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个人简介

1979-1983山东大学化学系本科 1986年获中国科学院化学所硕士,随后在中科院半导体所工作 1990年获中国科学院化学所博士 1990-1992武汉大学化学系博士后 1992-至今中国科学院化学所工作,现任研究员,博士生导师。 曾于1996-1997年、1999年10月-2000年2月和2001年10-11月,先后三次作为德国洪堡学者在BremenUniversity从事研究工作。 现任《CurrentChemicalBiology》、《科学通报》、《分析化学》、《分析科学学报》等刊物的编委;中国化学会永久会员。 2003年度中国分析测试协会科学技术二等奖(CAIA奖) 2006年度中国分析测试协会科学技术一等奖(CAIA奖) 2005年度获得国家基金委杰出青年基金项目资助

研究领域

研究方向 本课题组的研究方向为分析化学,生化分析,光学探针与标记分析,分子识别,具体内容包括: 1.光学识别试剂与生化分析:利用光诱导电子转移、电荷转移、能量转移等各种光物理过程,设计新型光学(包括吸光、荧光、发光)探针,研究对生物与环境毒物的标记、荧光显微分析等 2.分子光谱的基础研究 3.生物光谱学与选择性检测 4.研制生物、临床医学分析中的试剂盒、临床试纸等

1. 光学识别试剂与生化分析:利用光诱导电子转移、电荷转移、能量转移等各种光物理过程,设计新型光学(包括吸光、荧光、发光)探针,研究对生物与环境毒物的标记、荧光显微分析等 2. 分子光谱的基础研究 3. 生物光谱学与选择性检测 4. 研制生物、临床医学分析中的试剂盒、临床试纸等

近期论文

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发表论文 XiaohuaLi*,XinghuiGao,WenShi,HuiminMa*.Designstrategiesforwater-solublesmallmolecularchromogenicandfluorogenicprobes.Chem.Rev.2014,114,590-659. YangyangZhang,WenShi,XiaohuaLi,HuiminMa*.Sensitivedetectionofozonebyapracticalresorufin-basedspectroscopicprobewithextremelylowbackgroundsignal.Sci.Rep.2013,3,2830. DuanFeng,YanchaoSong,WenShi,XiaohuaLi,HuiminMa*.Distinguishingfolate-receptor-positivecellsfromfolate-receptor-negativecellsusingafluorescenceoff-onnanoprobe.Anal.chem.2013,85,6530-6535. ZhaoLi,XinghuiGao,WenShi,XiaohuaLi,HuiminMa*.7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-oneasaspectroscopicoff-onprobeforhighlysensitiveandselectivedetectionofnitroreductase.Chem.Commun.2013,49,5859-5861. QiongqiongWan,YanchaoSong,ZhaoLi,XinghuiGaoandHuiminMa*.Invivomonitoringofhydrogensulfideusingacresylviolet-basedratiometricfluorescenceprobe.Chem.Commun.,2013,49,502–504. TingtingFengandHuiminMa*.Fluorescencesensingofadenosinedeaminasebasedonadenosineinducedself-assemblyofaptamerstructures.Analyst,2013,138,2438–2442. ZhaoLi,XiaohuaLi*,XinghuiGao,YangyangZhang,WenShi,andHuiminMa*.Nitroreductasedetectionandhypoxictumorcellimagingbyadesignedsensitiveandselectivefluorescentprobe,7-[(5-nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one.Anal.Chem.,2013,85,3926–3932. TingtingFeng,DuanFeng,WenShi,XiaohuaLi*andHuiminMa*.Agrapheneoxide-peptidefluorescencesensorforproteolyticallyactiveprostate-specificantigen.Mol.BioSyst.,2012,8,1441–1445. WenShiandHuiminMa*.Spectroscopicprobeswithchangeableπ-conjugatedsystems.Chem.Commun.,2012,48,8732–8744. WenShi*,XiaohuaLi,andHuiminMa*.ATunableRatiometricpHSensorBasedonCarbonNanodotsfortheQuantitativeMeasurementoftheIntracellularpHofWholeCells.Angew.Chem.Int.Ed.,2012,51,6432–6435. YanchaoSong,WenShi,WeiChen,XiaohauLiandHuiminMa*.Fluorescentcarbonnanodotsconjugatedwithfolicacidfordistinguishingfolate-receptor-positivecancercellsfromnormalcells.J.Mater.Chem.,2012,22,12568–12573. SumingChen,WeiChen,WenShi,andHuiminMa*,SpectroscopicresponseofferrocenederivativesbearingaBODIPYmoietytowater:newdissociationreaction,Chem.Eur.J.,2012,18,925-930. WeiChen,ZhaoLi,WenShi,andHuiminMa*,Anewresorufin-basedspectroscopicprobeforsimpleandsensitivedetectionofbenzoylperoxideviadeboronation,Chem.Commun.,2012,48,2809-2811. YangyangZhang,WeiChen,DuanFeng,WenShi*,XiaohuaLi,andHuiminMa*,Aspectroscopicoff-onprobeforsimpleandsensitivedetectionofcarboxylesteraseactivityanditsapplicationtocellimaging,Analyst,2012,137,716-721. ChengdongSun,WenShi,YanchaoSong,WeiChenandHuiminMa*,Anunprecedentedstrategyforselectiveandsensitivefluorescencedetectionofnitricoxidebasedonitsreactionwithaselenide,Chem.Commun.,2011,47,8638-8640. DuanFeng,YangyangZhang,TingtingFeng,WenShi,XiaohuaLiandHuiminMa*,Agrapheneoxide–peptidefluorescencesensortailor-madeforsimpleandsensitivedetectionofmatrixmetalloproteinase2,Chem.Commun.,2011,47,10680-10682. WeiChen,WenShi,ZhaoLi,HuiminMa*,YangLiu,JinghuaZhang,QingjunLiu,SimpleandfastfluorescencedetectionofbenzoylperoxideinwheatflourbyN-methoxyrhodamine-6Gspirolactambasedonconsecutivechemicalreactions,Anal.Chim.Acta,2011,708(1-2),84-88. JinxinLu,ChengdongSun,WeiChen,HuiminMa*,WenShi,XiaohuaLi*,Determinationofnon-proteincysteineinhumanserumbyadesignedBODIPY-basedfluorescentprobeCatalyst,Talanta,2011,83,1050-1056. YangyangZhang,WenShi,DuanFeng,HuiminMa*,YanLiang,JianruZuo,ApplicationofrhodamineBthiolactonetofluorescenceimagingofHg2+inArabidopsisthaliana,SensorsActuat.B-Chem.,2011,153(1),261-265. JiaJiaandMaHuiMin*,Awater-solublefluorescenceresonanceenergytransferprobeforhypochlorousacidanditsapplicationtocellimaging,ChineseSci.Bull.,2011,56(31),3266-3272. MaHuiMin*,Bio-spectroscopicsensing,ChineseSci.Bull.,2011,56(31),3233. SunChengdong,ChenJianmingMaHuimin*,LiuYang,ZhangJinghuaandLiuQingjun,AnewCu2+-inducedcolorreactionofarhodaminederivativeN-(3-carboxy)acryloylrhodamineBhydrazide,Sci.ChinaChem.,2011,54(7),1107-1114. Su-MingChen,Jin-XinLu,Cheng-DongSunandHui-MinMa*,Ahighlyspecificferrocene-basedfluorescentprobeforhypochlorousacidanditsapplicationtocellimaging,Analyst,2010,135,577-582. JiaJia,WeiChen,Hui-MinMa*,KeWangandChuanZhao,Useofarhodamine-basedbifunctionalprobeinN-terminalspecificlabelingofthermomyceslanuginosusxylanase,MolecularBioSystems,2010,6,1829-1833. DuanFeng,Yang-YangZhang,WenShi,Xiao-HuaLiandHui-MinMa*,Asimpleandsensitivemethodforvisualdetectionofphosgenebasedontheaggregationofgoldnanoparticles,Chem.Commun.,2010,46,9203-9205. JiaJia,KeWang,WenShi,SumingChen,XiaohuaLi,HuiminMa*,RhodamineBpiperazinoacetohydrazineawater-solublespectroscopicreagentforpyruvicacidlabeling,Chem.Eur.J.,2010,16(22),6638-6643. WenShi,ShunaSun,XiaohuaLiandHuiminMa*,ImagingdifferentinteractionsofmercuryandsilverwithlivecellsbyadesignedfluorescenceproberhodamineBselenolactone,Inorg.Chem.,201049(3)1206-1210. XiaohuaLi*,WenShi,SumingChen,JiaJia,HuiminMa*andOttoS.Wolfbeis,Anear-infraredfluorescentprobeformonitoringtyrosinaseactivity,Chem.Commun.,2010,46,2560-2562. SumingChen,JinxinLu,ChengdongSun,HuiminMa*,Ahighlyspecificferrocene-basedfluorescentprobeforhypochlorousacidanditsapplicationtocellimaging,Analyst,2010,135,577-582. KeWang,WenShi,JiaJia,SumingChen,HuiminMa.*Characterizationof2-phenylbenzo[g]quinoxalinederivativesasviscosity-sensitivefluorescentprobes,Talanta,2009,77,1795-1799. XinqiChen,JiaJia,HuiminMa*,ShujuanWangandXiaochunWang.CharacterizationofrhodamineBhydroxylamideasahighlyselectiveandsensitivefluorescenceprobeforCu(II),Anal.Chim.Acta,2009,632,9-14. SumingChen,XiaohuaLi,HuiminMa*.Newapproachforlocalstructureanalysisoftyrosinedomaininproteinsbyusingsite-specificandpolarity-sensitivefluorescentprobe.ChemBioChem,2009,10,1200-1207. ShujuanWang,XiaochunWang,WenShi,KeWang,HuiminMa.*Detectionoflocalpolarityandconformationalchangesattheactivesiteofrabbitmusclecreatinekinasewithanewarginine-specificfluorescentprobe.Biochim.Biophys,Acta.ProteinsandProteomics,2008,1784,415-422. WenShiandHuiminMa*.RhodamineBthiolactone:asimplechemosensorforHg2+inaqueousmedia,Chem.Commun.,2008,1856-1858. ShunaSun,ZhijuanBao,HuiminMa*,DeqingZhang,XiaopingZheng.Singletoxygengenerationfromthedecompositionofα-linolenicacidhydroperoxidebycytochromecandlactoperoxidase,Biochemistry,2007,46,6668-6673. ZhijuanBao,ShujuanWang,WenShi,SuyingDongandHuiminMa.*SelectivemodificationofTrp19inβ-lactoglobulinbyanewdiazofluorescenceprobe,J.ProteomeRes.,2007,6,3835-3841. SuyingDong,ZhenwenZhao,HuiminMa.*Characterizationoflocalpolarityandhydrophobicbindingsitesofbeta-lactoglobulinbyusingN-terminalspecificfluorescencelabelingJ.ProteomeRes.2006,5,26-31. ZhijuanBao,ShunaSun,JunLi,XinqiChen,SuyingDongandHuiminMa*,Directidentificationoftryptophaninamixtureofaminoacidsbythenakedeye,Angew.Chem.Int.Ed.,2006,45,6723-6725. SuyingDong,HuiminMa*,XuejunDuan,XinqiChen,JunLi.Detectionoflocalpolarityofa-lactalbuminbyN-terminalspecificlabelingwithanewtailor-madefluorescentprobe,J.ProteomeRes.,2005,4,161-166. XuejunDuan,ZhenZhao,JianpingYe,HuiminMa*AndongXia*GuoqiangYangChihchenWang*.Donor-donorenergy-migrationmeasurementsofdimericDsbClabeledatitsN-terminalamineswithfluorescentprobes:astudyofproteinunfolding,Angew.Chem.Int.Ed.,2004,43,4216-4219. XiaohuaLi,GuanxinZhang,HuiminMa*DeqingZhang*,JunLiandDaobenZhu.*45-Dimethylthio-4'-[2-(9-anthryloxy)ethylthio]tetrathiafulvaleneahighlyselectiveandsensitivechemiluminescenceprobeforsingletoxygen,J.Am.Chem.Soc.,2004,126,11543-11548. LihuaNie,HuiminMa*,XiaohuaLi,MingSun,ShaoxiangXiong.Recognitionofthyminebyatriazinefluorescentprobethroughintermolecularmultiplehydrogenbonding,Biopolymers(Biospectroscopy),2003,72,274-281. MingSun,DihuaShangguan,HuiminMa*,LihuaNie,XiaohuaLi,ShaoxiangXiongGuoquanLiuWolframThiemann.SimplePb(II)fluorescentprobebasedonthePb(II)-catalyzedhydrolysisofphosphodiester,Biopolymers(Biospectroscopy),2003,72,413-420. Hui-MinMa*,Zhi-HuaWang,Mei-HongSu.NewtriazinespectroscopicreagentforseparationofDL-aminoacidsbymicellarelectrokineticchromatography,J.Chromatogr.A,2002,955,125-131. HuiminMa*,UteJarzakandWolframThiemann*,Insitufluorescentlabelingofhighlyvolatilemethylaminewith8-(46-dichloro-135-triazinoxy)quinoline,NewJ.Chem.,2001,25,872-874. HuiminMa*,JensWohlers,UweMeierhenrich,AxelBernecker,VeraSuling,WolframThiemann*,Analysisofoxidativedegradationproductsof246-trichlorophenoltreatedwithairions,Anal.Chem.,2001,73,3506-3510. MeihongSu,YongLiu,HuiminMa*,QuanliMa,ZhihuaWang,JunlinYangandMeixiangWang*,19-Dihydro-3-phenyl-4H-pyrazolo[34-b]quinolin-4-oneanovelfluorescentprobeforextremepHmeasurement,Chem.Commun.,2001,960-961.

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