Stephenson, Corey - University of Michigan

个人简介

Corey was born in 1974 in Collingwood, Ontario, Canada. Upon completion of secondary school in Collingwood, he began studies in chemistry at the University of Waterloo in the coop program. As part of this program, he was able to participate in internships in research labs at Apotex Inc., Merck Frosst Centre for Therapeutic Research and Astra Research Centre Montreal (now AstraZeneca). After graduation in 1998, he began graduate studies under the direction of Professor Peter Wipf at the University of Pittsburgh. His doctoral studies involved investigations into new C-C bond forming reactions of alkenylzirconocenes and cascade reaction sequences which were initiated by this bond formation. These new compounds were then utilized in a diversity-oriented approach to library synthesis and the methodologies implemented by the Pittsburgh CMLD. Following his departure from Pittsburgh, he began post-doctoral studies at Eidgenössische Technische Hochschule in Zürich, Switzerland under the direction of Professor Erick M. Carreira. The focus of his research activities in Zürich was in the area of catalytic asymmetric synthesis and alkaloid total synthesis. In September 2007, he joined the Department of Chemistry at Boston University as an Assistant Professor and is a co-PI in the Center for Methodologies and Library Development (CMLD-BU). He was granted tenure and promoted to Associate Professor in February, 2013. In July 2013, he joined the Department of Chemistry at the University of Michigan as Associate Professor of Chemistry. Since joining the department in 2007 Corey has been the recipient of the Thieme Synlett/Synthesis Journal Award (2009), the Boehringer–Ingelheim New Investigator Award (2010), an NSF CAREER award (2011-2016), the Alfred P. Sloan Research Fellowship (2011-2013), the Amgen Young Investigator Award (2011), the Novartis Early Career Award in Organic Chemistry (2012-2015), the Eli Lilly Grantee Award (2013-2015) the Camille Dreyfus Teacher-Scholar Award (2013) and the EROS Best Reagent Award (2014).

研究领域

Research in our group is focused primarily upon the development of new strategies and methodologies for the synthesis of natural products. Of particular interest are the discovery of practical new processes which utilize the redox chemistry of visible light activated metal complexes. Visible light sensitization is an attractive means to initiate organic reactions due to the lack of visible light absorbance by organic compounds thereby reducing the side reactions that are often associated with photochemical reactions conducted with high energy UV light. These photocatalysts offer a means to selectively functionalize organic molecules with the appropriate choice of an excited state quencher. These processes offer improved chemoselectivity (and strategic advantages when employed in total synthesis) over current approaches while also enabling the reduction of stoichiometric waste byproducts. In particular, we are focusing our efforts in the following areas: (1) the development of new methodologies based upon visible light initiated electron transfer reactions; (2) applications of these methods to complex natural product synthesis; (3) technology-enabled reaction discovery and photocatalysis using mesoflow and microfluidics chemistry; and (4) new approaches to biomass conversion.

近期论文

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"Synthesis of Resveratrol Tetramers via a Stereoconvergent Radical Equilibrium." Mitchell H. Keylor, Bryan S. Matsuura, Markus Griesser, Jean-Philippe R. Chauvin, Ryan A. Harding, Mariia S. Kirillova, Xu Zhu, Oliver J. Fischer, Derek A. Pratt and Corey R. J. Stephenson, Science 2016, 354, 1260. "Photocatalytic Oxidation of Lignin Model Systems by Merging Visible-Light-Induced Photoredox and Palladium Catalysis." Markus D. Kärkäs, Irene Bosque, Bryan S. Matsuura and Corey R. J. Stephenson, Org. Lett. 2016, 18, 5166. "Free Radical Chemistry Enabled by Visible Light-Induced Electron Transfer." Daryl Staveness, Irene Bosque and Corey R. J. Stephenson, Acc. Chem. Res. 2016, 49, 2295. Published as part of the special Issue on Photoredox Catalysis in Organic Chemistry. "Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on Kilogram Scale." Joel W. Beatty, James J. Douglas, Richard Miller, Rory McAtee, Kevin P. Cole and Corey R. J. Stephenson, Chem 2016, 1, 456. "Light-Mediated Reductive Debromination of Unactivated Alkyl and Aryl Bromides." James J. Devery, John D. Ngyuen, Chunhui Dai and Corey R. J. Stephenson, ACS Catalysis, 2016, 6, 5962. "Visible light photocatalysis: applications and new disconnections in the synthesis of pharmaceutical agents." James J. Douglas, Martin J. Sevrin and Corey R. J. Stephenson, Org. Proc. Res. Dev. 2016, 20, 1134. "Preparative Scale Demonstration and Mechanistic Investigation of a Visible Light-Mediated Radical Smiles Rearrangement." James J. Douglas, Martin J. Sevrin, Kevin P. Cole and Corey R. J. Stephenson, Org. Proc. Res. Dev. 2016, 20, 1148. "Microwave-assisted synthesis of heteroleptic Ir(III)+ polypyridyl complexes." Timothy M. Monos, Alexandra C. Sun, Rory C. McAtee, James J. Devery, III and Corey R. J. Stephenson, J. Org. Chem. 2016, 81, 6988. Selected as a Featured Article for the Special issue on Photocatalysis. "Visible Light Mediated Reductions of Ethers, Amines and Sulfides." Timothy M. Monos, Gabriel Magallanes, Leanne J. Sebren and Corey R. J. Stephenson, J. Photochem. Photobiol. A 2016, 328, 240. Invited feature article. "Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis." Markus D. Kärkäs, John. A. Porco, Jr. and Corey R. J. Stephenson, Chem. Rev. 2016, 116, 9683. Published a part of the special issue on Photochemistry in Organic Synthesis. "Formation and trapping of azafulvene intermediates derived from manganese-mediated oxidative malonate coupling." Verner A. Lofstrand, Bryan S. Matsuura, Laura Furst, Jagan M. R. Narayanam and Corey R. J. Stephenson, Tetrahedron 2016, 72, 3775. Published a part of the special issue in honor of Professor Neil Garg for his receipt of the Tetrahedron Young Investigator Award. "Transition-metal catalyzed valorization of lignin: the key to a sustainable carbon-neutral future." Markus D. Kärkäs, Bryan S. Matsuura, Timothy Monos, Gabriel Magallanes and Corey R. J. Stephenson, Org. Biomol. Chem. 2016, 14, 1853. "Intermolecular Photocatalytic C-H Functionalization of Electron-Rich Heterocycles with Tertiary Alkyl Halides." Elizabeth C. Swift, Theresa M. Williams and Corey R. J. Stephenson, Synlett 2016, 27, 754. Published in the special cluster of articles on modern radical chemistry.