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研究领域

1、功能基因中蛋白质内含子的结构与功能、剪接与应用的研究。 2、编码蜘蛛丝蛋白质基因的克隆、表达、结构与功能、成丝机理以及仿生研究。 3、原核生物基因内含子的结构与功能、剪接与转移机理的研究。

近期论文

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1.Marlene Andersson1*, Gefei Chen2*, Martins Otikovs3, Michael Landreh4, Kerstin Nordling5, Nina Kronqvist5, Per Westermark6, Hans Jörnvall4, Stefan Knight7, Yvonne Ridderstråle1, Lena Holm1, Kristaps Jaudzems3, Mitchell Chesler8, Qing Meng2*, Jan Johansson1,5,9* and Anna Rising 1,5*,CO2 and H+ drive spider silk formation via opposite effects on the terminal domains,PLoS Biology, 2014, 12(8): e1001921 (SCI) 2.Nina Kronqvist, Martins Otikovs, Volodymyr Chmyrov, Gefei Chen, Marlene Andersson, Kerstin Nordling, Michael Landreh, Médoune Sarr, Hans Jörnvall, Stefan Wennmalm, Jerker Widengren, Qing Meng, Anna Rising, Daniel Otzen, Stefan D. Knight, Kristaps Jaudzems and Jan Johansson,A charge network enables pH driven sequential dimerization and stabilization of the spider silk N-terminal domain,Nature Communications,5:3254, 2014 (SCI) 3.Changhua Shi, Qing Meng*, and David W. Wood*. Simple bacterial growth assay for the evalution of human thyroid hormone receptor beta mutants, Journal of Molecular Endocrinology, 52, 55-66, 2014 (SCI) 4.Lingling Xu, Marie-Laurence Tremblay , Kathleen E. Orrellb, Jérémie Leclerc, Qing Meng*, Xiang-Qin Liu*, Jan K. Rainey*,Nanoparticle self-assembly by a highly stable recombinant spider wrapping silk protein subunit,FEBS Lett. 587(19):3273-80,2013(SCI) 5.Ying Lin, Meng-Meng Li, Hui-Ling Song, Ling-Ling Xu, Xing-Mei Qi, Fang Hu, Qing Meng*, and Xiang-Qin Liu*,Protein trans-splicing of multiple atypical split inteins engineered from natural inteins,PLoS One,8(4),e59516,2013(SCI) 6.Gefei Chen, Xiangqin Liu, Yunlong Zhang, Senzhu Lin, Zijiang Yang, Jan Johansson, Anna Rising* and Qing Meng*,Full-length minor ampullate spidroin sequence reveals highly variable organization of spider silk genes,PLoS One,7(12),e52293,2012(SCI)7、Lingling Xu, Qing Meng*, and Xiang-Qin Liu*,Silk fibers self-assembled from repetitive domain of spider wrapping silk AcSp1 protein,PLoS One,7(11), e50227,2012(SCI) 8.Huiling Song, Qing Meng*, Xiang-Qin Liu*,Protein Trans-Splicing of an Atypical Split Intein Showing Structural Flexibility and Cross-Reactivity,PLoS One,7(9),e45355,2012(SCI) 9.Changhua Shi, Qing Meng*, and David W. Wood*,A split intein dual ELP system for recombinant protein purification,Appl Microbiol Biotechnol,96, 6, 4601-3,2012(SCI) 10.Lingling Xu, Marie-Laurence Tremblay, Qing Meng, Xiang-Qin Liu, Jan K. Rainey,1H, 13C and 15N NMR assignments of the aciniform spidroin(AcSp1) repetitive domain of Argiope trifasciata wrapping silk. Biomol NMR Assign, 6,2,147-51,2012(SCI) 11.Xingmei Qi, Qing Meng*, Xiangqi Liu*,Spontaneous C-cleavage of a mini-intein without its conserved N-terminal motif A. FEBS Letters,585, 2513-2518,2011(SCI) 12.Qi X, Wang J, Meng Q*, Liu XQ*,Alternative Nucleophilic Residues in Intein Catalysis of Protein Splicing,Protein Pept Lett.,18, 12, 1226-32,2011(SCI) 13.Meng Q, Zhang Y, Liu XQ. rare group I intron sequence element in a bacterial ribonucleotide reductase gene. J Bacteriol., 189, 5, 2150-2154,2007(SCI) 14.Meng Q, Wang Y, Liu XQ. An intron-encoded maturase splicing multiple introns including four group II introns in a cyanobacterial dnaN gene. J Biol Chem, 280, 42, 35085-8,2005(SCI) 15.Yang J, Meng Q, Liu XQ. Intein harbouring large tandem repeats in replicative DNA helicase of Trichodesmium erythraeum. Mol Microbiol, 51, 4, 1185-1192,2004(SCI) 16.Liu XQ, Yang J, Meng Q. Four inteins and three group II introns encoded in a bacterial ribonucleotide reductase gene. J Biol Chem, 278, 47, 46826-31,2003(SCI) 17.Qu Lianghu, Meng Q, Zhou H, Chen YQ. Identification of 10 novel SnoRNA gene clusters from Arabidopsis thaliana. Nucleic Acids Res, 29, 7, 1623-30,2001(SCI) 18.Shi C, Tarimala A, Meng Q, Wood DW. A general purification platform for toxic proteins based on intein trans-splicing,Appl Microbiol Biotechnol. 2014 Oct 9(SCI)

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