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研究领域

化学生物学:研究化学小分子以及材料等对生物大分子如核酸,蛋白的结构和性质的影响,以及它们在抗癌药物发现中的应用。无机药物化学:具有潜在药物活性的金属配合物的合成、药物活性以及作用机理研究。生物化学:含金属蛋白质的结构、活性、机理以及他们在药物合成中的应用

近期论文

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Wanjun Lan, Satoshi Yamaguchi, Teruyasu Yamamoto, Shinya Yamahira, Modong Tan, Naoka Murakami, Jingyan Zhang, Motonao Nakamura, and Teruyuki Nagamune, Visualization of the pH-dependent dynamic distribution of G2A in living cells FASEB J 2014, 28, 3965-3974. Jie Feng, Xin Du, Hui Liu, Xin Sui, Chen Zhang, Yun Tang and Jingyan Zhang Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity Dalton Trans., 2014, 43, 10930–10939 Bin Zheng, Chong Wang, Xiaozhen Xin, Fei Liu, Xuejiao Zhou, jingyan Zhang, and Shouwu Guo, Electron Transfer from Graphene Quantum Dots to the Copper Complex Enhances Its Nuclease Activity J. Phys. Chem. C 2014, 118, 7637?7642 Bin Zheng, Hui Liu, Jie Feng and Jingyan Zhang, Effect of coordination sphere of the copper center and Cu―Cu distance on catechol oxidase and nuclease activities of the copper complexes Appl. Organometal. Chem. 2014, 28, 372–378 Xiaochen Wu, Yan Zhang, Ting Han, Haixia Wu, Shouwu Guo and Jingyan Zhang, Composite of Graphene Quantum Dots and Fe3O4 Nanoparticles: Excellent Peroxidase Activity and Application in Phenolic Compound Removal, RSC Advances, 2014, 4, 3299–3305 Chong Wang, Congyu Wu, Xuejiao Zhou, Ting Han, Xiaozhen Xin, Jiaying Wu, Jingyan Zhang, Shouwu Guo, Enhancing Cell Nucleus Accumulation and DNA Cleavage Activity of Anti-Cancer Drug via Graphene Quantum Dots, Scientific Reports 2013, 3, 2852. Congyu Wu , Chong Wang , Ting Han , Xuejiao Zhou , Shouwu Guo and Jingyan Zhang Insight into the Cellular Internalization and Cytotoxicity of Graphene Quantum Dots, Adv. Healthcare Mater. 2013, 2, 1613–1619 Xuejiao Zhou, Shouwu Guo, and Jingyan Zhang Solution-Processable Graphene Quantum Dots, ChemPhysChem 2013, 14, 2627. Yan Zhang , Congyu Wu , Shouwu Guo and Jingyan Zhang Interactions of graphene and graphene oxide with proteins and peptides, Nanotechnol Rev 2013; 2(1): 27–45 Yan Zhang, Congyu Wu, Xuejiao Zhou, Xiaochen Wu, Yongqiang Yang, Haixia Wu, Shouwu Guo and Jingyan Zhang Graphene quantum dots/gold electrode and its application in living cell H2O2 detection Nanoscale, 2013, 5, 1816 Xin Chen, Xuejiao Zhou, Ting Han, Jiaying Wu, Jingyan Zhang, and Shouwu Guo, Stabilization and Induction of Oligonucleotide i-Motif Structure via Graphene Quantum Dots ACS Nano 2013, 7, 531–537. Xuejiao Zhou, Yan Zhang, Chong Wang, Xiaochen. Wu,Yang, Bin Zheng, Wu, Shouwu Guo, Jingyan Zhang, Photo-Fenton Reaction of Graphene Oxide: A New Strategy to Prepare Graphene Quantum Dots for DNA Cleavage, ACS Nano 2012, 6, 6592-6599. Bin Zheng, Chong Wang, Congyu Wu, Xuejiao Zhou, Min Lin, Xiaochen Wu, Xioazhen Xin, Xin Chen, Jing Zheng, Hui, Liu, Jingyan Zhang, Shouwu Guo; Nuclease Activity and Cytotoxicity Enhancement of the DNA Intercalators via Graphene Oxide J. Phys. Chem. C 2012, 116, 15839-15846. Wanjun Lan, Hongliu Ren, Yu Pang, Chuseng Huang, Yufang Xu, Robert J. Brooker and Jingyan Zhang, A facile transport assay for H+ coupled membrane transport using fluorescence probes, Analytical Methods,2012, 4, 44-46. Yan Zhang , Jingyan Zhang, Xuelei Huang , Xuejiao Zhou , Haixia Wu ,and Shouwu Guo, Assembly of Graphene Oxide–Enzyme Conjugates through Hydrophobic Interaction, Small,2012, 8, 154–159. Lijun Lu, Yanying Song, Hui Liu, Jingyan Zhang, Synthesis, characterization, and polyphenol oxidase activity of CuII, MnII, and FeIII complexes with a N2O2 Ligand. J. Coord. Chem. 2012, 65, 1278–1288. Y. Zhang, J.Zhang, H. Wu, S. Guo, J. Zhang, Glass carbon electrode modified with horseradish peroxidase immobilized on partially reduced graphene oxide for detecting phenolic compounds J. Electroanal. Chem. 2012, 681, 49–55. Rong Li, Jinlei Tian, Hui Liu, Shiping Yan, Shouwu Guo, Jingyan Zhang Direct evidence for the role of imidazole in disproportionation of hydrogen peroxide by a mononuclear manganese salen complex, Transition Met Chem 2011, 36, 811–817. Yan Zhang, Haixia Wu, Xuelei Huang, Jingyan Zhang and Shouwu Guo, Effect of substrate (ZnO) morphology on enzyme immobilization and its catalytic activity Nanoscale Res. Let. 2011, 6, 450-456. Xuejiao Zhou, Jiali Zhang, Haixia Wu, Haijun Yang, Jingyan Zhang, and Shouwu Guo , Reducing Graphene Oxide via Hydroxylamine: A Simple and Efficient Route to Graphene J. Phys. Chem. C 2011, 115, 11957–11961 Ren, Hongliu; Wang, Chong; Zhang, Jiali; Zhou, Xuejiao; Xu, Dafeng; Zheng, Jing; Guo, Shouwu; Zhang, Jingyan. DNA Cleavage System of Nanosized Graphene Oxide Sheets and Copper Ions. ACS Nano 2010, 4(12), 7169-7174. Feng Zhang, Bin Zheng, Jiali Zhang, Xuelei Huang, Hui Liu, Shouwu Guo, Jingyan Zhang Horseradish Peroxidase Immobilized on Graphene Oxide: Physical Properties and Applications in Phenolic Compound Removal. J. Phys. Chem. C, 2010, 114, 8469-8473. Jiali Zhang, Feng Zhang, Haijun Yang, Xuelei Huang, Hui Liu, Jingyan Zhang Shouwu Guo, Graphene Oxide as a Matrix for Enzyme Immobilization. Langmuir 2010, 26(9), 6083-6085. Rong Li, Fuqiang Huang, Xiaojun Jiang, Minyuan Liu, Yanying Song, Hui Liu, Jingyan Zhang Catalase-like Catalytic Reaction of the Dinuclear Manganese-salen Complex J. Coord. Chem. 2010, 63(9), 1611-1618. Guanke Zuo, Xiaojun Jiang, Hui Liu,Jingyan Zhang A Novel Urinary Oxalate Determination Method via a Catalase Model Compound with Oxalate Oxidase Analytical Methods 2010, 2, 254-258.

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