个人简介
教育经历
2010年9月 – 2013年6月，首都医科大学，药物化学
2007年9月- 2010年6月，首都医科大学，药物化学
2003年9月- 2007年6月，首都医科大学，药学
工作经历
2013年9月- 至今，首都医科大学，化学生物学与药学院 药物化学系，讲师
2014年4月-2015年8月，Harbor-UCLA LaBioMed博士后
近期论文
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Xiaoyi Zhang#, Lin Gui#, Xiaoyan Zhang, Stacie L. Bulfer, Valentina Sanghez, Daniel Wong, James Siho Lee, Pei-Yin Shih, Conrad C. Weihl, Henry J. Lin, Michelina Iacovino, Michelle R. Arkin, Yanzhuang Wang, and Tsui-Fen Chou Altered cofactor regulation of p97/VCP ATPase mutants in IBMPFD/ALS Proceedings of the National Academy of Sciences,2015, E1705–E1714 .(#Co-author)
Lin Gui#, Xiaoyi Zhang#, Kelin Li#, Kevin J. Frankowski#, Shan Li#,Daniel E. Wong, Derek R. Moen,Patrick R. Porubsky,Henry J. Lin, Frank J. Schoenen,and Tsui-Fen Chou]Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes. ChemMedChem, 2016, 11(9): 953–957. IF = 2.98
Chen-Jie Fang#, Lin Gui#, Xiaoyi Zhang#, Derek R. Moen, Kelin Li, Kevin J. Frankowski, Henry J. Lin, Frank J. Schoenen, and Tsui-Fen Chou Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97–p47 Complex. ChemMedChem, 2015, 10(1): 52-56. (#Co-author)
Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao, Shiqi Peng, Mechanism of forming trimer, self-assembling nano-particle and inhibiting tumor growth of small molecule CIPPCT, Medicinal Chemistry Communication, 2014,5, 1634-1643 DOI: 10.1039/C4MD00158C.
Xiaoyi Zhang, Yifan Yang, Ming Zhao, Liu Liu, Meiqing Zheng, Yuji Wang, Jianhui Wu, Shiqi Pen. A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis. European Journal of Medicinal Chemistry, 2011, 46, 3410-3419.
Chunyu Li, Xiaoyi Zhang, Ming Zhao, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng. A class of novel N-(1-methyl-b-carboline-3-carbonyl)-N’-(aminoacid-acyl)-hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Journal of Medicinal Chemistry 2011, 46, 11, 5598–5608.
Xiaoyi Zhang, Wei Wang, Shenling Cheng, Ming Zhao,Meiqing Zheng, Heng Wei Chang, Jianhui Wu, Shiqi Peng. 2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3- carboxylic acids:Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity. Bioorganic Medicinal Chemistry, 2010, 18, 1536–1554.
Jiangyuan Liu, Xiaoyi Zhang, Ming Zhao, Shiqi Peng. Synthesis, Evaluation and 3D QSAR Analysis of Novel Estradiol-RGD Octapeptide Conjugates with Oral Anti-osteoporosis Activity. European Journal of Medicinal Chemistry, 2009, 44, 1689-1704.
Shenling Cheng, Xiaoyi Zhang, Wei Wang, Ming Zhao, Meiqing Zheng, Heng Wei Chang, Jianghui Wu, Shiqi Peng. A Class of Novel N-(3S-1,2,3,4-Tetrahydroisoquinoline-3- carbonyl)-L-amino Acids: Their Synthesis, Antithrombotic Activity Evaluation and 3D QSAR Analysis. European Journal of Medicinal Chemistry, 2009, 44, 4904-4919.
Meiqing Zheng, Xiaoyi Zhang, Ming Zhao, Heng Wei Chang, Wei Wang, Yuji Wang, Shiqi Peng. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a Class of Novel Anti-thrombotic Agents: Synthesis, Bioassay, 3D QSAR, and ADME Analysis. Bioorganic Medicinal Chemistry, 2008, 16, 9574-9587.
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