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研究领域

1. 口服固体制剂的研究与开发。主要是提高难溶性药物的生物利用度、提高药物的稳定性、掩味制剂以及缓释微丸的工艺放大和质量控制等。 2. 外用制剂的研究与开发。主要是提高软膏的稳定性、改进外用制剂的过敏性及经皮制剂的渗透性等。 3. 注射用分散系统制剂的研究与开发。主要是针对高活性成分和生物大分子药物等,提高药物治疗效果和患者顺应性等。

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A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel. Journal of drug targeting. 2011, 19(7): 516-527. PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate. Drug development and industrial pharmacy. 2010, (36): 10: 1131-1138. Synthesis and characterization of d-α-tocopheryl polyethylene glycol 1000 succinate-block-poly (ε-caprolactone) copolymer used as carriers for microparticles. J. Disp. Sci. Techn. 2009, 30(8): 1129-1134. Self-nanoemulsifying drug delivery system (SNEDDS) of anethole trithione by combined use of surfactants. J. Disp. Sci. Techn. 2009, 30(5): 664-670. HPLC determination of anethole trithione and its application to pharmacokinetics in rabbits. Journal of Pharmaceutical & Biomedical Analysis. 2006, 42(5): 613-617. Characteristics of bicalutamide solid dispersions and improvement of the dissolution. Drug Development and Industrial Pharmacy. 2006, 32 (8): 967-972. Determination of nelfinavir mesylate as bulk drug and in pharmaceutical dosage form by stability indicating HPLC. Journal of Pharmaceutical & Biomedical Analysis. 2006, 41(3): 1065-1069. Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. Journal of Pharmaceutical & Biomedical Analysis. 2006, 41(2): 549-553. 青藤碱缓释片释放度影响因素的研究. 中草药. 2004, 35(4): 390-393. 葛根素复合骨架缓释片的处方及制备工艺. 华东理工大学学报. 2003, 29(2): 173-176. 葛根素缓释片释放度的研究. 中草药. 2002, 33(11): 991-993. 盐酸青藤碱在大鼠肠道吸收特性的研究. 沈阳药科大学学报. 2002, 19(3): 165-167. 参编:制药工程专业实验. 北京:高等教育出版社,2007. 参译:片剂包衣的工艺和原理. 北京:中国医药科技出版社,2001.

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