个人简介

1998-2003中科院武汉物数所物理专业博士 2004-2005武汉大学物理学院讲师 2005-2007台湾中研院原分所博士后 2007-2008美国普渡大学化学系博士后 2009-至今中科院化学所研究员

研究领域

生物质谱及便携式质谱仪研制

1. 生物颗粒（包括细胞、细菌和病毒）质谱分析。 2. 离子阱便携式质谱仪研制及质谱理论研究。 3. 活体质谱在线分析。 4. 基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF）小分子质谱分析。

近期论文

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S.M. Chen, H.Z. Zheng, J.N. Wang, J. Hou, Q. He, H.H. Liu, X.L. Kong, and Z.X. Nie*, Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in both Positive and Negative Ion MALDI-TOF MS and Quantification of Glucose and Uric Acid in Real Samples, Anal. Chem. 2013, 85, 6646-6652. C.Q. Xiong, X.Y. Zhou, J.N. Wang, N. Zhang, S.M. Chen, W.-P. Peng, H.-C. Chang, and Z.X. Nie*, Ambient Aerodynamic Desorption/ionization Method for Microparticle Mass Measurement, Anal. Chem. 2013, 85, 4370-4375. Y.F. Li, N. Zhang, J.N. Wang, Y.M. Zhou, C.Q. Xiong, S.M. Chen, and Z.X. Nie*, Induced Dual-Nanospray: A Novel Internal Calibration Method for Accurate Mass Measurement in Real Sample, J. Am. Soc. Mass Spectrom. 2013, 24, DOI: 10.1007/s13361-013-0670-5. X.Y. Zhou, C.Q. Xiong, S. Zhang, N. Zhang, and Z.X. Nie*, Study of nonlinear resonance effect in Paul trap, J. Am. Soc. Mass Spectrom. 2013, 24, 794-800. C. Zhen, Y.M. Zhou, N. Zhang, J.Y. Wang, and Z.X. Nie*, Differentiation of Chinese Liquors by Using Ambient Glow Discharge Ionization, Analyst 2013, 138, 3830-3835. Q. He, S.M. Chen, J.N. Wang, J. Hou, J.Y. Wang, S.X. Xiong, Z.X. Nie*, 1-Naphthylhydrazine Hydrochloride: A New Matrix for the Quantification of Glucose and Homogentisic Acid in Real Samples by MALDI-TOF MS, Clin. Chim. Acta 2013, 420, 94-98. N. Zhang, Y.F. Li, Y.M. Zhou, J. Hou, Q. He, X.G. Hu, Y.M. Jia, C.Y. Yu, and Z.X.Nie*, Rapid detection of polyhydroxy alkaloids in mulberry using leaf spray mass spectrometry, Anal. Meth. 2013, 5, 2455-2460. C.-C. Hsieh, J.Y. Gou, S.-U. Hung, R. Chen, Z.X. Nie, H.-C. Chang, and C.-C. Wu*, Quantitative Analysis of Oligosaccharides Derived from Sulfated Glycosaminoglycans byNanodiamond-Based Affinity Purification and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Anal. Chem. 2013, 85, 4342-4349. Y.T. Yang, F.J. Huo, C.X. Yin*, A.M. Zheng, J.B. Chao, Y.Q. Li, Z.X. Nie, R. Martines-Manez, and D.S. Liu, Thiol-Chromene click chemistry: A coumarin-based derivativeand its use as regenerable thiol probe and in bioimaging applications, Biosensors and Bioelectronics 2013, 47, 300-306. Li-Ping Li, Tao Zheng, Lin-Nan Xu, Ze Li, Ling-Dong Sun, Zong-Xiu Nie, Yu Bai, and Hu-Wei Liu, SnO2-ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection, Chem. Commun.2013, 49, 1762-1764. S.M. Chen, L. Chen, J.N. Wang, J. Hou, Q. He, J.A. Liu, J.Y. Wang, S.X. Xiong, G.Q. Yang and Z.X. Nie* , 2,3,4,5-Tetrakis (3',4'-dihydroxylphenyl) thiophene: A New Matrix for the Selective Analysis of Low Molecular Weight Amines and Direct Determination of Creatinine in Urine by MALDI-TOF MS, Anal. Chem. 84, 10291-10297 (2012). N. Zhang, Y.M Zhou, C. Zhen, Y.F. Li, C.Q. Xiong, J.Y. Wang, H.Y. Li, Z.X. Nie*, Structural characterization of synthetic polymers using Thermal-Assisted Atmospheric Pressure Glow Discharge Mass Spectrometry, Analyst , 137 , 5051-5056(2012). R. Chen, S.M. Chen, C.Q. Xiong, C.-C. Wu*, X.L. Ding, S.X. Xiong, H.-C. Chang, and Z. X. Nie*, N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules, J. Am. Soc. Mass Spectrom, 23, 1454-1460 (2012). C.Q. Xiong, X.Y. Zhou, J.N. Wang, R. Chen, Y. Tang, W.-P. Peng, H.-C. Chang, Z. X. Nie*, The development of charge detection quadrupole ion trap mass spectrometry (CD-ITMS) driven by rectangular and triangular waves, Analyst, 137, 1199-1204 (2012). X.Y. Zhou, G.P. Xu, C.Q. Xiong, R. Chen, H.X. Qiao, and Z. X. Nie*, Characteristicsof electrical field in surface-electrode ion traps, J. Mass Spectrom.47, 286-293 (2012). R. Chen, W.J. Xu, C.Q. Xiong, X.Y. Zhou, S.X. Xiong, Z. X. Nie*, L.Q. Mao, Y. Chen, and H.-C. Chang*, A high-salt-tolerance matrix for facile detection of glucose in rat brain microdialysates by MALDI mass spectrometry, Anal. Chem. 84, 465-469 (2012).