选模型的建立及应用。《应用与环境生物学报》2015,21:602-606. 31.Wei-HuaWang,YinNian,Yu-JiaoHe,Luo-ShengWan,Ni-ManBao,Guo-LeiZhu,FeiWang*,Ming-huaQiu*.NewcycloartanetriterpenesfromtheaerialpartsofCimicifugaheracleifolia.Tetrahedron2015,71:8018-8025. 32.YujiaoHe,JunmeiHuang,PingWang,ShengLi,LijuanYang,ApichartSuksamrarn,WanliLiu,GuolinZhang*andFeiWang*.EmodinpotentiatestheantiproliferativeeffectofInterferonα/βbyactivationofJAK/STATpathwaysignalingthroughinhibitionofthe26Sproteasome.Oncotarget2015,DOI:10.18632/oncotarget.6616. 33.GuoyongLuo,QiYe,BaowenDu,FeiWang,Guo-linZhang,YinggangLuo.IridoidGlucosidesandDiterpenoidsfromCaryopterisglutinosa.JournalofNaturalProducts2016.79:886–893. 34.Lian-qiChen,Xiao-feiShen,Bo-yangHu,YuanLin,IghodaroIgbe,Cheng-gangZhang,Guo-linZhang,Xiao-hongYuan*,FeiWang*.Nitricoxideproductioninhibitionandmechanismofphenanthreneanalogsinlipopolysaccharide-stimulatedRAW264.7macrophages.Bioorganic&MedicinalChemistryLetters2016,26:2521-2525. 35.JiasiWu,HaiZhang,BoyangHu,LijuanYang,PingWang,FeiWang*,XianliMeng*.CoptisinefromCoptischinensisinhibitsproductionofinflammatorymediatorsinlipopolysaccharide-stimulatedRAW264.7murinemacrophagecells.EuropeanJournalofPharmacology2016.780:106-114. 36.Zhong-HuaGao,Yi-MingShi,ZheQiang,XiaWang,Shan-ZhaiShang,YanYang,Bao-WenDu,Hui-PanPeng,XuJi,HonglinLi*,FeiWang*,Wei-LieXiao*.Plasiatine,anUnprecedentedIndole–PhenylpropanoidHybridfromPlantagoasiaticaasaPotentActivatoroftheNonreceptorProteinTyrosinePhosphataseShp2.ScientificReports20166:24945. 37.ShengLi,Li-juanYang,PingWang,Yu-jiaoHe,Jun-meiHuang,Han-weiLiu,Xiao-feiShen,FeiWang*.Dietaryapigeninpotentiatestheinhibitoryeffectofinterferon-αoncancercellviabilitythroughinhibitionof26Sproteasome-mediatedinterferonreceptordegradation.Food&NutritionResearch2016,60:31288. 38.WenchenPu,YunYuan,DanfengLu,XinWang,HanweiLiu,ChunWang,FeiWang,GuolinZhang*.2-Phenylbenzo[b]furans:Synthesisandpromotingactivityonestrogenbiosynthesis.Bioorganic&MedicinalChemistryLetters2016,26:5497–5500. 39.SaminaShaheen,ZhengpengWan,ZongyuLi,AliciaChau,XinxinLi,ShaosenZhang,YangLiu,JunyangYi,YingyueZeng,JingWang,XiangjunChen,LilingXu,WeiChen,FeiWang,YunLu,WenjieZheng,YanShi,XiaolinSun,ZhanguoLi,ChunyangXiong,WanliLiu.SubstratestiffnessgovernstheinitiationofBcellactivationbytheconcertedsignalingofPKCβandfocaladhesionkinase.eLife2017,6:e23060. 40.FuLi,Bao-WenDu,Dan-FengLu,Wen-XuanWu,KanjanaWongkrajang,LunWang,Wen-ChenPu,Chang-LuLiu,Han-WeiLiu,Ming-KuiWang*,FeiWang*.FlavonoidglycosidesisolatedfromEpimediumbrevicornumandtheirestrogenbiosynthesis-promotingeffects.ScientificReports2017,7:7760. 41.OrawanWonganan,Yu-jiaoHe,Xiao-feiShen,KanjanaWongkrajang,ApichartSuksamrarn,Guo-linZhang*,FeiWang*.6-Hydroxy-3-O-methyl-kaempferol6-O-glucopyranosidepotentiatestheanti-proliferativeeffectofinterferonα/βbypromotingactivationoftheJAK/STATsignalingbyinhibitingSOCS3inhepatocellularcarcinomacells.ToxicologyandAppliedPharmacology2017,336:31-39. 42.IghodaroIgbe,Xiao-feiShen,WeiJiao,ZheQiang,TengDeng,ShengLi,Wan-liLiu,Han-weiLiu,Guo-linZhang,FeiWang*.Dietaryquercetinpotentiatestheantiproliferativeeffectofinterferon-αinhepatocellularcarcinomacellsthroughactivationofJAK/STATpathwaysignalingbyinhibitionofSHP2phosphatase.Oncotarget2017,8:113734-113748. 43.XiaojuanHan,HonghanChen,JiaoZhou,HaoranTai,HuiGong,XiaoboWang,NingHuang,JianqiongQin,TingtingFang,FeiWang,HengyiXiao.TheinhibitoryeffectofFraxinelloneonoxidativestress-inducedsenescencecorrelateswithAMP-activatedproteinkinase-dependentautophagyrestoration.JournalofCellularPhysiology2018,233:3945-3954. 44.GuidongGong,YuanCao,FeiWang*,GangZhao*.Planarchiralferrocenecyclopalladatedderivativesinducecaspase-dependentapoptosisandantimetastasisincancercells.Organometallics2018.37:1103-1113. 45.GuidongGong,YuanCao,HongyunQian,YangyangZhou,HaihangZhao,LinLi,FeiWang*,GangZhao*.Assessmentoftheantitumoractivityofacyclopalladatedferrocenecompoundassistedbyadual-targetingdrugdeliverysystem.ChemicalCommunications2018,54:8312-8315. 46.Jean-BoscoJouda,EmmanuelMfotieNjoya,CélineDjamaMbazoa,ZongYuanZhou,AlainMeliLannang*,JeanWandji,YoshihitoShiono,FeiWang*.LambertellinfromPycnoporussanguineusMUCL51321anditsanti-inflammatoryeffectviamodulationofMAPKandNF-κBsignalingpathways.BioorganicChemistry2018,80:216-222. 47.JunyiWang,FengLin,ZhengpengWan,XiaolinSun,YunLu,JianyongHuang,FeiWang,YingyueZeng,Ying-HuaChen,YanShi,WenjieZheng,ZhanguoLi,ChunyangXiong,andWanliLiu.Profilingtheorigin,dynamics,andfunctionoftractionforceinBcellactivation.ScienceSignaling2018,11:eaai9192. 48.De-BingPu,Bao-wenDu,WenChen,Jun-boGao,KunHu,NanShi,Yi-mingLi,Xing-jieZhang,RuihanZhang,Xiao-NianLi,HongbinZhang,FeiWang*,Wei-LieXiao*.PremnafulvolA:aDiterpenoidwitha6/5/7/3-FusedTetracyclicCoreanditsBiosyntheticallyRelatedAnaloguesfromPremnafulva.OrganicLetters2018,20:6314-6317. 49.AzubuikeP.Ebokaiwe,OmamuyovwiM.Ijomone,SharonO.Osawe,ChukwumaJ.Chukwu,ChukwunonsoE.C.C.Ejike,GuolinZhang,FeiWang.Alterationinspermcharacteristics,endocrinebalanceandredoxstatusinratsrendereddiabeticbystreptozotocintreatment:attenuatingroleofLoranthusmicranthus.RedoxReport2018,23:194-205. 50.ZheQiang,Zong-yuanZhou,TingPeng,Pu-ziJiang,NanShi,EmmanuelMfotieNjoya,BahtigulAzimova,Wan-liLiu,Wei-huaChen,Guo-linZhang*,FeiWang*.InhibitionofTPL2byinterferon-αsuppressesbladdercancerthroughactivationofPDE4D.JournalofExperimental&ClinicalCancerResearch2018,37:288. 51.RuiLi,FangLiu,XiaoYang,Lian-qiChen,FeiWang,Guo-linZhang,QianZhang,LiangZhang,Yu-xinHe,Yu-fengLi,PengLai,Xiang-guiChen,MinYe,Hong-taoXiao,HangXiao.Analysisofbisabolocurcuminether(aterpene-conjugatedcurcuminoid)andthreecurcuminoidsinCurcumaspeciesfromdifferentregionsbyUPLC-ESIMS/MSandtheirinvitroanti-inflammatoryactivities.JournalofFunctionalFoods2019,52:186-195.

学术兼职

2011年入选中国科学院青年创新促进会,并当选首届青年创新促进会理事会成员 2013年入选四川省科技青年联合会理事 2013年当选中国科学院青年创新促进会成都分会理事长 2013年荣获成都市九三学社“优秀青年”称号 2014年入选四川省青年联合会第十三届委员会委员 2014年入选四川省杰出青年学术技术带头人计划

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