郑文云 - 华东理工大学

研究领域

1）蛋白多肽药物及其药理药效学药剂学研究；2）保健品、生化药学与微生物合成生物学。

近期论文

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Liqun Wang, Yanyan Kang, Wenyun Zheng *, Linfeng Li, Lei Shi, Xingyuan Ma. Effect on apoptosis and cell cycle of recombinant double negative dominant mutation Survivin (T34/117A) in breast cancer cell B-Cap-37. Biomedicine & Pharmacotherapy, 2014, 68(3): 277–284 Nanjing Lin#, Wenyun Zheng#, Linfeng Li ,Hui Liu, Tianwen Wang, Ping Wang, Xingyuan Ma,. A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells. Targeted Oncology. 2014, 9(2): 163-170 (coauthor) Wenyao Zhang, Wenyun Zheng, Miaowei Mao, Yi Yang. Highly Ef?cient Folding of Multi-Disul?de Proteins in Superoxidizing Escherichia coli Cytoplasm. Biotechnology and Bioengineering, 2014,9(6)138-245 Wenyun Zheng, Wenyao Zhang, Wei Hu, and Yi Yang，Exploring the Smallest Active Fragment of HsQSOX1b and Discovery of a Highly Efficient Oxidative Engine, PLOS ONE. 2012,7 (7): e40935. doi:10.1371 Yuxin Xu#, Wenyun Zheng#，Tianwen Wang, Ping Wang, Ling Zhu, Xingyuan Ma*., Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin. Biomedicine & Pharmacotherapy, 2012, 66(5): 368-372 (#Contributed equally to this work) Hailong Chen,Xingyuan Ma*, Zhi Li, Qiaoyun Shi, Wenyun Zheng, Yang Liu, Ping Wang. Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth. Biomedicine & Pharmacotherapy, 2012, 66 (5) :334-338. Wenyun Zheng, Yanyan Chu, Qin Yin, Charles Yang, Wenyao Zhang, Yun Tang, Yi Yang. Crucial effect of the First CXXC Motif of Human QSOX 1b on the Activity to different substrates. J ournal of Biochemistry. 2011, 149(3):293-300 Wenyun Zheng, Yanyan Kang, Linfeng Li, Yuxin Xu, Xingyuan Ma, Levels of effectiveness of gene therapies targeting survivin and its splice variants in human breast cancer cells. Drug Discoveries & Therapeutics. 2011, 5(6):293-298 Xingyuan Ma, Bi Yao, Wenyun Zheng, Linfeng Li*. Comparative study on characterization of recombinant B subunit of E. coli heat-labile enterotoxin (rLTB) prepared from E. coli and P. patoris. J. Microbiol. Biotechnol. 2010, 20(3):550-557. Chu YY, Yang C, Chen XJ, Zheng WY, Yang Y*, Tang Y*. Structure–function analysis of human protein Ero1-Lα. Biochemical and Biophysical Research Communications, 2009, 389(4) : 645-650 Yanyan Chu, Charles Yang, Xianjun Chen, Wenyun Zheng, Yi Yang, Yun Tang，Structure–function analysis of human protein Ero1-La，Biochemical and Biophysical Research Communications, 2009, 389:645–650. Haiyi Zhang, Yu Zheng, QinghaiLiu, Xinyi Tao, Wenyun Zheng, Xingyuan Ma*, Dongzhi Wei*. Development of a fed-batch process for the production of anticancerdrug TATm-survivin(T34A) in Escherichia coli. Biochemical Engineering Journal. 2009, 43(2):163–168. Xingyuan Ma*, Wenyun Zheng, Haiyi Zhang，Xinyi Tao，Qinghai Liu，Dongzhi Wei*. Large scale preparation and characterization of a genetically engineering protein and biological activity of suppressing proliferation and rapid pro-apoptosis to carcinoma cells. Journal of Biotechnology. 2008, S75-S98 (13-P-022).