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女,博士,教授,硕士生导师。现任江苏大学医学院检验医学实验室副主任、医学院教工第四党支部宣传委员,兼任中华医学会微生物与免疫分会青年委员、江苏省医学微生物与免疫学会委员。 长期从事临床生物化学检验工作,曾在美国UniversityofMarylan(Postdoctoral)从事免疫学研修工作。科研方向主要集中在免疫调节与自身免疫性疾病、树突状细胞生物学功能以及肿瘤免疫学治疗等方面。 作为课题负责人主持国家自然科学基金1项、中国博士后基金、江苏省博士后基金1项、江苏省重点实验室课题1项、江苏大学高级人才项目1项、江苏大学青年基金扶持项目1项。近年来以第一作者和通讯作者在AmJPathol、MolecularOncology、JClinEndocrinolMetab、CancerLetts等SCI期刊发表论文36篇,主持和参加的科研成果有4项通过省市科技鉴定,获省部级科技进步奖1项、市厅级科技进步奖3项。主编、参编教材9部。培养和指导博士、硕士研究生5名。 主持或参加科研项目及人才计划项目情况: 1.GITRL调控Tfh细胞促进小鼠胶原诱导性关节炎发病的实验研究,国家自然科学基金(31100648),项目负责人 2.髓源性抑制细胞来源的exosomes抑制小鼠胶原诱导性关节炎的实验研究,国家自然科学基金(31470881),参与 3.长链非编码RNA作为肺癌早期预测标志物的实验及临床研究,,江苏省重点实验室开放课题(JSKLM-2014-013),项目负责人 4.长链非编码RNA通过调控粒系髓源性抑制细胞影响小鼠肺癌抗瘤免疫应答的实验研究,江苏大学青年基金扶持项目(FCJJ2015022),项目负责人 5.mGITRL调控Tfh细胞功能及在CIA中的作用机制,江苏大学高级人才项目(11JDG093),项目负责人

近期论文

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一、第一作者论文 1.MaJ(马洁),XuH,WangS.ImmunosuppressiveRoleofMyeloid-DerivedSuppressorCellsandTherapeuticTargetinginLungCancer.JImmunolRes.2018Mar25;2018:6319649.doi:10.1155/2018/6319649.eCollection2018.Review.(SCIIF3.298) 2.MaJ(马洁),GuarneraMA,ZhouW,FangH,JiangF.APredictionModelBasedonBiomarkersandClinicalCharacteristicsforDetectionofLungCancerinPulmonaryNodules.2017,TranslOncol,10(1):40-45.(SCIIF2.392) 3.MaJie(马洁),TianJie,WangShengjun,BlockadeofGITRsignalingamelioratesmurinecollagen-inducedarthritisbymodulatingfollicularhelperTcells,AmJPathol,2016.186(6):1559-1567.(SCIIF4.591) 4.MaJ(马洁),LiN,LinY,GuptaC,JiangF.CirculatingNeutrophilMicroRNAsasBiomarkersfortheDetectionofLungCancer.BiomarkCancer.2016Jan24;8:1-7.doi:10.4137/BIC.S37333. 5.Ma,Jie(马洁),Lin,Yanli,ZhanMin,MannDeanL,StassSanfordA,Jiang,Feng,DifferentialmiRNAexpressionsinperipheralbloodmononuclearcellsfordiagnosisoflungcancer,LaboratoryInvestigation,2015,95(10):1197-1206.(SCIIF3.676) 6.MaJ(马洁),MannoorK,GaoL,TanA,GuarneraMA,ZhanM,ShettyA,StassSA,XingL,JiangF,CharacterizationofmicroRNAtranscriptomeinlungcancerbynext-generationdeepsequencing,MolOncol,2014,8(7):1208-1219.(SCIIF5.331) 7.LiN,MaJ(马洁)(共同第一作者),GuarneraMA,FangH,CaiL,JiangF,DigitalPCRquantificationofmiRNAsinsputumfordiagnosisoflungcancer,CancerResClinOncol,2014,140(1):145-150.(SCIIF3.081) 8.GaoL,MaJ(马洁)(共同第一作者),MannoorK,GuarneraMA,ShettyA,ZhanM,XingL,StassSA,JiangF,Genome-widesmallnucleolarRNAexpressionanalysisoflungcancerbynext-generationdeepsequencing,IntJCancer,2014,136(6):623-629.(SCIIF5.085) 9.MaJ(马洁),LiN,GuarneraM,JiangF,QuantificationofPlasmamiRNAsbyDigitalPCRforCancerDiagnosis,BiomarkInsights,2013,14(8):127-136. 10.MaJie(马洁),ZhuChenlu,MaBin,TianJie,BaidooSamuelEssien,MaoChaoming,WuWei,ChenJianguo,TongJia,YangMin,JiaoZhijun,XuHuaxi,LuLiwei,WangShengjun,IncreasedFrequencyofCirculatingFollicularHelperTCellsinPatientswithRheumatoidArthritis,ClinDevImmunol,2012;2012:827480.doi:10.1155/2012/827480.(SCIIF2.934) 11.ZhuChenlu,MaJie(马洁)(共同第一作者),LiuYingzhao,TongJia,TianJie,ChenJianguo,TangXinyi,XuHuaxi,LuLiwei,WangShengjun,IncreasedFrequencyofFollicularHelperTCellsinPatientswithAutoimmuneThyroidDisease,JournalofClinicalEndocrinology&Metabolism,2012,97(3):943-950.(SCIIF6.209) 12.MaJ(马洁),WangS,MaB,MaoC,TongJ,YangM,WuC,JiaoZ,LuL,XuH,DendriticcellsengineeredtoexpressGITRLenhancetherapeuticimmunityinmurineLewislungcarcinoma,CancerLett,2011,301(2):142-150.(SCIIF5.621) 13.TianJ,MaJ(马洁)(共同第一作者),WangS,YanJ,ChenJ,TongJ,WuC,LiuY,MaB,MaoC,JiaoZ,ShaoQ,LuL,XuH,IncreasedexpressionofmGITRLonD2SC/1cellsbyparticulateβ-glucanimpairsthesuppressiveeffectofCD4(+)CD25(+)regulatoryTcellsandenhancestheeffectorTcellproliferation,CellImmunol,2011,270(2):183-187.(SCIIF1.924) 二、通讯作者论文 1.ChenJuan,MaJie(马洁)(共同通讯作者),TianJie,TangXinyi,RuiKe,MaoChaoming,LiuYingzhao,LuLiwei,XuHuaxi,WangShengjun,MiR-346regulatesCD4(+)CXCR5(+)TcellsinthepathogenesisofGraves'disease,Endocrine,2015,49(3):752-760.(SCIIF3.878) 三、既非第一作者又非通讯作者论文 1.ZhouQ,TangX,TianX,TianJ,ZhangY,MaJ(马洁),XuH,WangS.LncRNAMALAT1negativelyregulatesMDSCsinpatientswithlungcancer.JCancer.2018Jun14;9(14):2436-2442.doi:10.7150/jca.24796.eCollection2018. 2.TianX,MaJ(马洁),WangT,TianJ,ZhengY,PengR,WangY,ZhangY,MaoL,XuH,WangS.Longnon-codingRNARUNXORacceleratesMDSC-mediatedimmunosuppressioninlungcancer.BMCCancer.2018Jun18;18(1):660.doi:10.1186/s12885-018-4564-6. 3.TianX,MaJ(马洁),WangT,TianJ,ZhangY,MaoL,XuH,WangS.LongNon-CodingRNAHOXATranscriptAntisenseRNAMyeloid-Specific1-HOXA1AxisDownregulatestheImmunosuppressiveActivityofMyeloid-DerivedSuppressorCellsinLungCancer.FrontImmunol.2018Mar12;9:473.doi:10.3389/fimmu.2018.00473.eCollection2018. 4.PengHuiyong,LiuYingzhao,TianJie,MaJie(马洁),TangXinyi,RuiKe,TianXinyu,MaoChaoming,LuLiwei,XuHuaxi,JiangPengcheng,WangShengjun.TheLongNoncodingRNAIFNG-AS1PromotesTHelperType1CellsResponseinPatientswithHashimoto'sThyroiditis.ScientificReports,2015Dec4;5:17702.doi: 10.1038/srep17702. 5.TianJie,RuiKe,TangXinyi,MaJie(马洁),WangYungang,TianXinyu,ZhangYue,XuHuaxi,LuLiwei,WangShengjun.MicroRNA-9RegulatestheDifferentiationandFunctionofMyeloid-DerivedSuppressorCellsviaTargetingRunx1.TheJournalofImmunology,2015,195(3):1301-1311. 6.PengHuiyong,LiuYingzhao,TianJie,MaJie(马洁),TangXinyi,YangJun,RuiKe,ZhangYue,MaoChaoming,LuLiwei,XuHuaxi,WangShengjun.DecreasedexpressionofmicroRNA-125a-3pupregulatesinterleukin-23receptorinpatientswithHashimoto'sthyroiditis.ImmunologicResearch,2015,62(2):129-136. 7.YuanJing,TangXinyi,YinKai,TianJie,RuiKe,MaJie(马洁),MaoChaoming,ChenJianguo,LuLiwei,XuHuaxi,WangShengjun.GITRLasageneticadjuvantenhancesenterovirus71VP1DNAvaccineimmunogenicity,ImmunologicResearch,2015,62(1):81-88. 8.TianXinyu,TianJie,TangXinyi,RuiKe,ZhangYue,MaJie(马洁),WangYungang,XuHuaxi,LuLiwei,WangShengjun.Particulatebeta-glucanregulatestheimmunosuppressionofgranulocyticmyeloid-derivedsuppressorcellsbyinhibitingNFIAexpression.Oncoimmunology,2015Jul1;4(9):e1038687. 9.LiuYingzhao,TangXinyi,TianJie,ZhuChenlu,PengHuiyong,RuiKe,WangYungang,MaoChaoming,MaJie(马洁),LuLiwei,XuHuaxi,WangShengjun.Th17/TregCellsImbalanceandGITRLProfileinPatientswithHashimoto'sThyroiditis,InternationalJournalofMolecularSciences,2014,15(12):21674-21686. 10.TianJie,ZhangYue,YangXiaomin,RuiKe,TangXinyi,MaJie(马洁),Chen,Jianguo,XuHuaxi,LuLiwei,WangShengjun,FicuscaricaPolysaccharidesPromotetheMaturationandFunctionofDendriticCells,InternationalJournalofMolecularSciences,2014,15(7):12469-12479. 11.LiuY,TangX,TianJ,ZhuC,PengH,RuiK,WangY,MaoC,MaJ(马洁),LuL,XuH,WangS.Th17/TregCellsImbalanceandGITRLProfileinPatientswithHashimoto'sThyroiditis.IntJMolSci,2014,15(12):21674-21686. 12.TianJie,MaJie(马洁),MaKe,GuoHongye,BaidooSamuelEssien,ZhangYue,Yan,Jun,LuLiwei,XuHuaxi,WangShengjun.beta-Glucanenhancesantitumorimmuneresponsesbyregulatingdifferentiationandfunctionofmonocytic myeloid-derivedsuppressorcells.EuropeanJournalofImmunology,2013,43(5):1220-1230. 13.WangS,BaidooS.E,LiuY,ZhuC,TianJ,MaJ(马洁),TongJ,ChenJ,TangX,XuH,LuL.Tcell-derivedleptincontributestoincreasedfrequencyofThelpertype17cellsinfemalepatientswithHashimoto';sthyroiditis,ClinicalandExperimentalImmunology.2013,171(1):63-68. 14.TianJ,MaJ(马洁),MaK,GuoH,BaidooSE,ZhangY,YanJ,LuL,XuH,WangS.β-Glucanenhancesantitumorimmuneresponsesbyregulatingdifferentiationandfunctionofmonocyticmyeloid-derivedsuppressorcells,EurJImmunol,2013,43(5):1220-1230. 15.TianJie,MaJie(马洁),MaKe,MaBin,TangXinyi,BaidooSamuelEssien,TongJia,YanJun,LuLiwei,XuHuaxi,WangShengjun.Up-RegulationofGITRLonDendriticCellsbyWGPImprovesAnti-TumorImmunityinMurineLewisLungCarcinoma.PLOSONE,2012,7(10):e46936. 16.HeZ,ShotorbaniS.SmJiaoZ,SuZ,Tong,LiuY,ShenP,MaJ(马洁),GaoJ,WangT,XiaS,ShaoQ,WangS,XuH.HMGB1PromotestheDifferentiationofTh17viaUp-RegulatingTLR2andIL-23ofCD14+MonocytesfromPatientswithRheumatoidArthritis.ScandinavianJournalofImmunology,2012,76(5):483-490. 17.WangShengjun,ShiYe,YangMin,MaJie(马洁),TianJie,ChenJianguo,MaoChaoming,JiaoZhijun,KoKing-Hung,BaidooSamuelEssien,XuHuaxi,HuaZichun,LuLiwei.Glucocorticoid-InducedTumorNecrosisFactorReceptorFamily-RelatedProteinExacerbatesCollagen-InducedArthritisbyEnhancingtheExpansionofTh17Cells.AmJPathol,2012,180(3):1059-1067. 18.TianJ,MaJ(马洁),MaK,MaB,TangX,BaidooSE,TongJ,YanJ,LuL,XuH,WangS.Up-regulationofGITRLondendriticcellsbyWGPimprovesanti-tumorimmunityinmurineLewislungcarcinoma.PLoSOne,2012,7(10):46936. 19.JiaoZ,WangW,MaJ(马洁),WangS,SuZ,XuH.NotchsignalingmediatesTNF-α-inducedIL-6productioninculturedfibroblast-likesynoviocytesfromrheumatoidarthritis.ClinDevImmunol,2011,350209. 20.DaweiCui,ShengjunWang,YuChen,JiaTong,JieMa(马洁),LiTang,XianzhiYang,YeShi,JieTian,LiweiLu,HuaxiXu.AnIsoleucineZipperMotifEnhancesCostimulationofHumanSolubleTrimericGITRligand.CellMolImmunol,2010,7(4)316-322. 21.ChaomingMao,ShengjunWang,QianJiang,JiaTong,JieMa(马洁),MinYang,XiaopengXu,GufengQiu,QixiangShao,LongLi,HuaxiXu.IncreasedCD4+CD25+FOXP3+RegulatoryTCellsinCancerPatientsfromConversionofCD4+CD25-TCellsthroughTumor-derivedFactors.Oncologie,2008,31(5)243-248. 22.WangSJ,XuHX,WangYZ,MaJ(马洁),MaoCM,ShaoQX,MaB,XuWR,YangSL.RegulatoryTcellsinducedbyrAAVcarryingtheforkheadboxP3genepreventautoimmunethyroiditisinmice.InternationalJournalofMolecularMedicine,2006;18(6):1193-1200.

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