汪福意 - 中国科学院化学研究所 -

个人简介

学习经历 1999年6月武汉大学化学系毕业，获理学博士学位学位论文聚四氟乙烯修饰悬浮体进样电热原子吸收光谱直接分析固体样品研究（获2000年湖北省优秀博士学位论文） 1991年6月华中师范大学化学系毕业，获理学硕士学位学位论文火焰原子吸收光谱分析中表面活性增感和抑制干扰作用的机理研究 1983年7月华中师范大学化学系毕业，获理学学士学位学位论文过渡金属席夫碱配合物的合成、表征和抗癌作用研究工作经历 2007 – 至今中国科学院化学研究所研究员，课题组长，博士生导师 2002 – 2007 英国爱丁堡大学化学系英国研究基金会（RCUK）研究员（Research Fellow）,研究组实验室主管，博士研究生、本科生毕业设计的导师助理 2000 – 2002 英国爱丁堡大学化学系英国皇家学会奖学金研究员（Research Fellow） 1997 – 1999 华中师范大学分析测试中心副教授，副主任，硕士生导师 1991 – 1997 华中师范大学分析测试中心湖北咸宁师范高等专科学校 1983 – 1988讲师，无机分析部主管助教，讲师

研究领域

1. 药物相互作用组学研究的分析新方法发展和建立基于质谱，包括ESI-MS，MALDI-MS和ICP-MS的分析新方法，研究抗肿瘤化合物与生物靶分子的相互作用；发展和建立二次离子质谱成像分析新方法，研究抗肿瘤药物细胞摄入、分布和归宿； 2. 原位液相二次离子质谱分析新方法、新装置通过构建高真空兼容的微流控液体池，发展原位、实时液相二次离子质谱分析新方法；应用原位液相二次离子质谱技术作为原位“分子眼”，开展针对液体表面或固液界面（电极与电解质界面、异相催化反应界面、生物软物质界面如细胞膜）等的原位实时分析。开展高质量分辨原位液相二次离子质谱新系统的研制工作，拓展该技术的应用范围。 3. 基于信号传导过程的多靶点抗肿瘤药物的研究和开发设计、合成既能识别特异信号转导蛋白，又能识别 DNA 碱基和双螺旋结构域的多靶点金属抗肿瘤化合物；多靶点金属抗肿瘤化合物的活性筛选和评价；多靶点金属抗肿瘤化合物的构效关系研究；多靶点金属抗肿瘤化合物药理、毒理以及药物动力学、药物代谢学研究。 4. 基于多功能分子探针的化学生物学研究设计、构建既能识别特异信号转导蛋白，又能识别 DNA 碱基和双螺旋结构域的多功能化学小分子探针；研究多功能分子探针与生物受体分子的相互作用，探索细胞内的信号转导过程和细胞凋亡机制；研究多功能分子探针与靶标分子的相互作用及其对信号转导过程的调控作用，发现和优化具有药理学价值和临床应用前景的药物先导结构；利用小分子探针的多识别功能，筛选和确认与重大疾病相关的生物标记物和药物靶标。

近期论文

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Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *, F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555. W. Zeng, Y. Zhang, W. Zheng, Q. Luo, J. Han, J. Liu, Y. Zhao, F. Jia, K. Wu*, and F. Wang*, Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry, Molecules, 2019, 24, 1852. L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486. Y. Zhang, W. Zeng, L. Huang, W. Liu, E. Jia, Y. Zhao, F. Wang*, Z. Zhu*, In Situ Liquid Secondary Ion Mass Spectrometry: A Surprisingly Soft Ionization Process for Investigation of Halide Ion Hydration, Anal. Chem. 2019, 91, 7039-7046. W. Zeng, Z. Du, Q. Luo, Y. Zhao, Y. Wang, K. Wu, F. Jia, Y. Zhang,* F. Wang*, Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA, Anal. Chem. 2019, 91, 6035-6042. Y. Zhang, J.G. Wang, X. Yu, D. R. Baer, Y. Zhao, L. Mao, F. Wang,* Z. Zhu*, Potential-Dynamic Surface Chemistry Controls the Electrocatalytic Processes of Ethanol Oxidation on Gold Surfaces, ACS Energy Lett. 2019, 4, 215-221. J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584. Y. Y. Zhang, M. Su, X. F. Yu, Y. F. Zhou, J. G. Wang, R. G. Cao, W. Xu, C. M. Wang, D. R. Baer, O. Borodin, K. Xu, Y. T. Wang, X. L. Wang, Z, J. Xu, F. Y. Wang* and Z. H. Zhu*，Investigation of Ion-Solvent Interactions in Nonaqueous Electrolytes Using in Situ Liquid SIMS, Anal. Chem. 2018, 90, 3341-3348. Y. Zhang, Q. Luo, W. Zheng,* Z. Y. Wang, Y. Lin, E. L. Zhang, S. Lü, J. F. Xiang, Y. and F. Y. Wang*, Luminescent cyclometallated platinum(II) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents, Inorg. Chem. Front. 2018, 5, 413-424. Y. Y. Cheng, W. J. Zeng, Y. Cheng, J. S. Zhang, T. Zou, K. Wu* and F. Y. Wang*, Selective binding of an organoruthenium complex to G-rich human telomeric sequence by tandem mass spectrometry, Rapid Commun. Mass Spectrom. 2018, 32, 2152-2158. Z. Y. Wang, Y. Y. Zhang, B. W. Liu, K. Wu, S. Thevuthasan, D. R. Baer, Z. H. Zhu,* X. Y. Yu* and F. Y. Wang*, In situ Mass Spectrometric Monitoring of the Dynamic Electrochemical Process at the Electrode-Electrolyte Interface: a SIMS Approach, Anal. Chem. 2017, 89, 960-965. S. Y. Liu, W. Zheng, K. Wu,* Y. Lin, F. F. Jia, Y. Zhang, Z. Y. Wang, Q. Luo, Y. Zhao, F. Y. Wang* Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex, Chem. Commum. 2017, 53, 4136-4139. Y. L. Jin, Y. F. Xie, K. Wu, Y. Y. Huang,* F. Y. Wang,* R. Zhao,* Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor, ACS Appl. Mater. Interfaces 2017, 9, 8490-8497. Y. Y. Wang, Z. F. Du,* W. Zheng, K. Wu, D. C. Xu, Q. Luo, Y. Zhao, J. J. Han, Y. Z. Liu, F. Y. Wang,* Deciphering of Interactions between Platinated DNA and HMGB1 by Hydrogen/Deuterium Exchange Mass Spectrometry, Dalton Trans. 2017, 46, 6133-6484. K. Wu, F. F. Jia, W. Zheng, Q. Luo, Y. Zhao, F. Y. Wang,* Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging, J. Biol. Inorg. Chem. 2017, 22, 653-661. W. Zheng, Y. Zhao*, Q. Luo, Y. Zhang, K. Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249. J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605. L. J. Li, W. Guo, K. Wu,* X. L. Wu, L. H. Zhao, Y. Zhao, Q. Luo, Y. Y. Wang, Y. Z. Liu, Q. W. Zhang, F. Y. Wang,* A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106. Z. Y. Wang, J. Liu, Y. F. Zhou J. J. Neeway, D. K. Schreiber, J. V. Crum, J. V. Ryan, X. L. Wang, F. Y. Wang,* Z. H. Zhu,* Nanoscale imaging of Li and B in nuclear waste glass, a comparison of ToF-SIMS, NanoSIMS, and APT, Surf. Interface Anal. 2016, 48, 1392-1401. J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.