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个人简介

简历 主要从事免疫细胞的增殖、分化以及宿主抵抗病原微生物侵染的免疫机制研究。 2016.03-中国科学院昆明动物研究所,研究员 2014.01-2016.02美国圣犹大儿童研究医院(St.JudeChildren’sResearchHospital),博士后 2010.06-2013.12美国犹太医学中心(NationalJewishHealth),博士后 2009.01-2010.05美国印第安纳大学(IndianaUniversity),博士后 2007.10-2008.12美国德州理工大学(TexasTechUniversity),博士后 2006.07-2007.10浙江省农科院,助理研究员 2001.09-2006.07浙江大学,遗传学专业获博士学位 1997.09-2001.07聊城大学,生物教育专业获学士学位 承担科研项目 国家重点研发计划重点专项“畜禽重要胞内菌基因调控及其与宿主互作的分子机制研究”项目,2017-2020,课题三负责人。

研究领域

实验室主要研究病原体感染诱导的宿主免疫激活和免疫细胞的发育、分化调控机制,以及慢性炎症疾病发生的内在机理。具体包括以下方面内容: a.耐药性胞外菌和高致病性胞内菌的感染致病机理; b.蚊媒介导的病毒感染、传播机制; c.过敏及环境污染等因素导致的慢性炎症疾病; d.过敏及环境因素导致的病原体易感机制研究。

近期论文

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1.FubingLi*,YangLi*,HuichunLiang*,TaoXu*,YanjieKong,MaoboHuang,JiXiao,XiChen,HoujunXia,YingyingWu,ZhongmeiZhou,XiaominGuo,ChunmiaoHu,ChuanyuYang,XuCheng,CeshiChen#,andXiaopengQi#.2018.HECTD3mediatesTRAF3polyubiquitinationandtypeIinterferoninductionduringbacterialinfection.JournalofClinicalInvestigation,doi:10.1172/JCI120406(IF:13.251) 2.LinJin*,XiaominGuo*,ChuanbinShen*,XueHao*,PengSun*,PengpengLi,TaoXu,ChunmiaoHu,OmbatiRose,HongningZhou,MingdongYang,Cheng-FengQin,JingyaGuo,HuaPeng,MingzhaoZhu,GongCheng#,XiaopengQi#,andRenLai#.2018.SalivaryfactorLTRINfromAedesaegyptifacilitatesZikavirustransmissionbyinterferingwiththelymphotoxin-breceptor.NatureImmunology,19:342–353.(IF:21.809) 3.YangLi*,XiaominGuo*,ChunmiaoHu,YanDu,ChuanshengGuo,DiWang,WeihengZhao,GonghuaHuang,ChunliangLi,QiuminLu,RenLai,TaoXu,andXiaopengQi#.2018.TypeIIFNoperatespyroptosisandnecroptosisduringmultidrug-resistantA.baumanniiinfection.CellDeath&Differentiation,doi:10.1038/s41418-017-0041-z(IF:8.339) 4.Yan-HuLiu*,LuWang*,TaoXu*,XiaominGuo,YangLi,Ting-TingYin,He-ChuanYang,YangHu,AdeniyiC.Adeola,OscarJ.Sanke,NewtonO.Otecko,MengWang,YapingMa,OlaogunS.Charles,Mikkel-HolgerS.Sinding,ShyamGopalakrishnan,JoséAlfredoSamaniego,AndersJ.Hansen,CarlosFernandes,PhilippeGaubert,JaneBudd,PhilipM.Dawuda,LubinJiang,M.T.PGilbert,WeiweiZhai,XiaopengQi#,Guo-DongWang#,Ya-PingZhang#.2018.Whole-genomesequencingofAfricandogsprovidesinsightsintoadaptationsagainsttropicalparasites.MolecularBiologyandEvolution,35(2):287-298.(IF:10.217) 5.QiangShao,StephanieHerrlinger,Ya-NanZhu,MeiYang,ForrestGoodfellow,StevenL.Stice,XiaopengQi,MelindaA.Brindley,Jian-FuChen.2017.TheAfricanZikavirusMR-766ismorevirulentandcausesmoreseverebraindamagethancurrentAsianlineageandDenguevirus.Development,144(22):4114-4124.(IF:6.059) 6.XiaopengQi#.2016.Formationofmembraneporesbygasdermin-Ncausespyroptosis.SciChina-LifeSci,07.26,59(10):1071-1073.(IF:3.085) 7.XiaopengQi,SiMingMan,RKSubbaraoMalireddi,RajendraKarki,ChristopherLupfer,PrajwalGurung,GeoffreyNeale,CliffordGuy,MohamedLamkanfi,Thirumala-DeviKanneganti.2016.CathepsinBmodulateslysosomalbiogenesisandhostdefenseagainstFrancisellanovicidainfection.TheJournalofExperimentalMedicine,213(10):2081-97.(IF:13.912) 8.RajendraKarki,SiMingMan,SubbaraoMalireddi,SannulaKesavardhana,QifanZhu,AmandaR.Burton,BheshRajSharma,XiaopengQi,StephanePelletier,PeterVogel,PhilipRosenstiel&Thirumala-DeviKanneganti.2016.NLRC3isaninhibitorysensorofPI3K–mTORpathwaysincancer.Nature,540:583–587.(IF:38.138) 9.XiaopengQi,PrajwalGurung,R.K.SubbaraoMalireddi,PeerW.F.Karmaus,DeepikaSharma,PeterVogel,HongboChi,DouglasR.GreenandThirumala-DeviKanneganti.2016.Criticalroleofcaspase-8–mediatedIL-1signalinginpromotingTh2responsesduringasthmapathogenesis.MucosalImmunology,10(1):128-138.(IF:7.374) 10.YapengLi,XiaopengQi,BingLiu,HuaHuang.2015.TheSTAT5–GATA2PathwayIsCriticalinBasophilandMastCellDifferentiationandMaintenance.TheJournalofImmunology,194(9):4328-38.(IF:4.92) 11.XiaopengQi,JessieHong,LeeChaves,YonghuaZhuang,YuhongChen,DeminWang,JacobChabon,BrianGraham,KeitaroOhmori,YapengLi,andHuaHuang.2013.AntagonisticregulationbythetranscriptionfactorsC/EBPaandMITFspecifiesbasophilandmastcellfates.Immunity,39(1):97-110.(IF:24.082) 12.ZhihongChen,ShanzeWang,NkirukaErekosima,YapengLi,JessieHong,XiaopengQi,PatriciaMerkel,VijayaNagabhushanam,EugeneChoo,RohitKatial,RafeulAlam,AnitaTrikha,HongWeiChu,YonghuaZhuang,MeilingJin,ChunxueBai,andHuaHuang.2013.IL-4confersresistancetoIL-27-mediatedsuppressiononCD4+TcellsbyimpairingSTAT1signaling.TheJournalofAllergyandClinicalImmunology,132(4):912-921.(IF:13.258) 13.XiaopengQi,JunNishida,LeeChaves,KeitaroOhmoriandHuaHuang.2011.C/EBPαiscriticalforinterleukin-4expressioninresponsetoFcεR1receptorcross-linking.TheJournalofBiologicalChemistry,286(18):16063-16073. 14.XiaopengQi,TylerDrosteandChengKao.2011.Cell-PenetratingPeptidesDerivedfromViralCapsidProteins.MolecularPlant-MicrobeInteractions.24(1):25-36. 15.XiaopengQi,ForrestShengBaoandZhixinXie.2009.SmallRNADeepSequencingRevealsRoleforArabidopsisthalianaRNA-dependentRNApolymerasesinViralsiRNABiogenesis.PLoSone,4(3):e4971. 16.XiaopengQi,ZhongchangWu,JinhuiLi,XiaorongMo,ShihuaWu,JunChu,PingWu.2007.AtCYT-INV1,aneutralinvertase,isinvolvedinosmoticstress-inducedinhibitiononlateralrootgrowthinArabidopsis.PlantMolecularBiology,64:575-587.

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