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个人简介

医学博士,教授,博士生导师,美国康奈尔大学博士后。现任江苏大学医学院医学检验系副主任,免疫学与免疫检验学教研室主任,江苏省免疫学会理事,江苏省医学会微生物与免疫学会理事。在Blood、JBC、Endocrinology、CancerImmun&Immunother、Diabetes、JImmunol、《中国免疫学杂志》、《临床检验杂志》等国内外期刊上发表研究论文,主编及参编教材、专著十余部,主持省精品课程一门。 主讲课程: 《医学免疫学》(本科)、《临床免疫检验学》(本科)、《医学免疫学技术》(硕士研究生)、《Immunology》(MBBS留学生)、《免疫学进展》(博士研究生)、《AdvanceinImmunology》(留学研究生)等。 主要科研项目: 1.新型NKT细胞亚群治疗晚期肿瘤的I/II期临床研究(BE2017696),江苏省社会发展重点研发项目(临床前沿技术), 2.高脂肥胖对肠道区域树突状细胞的影响及相关机制研究(31570879),国家自然科学基金面上项目, 3.肥胖通过调控肠道菌群影响调节性T细胞功能的研究(31428006),国家自然科学基金海外及港澳学者合作研究项目, 4.ω-3脂肪酸诱导免疫耐受、促造血干细胞分化机制及其应用研究(81172834),国家自然科学基金面上项目,

研究领域

免疫调节、免疫治疗、免疫检验。

近期论文

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1.JinH,YanC,XiaoT,YanN,XuJ,ZhouL,ZhouX,ShaoQ,XiaS*.Highfishoildietpromotesliverinflammationandactivatesthecomplementsystem.MolMedRep.2018;17(5):6852-6858 2.QiangY,XuJ,YanC,JinH,XiaoT,YanN,ZhouL,AnH,ZhouX,ShaoQ,XiaS*.Butyrateandretinoicacidimprintmucosal-likedendriticcelldevelopmentsynergisticallyfrombonemarrowcells.CinExpImmunol.2017;189(3):290-297. 3.LiuX,WangJ,WangH,ZhouC,YuQ,YinL,WuW,XiaS,ShaoQCellpenetrablemouseforkheadboxP3suppressestype1Thelpercellmediatedimmunityinamurinemodelofdelayedtypehypersensitivity.ExpTherMed.2017;13(2):421-428. 4.ChengL,JinH,QiangY,WuS,YanC,HanM,XiaoT,YanN,AnH,ZhouX,ShaoQ,XiaS*.Highfatdietexacerbatesdextransulfatesodiuminducedcolitisthroughdisturbingmucosaldendriticcellhomeostasis.IntImmunopharmacol.2016,40(5):1-10. 5.XiaS*,LiXP,ChengL,HanMT,ZhangMM,ShaoQX,XuHX,QiL.FishOil-RichDietPromotesHematopoiesisandAltersHematopoieticNiche.Endocrinology.2015;156(8):2821-30. 6.ChenD,WangY,WangH,WuY,XiaS*,ZhangM.CD8(+)TactivationattenuatesCD4(+)Tproliferationthroughdendriticcellsmodification.CellImmunol.2015;296(2):138-48. 7.LiuX,JiB,SunM,WuW,HuangL,SunA,ZongY,XiaS,ShiL,QianH,XuW,ShaoQ.Cell-penetrablemouseforkheadboxprotein3alleviatesexperimentalarthritisinmicebyup-regulatingregulatoryTcells.ClinExpImmunol.2015;181(1):87-99. 8.LiY,JiX,SuZ,TongJ,XiaS,ChenX,LuP,BarniePA,WangS,HuangX,XuH.DownregulationofRunx3iscloselyrelatedtothedecreasedTh1-associatedfactorsinpatientswithgastriccarcinoma.TumourBiol.2014;35(12):12235-44.. 9.LiuX,ZhaoQ,PengX,XiaS,ShenW,ZongY,ChengJ,WuW,ZhangM,DuF,XuW,QianH,ShaoQ.PTD-mediatedintracellulardeliveryofmutantNFATminimumDNAbindingdomaininhibitedtheproliferationofTcells.IntImmunopharmacol.2014;19(1):110-8 10.XiaS*,LiX,ChengL,HanM,ZhangM,LiuX,XuH,ZhangM,ShaoQ,QiL.Chronicintakeofhighfishoildietinducesmyeloid-derivedsuppressorcellstopromotetumorgrowth.CancerImmunolImmunother.2014;63(7):663-73. 11.XiaS*,HanM,LiX,ChengL,QiangY,WuS,ZhangM,XuH,LiuX,ShaoQ.DietaryfishoilexacerbatesconcanavalinAinducedhepatitisthroughpromotinghepatocyteapoptosisandalteringimmunecellpopulations.JToxicolSci.2014;39(2):179-90. 12.ShaH,YangL,LiuM,XiaS,LiuY,LiuF,KerstenS,QiL.AdipocytesplicedformofX-box-bindingprotein1promotesadiponectinmultimerizationandsystemicglucosehomeostasis.Diabetes.2014;63(3):867-79. 13.GuY,YangP,ShaoQ,LiuX,XiaS,ZhangM,XuH,ShaoQ.InvestigationoftheexpressionpatternsandcorrelationofDNAmethyltransferasesandclassIhistonedeacetylasesinovariancancertissues.OncolLett.2013;5(2):452-458. 14.TongJ,HanQ,WangS,SuZ,ZhengD,ShenP,XiaS,HuangX,ShaoQ,XuH.Corynebacteriumpyruviciproducens,asanimmunemodulator,canpromotetheactivityofmacrophagesandup-regulateantibodyresponsetoparticulateantigen.ExpBiolMed(Maywood).2012;237(11):1322-30. 15.SunS,XiaS,JiY,KerstenS,QiL.TheATP-P2X7signalingaxisisdispensableforobesity-associatedinflammasomeactivationinadiposetissue.Diabetes.2012;61(6):1471-8. 16.XuX,YiH,GuoZ,QianC,XiaS,YaoY,CaoX.Splenicstroma-educatedregulatorydendriticcellsinduceapoptosisofactivatedCD4TcellsviaFasL-enhancedIFN-[gamma]andnitricoxide.JImmunology.2012188(3):(3):1168-77 17.LiuX,XuX,LinX,TianY,JiB,XiaS,XuS,YinQ,ZhangM,JiaoZ,WangS,XuH,ShaoQ.PTD-hFOXP3proteinactsasanimmuneregulatortoconverthumanCD4(+)CD25(-)TcellstoregulatoryT-likecells.JCellBiochem.2012;113(12):3797-809. 18.JiY,SunS,XiaS,YangL,LiX,QiL.ShorttermhighfatdietchallengepromotesalternativemacrophagepolarizationinadiposetissuevianaturalkillerTcellsandinterleukin-4.JBiolChem.2012;287(29):24378-86 19.QingzhenH,JiaT,ShengjunW,YangZ,YanfangL,PeiS,EssienBS,ZhaoliangS,ShengX,QixiangS,FinegoldSM,XuH.Corynebacteriumpyruviciproducenspromotestheproductionofovalbuminspecificantibodyviastimulatingdendriticcelldifferentiationandup-regulatingTh2biasedimmuneresponse.Vaccine.2012;30(6):1115-23 20.HeZ,ShotorbaniSS,JiaoZ,SuZ,TongJ,LiuY,ShenP,MaJ,GaoJ,WangT,XiaS,ShaoQ,WangS,XuH.HMGB1promotesthedifferentiationofTh17viaup-regulatingTLR2andIL-23ofCD14+monocytesfrompatientswithrheumatoidarthritis.ScandJImmunol.2012Nov;76(5):483-90. 21.XiaS*,ShaH,YangL,JiY,Ostrand-RosenbergS,QiL.Gr-1+CD11b+myeloid-derivedsuppressorcellssuppressinflammationandpromoteinsulinsensitivityinobesity.JBiolChem.2011,286:(26):23591-9.

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