肖姗 - 南方医科大学

个人简介

个人简介主要从事RNA代谢与生殖细胞发育相关研究，近五年以以第一/共第一/共通讯作者发表SCI论文6篇，其中4篇IF>10, 1篇IF>5。承担国家级基金项目2项，校级基金项目1项。主持课题序号课题名称项目来源资助金额起止年份 1 核酸结构对基因表达的调控南方医科大学第四层次人才引进科研启动项目 100万元 2015年6月-2018年6月 2 体内翻译过程中G四链体的形成机制及功能探讨国家自然科学基金 20万元 2016年01月-2018年12月 3 lncRNA 甲基化修饰在多能干细胞维持与分化中的作用及机制研究国家重点研发计划重点专项分任务 90.4万元 2017年7月-2021年12月

研究领域

RNA代谢与生殖细胞发育

近期论文

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代表性著作/论文 1. Xiao, S., Cao, S., Huang, Q., Xia, L., Deng, M., Yang, M., Jia, G., Liu, X., Shi, J., Wang, W., et al. (2019). The RNA N6-methyladenosine modification landscape of human fetal tissues. Nature cell biology 21, 651-661. 2. Han, Y., Feng, J., Xia, L., Dong, X., Zhang, X., Zhang, S., Miao, Y., Xu, Q., Xiao, S., Zuo, Z., et al. (2019). CVm6A: A Visualization and Exploration Database for m(6)As in Cell Lines. Cells 8. 3. Liu, T., Wang, Q., Li, W., Mao, F., Yue, S., Liu, S., Liu, X., Xiao, S., and Xia, L. (2017). Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31, 2185-2194.（共通讯） 4. Xiong, J., Liu, X., Cheng, Q.Y., Xiao, S., Xia, L.X., Yuan, B.F., and Feng, Y.Q. (2017). Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells. ACS chemical biology 12, 1636-1643. 5. Xiao, S., and Xia, L. (2016). Quantity versus quality: the sperm war. Asian journal of andrology 18, 900-901. 6. Liu, J.Q., Xiao, S., Hao, Y.H., and Tan, Z. (2015). Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase. Angewandte Chemie 54, 8992-8996. （共一） 7. Shrestha, P., Xiao, S., Dhakal, S., Tan, Z., and Mao, H. (2014). Nascent RNA transcripts facilitate the formation of G-quadruplexes. Nucleic acids research 42, 7236-7246. （共一） 8. Xiao, S., Zhang, J.Y., Wu, J., Wu, R.Y., Xia, Y., Zheng, K.W., Hao, Y.H., Zhou, X., and Tan, Z. (2014). Formation of DNA:RNA hybrid G-quadruplexes of two G-quartet layers in transcription: expansion of the prevalence and diversity of G-quadruplexes in genomes. Angewandte Chemie 53, 13110-13114. 9. Zhang, J.Y., Zheng, K.W., Xiao, S., Hao, Y.H., and Tan, Z. (2014). Mechanism and manipulation of DNA:RNA hybrid G-quadruplex formation in transcription of G-rich DNA. Journal of the American Chemical Society 136, 1381-1390. 10. Zheng, K.W., Wu, R.Y., He, Y.D., Xiao, S., Zhang, J.Y., Liu, J.Q., Hao, Y.H., and Tan, Z. (2014). A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic acids research 42, 10832-10844. 11. Xiao, S., Zhang, J.Y., Zheng, K.W., Hao, Y.H., and Tan, Z. (2013). Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. Nucleic acids research 41, 10379-10390. 12. Zheng, K.W., Xiao, S., Liu, J.Q., Zhang, J.Y., Hao, Y.H., and Tan, Z. (2013). Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. Nucleic acids research 41, 5533-5541.