赖仞 - 中国科学院昆明动物研究所 -

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中国科学院昆明动物研究所
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个人简介

简历研究员，1972年出生，国家杰出青年基金获得者；中国科学院昆明动物研究所研究员，博士生导师主要学历 1991.9-1995.7西南师范大学，生物学，学士 1995.9-2001.7中科院昆明动物研究所，动物学，博士主要科研工作经历 2001.8-2002.3，中国科学院昆明动物研究所，助理研究员 2002.4-2004.6，利物浦大学，博士后 2004.7-今，中国科学院昆明动物研究所，副所长，研究员到目前以第一或者通讯作者身份共发表SCI论文200余篇，如NatureImmunology、Immunity、NatureCommunications、ChemicalReviews、ProcNatlAcadSci、MolCellProteomics、Hypertension、JMedChem、FASEBJ、Allergy、FreeRadicBiolMed、JBC等；受邀担任JVenomRes副主编；申请发明专利70多项获奖及荣誉 1.国家杰出青年基金获得者，2010年 2.基于生物生存策略的有毒动物中药功能成分定向挖掘技术体系，2013年，国务院，国家技术发明奖，二等，第一完成人 3.两栖动物活性多肽的结构与功能研究，2008年，云南省政府,云南省自然科学奖，一等，第一完成人 4.吸血蜱与其宿主相互作用的分子机制研究，2009年，云南省政府，云南省自然科学奖，二等，第一完成人 5.全国创新争先奖状，2017年，中国科协、科技部、人力资源和社会保障部、国有资产监督管理委员会，个人奖 6.中医药管理局突出贡献奖，2017年，中医药管理局，个人奖 7.中国青年科技奖，2011年，中国科协，个人奖 8.中国科学院王宽诚西部学者突出贡献奖，2010年，中国科学院，个人奖 9.第十届“中国科学院十大杰出青年”，2010年，中国科学院，个人奖 10.谈家桢生命科学创新奖，2010年，科技部、上海市生物医药行业协会，个人奖 11.“万人计划”科技领军人才，科技部 12.连续2年（2016、2017）指导的博士研究生获得中科院百篇博优秀论文 13.云南省“十二五”十大科技人物 14.云南省“天然活性多肽研究与利用”重点实验室主任 15.云南省“天然活性多肽”工程实验室主任

研究领域

长期致力于生物生存策略及环境适应机制研究、探索有毒动物（如蜈蚣、牛虻等）捕食和防御策略，揭示生物环境适应的物质基础与分子机制、并基于天然活性物质进行新药研发 1）研究高原两栖动物环境适应机制，从臭蛙皮肤发现第三套抗氧化系统，对皮肤保护、衰老研究与药物研究应用具重要意义(MolCellProteomics2009，8:571-583)，该工作得到德国哥廷根大学BurkhardPoeggeler教授高度赞赏“这是该领域的先驱工作，近期内没有任何其他工作在同领域有类似影响”； 2）研究两栖动物微生物防御机制，从铃蟾等识别了超过400种抗菌肽，占目前世界两栖动物抗菌肽总数40%以上，揭示两栖动物环境适应机制，也为抗感染药物研发提供源头资源(ChemRev.2015;115:1760-846)，并利用抗菌肽作为工具研究动脉粥样硬化疾病机理(Immunity2015;43:1137-47）； 3）研究树蛙对捕食者的防御策略，从华西树蛙发现神经毒素，这是首次发现的两栖动物基因编码的神经毒(JBiolChem.2009，284:22079-86)，为镇痛新药研发提供了候选药物、并被美国生物化学与分子生物学联合会作为亮点工作重点报道及被ScienceDaily等二十多家国际媒体报道； 4）研究吸血节肢动物吸血策略，揭示牛虻从其宿主成功吸血分子机制，从牛虻唾液腺发现>100种抗血栓和抗感染多肽，为药物研发提供源头资源(MolCellProteomics.2008;7:582-90.MolCellProteomics.2009;8:2071-9)；探索埃及伊蚊与宿主互作机制及吸血策略，发现其唾液腺成分通过抑制宿主免疫而协助寨卡病毒传播(NatureImmunology,19(4):342-353)，并为自身免疫药物研发提供及源头资源; 5）研究蜈蚣捕食策略，首次发现钠通道NaV1.7专一抑制剂（PNAS2013;110:17534-9），被Nature、NatureMedicine进行专门评论，并被推为Faculty1000，认为是目前全世界发现的最好的治疗慢性疼痛候选药物；蜈蚣毒素成分SsTx阻断离子通道KCNQ从而实现对巨大猎物高效捕食（PNAS2018；115:1646-1651），该工作被Science、华盛顿邮报、德国新闻社等专门评论;蜈蚣通过其毒素成分激活辣椒素受体诱导捕食者产生剧烈疼痛，从而逃避捕食(NatCommun.2015;6:8297)，为镇痛药物研发提供新思路和新的工具药物；通过这些工作，揭示有毒动物环境适应策略；以通讯作者身份在Immunity（IF25）、NatureImmunology（IF22）,PNAS(2篇)，NatureCommunications,ChemicalReviews（IF50）等著名国际刊物上发表SCI研究论文170篇（具体论文情况可通过如下链接查询：https://www.ncbi.nlm.nih.gov/pubmed/?term=lai+ren），识别了自主知识产权活性多肽1300多种，提供候选药物资源，获发明专利授权60项，奠定了我们在该领域的国际领先地位，受邀在国际顶级刊物ChemicalReviews（IF50）发表长篇综述论文（ChemRev.2015;115:1760-846）、利用毒素多肽研发药物或工具药物（如一工具药物已在全球销售RHT-3832-PI，https://www.pepnet.com/Products/Detail/3766/Rh-Tx）；利用有毒动物资源推动山区农村脱贫致富，十一五、十二五期连续两次被云南省评为“扶贫工作”先进集体。

近期论文

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2018 1.WangG,LongC,LiuW,XuC,ZhangM,LiQ,LuQ,MengP,LiD,RongM,SunZ,LuoX,LaiR.NovelSodiumChannelInhibitorFromLeeches.FrontPharmacol.2018Mar6;9:186. 2.JinL,GuoX,ShenC,HaoX,SunP,LiP,XuT,HuC,RoseO,ZhouH,YangM,QinCF,GuoJ,PengH,ZhuM,ChengG,QiX,LaiR.SalivaryfactorLTRINfromAedesaegyptifacilitatesthetransmissionofZikavirusbyinterferingwiththelymphotoxin-βreceptor.NatImmunol.2018Apr;19(4):342-353. 3.ZengX,LiP,ChenB,HuangJ,LaiR,LiuJ,RongM.SelectiveClosed-StateNav1.7BlockerJZTX-34ExhibitsAnalgesicEffectsagainstPain.Toxins(Basel).2018Feb2;10(2).pii:E64. 4.TuQ,HaoJ,ZhouX,YanL,DaiH,SunB,YangD,AnS,LvL,JiaoB,ChenC,LaiR,ShiP,ZhaoX.CDKN2Bdeletionisessentialforpancreaticcancerdevelopmentinsteadofunmeaningfulco-deletionduetojuxtapositiontoCDKN2A. Oncogene.2018Jan4;37(1):128-138. 5.LuoL,LiB,WangS,WuF,WangX,LiangP,OmbatiR,ChenJ,LuX,CuiJ,LuQ,ZhangL,ZhouM,TianC,YangS,LaiR.CentipedessubduegiantpreybyblockingKCNQchannels.ProcNatlAcadSciUSA.2018Feb13;115(7):1646-1651. 6.LiY,GuoX,HuC,DuY,GuoC,DiWang,ZhaoW,HuangG,LiC,LuQ,LaiR,XuT,QiX.TypeIIFNoperatespyroptosisandnecroptosisduringmultidrug-resistantA.baumanniiinfection.CellDeathDiffer.2018Jan19.doi:10.1038/s41418-017-0041-z. 2017 1.AluthwatthaST,HarrisonRD,RanawanaKB,XuC,LaiR,ChenJ.Doesspatialvariationinpredationpressuremodulateselectionforaposematism?EcolEvol.2017Aug15;7(18):7560-7572. 2.YangS,YangF,ZhangB,LeeBH,LiB,LuoL,ZhengJ,LaiR.Abimodalactivationmechanismunderliesscorpiontoxin-inducedpain.SciAdv.2017Aug2;3(8):e1700810. 3.JinL,FangM,ChenM,ZhouC,OmbatiR,HakimMA,MoG,LaiR,YanX,WangY,YangS.AninsecticidaltoxinfromNephilaclavataspidervenom.AminoAcids.2017Jul;49(7):1237-1245. 4.FangYQ,ShenCB,LuanN,YaoHM,LongCB,LaiR,YanXW.InvivoantimalarialactivityofsynthetichepcidinagainstPlasmodiumbergheiinmice.ChinJNatMed.2017Mar;15(3):161-167. 5.LuanN,ZhouC,LiP,OmbatiR,YanX,MoG,RongM,LaiR,DuanZ,ZhengR. Joannsin,anovelKunitz-typeFXainhibitorfromthevenomofProspirobolusjoannsi.ThrombHaemost.2017Jun2;117(6):1031-1039. 2016 1.MengP,HuangH,WangG,YangS,LuQ,LiuJ,LaiR,RongM.ANovelToxinfromHaplopelmalividumSelectivelyInhibitstheNaV1.8ChannelandPossessesPotentAnalgesicEfficacy.Toxins(Basel).2016Dec26;9(1).pii:E7. 2.HeX,ShenC,LuQ,LiJ,WeiY,HeL,BaiR,ZhengJ,LuanN,ZhangZ,RongM,LaiR.Prokineticin2PlaysaPivotalRoleinPsoriasis.EBioMedicine.2016Nov;13:248-261. 3.LuanN,ShenW,LiuJ,WenB,LinZ,YangS,LaiR,LiuS,RongM.ACombinationalStrategyuponRNASequencingandPeptidomicsUnravelsaSetofNovelToxinPeptidesinScorpionMesobuthusmartensii.Toxins(Basel).2016Oct5;8(10). 4.LiuWH,ChenY,BaiXW,YaoHM,ZhangXG,YanXW,LaiR.Identificationandcharacterizationofanovelneuropeptide(neuropeptideY-HS)fromleechsalivaryglandofHaemadipsasylvestris.ChinJNatMed.2016Sep;14(9):677-682. 5.YaoHM,WangG,LiuYP,RongMQ,ShenCB,YanXW,LuoXD,LaiR.PhenolicacidsisolatedfromthefungusSchizophyllumcommuneexertanalgesicactivitybyinhibitingvoltage-gatedsodiumchannels.ChinJNatMed.2016Sep;14(9):661-670. 6.MaH,Xiao-PengT,YangSL,LuQM,LaiR.Proteaseinhibitorinscorpion(Mesobuthuseupeus)venomprolongsthebiologicalactivitiesofthecrudevenom.ChinJNatMed.2016Aug;14(8):607-14. 7.LaiY,LiB,LiuW,WangG,DuC,OmbatiR,LaiR,LongC,LiH.PurificationandCharacterizationofaNovelKazal-TypeTrypsinInhibitorfromtheLeechofHirudinariamanillensis.Toxins(Basel).2016Jul23;8(8). 8.RongM,LiuJ,ZhangM,WangG,ZhaoG,WangG,ZhangY,HuK,LaiR.AsodiumchannelinhibitorISTX-Iwithanovelstructureprovidesanewhintattheevolutionarylinkbetweentwotoxinfolds.SciRep.2016Jul13;6:29691. 9.JinL,BaiX,LuanN,YaoH,ZhangZ,LiuW,ChenY,YanX,RongM,LaiR,LuQ.ADesignedTryptophan-andLysine/Arginine-RichAntimicrobialPeptidewithTherapeuticPotentialforClinicalAntibiotic-ResistantCandidaalbicansVaginitis.JMedChem.2016Mar10;59(5):1791-9. 10.KangD,LiB,LuoL,JiangW,LuQ,RongM,LaiR.Curcuminshowsexcellenttherapeuticeffectonpsoriasisinmousemodel.Biochimie.2016Apr;123:73-80. 11.WeiNN,LvHN,WuY,YangSL,SunXY,LaiR,JiangY,WangK.SelectiveActivationofNociceptorTRPV1ChannelandReversalofInflammatoryPaininMicebyaNovelCoumarinDerivativeMuralatinLfromMurrayaalata.JBiolChem.2016Jan8;291(2):640-51. 12.HaoX,TangX,LuoL,WangY,LaiR,LuQ.Anovelranacyclin-likepeptidewithanti-plateletactivityidentifiedfromskinsecretionsofthefrogAmolopsloloensis.Gene.2016Jan15;576(1Pt1):171-5. 2015 1.ZhangZ,MengP,HanY,ShenC,LiB,HakimMA,ZhangX,LuQ,RongM,LaiR.MitochondrialDNA-LL-37ComplexPromotesAtherosclerosisbyEscapingfromAutophagicRecognition.Immunity.2015;43(6):1137-47. 2.HakimMA,YangS,LaiR.CentipedeVenomsandTheirComponents:ResourcesforPotentialTherapeuticApplications.Toxins(Basel).2015Nov17;7(11):4832-51. 3.HaoX,TangX,LuoL,WangY,LaiR,LuQ.Anovelranacyclin-likepeptidewithanti-plateletactivityidentifiedfromskinsecretionsofthefrogAmolopsloloensis.Gene.2016Jan15;576(1Pt1):171-5. 4.YangS,YangF,WeiN,HongJ,LiB,LuoL,RongM,Yarov-YarovoyV,ZhengJ,WangK,LaiR.Apain-inducingcentipedetoxintargetstheheatactivationmachineryofnociceptorTRPV1.NatCommun.2015Sep30;6:8297.. 5.HakimMA,JiangW,LuoL,LiB,YangS,SongY,LaiR.ScorpionToxin,BmP01,InducesPainbyTargetingTRPV1Channel.Toxins(Basel).2015Sep14;7(9):3671-87. 6.FangY,LongC,BaiX,LiuW,RongM,LaiR,AnS.Twonewtypesofallergensfromthecockroach,Periplanetaamericana.Allergy.201570(12):1674-8. 7.BaiX,YaoH,DuC,ChenY,LaiR,RongM.AnimmunoregulatorypeptidefromtsetseflysalivaryglandsofGlossinamorsitansmorsitans.Biochimie.2015Nov;118:123-8. 8.WangYW,TanJM,DuCW,LuanN,YanXW,LaiR,LuQM.ANovelTrypsinInhibitor-LikeCysteine-RichPeptidefromtheFrogLepidobatrachuslaevisContainingProteinase-InhibitingActivity.NatProdBioprospect.2015Aug;5(4):209-14. 9.HuK,JiangY,XieY,LiuH,LiuR,ZhaoZ,LaiR,YangL.Small-AnionSelectiveTransmembrane"Holes"InducedbyanAntimicrobialPeptideTooShorttoSpanMembranes.JPhysChemB.2015Jul9;119(27):8553-60. 10.ZhongS,WuJ,CuiY,LiR,ZhuS,RongM,LuQ,LaiR.VascularendothelialgrowthfactorfromTrimeresurusjerdoniivenomspecificallybindstoVEGFR-2.Biochimie.2015Sep;116:1-7. 11.JiangWB,HakimM,LuoL,LiBW,YangSL,SongYZ,LaiR,LuQM.PurificationandcharacterizationofcholecystokininfromtheskinofsalamanderTylototritonverrucosus.DongwuxueYanjiu.2015May18;36(3):174-7. 12.XuX,LaiR.Thechemistryandbiologicalactivitiesofpeptidesfromamphibianskinsecretions.ChemRev.2015Feb25;115(4):1760-846. 13.RongM,YangS,WenB,MoG,KangD,LiuJ,LinZ,JiangW,LiB,DuC,YangS,JiangH,FengQ,XuX,WangJ,LaiR.PeptidomicscombinedwithcDNAlibraryunravelthediversityofcentipedevenom.JProteomics.2015Jan30;114:28-37. 14.TangJ,FangY,HanY,BaiX,YanX,ZhangY,LaiR,ZhangZ.YY-39,atickanti-thrombosispeptidecontainingRGDdomain.Peptides.2015Jun;68:99-104. 2014 1.ZhuY,LiZ,LiuH,HeX,ZhangY,JinJ,CheJ,LiC,ChenW,LaiR,LiuJ.NovelanalgesicpeptidesfromthetreefrogofHylajaponica.Biochimie.2014,99:38-43. 2.ZhuY,DuanZ,MoG,ShenC,LvL,ChenW,LaiR.Anovel26RFapeptidecontainingbothanalgesicandanti-inflammatoryfunctionsfromChinesetreeshrew.Biochimie.2014,102:112-6. 3.ZhangK,DingW,SunJ,ZhangB,LuF,LaiR,ZouY,YedidG.Antioxidantandantitumoractivitiesof4-arylcoumarinsand4-aryl-3,4-dihydrocoumarins.Biochimie.2014Dec;107PtB:203-10 4.MuL,TangJ,LiuH,ShenC,RongM,ZhangZ,LaiR.Apotentialwound-healing-promotingpeptidefromsalamanderskin.FASEBJ.2014，Sep;28(9):3919-29. 5.LiuH,DuanZ,TangJ,LvQ,RongM,LaiR.Ashortpeptidefromfrogskinacceleratesdiabeticwoundhealing.FEBSJ.2014，281(20):4633-43. 6.ZhangZ,GaoL,ShenC,RongM,YanX,LaiR.Apotentanti-thrombosispeptide(vasotabTY)fromhorseflysalivaryglands.IntJBiochemCellBiol.2014，54:83-8. 7.LiuH,MuL,TangJ,ShenC,GaoC,RongM,ZhangZ,LiuJ,WuX,YuH,LaiR.Apotentialwoundhealing-promotingpeptidefromfrogskin.IntJBiochemCellBiol.2014,49:32-41. 8.ZhongY,SongB,MoG,YuanM,LiH,WangP,YuanM,LuQ.ANovelNeurotoxinfromVenomoftheSpider,Brachypelmaalbopilosum.PLoSOne.2014,9(10):e110221. 9.TangJ,LiuH,GaoC,MuL,YangS,RongM,ZhangZ,LiuJ,DingQ,LaiR.Asmallpeptidewithpotentialabilitytopromotewoundhealing.PLoSOne.2014,9(3):e92082. 10.TangJ,FangY,HanY,BaiX,YanX,ZhangY,LaiR,ZhangZ.YY-39,atickanti-thrombosispeptidecontainingRGDdomain.Peptides.2015Jun;68:99-104. 2013 1.ZhuY,LiZ,LiuH,HeX,ZhangY,JinJ,CheJ,LiC,ChenW,LaiR,LiuJ.NovelanalgesicpeptidesfromthetreefrogofHylajaponica.Biochimie.2014Apr;99:38-43.. 2.YangS,XiaoY,KangD,LiuJ,LiY,UndheimEA,KlintJK,RongM,LaiR,KingGF.DiscoveryofaselectiveNaV1.7inhibitorfromcentipedevenomwithanalgesicefficacyexceedingmorphineinrodentpainmodels.ProcNatlAcadSciUSA.2013;110(43):17534-9. 3.LiuYP,LaiR,YaoYG,ZhangZK,PuET,CaiXH,LuoXD.Inducedfuroeudesmanes:adefensemechanismagainststressinLaggerapterodonta,aChineseherbalplant.OrgLett.20134;15(19):4940-3. 4.ZhangZ,MuL,TangJ,DuanZ,WangF,WeiL,RongM,LaiR.Asmallpeptidewiththerapeuticpotentialforinflammatoryacnevulgaris.PLoSOne.2013;8(8):e72923. 5.YanH,LiuY,TangJ,MoG,SongY,YanX,WeiL,LaiR.AnovelantimicrobialpeptidefromskinsecretionsofthetreefrogThelodermakwangsiensis.ZoologSci.2013;30(9):704-9. 6.LiuR,ZhangZ,LiuH,HouP,LangJ,WangS,YanH,LiP,HuangZ,WuH,RongM,HuangJ,WangH,LvL,QiuM,DingJ,LaiR.Humanβ-defensin2isanovelopenerofCa2+-activatedpotassiumchannelsandinducesvasodilationandhypotensioninmonkeys.Hypertension.2013;62(2):415-25. 7.LiuH,ZhaoB,ChenY,YouD,LiuR,RongM,JiW,ZhengP,LaiR.Multiplecoagulationfactordeficiencyprotein2containstheabilitytosupportstemcellself-renewal.FASEBJ.2013;27(8):3298-305. 8.SongY,JiS,LiuW,YuX,MengQ,LaiR.DifferentexpressionprofilesofbioactivepeptidesinPelophylaxnigromaculatusfromdistinctregions.BiosciBiotechnolBiochem.2013;77(5):1075-9. 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