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个人简介

招生专业 071010-生物化学与分子生物学 071005-微生物学 招生方向 DNA错配修复系统的基础和应用研究 结核菌非编码RNA的系统发现和功能研究 教育背景 2000-09--2003-07 中国科学院武汉病毒研究所 博士 1997-09--2000-07 沈阳农业大学 硕士 1993-09--1997-07 河南理工大学 本科 工作简历 2008-07--今 中国科学院生物物理研究所 教授 2004-07--2008-07 中国科学院生物物理研究所 副教授 2003-07--2004-07 日本近畿大学 博士后 奖励信息 (1) 湖北省第十届自然科学优秀学术论文特等奖,特等奖,市地级,2004 科研项目 (1) 结核杆菌非编码RNA与耐药发生和毒力调控研究,主持,国家级,2012-01--2015-12 (2) 结核分枝杆菌ESX-1 分泌系统与毒力因子相互作用机制的晶体学研究,主持,国家级,2012-01--2015-12 (3) 基因损伤修复相关蛋白质复合物的结构与机理研究,参与,国家级,2011-01--2013-12 (4) 非编码RNA与蛋白质相互作用在干细胞命运决定过程中的调控网络,参与,国家级,2011-01--2013-12 (5) 结核病诊断分子标识研究,参与,国家级,2009-05--2011-12 (6) 新非编码RNA及其基因的系统发现和“双色网络”构建,参与,国家级,2008-12--2013-12 参与会议 (1) Crystal structure and function of DNA gyrase sheds lights on the mechanism for T-segment navigation,第十二届日中韩酶工程学术研讨会,2012-05,毕利军 (2) Crystal structure and function of DNA gyrase sheds lights on the mechanism for T-segment navigation,第一届JIC-CAS双边研讨会,2012-04,吴进军 (3) 结核分枝杆菌耐药机制研究,首届厦门大学抗癌研究中心-中科院生物物理研究所癌症学术研讨会,2012-04,毕利军 (4) 结核分枝杆菌的基因组稳定性与致病及耐药机制,2011年楔石研讨会:结核分枝杆菌生理、代谢和发病机理研究专题会议,2011-01,毕利军 (5) Genome Stability in Mycobacterium tuberculosis and occurrence of drug resistance,病原菌基因组学、进化与致病机制国际研讨会,2010-11,毕利军 (6) 结核分枝杆菌的基因组不稳定性与致病及耐药发生,第三届全国微生物基因组学学术研讨会,2010-11,毕利军 (7) 细菌sRNA, ncRNA分析策略,2010年人类病原微生物基因组学专题研讨会,2010-07,毕利军 (8) 结核分枝杆菌基因组稳定与耐药,中国科学院—北京胸科医院首届结核病学术研讨会,2009-11,毕利军 (9) 蛋白激酶检测肽芯片研究,第十届中日韩酶工程会议,2008-11,毕利军 (10) DNA错配修复与DNA复制的偶联机制,DNA 修复与癌症生物学,2008-04,毕利军 (11) Cooperation between DNA replication and mismatch repair,2007-07,毕利军

研究领域

结核病系统生物学研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(1) QUICK Identification and SPR Validation of Signal Transducers and Activators of Transcription 3 (Stat3) Interacting Proteins,Journal of Proteomics,2012,通讯作者 (2) MutL associates with Escherichia coli RecA and inhibits its ATPase activity,Archives of Biochemistry and Biophysics,2012,通讯作者 (3) Determination of the crystal structure and active residues of FabV, the Enoyl-ACP reductase from Xanthomonas oryzae, Plos one,2011,第3作者 (4) Proteomic analysis of multiple myeloma: Current status and future perspectives,Proteomics Clin,2011,通讯作者 (5) Crystal structure of YdaL, a stand-alone small MutS-related protein from E.coli, Journal of Structural Biology,2011,通讯作者 (6) Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for inactivation of anti-tuberculosis drugs,Molecular Microbiology,2011,第4作者 (7) Proteomics: addressing the challenges of multiple myeloma,Acta Biochim Biophys Sin (Shanghai),2011,第3作者 (8) Quantitative Proteomic Analysis of Tumor Reversion in Multiple Myeloma Cells,J Proteome Res,2011,通讯作者 (9) The dimer state of GyrB of Mycobacterium tuberculosis is an active form: implications for the initial complex assembly and processive strand passage,Nucleic Acid Research,2011,通讯作者 (10) Experimental RNomics and genomic comparative analysis reveal a large group of species-specific small non-message RNAs in the silkworm Bombyx mori,Nucleic Acids Res,2011,第5作者 (11) A Sir2-like protein participates in mycobacterial NHEJ,Plos One,2011,通讯作者 (12) Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis,,Biochemical Biophysical Research Communication,2011,通讯作者 (13) A simplified method for reconstituting active E.coli DNA polymerase III,Protein and cell,2011,通讯作者 (14) MutS-mediated enrichment of mutated DNA produced by directed evolution in vitro,Journal of Microbiology and Biotechnology,2011,通讯作者 (15) Novel auto-biotinylated bifunctional protein nanowires applied in ultra-sensitivity biosensing,Biosensors and Bioelectronics,2010,第5作者 (16) Electrostatic interaction in the NH2-terminus accelerates inactivation of Kv1.4 channel,BBA-Biomembranes,2010,通讯作者 (17) Functional interaction between MutL and 3-5 Exonuclease X in Escherichia coli,Archives of Biochemistry and Biophysics,2010,通讯作者 (18) MutS-mediated enrichment of mutated DNA produced by directed evolution in vitro,World Journal of Microbiology and Biotechnology,2010,通讯作者 (19) New functional sites in MutS affect DNA mismatch repair. ZHONG Tianying,Science China Bulletin life science,2010,通讯作者 (20) Regulatory role of the extreme C-terminal end of the S6 inner helix in C-terminal truncated Kv1.2 channel activation,Cell Biology International,2010,第4作者 (21) Seeing Mutations in Living Cells,Current Biology,2010,第4作者 (22) Identification of Novel 14-3-3 Interacting Proteins by Quantitative Immunoprecipitation Combined with Knockdown (QUICK),J Proteome Res,2010,第3作者 (23) Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells,PLoS One,2010,第3作者 (24) Functional Analyses of Escherichia coli MutS-beta Clamp Interaction In Vitro and In Vivo,Curr Microbiol,2010,通讯作者 (25) CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY,Molecular Microbiology,2010,第5作者 (26) Crystal structure of DNA gyrase B domain of Mycobacterium tuberculosis sheds lights on the mechanism for T-segment navigation, Nucleic Acids Res,2009,通讯作者 (27) Mutations Found in the pncA Gene of Mycobacterium tuberculosis in Clinical Pyrazinamid-eresistant Isolates from a Local Region of China,The Journal of Inte-rnational Medical Research,2009,第2作者 (28) Characterization of Mycobacterium tuberculosis Nicotinamidase/Pyrazinamidase,FEBS Journal,2008,第3作者 (29) THE KEY DNA-BINDING RESIDUES IN THE C-TERMIANL DOMAIN OF Mycobacterium tuberculosis DNA GYRASE A SUBUNIT (gYRa),Nucleic Acides Research,2006,第5作者 (30) Construction and Characterization of Different MutS Fusion Proteins as Recognition Elements of DNA Chip for Detection of DNA Mutations,Biosensors and Bioelectronics,2005,第1作者 (31) A MutS based protein chip for detection of DNA mutations in Mycobacterium tuberculosis,Anal Chem,2003,第1作者

学术兼职

2011-08--今 中国微生物学会分析微生物专业委员会,委员会委员 2011-07--2012-05 广东省结核病防治研究所 ,指导专家 2011-04--今 中国防痨协会基础细菌免疫专业委员会,副主任 2010-04--今 国家“十一五”科区防治结核病规模和干预的研究”科技重大专项“宝安区防治结核病规模化现场流行病学和干预的研究”,专家顾问委员会委员 2009-01--今 中国生物物理学会,副秘书长

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