陈以昀 - 中国科学院上海有机化学研究所 - 生命有机化学国家重点实验室

个人简介

陈以昀博士任中国科学院上海有机化学研究所生命有机化学国家重点实验室研究员,兼任上海科技大学物质学院教授。他本科期间在北京大学杨震教授指导下从事全合成研究并于2002年获得化学学士学位。在Joseph Z. Tsien教授实验室进行了短期的神经科学研究之后，他在普林斯顿大学Chulbom Lee教授实验室发展了过渡金属催化下的炔烃1，1位修饰方法学，并于2007年获得有机化学博士学位。在哈佛大学和霍华德休斯医学研究所David R. Liu教授实验室，他作为博士后研究人员进行了化学生物学相关的研究课题：利用DNA编码的新化学反应探索系统，他发现了生物相容的可见光引发的叠氮化合物还原反应。2011年秋，他加入上海有机化学研究所任课题组长，研究兴趣为生物相容光化学，具体包括有机光化学与光化学生物学。陈以昀获得的学术和研究荣誉包括药明康德生命化学研究奖（2021）、上海有机所拜耳研究奖（2021）、上海市优秀学术/技术带头人（2021）、上海市科技系统青年五四奖章（2018）、蒂姆化学期刊奖（2018）、中国光化学泊菲莱优秀青年科学家奖（2017）、国家自然科学基金委员会优秀青年科学基金（2016）、上海浦江人才计划（2012）、普林斯顿大学百时美施贵宝研究生合成化学奖（2005）、北京大学明德奖学金（1998-2002）、第30届国际化学奥林匹克竞赛银牌（1998）。陈以昀任Organic Chemistry Frontiers杂志顾问编委、欧盟研究委员会评审专家、中国化学会光化学专业委员会委员、中国感光学会光化学和光生物专业委员会委员、中国神经科学学会离子通道与受体专业委员会常委委员、ChemPhotoChem杂志创刊编委。

研究领域

课题组通过设计新反应模式的可见光催化反应进行生物相容性、新型化学反应性、及生物应用的系统性探索。光催化剂可被可见光甚至近红外光激发，进而与底物分子发生电子或能量转移的化学反应。不同电子性质的底物分子对也可以生成分子复合物，进而吸收光谱红移发生可见光激发的化学反应。相比于紫外光照直接激发的高能量激发态化学，光催化反应或分子复合物可以在温和条件下发生可控的化学反应，并且无需可见光敏感底物。

近期论文

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Distal Amidoketone Synthesis Enabled by Dimethyl Benziodoxoles via Dual Copper/Photoredox Catalysis. Ge, Y.; Shao, Y.; Wu, S.; Liu, P.; Li, J.; Qin, H.; Zhang, Y.; Xue, X.*; Chen, Y.* ACS Catal. 2023, 13, 3749−3756. Visible-Light-Induced Proteins Labeling in Live Cells with Aryl Azides. Zhang, Y.1; Tan, J.1; Chen, Y.* Chem. Commun. 2023, 59, 2413−2420. Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Liu, D.1; Yang, K.1; Fang, D.1; Li, S.; Lan, Y.*; Chen, Y.* Angew. Chem., Int. Ed. 2023, 62, e202213686. Hypervalent Iodine Reagents Enable C(sp2)–H Amidation of (Hetero)arenes with Iminophenylacetic Acids. Pan, Y.1; Liu, Z.1; Zou, P.; Chen, Y.; Chen, Y.* Org. Lett. 2022, 24, 6681−6685. Hypervalent Iodine Reagents Enable C−H Alkynylation with Iminophenylacetic Acids via Alkoxyl Radicals. Liu, Z.1; Pan, Y.1; Zou, P.; Huang, H.; Chen, Y.; Chen, Y.* Org. Lett. 2022, 24, 5951−5956. Endogenous Proteins Modulation in Live Cells with Small Molecules and Light. Zeng, K.; Han, L.; Chen, Y.* Chembiochem 2022, 23, e202200244. Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols. Fang, D.; Zhang, Y.; Chen, Y.* Org. Lett. 2022, 24, 2050-2054. Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells. Zhang, Y.1; Han, L.1; Tian, X.; Peng, C.; Chen, Y.* Angew. Chem., Int. Ed. 2022, doi: 10.1002/anie.202115472. Highlighted by Wiley Chem, Chinese Academy of Sciences. Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents. Wu, S.; Li, J.; He, R.; Jia, K.; Chen, Y.* Org. Lett. 2021, 23, 9204-9209. Oxygen-Centered Radicals. Zhang, J.; Liu, D.; Chen, Y.* Science of Synthesis: Free Radicals: Fundamentals and Applications in Organic Synthesis. Fensterbank, L.; Ollivier, D., Ed.; Thieme: Stuttgart, 2021.Vol. 1, 323-380. Selective C(sp3)-C(sp3) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagents. Liu, Z.; Wu, S.; Chen, Y.* ACS Catal. 2021, 11, 16, 10565-10573. Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells. Wang, H.1; Zhang, Y.1; Zeng, K.1; Qiang, J.1; Cao, Y.; Li, Y.; Fang, Y.; Zhang, Y.*; Chen, Y.* JACS Au. 2021, 1, 7, 1066–1075. Highlighted by NSFC, Chinese Academy of Sciences. Investigations on 1,2-Hydrogen Atom Transfer Reactivity of Alkoxyl Radicals under Visible-Light-Induced Reaction Conditions. Liu, D.; Zhang, J.; Chen, Y.* Synlett. 2021, 32, 356-361. Invited Account. Special Cluster for Radicals – by Young Chinese Organic Chemists. Illuminating Biology with Visible-Light-Induced Biocompatible Reactions. Chen, Y.* Chemphotochem. 2020, 4, 319-320. Meet the board. Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation. Zhang, J.1; Liu, D.1.; Liu, S.; Ge, Y.; Lan, Y.*; Chen, Y.* iScience. 2020, 23, 100755. DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space. Huang, Y.; Savych, O.; Moroz, Y.; Chen, Y.*; Goodnow, R. A.* Aldrichimica Acta. 2019, 52, 3, 75-87. Invited Review. Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation. Xie, S.; Li, D.; Huang, H.; Zhang, F.; Chen, Y.* J. Am. Chem. Soc. 2019, 141, 41, 16237-16242. Acyl Radical Smiles Rearrangement to Construct Hydroxybenzophenones by Photoredox Catalysis. Li, J.; Liu, Z.; Wu, S.; Chen, Y.* Org. Lett. 2019, 21, 2077-2088. Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells. Wang, H; Li, W.; Zeng, K.; Wu, Y.; Zhang, Y.; Xu, T.*; Chen, Y.* Angew. Chem., Int. Ed. 2019, 58, 561-565. Visible Light-Driven Organic Photochemical Synthesis in China. Chen, Y.*; Lu, L. Q.*; Yu, D. G.*; Zhu, C. J.*; Xiao, W. J.* Sci. China Chem. 2019, 62, 24–57. Invited Review. Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis. Liu, M; Huang, H.; Chen, Y.* Chin. J. Chem. 2018, 36, 1209-1212. Special Issue for Prof. Xiyan Lu’s 90th Birthday. Photochemistry of Hypervalent Iodine Compounds. Jia, K.; Chen, Y.* Patai’s Chemistry of Functional Groups. Marek, I, Olofsson, B., Rappoport, Z., Ed.; John Wiley & Sons, 2018. Metal-Free C(sp3)-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex. Li, Y.1; Zhang, J.1; Li, D.; Chen, Y.* Org. Lett. 2018, 20, 3296-3299. Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations. Jia, K.; Chen, Y.* Chem. Commun. 2018, 54, 6105-6112. Invited Feature Article. Investigations of Alkynyl Benziodoxole Derivatives for Radical Alkynylations in Photoredox Catalysis. Pan, Y.; Jia, K.; Chen, Y.*; Chen, Y.* Beilstein J. Org. Chem. 2018, 14, 1215-1221. Invited Thematic Series “Hypervalent Iodine Chemistry in Organic Synthesis”. Selective P-C(sp3) Bond Cleavage and Radical Alkynylation of α-Phosphorus Alcohols by Photoredox Catalysis. Jia, K.; Li, J.; Chen, Y.* Chem. Eur. J. 2018, 24, 3174–3177.