罗应刚 - 中国科学院成都生物研究所 -

个人简介

1993.9——1997.7西南师范大学生命科学学院,获理学学士学位，生物学专业。 1997.7——2000.7中国科学院成都生物研究所天然产物研究中心,从事天然药物化学研究，获理学硕士学位，植物学专业。 2000.9——2003.7中国科学院成都有机化学研究所，从事有机化学、药物化学研究，获理学博士学位，有机化学专业。 2003.7——现在中国科学院成都生物研究所天然产物研究中心，从事有机化学、药物化学研究，助理研究员（2003）、副研究员（2006）、研究员（2013）。 2007.4——2008.4美国威斯康星大学麦迪逊分校(SchoolofPharmacy,UniversityofWisconsin-Madison)，从事次级代谢产物的组合生物合成与酶促生化反应研究，访问学者迄今在J.Am.Chem.Soc.,J.Biol.Chem.,Appl.Microbiol.Biotechnol.,J.Nat.Prod.,J.Agr.FoodChem.,J.Ind.Microbiol.Biotechnol.等刊物上发表论文70余篇；申请发明专利8项，已获授权6项；参编《生物碱化学》、《有机化学学科前沿与展望》等专著；应邀为JournalofNaturalProducts,CurrentMedicinalChemistry,Steroids,FoodandChemicalToxicology,Fitoterapia等国际刊物及有机化学等国内刊物审稿。

近期论文

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1.YunYang,WeiLi,JingPang,LiangzhenJiang,XixingQu,XiangPu,GuolinZhang,andYinggangLuo*.BifunctionalCytochromeP450EnzymesInvolvedinCamptothecinBiosynthesis.ACSChemicalBiology2019,14,1091-1096. 2.XiangPu*,Cheng-RuiZhang,LinZhu,Qi-LongLia,Qian-MingHuang,LiZhang,andYinggangLuo*.Possiblecluesforcamptothecinbiosynthesisfromthemetabolitesincamptothecin-producingplants.Fitoterapia2019,134,113-128. 3.WeiLi,YunYang,ChongQiao,GuolinZhang,andYinggangLuo*.Functionalcharacterizationofphenylalanineammonia-lyase-andcinnamate4-hydroxylase-encodiinggenesfromLycorisradiata,agalanthamine-producingplant,InternationalJournalofBiologicalMacromolecules,2018,117,1264-1279. 4.JinzhiZhao,YunYang,MengyaoYu,KeYao,XiaLuo,HuayiQi,GuolinZhang*,andYinggangLuo*.Lanostane-typeC31triterpenoidderivativesfromthefruitingbodiesofcultivatedFomitopsispalustris.Phytochemistry2018,152,10-21 5.YunYang,XiangPu,XixingQu,FeiChen,GuolinZhang,andYinggangLuo*.EnhancedproductionofcamptothecinandbiologicalpreparationofN1-acetylkynuramineinCamptothecaacuminatacellsuspensioncultures.AppliedMicrobiologyandBiotechnology2017,101(10),4053-4062. 6.FeiChen,WeiLi,LiangzhenJiang,XiangPu,YunYang,GuolinZhang,andYinggangLuo*.Functionalcharacterizationofageraniolsynthase-encodinggenefromCamptothecaacuminataanditsapplicationintheproductionofgeraniolinEscherichiacoli.JournalofIndustrialMicrobiology&Biotechnology2016,43(9),1281-1292. 7.GuoyongLuo,QiYe,BaowenDu,FeiWang,GuolinZhang*,andYinggangLuo*.IridoidglucosidesandditeropenoidsfromCaryopterisglutinosa.JournalofNaturalProducts2016,79(4),886-893. 8.XiangPu,FeiChen,YunYang,XixingQu,GuolinZhang,andYinggangLuo*.IsolationandcharacterizationofPaenibacilluspolymyxaLY214,acamptothecin-producingendophyticbacteriumfromCamptothecaacuminata.JournalofIndustrialMicrobiology&Biotechnology2015,42,1197-1202. 9.XixingQu,XiangPu,FeiChen,YunYang,LixiaYang,GuolinZhang,andYinggangLuo*.Molecularcloning,heterologousexpression,andfunctionalcharacterizationofanNADPH-cytochromeP450reductasegenefromCamptothecaacuminata,acamptothecin-producingplant.PLoSONE2015,10(8),e0135397.doi:10.1371/journal.pone.0135397. 10.GuoyongLuo,MinZhou,QiYe,YanLiu,JianGu,TianfangHuang,Guo-linZhang*,andYinggangLuo*.Dimeric2-ArylbenzofuransandPolyisoprenylatedFlavanonesfromSophoratonkinensis.Fitoterapia2014,99,21-27. 11.YinggangLuo*,XiangPu,GuoyongLuo,MinZhou,QiYe,YanLiu,JianGu,HuayiQi,Guo-youLi,andGuo-linZhang*.Nitrogen-containingDihydro-b-agarofuranDerivativesfromTripterygiumwilfordii.JournalofNaturalProducts2014,77(7),1650-1657. 12.XiangPu,XixingQu,FeiChen,JinkuBao,GuolinZhang*,andYinggangLuo*.Camptothecin-producingEndophyticFungusTrichodermaatrovirideLY357:Isolation,Identification,andFermentationConditionsOptimizationforCamptothecinProduction.AppliedMicrobiologyandBiotechnology2013,97(21),9365-9375. 13.Shou-ZhengTian,XiangPu,GuoyongLuo,Li-XingZhao,Li-HuaXu,Wen-JunLi,andYinggangLuo*.IsolationandCharacterizationofNewp-TerphenylswithAntifungal,Antibacterial,andAntioxidantActivitiesfromHalophilicActinomyceteNocardiopsisgilvaYIM90087.JournalofAgriculturalandFoodChemistry2013,61(12),3006-3012. 14.YinggangLuo,MinZhou,QiYe,QiangPu,andGuolinZhang*.DihydroagarofuranderivativesfromthedriedrootsofTripterygiumwilfordii.JournalofNaturalProducts2012,75(1),98-102. 15.YinggangLuo*,GuangzhouLi,GuoyouLi,JufangYan,JinhaiYi,andGuolinZhang.Discoveryandidentificationof2-phenylethyl2,6-dihydroxybenzoateasanaturallipid-loweringlead.PlantaMedica2011,77(18),2047-2049. 16.JianyuZhao,MinZhou,YanLiu,GuolinZhang,andYinggangLuo*.ChromonesandcoumarinsfromthedriedfructusofCnidiummonnieri.Fitoterapia2011,82,767-771. 17.SijiuLiu,ZhihongYu,XiaoYu,Sheng-XiongHuang,YinggangLuo,LiWu,ZhenyunYang,LinaWang,AndreaGunawan,RebeccaJ.Chan,BenShen,andZhong-YinZhang*.SHP2isaTargetoftheImmunosuppressantTautomycetin.Chemistry&Biology2011,18(1),101-110. 18.JianyaLing,GeoffreyP.Horsman,Sheng-XiongHuang,YinggangLuo,ShuangjunLin,andBenShen*.EnediyneAntitumorAntibioticMaduropeptinBiosynthesisFeaturingaC-MethyltransferaseThatActsonaCoA-TetheredAromaticSubstrate.JournaloftheAmericanChemicalSociety2010,132(36),12534-12536. 19.YinggangLuo,WenliLi,JianhuaJu,QiupingYuan,NoelR.Peters,F.MichaelHoffmann,Sheng-XiongHuang,TimS.Bugni,ScottRajski,HiroyukiOsadaandBenShen*.FunctionalcharacterizationofTtnDandTtnF,unveilingnewinsightsintotautomycetinbiosynthesis.JournaloftheAmericanChemicalSociety2010,132(19),6663-6671. 20.HeatherA.Cooke,ElizabethL.Guenther,YinggangLuo,BenShenandStevenD.Bruner*.MolecularbasisofsubstratepromiscuityfortheSAM-dependentO-methyltransferaseNcsB1,involvedinthebiosynthesisoftheenediyneantitumorantibioticneocarzinostatin.Biochemistry2009,48(40),9590-9598. 21.GuoyouLi,TaoYang,YinggangLuo,XiaozhenChen,DongmeiFang,andGuolinZhang*.BrevianamideJ,ANewIndoleAlkaloidDimerfromFungusAspergillusversicolor.OrganicLetters2009,11(16),3714-3717. 22.JoelT.Adler,MackenzieCook,YinggangLuo,SusanC.Pitt,JianhuaJu,WenliLi,BenShen,MuthusamyKunnimalaiyaanandHerbertChen*.Tautomycetinandtautomycinsuppressthegrowthofmedullarythyroidcancercellsviainhibitionofglycogensynthasekinase-3beta.MolecularCancerTherapeutics2009,8(4),914-920. 23.WenliLi,YinggangLuo,JianhuaJu,ScottR.Rajski,HiroyukiOsada,andBenShen*.CharacterizationofthetautomycetinbiosyntheticgeneclusterfromStreptomycesgriseochromogenesprovidesnewinsightintodialkylmaleicanhydridebiosynthesis.JournalofNaturalProducts2009,72(3),450-459. 24.FeiyanTao,YinggangLuo*,QingchunHuang,YanLiu,BogangLi,GuolinZhang.FacilesyntheseofL-b-haloalaninederivativesfromL-cysteineorL-cystine.AminoAcids2009,37(4),603-607. 25.ScottN.Pinchot,JoelT.Adler,YinggangLuo,JianhuaJu,WenliLi,BenShen,MuthusamyKunnimalaiyaan,HerbertChen*.TautomycinsuppressesgrowthandneuroendocrinehormonemarkersincarcinoidcellsthroughactivationoftheRaf-1pathway.AmericanJournalofSurgery2009,197(3),313–319. 26.ScottN.Pinchot,JoelT.Adler,YinggangLuo,JianhuaJu,WenliLi,BenShen*,MuthusamyKunnimalaiyaan,HerbertChen*.Tautomycetinsuppressescarcinoidtumorgrowthandbioactivehormoneproductionthroughinactivationofglycogensynthasekinase-3beta.JournaloftheAmericanCollegeofSurgeons2008,207(3),S103-S104. 27.YinggangLuo,ShuangjunLin,JianZhang,HeatherA.Cooke,StevenD.Bruner,andBenShen*.RegiospecificO-MethylationofNaphthoicAcidsCatalyzedbyNcsB1,anO-MethyltransferaseInvolvedintheBiosynthesisoftheEnediyneAntitumorAntibioticNeocarzinostatin.TheJournalofBiologicalChemistry2008,283,14694-14702. 28.YihuaChen,YinggangLuo,JianhuaJu,EvelynWendt-Pienkowski,ScottR.Rajski,BenShen*.IdentificationofFredericamycinEfromStreptomycesgriseus:InsightsintoFredericamycinABiosynthesisHighlightingCarbaspirocycleFormation.JournalofNaturalProducts2008,71,431-437. 29.YinggangLuo*,ZhihengHe,HongjuanLi,2-ArylBenzofuransandTheirDerivativesfromSeedsofStyraxmacranthus,Fitoterapia2007,78(3),211-214.

个人简介

研究领域

近期论文