个人简介
籍贯：浙江兰溪(1975/10) 2007年3月始研究员，中国科学院上海有机化学研究所； 2002年7月—2007年3月博士后，BrandeisUniversity(LiDeng教授)； 2001年8月—2002年6月博士后，UniversityofHouston(JayK.Kochi教授)； 1996年9月—2001年7月硕博研究生，中国科学院上海有机化学研究所； 1992年9月—1996年7月四川大学化学系获学士学位。
研究领域
我们小组侧重于基于不对称催化反应的天然产物全合成。在自然界中，许多生物活性分子来源于富电子不饱和碳氢化合物的氧化偶联反应。这类反应过程中高活性的自由基和碳正离子中间体不利于产物的立体化学控制。虽然通过手性底物和手性辅基的策略能在一定程度上控制产物的立体构型，但若能直接从简单易得的潜手性底物出发，通过不对称催化反应得到目标产物则更具有意义。我们将“阳离子-π电子相互作用”的概念用于新的催化剂的设计和合成，通过模拟生物酶来稳定高活性的自由基和碳正离子中间体，从而有效地控制反应产物的立体化学。这些转化策略不仅给复杂天然产物的全合成提供了更为简洁的合成路线，也有助于我们从化学转化的角度更好地理解天然产物的多样性。同时，仿酶的催化反应过程也使生物合成的策略在天然产物全合成的设计过程中得到完美的体现。
近期论文
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Rui Yan, Ye Tang, Yan Wang, and Ran Hong*, 2017, manuscript in preparation.
Lin Yang, Zuming Lin, Shunjie Shao, and Ran Hong*, 2017, manuscript in preparation.
Xiaotong Li, Yan Wang, Shiqing Han, Sha-Hua Huang*, Hui-Lei Yu, Jian-He Xu, and Ran Hong*, 2017, manuscript in preparation.
Lili Zhu and Ran Hong*, 2017, manuscript in preparation.
Kuan Zheng, Changmin Xie, and Ran Hong*, "Concise Synthesis and Revision to the Proposed Biogenesis of Helicascolides" Tetrahedron Lett. 2017, 58, 4459-4464.
Chao Wang, Shiju Zhang, Yan Wang, Sha-Hua Huang*, and Ran Hong*, "Total Synthesis of Strictamine: A Tutorial for Novel and Efficient Synthesis" Org. Chem. Front. 2017, 4, doi: 10.1039/C7QO00837F.
Kuan Zheng, Defeng Shen, and Ran Hong*, "Biomimetic Synthesis of Lankacidin Antibiotics" J. Am. Chem. Soc. 2017, 139, 12939-12942.
Li Zhai, Xuechao Tian, Chao Wang, Qi Cui, Wenhua Li, Sha-Hua Huang*, Zhi-Xiang Yu*, and Ran Hong*, "Construction of Morphan Derivatives by Nitroso-Ene Cyclization: Mechanistic Insight and Total Synthesis of rac-Kopsone" Angew. Chem. Int. Ed. 2017, 56, 11599-11603.
Changmin Xie#, Jisheng Luo#, Yan Zhang, Lili Zhu, and Ran Hong*, "A Chiral Pentenolide-Based Unified Synthesis of Dihydrocorynantheal, Dihydrocorynantheol, Protoemetine, Protoemetinol, and Yohimbane" Org. Lett. 2017, 19, 3592-3595 (# Equal contribution)
Yu-Cong Zheng, Jian-He Xu, Hui Wang, Guo-Qiang Lin, Ran Hong*, and Hui-Lei Yu*, "Hydroxynitrile lyase isozymes from Prunus communis: identification, characterization and synthetic application". Adv. Synth. Catal. 2017, 359, 1185-1193.
Jie Ouyang, Xianwei Mi, Yan Wang*, and Ran Hong*, "Crossing the Ring: A Journey of the Nitroso-ene Reaction" Synlett 2017, 28, 762-772 (account).
Guoli He, Yan Wang, Calvine Lai, Wenhua Li, and Ran Hong*, "Stereoselective construction of skipped polyol in polyketides enabled by oxonia-Cope rearrangement and iodolactonization: Enantioselective synthesis of (+)-yashabushitriol” Sci. China Chem. 2016, 59, 1197-1204.
Lin Yang, Zuming Lin, Sha-Hua Huang*, and Ran Hong*, "Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired oxa-Michael Cyclization" Angew. Chem. Int. Ed. 2016, 55, 6280-6284.
Lumin Zhang, Lili Zhu, Jun Yang*, Jisheng Luo, and Ran Hong*, "Stereoselective alpha-Hydroxylation of Amides with Oppolzer's Sultam as Chiral Auxiliary" J. Org. Chem. 2016, 81, 3890-3900.
Wenhua Li, Zuming Lin, Long Chen, Xuechao Tian, Sha-Hua Huang*, and Ran Hong*, "Highly Stereoselective Kinetic Resolution of alpha-Allenic Alcohols: An Enzymatic Approach" "Tetrahedron Lett. 2016, 57, 603-606.
Sha-Hua Huang*, Xuechao Tian, Xianwei Mi, Yan Wang*, Ran Hong, "Nitroso-ene Cyclization Enabled Access To 1-Azaspiro[4.4]nonane and Its Application In a Modular Synthesis Toward (±)-Cephalotaxine" Tetrahedron Lett. 2015, 56, 6656-6658. DOI:10.1016/j.tetlet.2015.10.002
Hao Liu#, Jing Yu#, Xinyu Li, Rui Yan, Ji-Chang Xiao, and Ran Hong*, "Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine" Org. Lett. 2015, 17, 4444-4447. DOI: 10.1021/acs.orglett.5b02106. (# These authors contributed equally to the work.)
Jie Ouyang#, Rui Yan#, Xianwei Mi, and Ran Hong*, "Enantioselective Total Synthesis of (−)-Hosieine A" Angew. Chem. Int. Ed. 2015, 54, 10940-10943. DOI: 10.1002/anie.201505251. (#These authors contributed equally to the work.)
Kuan Zheng, Changmin Xie, and Ran Hong*, "Bioinspired Iterative Synthesis of Polyketides", Front. Chem. 2015, 3, e32.
Lili Zhu*, Sha-Hua Huang, Jing Yu, and Ran Hong*, "Constructive Innovation of Approaching Bicyclo[3.2.1]octane in ent-Kauranoids" (Digest paper) Tetrahedron Lett. 2015, 56, 23-31. doi:10.1016/j.tetlet.2014.11.035
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