个人简介
CarolineS.Harwood院士，美国华盛顿大学教授，青岛农业大学“特聘教授”，“山东省高端外国专家”。
CarolineS.Harwood，1982年获美国麻省大学微生物学博士，2000年当选为美国微生物学会资深会员，2008年当选为美国科学促进会(AAAS)资深会员，2009年被评为美国科学院院士，2010年获宝洁公司应用环境微生物学奖。Harwood院士在微生物生理学及生物能源领域享有国际声誉。其研究工作已在国际著名期刊（如Science,Nature,NatureBiotechnology,PNAS,mBio,NucleicAcidsResearch,Curr.OpinioninMicrobiol.,Appl.Environ.Microbiol.J.Bacteriol.等）发表SCI论文100多篇，其中单篇文章最高他引次数达500多次。目前正在主持来自美国能源部（DOE）、国家卫生研究所、陆军研究局、美国国家科学基金等多项课题，总经费达450多万美元。出生于布鲁克莱恩,马萨诸塞州;美国公民
教育背景：
1982-1984
博后
耶鲁大学
1982
博士
微生物专业
马萨诸塞大学
1976
硕士
生物学专业
波士顿大学
1973
学士
生物学专业科尔比学院
,ME
教职：
2013-华盛顿大学校长助理（主管科研）
2006-华盛顿大学杰拉德和林恩格林施泰因的微生物学教授
2005-华盛顿大学教授
1996-2004爱荷华大学教授
1993-1996爱荷华大学副教授
1988-1993爱荷华大学助理教授
1984-1988康奈尔大学高级研究助理
荣誉：
2010获宝洁公司应用环境微生物学奖
2009华盛顿州科学院院士
2009美国科学院院士
2008美国科学促进会资深会员
2006当选华盛顿大学杰拉德和林恩格林施泰因的微生物学教授
2000美国微生物学会资深会员Patents
USpatentnumber7,745,023;Structuredmaterialfortheproductionofhydrogen.Issued6/29/10.
USpatentnumber8,268,584:Hydrogenproductionfrommicrobialstrains.Issued9/18/12Inventors:CarolineHarwoodandFedericoRey
Reviews,proceedingsandchapters.
Lang,A.S.,C.S.HarwoodandJ.T.Beatty.2011.Evolutionaryrelationshipsamongantennaproteinsofpurplephototrophicbacteria.IN:R.BurnapandW.Vermaas(eds.),FunctionalGenomicsandEvolutionofPhotosyntheticSystems,AdvancesinPhotosynthesisandRespiration33,pp.253–264,DOI10.1007/978-94-007-1533-2_10,
McKinlay,J.B.andC.S.Harwood.2011.Applicationsofstressresponsestudies:biofuelproduction.IN:G.StorzandR.Hengge(eds).BacterialStressResponses,2nded.,Washington,D.C.:ASMPress.
Harwood,C.S.2010.Roleofcyclicdi-GMPinPseudomonasaeruginosabiofilmdevelopment.
IN:A.J.Wolfe,andK.L.Visick(eds.)TheSecondMessengerCyclicDi-GMP.
(pp.156-172).Washington,DC:ASMPress.
Harwood,C.S.2009.Degradationofaromaticcompoundsbypurplenonsulfurbacteria
IN:HunterCN,Daldal,F,ThurnauerMC,andBeattyJT(eds)ThePurplePhototrophicBacteria.AdvancesinPhotosynthesisandRespiration,Vol.28,pp.577-594,Springer,Dordrecht,TheNetherlands
Harwood,C.S.2008.Nitrogenase-catalyzedhydrogenproductionbypurplenonsulfurphotosyntheticbacteria.p.259-271.IN:A.Demain,C.S.HarwoodandJ.Wall(eds.)Bioenergy.AmericanSocietyforMicrobiologyPress.
Harwood,C.S.2008Amicrobiologisthopestodisruptbacterial'decisions'.Nature.2008455:5.
Parales,R.E.,A.Ferrández,andC.S.Harwood..ChemotaxisinPseudomonads.2004.VolIpp
793-815.In:ThePseudomonads,J.L.Ramos,ed,KluwerAcademic/PlenumPress.
Gibson,J.andC.S.Harwood.2002.Metabolicdiversityinaromaticcompoundutilizationbyanaerobicmicrobes.Annu.Rev.Microbiol.56:345-369.
Parales,R.E.andC.S.Harwood.2002.Bacterialchemotaxistopollutantsandplant-derivedaromaticmolecules.Curr.OpinioninMicrobiol.5:266-273.
Aizawa,S-I,C.S.Harwood,andR.J.Kadner.2000.Signalingcomponentsinbacteriallocomotionandsensoryreception.J.Bacteriol.182:1459-1471.
Harwood,C.S.,G.Buchhardt,H.Herrmann,andG.Fuchs.1999.Anaerobicmetabolismofaromaticcompoundsviathebenzoyl-CoApathway.FEMSMicrobiol.Rev.22:439-458
Harwood,C.S.andE.P.Greenberg.1999.MegaRolesforMicroorganisms(reviewof"IntimateStrangers:UnseenLifeonEarth").Science286:1096.
Harwood,C.S.,andJ.Gibson.1997.Sheddinglightonanaerobicbenzeneringdegradation:aprocessuniquetoprokaryotes?J.Bacteriol.179:634-642.
Gibson,J.,andC.S.Harwood.1995.Anaerobicutilizationofaromaticcarboxylatesbybacteria.p.298-313.IN:R.G.Chaudhry(ed.),Biologicaldegradationandbioremediatonoftoxicchemicals.TimberPress,Portland,OR.
Gibson,J.,andC.S.Harwood.1995.Degradationofaromaticcompoundsbynon-sulfurpurplebacteria.IN:R.E.Blankenshipetal.(eds.),AnoxygenicPhotosyntheticBacteria.p.991-1003.KluwerAcademicPublishers.
Harwood,C.S.,andR.E.Parales.1996.Theb-ketoadipatepathwayandthebiologyofself-identity.Annu.Rev.Microbiol.50:553-590.
Gibson,J.,J.F.GeisslerandC.S.Harwood.1990.Benzoate-coenzymeAligasefromRhodopseudomonaspalustris.MethodsinEnzymology(HydrocarbonsandMethylotrophy)188:154-159.
Harwood,C.S.,andE.Canale-Parola.1984.Ecologyofspirochetes.Ann.Rev.Microbiol.
38:161-192
近期论文
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RefereedPublications
Heiniger,E.K.,andC.S.Harwood.2015.Posttranslationalmodificationofavanadiumnitrogenase.MicrobiologyOpen.Inpress.
HirakawaH,HirakawaY,GreenbergEP,HarwoodCS.2015.BadRandBadMproteinstranscriptionallyregulatetwooperonsneededforanaerobicbenzoatedegradationbyRhodopseudomonaspalustris.ApplEnvironMicrobiol.Apr17.pii:AEM.00377-15.[Epubaheadofprint]
Chen,A.I.,E.FDolben,C.Okegbe,C.E.Harty,Y.Golub,S.Thao,D.G.Ha,S.D.Willger,G.
O’Toole,C.S.Harwood,L.E.P.DietrichandD.A.Hogan.2014.CandidaalbicansethanolstimulatesPseudomonasaeruginosaWspR-controlledbiofilmformationaspartofacyclicrelationshipinvolvingphenazines.PlosPathogens10(10):e1004480.doi:10.1371/journal.ppat.1004480
FixenKR,A.W.Baker,E.A.Stojković,J.TBeatty,andC.S.Harwood.2014.Apo-bacteriophytochromesmodulatebacterialphotosynthesisinresponsetolowlight.Proc.Natl.Acad.Sci.USA.111:E237-44.
McKinlayJB,Y.Oda,M.Ruhl,ALPosto,U.SauerandCSHarwood.2014.Non-growingRhodopseudomonaspalustrisincreasesthehydrogengasyieldfromacetatebyshiftingfromtheglyoxylateshunttothetricarboxylicacidcycle.JBiolChem.289:1960-70.
Baraquet,C.andC.S.Harwood.2013.C-di-GMPrepressesbacterialflagellasynthesisbyinteractingwiththeWalkerAmotifoftheenhancerbindingproteinFleQ.Proc.Natl.Acad.Sci.USA.110:18478-18483.PMID:24167275
Schaefer,A,L.,C.R.Lappala,R.P.Morlen,D.A.Pelletier,T.Y.Lu,P.K.Lankford,C.S.HarwoodandE.P.Greenberg.2013.LuxR-andLuxI-typequorumsensingcircuitsareprevalentinmembersofthePopulusdeltoidesmicrobiome.Appl.Environ.Microbiol.79:5745-4752.PMID:23851092
Huangyutitham,V.,Z,T,Guvener,andC.S.Harwood.2013.SubcellularclusteringofthephosphorylatedWspRresponseregulatorproteinstimulatesitsdiguanylatecyclaseactivity.mBIO.May7;4(3).doi:pii:e00242-13.10.1128/mBio.00242-13.
IrieY,B.R.Borlee,J.R.O'ConnorJR,P.J.Hill,CS.Harwood,D.J.WozniakandM.R.Parsek.2012.Self-producedexopolysaccharideisasignalthatstimulatesbiofilmformationinPseudomonasaeruginosa.Proc.Natl.Acad.Sci.USA.109:E2823-31.PMID:23175784
Adessi,A.,J.B.McKinlay,C.S.HarwoodandR.DePhilippis.2012.ARhodopseudomonaspalustrisnifA*mutantproducesH2fromNH4+-containingvegetablewastes.Int.J.HydrogenEnergyRes.37:15893-900.
ChugaiS.,B.S.Kim,S.Phattarasukol,M.J.Brittnacher,S,H.Choi,C.S.HarwoodandE.P.Greenberg.2012.Strain-dependentdiversityinthePseudomonasaeruginosaquorum-sensingregulon.Proc.Natl.Acad.Sci.USA.109:E2823-31
O’Connor,J.,N.Kuwada,V.Huangyutitham,P.Wiggins,andC.S.Harwood.2012.SurfacesensingandlateralsubcellularlocalizationofWspA,thereceptorinachemosensory-likesystemleadingtoc-di-GMPproduction.Mol.Microbiol.Sep7.doi:10.1111/mmi.12013.
Phattrasukol,S.,M.C.Radey,C.R.Lappala,Y,Oda,H.Hirakawa,M.J.Brittnacher,andC.S.Harwood.2012.Identificationofap-coumaratedegradationregulonin
RhodopseudomonaspalustrisusingXpression,anintegratedtoolforprokaryoticRNA-seqdataprocessing.Appl.Environ.Microbiol.78:6812-8
Hirakawa,H.,C.S.Harwood,K.B.Pechter,A.L.SchaeferandE.P.Greenberg.2012.AnantisenseRNAthataffectsRhodopseudomonaspalustrisquorum-sensingsignalreceptorexpression.Proc.Natl.Acad.Sci.USA.109:12141-6.
Baraquet,C.,K.Murikami,M.R.ParsekjandC.S.Harwood.2012.TheFleQproteinfromPseudomonasaeruginosafunctionsasbotharepressorandanactivatortocontrolgeneexpressionfromthepeloperonpromoterinresponsetoc-di-GMP.NucleicAcidsResearch.40:7207-18.
HirakawaH.,A.L.Schaefer,E.P.GreenbergandC.S.Harwood.2012.Anaerobicp-coumaratedegradationbyRhodopseudomonaspalustrisandidentificationofCouR,aMarRrepressorproteinthatbindsp-coumaroyl-CoA.J.Bacteriol.194:1960-1967.
Heiniger,E.K.,Y.Oda,S.K.SamantaandC.S.Harwood.2012.Howpost-translationalmodificationofnitrogenaseiscircumventedinRhodopseudomonaspalustrisstrainsthatproducehydrogengasconstitutively.AppliedandEnviron.Microbiol.78:1023-32.
Lindemann,A.,G.Pessi,A.L.Schaefer,M.E.Mattmann,Q.H.Christensen,A.Kessler,H.Hennecke,H.E.Blackwell,E.P.GreenbergandC.S.Harwood.2011.Quorumsensinginthesoybeanroot-nodulatingbacteriumBradyrhizobiumjaponicum:identificationofisovaleryl-homoserinelactone,anunusualbranched-chainsignal.Proc.Natl.Acad.
Sci.USA.108:16750-16770.
Ahlgren,N.S.,C.S.Harwood,A.L.Schaefer,E.Griaud,andE.P.Greenberg.2011.Aryl-homoserinelactonequorumsensinginstem-nodulatingphotosyntheticbradyrhizobia.Proc.Natl.Acad.Sci.USA108:7183-7188.
McKinlay,J.B.andC.S.Harwood.2011.Calvincycleflux,pathwayconstraintsandsubstrateoxidationstatetogetherdeterminetheH2biofuelyieldinphotoheterotrophicbacteria.mBIO.March22:2.
HirakawaH,Y.Oda,S.Phattarasukol,C.D.Armour,J.C.Castle,C.K.Raymond,C.R.Lappala,A.L.Schaefer,C.S.HarwoodandE.P.Greenberg.2011.ActivityoftheRhodopseudomonaspalustrisp-coumaroyl-homoserinelactoneresponsivetranscriptionfactorRpaR.J.Bacteriol.193:2598-2607.
HuangJ.J.,E.K.Heiniger,J.B.McKinlayandC.S.Harwood.2010.ProductionofhydrogengasfromlightandtheinorganicelectrondonorthiosulfatebyRhodopseudomonaspalustris.Appl.Environ.Microbiol.76:7717-7712.
Gosse,J.L.,B.J.Engel,J.C.Hui,C.S.Harwood,andM.C.Flickinger.2010.Progresstowardabiomimeticleaf:4,000hofhydrogenproductionbycoating-stabilizednongrowingphotosyntheticRhodopseudomonaspalustris.BiotechnolProg.26:907-918.
McKinlay,J.B.andC.S.Harwood.2010.Carbondioxidefixationasacentralredoxcofactorrecyclingmechanisminbacteria.Proc.Natl.Acad.Sci.USA105:18543-18548.
Crosby,H.A.,Heiniger,E.K.,C.S.Harwood,andJ.C.Escalante-Semerana.2010ReversibleN-lysineacetylationregulatestheactivityofacyl-CoAsynthetasesinvolvedinanaerobicbenzoatecatabolisminRhodopseudomonaspalustris.Mol.Microbiol.75:1007-1020.
McKinlay,J.B.andC.S.Harwood.2010.Photobiologicalproductionofhydrogengasasabiofuel.Curr.Opin.Biotechnol.21:244-251.
Rey,F.andC.S.Harwood.2010.FixK,aglobalregulatorofmicroaerobicgrowth,controlsphotosynthesisinRhodopseudomonaspalustris.Mol.Microbiol.75:1007-1020.
StarkeyM,J.H.Hickman,L.Ma,N.Zhang,S.DeLong,A.HinzA,S.Palacios,C.Manoil,M.J.Kirisits,T.D.Starner,D.J.Wozniak,C.S.Harwood,M.R.Parsek.2009.Pseudomonasaeruginosarugosesmallcolonyvariantshaveadaptationslikelytopromotepersistenceinthecysticfibrosislung.J.Bacteriol.191:3492-3503.
OdaY.,F.W.Larimer,P.S.Chain,S.Malfatti,M.V.Shin,L.M.,Vergez,L.Hauser,M.L.Land,S.Braatsch,J.T.Beatty,D.A.Pelletier,A.L.SchaeferandC.S.Harwood.2008.Multiplegenomesequencesrevealadaptationsofaphototrophicbacteriumtosedimentmicroenvironments.Proc.Natl.Acad.Sci.USA.105:18543-18548.Epub2008Nov1
Schaefer,A.L.,E.P.Greenberg,C.M.Oliver,Y.Oda,J.J.Huang,G.Bittan-Banin,C.M.Peres,S.Schmidt,K.Juhaszova,J.R.SufrinandC.S.Harwood.2008.Anewclassofhomoserinelactonequorum-sensingsignals.Nature454:595-599.
Hickman,J.W.andC.S.Harwood.2008.IdentificationofFleQfromPseudomonasaeruginosa
asac-di-GMP-responsivetranscriptionfactor.Mol.Microbiol.69:376-389.
Pan,C.,Y.Oda,P.K.Lankford,B.Zhang,N.F.Samatova,D.A.Pelletier,C.S.Harwood,andR.L.Hettich.2008.Characterizationofanaerobiccatabolismofp-coumarateinRhodopseudomonaspalustrisbyintegratingtranscriptomicsandquantitativeproteomics.Mol.Cell.Proteomics.7:938-948.
Güvener,Z.T.andC.S.Harwood.2007.SubcellularlocationcharacteristicsofthePseudomonasaeruginosaGGDEFprotein,WspR,indicatethatitproducescyclic-di-GMPinresponsetogrowthonsurfaces.Mol.Microbiol.66:1459-147.
Alvarez-Ortega,C.andC.S.Harwood.2007.IdentificationofamalatechemoreceptorinPseudomonasaeruginosabyscreeningforchemotaxisdefectsinanenergytaxis-deficientmutant.Appl.Environ.Microbiol.73:7793-7795.
Alvarez-Ortega,C.andC.S.Harwood.2007.ResponsesofPseudomonasaeruginosatolowoxygenindicatethatgrowthinthecysticfibrosislungisbyaerobicrespiration.Mol.
Microbiol.65:153-165.
Rey,F.E.,E.K.HeinigerandC.S.Harwood.2007.Redirectionofmetabolismforbiologicalhydrogenproduction.Appl.Environ.Microbiol.73:1665-1671.
Gosse,J.L.,B.J.Engel,F.Rey,C.S.Harwood,L.E.ScrivenandM.C.Flickinger,2007Hydrogenproductionbynano-porouslaxtexcoatingofnon-growingRhodopseudomonaspalustrisCGA009.BiotechnologyProg.23:124-130.
Braatsch,S.,J.R.Bernstein,F.Lessner,J.Morgan,J.C.Liao,C.S.HarwoodandJ.T.Beatty.
2006.RhodopseudomonaspalustrisCGA009hastwoppsRgenesthateachencoderepressorsofphotosynthesisgeneexpression.Biochemistry45:14441-14451.
Peres.C.M.andC.S.Harwood.2006.BadMisatranscriptionalrepressorandoneofthreeregulatorsthatcontrolsbenzoyl-CoAreductasegeneexpressioninRhodopseudomonaspalustris.J.Bacteriol.188:8662-8665.
Rey,F.E.,Y.OdaandC.S.Harwood.2006.RegulationofuptakehydrogenaseandeffectsofhydrogenutilizationongeneexpressioninRhodopseudomonaspalustris.J.Bacteriol.188:6143-6152.
Güvener,Z.T.,D.F.TifreaandC.S.Harwood.2006.TwodifferentPseudomonasaeruginosachemosensorysignaltransductioncomplexeslocalizetocellpolesandformandremoldinstationaryphase.Mol.Microbiol.61:106-118.
VerBerkmoes,N.C.,M.B.Shah,P.K.Lankford,D.A.Pelletier,M.B.Strader,D.L.Tabb,W.
H.McDonald,J.W.Barton,G.B.Hurst,L.Hauser,B.H.Davison,J.T.Beatty,C.S.Harwood,F.R.Tabita,R.L.Hettich,andF.W.Larimer.2006DeterminationandcomparisonofthebaselineproteomesoftheversatilemicrobeRhodopseudomonaspalustrisunderitsmajormetabolicstates.J.ProteomeResearch.5:287-298.
HickmanJ.W.,D.F.TifreaandC.S.Harwood.2005.Achemosensorysystemthatregulatesbiofilmformationthroughmodulationofcyclicdiguanylatelevels.Proc.Natl.Acad.Sci.USA.102:14422-14427.
Oda,Y.,S.K.Samanta,F.Rey,L.Wu,X.-D.Liu,T.-F.Yan,J.Zhou,andC.S.Harwood.2005.
FunctionalgenomicanalysisofthreenitrogenaseisozymesinRhodopseudomonaspalustris.J.Bacteriol.187:7784-7794.
Harrison,F.H.andC.S.Harwood.2005.ThepimFABCDEoperonfromRhodopseudomonaspalustrismediatesdicarboxylicaciddegradationandparticipatesinanaerobicbenzoatedegradation.Microbiology151:727-736.
Samanta,S.K.andC.S.Harwood.2005.UseoftheRhodopseudomonaspalustrisgenometoidentifyasingleaminoacidthatcontributestotheactivityofacoenzymeAligasewithchlorinatedsubstrates.Mol.Microbiol.55:1151-1159.
Larimer,F.W.,P.Chain,J.Lamerdin,S.StilwagenMalfatti,L.Do,M.Land,L.Hauser,D.A.Pelletier,J.T.Beatty,A.S.Lang,F.R.Tabita,J.L.Gibson,T.E.Hanson,C.Bobst,J.TorresYTorres,C.Peres,F.Harrison,J.GibsonandC.S.Harwood.2004.ThegenomesequenceofthemetabolicallyversatilephotosyntheticbacteriumRhodopseudomonaspalustris.NatureBiotech.22:55-61.
Schuster,M.,A.C.Hawkins,C.S.HarwoodandE.P.Greenberg.2004.ThePseudomonasaeruginosaRpoSregulonanditsrelationshiptoquorumsensing.Mol.Microbiol.
51:973-985.
Ferrández,,A.,A.C.Hawkins,D.T.Summerfield,andC.S.Harwood.2002.ClusterIIchegenesfromPseudomonasaeruginosaarerequiredforanoptimalchemotacticresponse.J.Bacteriol.184:4374-4383.
Ditty,J.L.andC.S.Harwood.2002.Chargedaminoacidsconservedinthearomaticacid/H+
symporterfamilyofpermeasesarerequiredfor4-hydroxybenzoatetransportbyPcaKfromPseudomonasputida.J.Bacteriol.184:1444-1448
Hawkins,A.C.andC.S.Harwood.2002.ChemotaxisofRalstoniaeutrophaJMP134(pJP4)totheherbicide2,4-dichlorophenoxyacetate.Appl.Environ.Microbiol.68:968-972
Egland,P.G.,J.GibsonandC.S.Harwood.2001.Areductive,coenzymeA-mediated,pathwayfor3-chlorobenzoatedegradationinthephototrophicbacterium,Rhodopseudomonaspalustris.Appl.Environ.Microbiol.67:1396-1399.
Parales,R.E.,J.L.DittyandC.S.Harwood.2000.Toluene-degradingbacteriaarechemotactictowardstheenvironmentalpollutantsbenzene,toluene,andtrichloroethylene.Appl.Environ.Microbiol.66:4098-104.
Cowles,C.E.,N.N.NicholsandC.S.Harwood.2000.BenR,aXylShomologue,regulatesthreedifferentpathwaysofaromaticaciddegradationinPseudomonasputida.J.Bacteriol.182:6339-6346.
Pelletier,D.A.andC.S.Harwood.2000.2-HydroxycyclohexanecarboxylcoenzymeAdehydrogenase,anenzymecharacteristicoftheanaerobicbenzoatedegradationpathwayusedbyRhodopseudomonaspalustris.J.Bacteriol.182:2753-2760.
Nichols,N.N.andC.S.Harwood.2000.AnaerotaxistransducergenefromPseudomonasputida.FEMSMicrobiol.Letts.182:177-183.
Egland,P.G.andC.S.Harwood.2000.HbaR,a4-hydroxybenzoatesensorandFNR-CRPsuperfamilymember,regulatesanaerobic4-hydroxybenzoatedegradationbyRhodopseudomonaspalustris.J.Bacteriol.182:100-106.
Ditty,J.L.andC.S.Harwood.1999.ConservedcytoplasmicloopsareimportantforboththetransportandchemotaxisfunctionsofPcaK,aproteinfromPseudomonasputidawith12membrane-spanningregions.J.Bacteriol.181:5068-5074.
Grimm,A.C.andC.S.Harwood.1999.NahY,acatabolicplasmid-encodedreceptorrequiredforchemotaxisofPseudomonasputidatothearomatichydrocarbonnaphthalene.J.Bacteriol.181:3310-3316.
Egland,P.G.,andC.S.Harwood.1999.BadR,anewMarRfamilymember,regulatesanaerobicbenzoatedegradationbyRhodopseudomonaspalustrisinconcertwithAadR,anFnrfamilymember.J.Bacteriol.181:2102-2109.
Pelletier,D.A.,andC.S.Harwood.1998.2-Ketocyclohexanecarboxyl-CoAhydrolase,thering-cleavageenzymerequiredforanaerobicbenzoatedegradationbyRhodopseudomonaspalustris.J.Bacteriol.180:2330-2336.
Ditty,J.L.,A.C.Grimm,andC.S.Harwood.1998.IdentificationofachemotaxisgeneregionfromPseudomonasputida.FEMSMicrobiol.Letts.159:267-273
Grimm,A.C.,andC.S.Harwood.1997.ChemotaxisofPseudomonasspp.tothepolyaromatichydrocarbonnaphthalene.Appl.andEnviron.Microbiol.63:4111-4115.
Nichols,N.N.,andC.S.Harwood.1997.PcaK,ahighaffinitypermeaseforthearomaticcompounds4-hydroxybenzoateandprotocatechuatefromPseudomonasputida.J.Bacteriol.179:5056-5061.
Egland,P.G.,D.A.Pelletier,M.Dispensa,J.Gibson,andC.S.Harwood.1997.Aclusterofbacterialgenesforanaerobicbenzeneringbiodegradation.Proc.Natl.Acad.Sci.
USA94:6484-6489.
Gibson,J.,M.Dispensa,andC.S.Harwood.1997.4-Hydroxybenzoyl-CoAreductase(dehydroxylating)isrequiredforanaerobicdegradationof4-hydroxybenzoatebyRhodopseudomonaspalustrisandsharesfeatureswithmolybdenum-containinghydroxylases.J.Bacteriol.179:301-309.
Egland,P.G.,J.Gibson,andC.S.Harwood.1995.Benzoate-coenzymeAligase,encodedbybadA,isoneofthreeligasesabletocatalyzebenzoyl-CoAformationduringanaerobicgrowthofRhodopseudomonaspalustrisonbenzoate.J.Bacteriol.177:6545-6551,
NicholsN.N.,andC.S.Harwood.1995.Repressionof4-hydroxybenzoatetransportanddegradationbybenzoate:anewlayerofregulatorycontrolinthePseudomonasputida
b-ketoadipatepathway.J.Bacteriol.177:7033-7040.
Harwood,C.S.,N.N.Nichols,M-K.Kim,J.L.Ditty,andR.E.Parales.1994.IdentificationofthepcaRKFgeneclusterfromPseudomonasputida,involvementinchemotaxis,biodegradation,andtransportof4-hydroxybenzoate.J.Bacteriol.176:6479-6488.
Romero-Steiner,S.,R.E.Parales,C.S.Harwood,andJ.E.Houghton.1994.CharacterizationofthepcaRregulatorygenefromPseudomonasputida,whichisrequiredforthecompletedegradationofp-hydroxybenzoate.J.Bacteriol.176:5771-5779
Perrotta,J.A.,andC.S.Harwood.1994.Anaerobicmetabolismofcyclohex-1-ene-1-carboxylate,aproposedintermediateofbenzoatedegradationbyRhodopseudomonaspalustris.Appl.Environ.Microbiol.60:1775-1782.
Gibson,J.,M.Dispensa,G.C.Fogg,D.T.Evans,andC.S.Harwood.1994.4-Hydroxybenzoate-coenzymeAligasefromRhodopseudomonaspalustris:purification,genesequence,androleinanaeroabicdegradation.J.Bacteriol.176:634-641.
Parales,R.E.,andC.S.Harwood.1993.RegulationofthepcalJgenesforaromaticaciddegradationinPseudomonasputida.J.Bacteriol.175:5829-5838.
Parales,R.E.,andC.S.Harwood.1993.Constructionanduseofabroad-host-rangelacZ
transcriptionalfusionvector,pHRP309,forGram-negativebacteria.Gene133:23-30.Dispensa,M.,C.T.Thomas,M.-K.Kim,J.A.Perrotta,J.Gibson,andC.S.Harwood.1992.
AnaerobicgrowthofRhodopseudomonaspalustrison4-hydroxybenzoateisdependentonAadR,amemberofthecyclicAMPreceptorproteinfamilyoftranscriptionalregulators.J.Bacteriol.174:5803-5813.
Parales,R.E.,andC.S.Harwood.1992.Characterizationofthegenesencodingß-ketoadipate:succinyl-CoAtransferaseinPseudomonasputida.J.Bacteriol.174:4657-4666.
Han,C.-Y.,I.P.Crawford,andC.S.Harwood.1991.Up-promotermutationsinthetrpBA
operonofPseudomonasaeruginosa.J.Bacteriol.173:3756-3762.Kim,M.-K.,andC.S.Harwood.1991.Regulationofbenzoate-CoAligasein
Rhodopseudomonaspalustris.FEMSMicrobiol.Letts.83:199-204.
Harwood,C.S.,R.E.Parales,andM.Dispensa.1990.ChemotaxisofPseudomonasputida
towardchlorinatedbenzoates.Appl.Environ.Microbiol.56:1501-1503.
Parales,R.E.,andC.S.Harwood.1990.NucleotidesequenceofthegyrBgeneof
Pseudomonasputida.NucleicAcidsRes.18:5880.
Harwood,C.S.,K.Fosnaugh,andM.Dispensa.1989.FlagellationofPseudomonasputida
andanalysisofitsmotilebehavior.J.Bacteriol.171:4063-4066.
Harwood,C.S.1989.Amethyl-acceptingproteinisinvolvedinbenzoatetaxisin
Pseudomonasputida.J.Bacteriol.171:4603-4608.
Merkel,S.M.,A.E.Eberhard,J.Gibson,andC.S.Harwood.1989.InvolvementofcoenzymeAthioestersintheanaerobicmetabolismof4-hydroxybenzoatebyRhodopseudomonaspalustris.J.Bacteriol.171:1-7.
Harwood,C.S.,andJ.Gibson.1988.AnaerobicandaerobicmetabolismofdiversearomaticcompoundsbythephotosyntheticbacteriumRhodopseudomonaspalustris.Appl.
Environ.Microbiol.54:712-717.
Geissler,J.F.,C.S.Harwood,andJ.Gibson.1988.Purificationandpropertiesofbenzoate-coenzymeAligase,aRhodopseudomonaspalustrisenzymeinvolvedintheanaerobicdegradationofbenzoate.J.Bacteriol.170:1709-1714.
Harwood,C.S.,andL.N.Ornston.1988.Futilehigh-leveltransportactivityimpairssurvivalof
Pseudomonasputidaunderstarvationconditions.J.Gen.Microbiol.134:2421-2427.
Harwood,C.S.,andJ.Gibson.1986.UptakeofbenzoatebyRhodopseudomonaspalustris
grownanaerobicallyinlight.J.Bacteriol.165:504-509.
Harwood,C.S.,andL.N.Ornston.1984.TOLplasmidcanpreventinductionofchemotacticresponsestoaromaticacids.J.Bacteriol.160:797-800.
Harwood,C.S.,M.Rivelli,andL.N.Ornston.1984.Aromaticacidsarechemoattractantsfor
Pseudomonasputida.J.Bacteriol.160:622-628.
Harwood,C.S.,andE.Canale-Parola.1983.Spirochaetaisovalerciasp.nov.,amarineanaerobethatformsbranched-chainfattyacidsasfermentationproducts.Int.J.Syst.Bacteriol.33:573-579.
Harwood,C.S.,H.W.Jannasch,andE.Canale-Parola.1982.Anaerobicspirochetefromadeep-seahydrothermalvent.Appl.Environ.Microbiol.44:234-237.
Harwood,C.S.,andE.Canale-Parola.1982.Propertiesofacetatekinaseisozymesandabranched-chainfattyacidkinasefromaspirochete.J.Bacteriol.152:246-254.
Harwood,C.S.,andE.Canale-Parola.1981.Adenosine5'-triphosphate-yieldingpathwaysofbranched-chainaminoacidfermentationbyamarinespirochete.J.Bacteriol.148:117-123.
Harwood,C.S.,andE.Canale-Parola.1981.Branched-chainaminoacidfermentationbyamarinespirochete:strategyforstarvationsurvival.J.Bacteriol.148:109-116.
Harwood,C.S.,S.S.Bang,P.Baumann,andK.H.Nealson.1980.Photobacteriumlogeisp.nov.,nom.rev.;Beneckeanereidasp.nov.,nom.rev.;andBeneckeagazogenessp.nov.,nom.rev.Int.J.Syst.Bacteriol.30:655.
Harwood,C.S.1978.Beneckeagazogenessp.nov.,ared,facultativelyanaerobicmarinebacterium.CurrentMicrobiol.1:233-238.
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