倪嘉缵 - 中国科学院长春应用化学研究所 - 稀土资源利用国家重点实验室

研究领域

硒蛋白及稀土化合物与疾病发生、发展的关系及其抗老年痴呆症和抗癌的作用机制的研究（深圳大学）多功能纳、微米粒子载体的合成及其生物医学应用研究（长春应用化学研究所）研究领域 1. 硒蛋白及稀土化合物与疾病发生、发展的关系及其抗老年痴呆症和抗癌的作用机制的研究研究硒蛋白的合成结构及与重大疾病的关系（如用生物信息学研究）；不同物种中硒蛋白的预测；研究硒蛋白的克隆、表达及结构与功能；探索硒蛋白及稀土化合物与老年痴呆症、癌症等重大疾病的关系。硒在生物体内主要以硒蛋白形式参与调节各种生理环节、发挥不同生物功能，直接或间接地与多种重大疾病（癌症、神经退行性病变和病毒等）相关联。然而因硒蛋白基因结构的复杂性，故有关对重大疾病的机理研究尚很不深入，极大地限制了其应用。因此，对硒蛋白生物信息学预测，用基因工程表达及化学修饰等方法研究硒蛋白的结构与功能的关系，将为探索不同硒化合物作为预防药物提供基础数据，稀土化合物作为癌症药物尚有很大争议。故用蛋白质组学及代谢组学及细胞生物无机化学方法。研究稀土化合物与癌细胞的作用。将有助于澄清有关的争议。为稀土药用前景提供重要信息。 2．多功能纳、微米粒子载体的合成及其生物医学应用研究　针对癌症的发病机理、早期诊断和靶向治疗，设计合成出集荧光、磁性和特异识别于一体的新型多功能载体用于功能生物分子的富集分离检测、癌细胞的生物探针诊断和靶向控释药物治疗。该多功能载体同时具有选择富集、磁控操纵、荧光成像、磁共振成像和靶向药物控制释放等多种功能。基于该多功能载体，对蛋白质、酶、DNA等功能生物分子可进行高效选择富集、快速磁分离和高灵敏度检测；对外周血液中的癌细胞可实现特异识别和可视化捕获用于富集鉴别；对恶性肿瘤实体可进行荧光成像和磁共振成像检测；还可以通过药物靶向定位和控制释放对恶性肿瘤实现有效地治疗。在癌细胞的早期诊断和癌症的靶向药物治疗等领域具有极大的应用前景。

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Gong Cheng, Ji-Lin Zhang, Yan-Lin Liu, De-Hui Sun, and Jia-Zuan Ni. Monodisperse REPO4 (RE=Yb, Gd, Y) Hollow Microspheres Covered with Nanothorns as Affinity Probes for Selectively Capturing and Labeling Phosphopeptides. Chem. Eur. J. 2012, 18, 2014-2020. Gong Cheng, Ji-Lin Zhang, Yan-Lin Liu,ad De-Hui Sun and Jia-Zuan Ni. Synthesis of Novel Fe3O4@SiO2@CeO2 microspheres with mesoporous shell for phosphopeptide capturing and labeling. Chem. Commun., 2011, 47 (20), 5732-5734. Sun De-Hui, Zhang Ji-Lin, Liu Yan-Lin, Hong Guang-Yan, and Ni Jia-Zuan. Synthesis and Characterization of [Eu(DBM)3phen]Cl3@SiO2-NH2 Composite Nanoparticles. Journal of Nanoscience and Nanotechnology, 2011, 11(11), 9656-9660. Sun De-Hui, Lu Ping, Zhang Ji-Lin, Liu Yan-Lin and Ni Jia-Zuan. Synthesis of the Fe3O4@SiO2@SiO2-Tb(PABA)3 luminomagnetic microspheres. Journal of Nanoscience and Nanotechnology, 2011, 11(11), 9774-9779. 高倩，张吉林，洪广言，倪嘉缵. 具有不同形貌的Fe3O4微-纳米粒子的溶剂热合成. 高等学校化学学报, 2011, 32 (3), 552-559. Ping Lu, Ji-Lin Zhang, Yan-Lin Liu, De-Hui Sun, Gui-Xia Liu, Guang-Yan Hong, Jia-Zuan Ni. Synthesis and characteristic of the Fe3O4@SiO2@Eu(DBM)3•2H2O/SiO2 luminomagnetic microspheres with core-shell structure. Talanta, 2010, 82(2), 450-457. Qian Gao, Jilin Zhang, Guangyan Hong, and Jiazuan Ni. One-Pot Reaction to Synthesize PEG-Coated Hollow Magnetite Nanostructures with Excellent Magnetic Properties. J. Nanosci. Nanotechnol.，2010, 10(10), 6400-6406. 路苹，张吉林，孙德慧，刘桂霞，洪广言，倪嘉缵. 单分散Fe3O4亚微米球的合成与表征，无机化学学报，2010, 26(7), 1177-1182. 张吉林,　洪广言, 倪嘉缵. 单分散磁性纳米粒子靶向药物载体. 化学进展，2009，21(5)，880-888. Qian Gao, Fenghua Chen, Jilin Zhang, Guangyan Hong, Jiazuan Ni, Xiao Wei, Dejun Wang. The study of novel Fe3O4@γ-Fe2O3 core/shell nanomaterials with improved properties. Journal of Magnetism and Magnetic Materials, 2009, 321(8), 1052-1057. Qian Gao, Guangyan Hong, Jiazuan Ni, Wendong Wang, Jinke Tang, and Jibao He. Uniaxial anisotropy and novel magnetic behaviors of CoFe2O4 nanoparticles prepared in a magnetic field. Journal of Applied Physics, 2009,105, 1-3. Fenghua Chen, Qian Gao, Guangyan Hong and Jiazuan Ni. Grafting and release behavior of Doxorubincin from Fe3O4@SiO2 core-shell structure nanoparticles via acid cleaving amide bond: The potential magnetic targeting drug delivers, Nanotechnology, 2008, 19, 511-519. Fenghua Chen, Qian Gao, Guangyan Hong and Jiazuan Ni. Synthesis and characterization of magnetite dodecahedron nanostructure by hydrothermal method, Journal of Magnetism and Magnetic Materials, 2008, 320(11): 1775-1780. Fenghua Chen, Qian Gao and Jiazuan Ni. Synthesis of magnetite core-shell nanoparticles by surface-initiated ring-openning polymerization of L-lactide, Journal of Magnetism and Magnetic Materials, 2008, 320(13): 1921-1927. Liao PQ , Wei L, Zhang XY, Li XJ, Wu HF, Wu YJ, Ni JZ, Pei FK. Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy. Analytical biochemistry, 2007, 364(2), 112-121. Xiaoyu Zhang, Fenghua Chen, Pinghui Wei and Jiazuan Ni. Studies on the Effects of Epimedium Extract on Erythrocytes. Chinese Chemical Letters. 2006, 17(8): 1105-1108. Xiaoyu Zhang, Huifeng Wu, Peiqiu Liao, Xiaojing Li, Jiazuan Ni, Fengkui Pei. NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats. Food and Chemical Toxicology, 2006, 44( 7): 1006-1014. Xiaoyu Zhang, Yanjie Li, Xiaoda Yang, Kui Wang, Jiazuan Ni, Xiaogang Qu. Inhibitory effect of Epimedium extract on S-adenosyl-l-homocysteine hydrolase and biomethylation. Life Sciences, 2005, 78(2): 180-186. 李荣昌, 杨晓达, 王夔, 倪嘉缵. 我国稀土生物无机化学研究进展. 中国稀土学报, 2004, 22(1), 1-6. Yujuan Zheng, Jun Lu, Liyan Liu, Daqing Zhao, Jiazuan Ni. Fluorescence analysis of aldolase dissociation from the N-terminal of the cytoplasmic domain of band 3 induced by lanthanide. Biochemical and Biophysical Research Communications, 2003, 303(2): 433-439."