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1. Li Ma1, †, Kangyu Lin1, †, Guoqiang Chang2, Chen Yue1, Qing Guo1, Sicong Zhang1, Yiwen Chen3, Tony T. Huang4, Aidong Zhou1,*, Suyun Huang1, 5,** Aberrant Activation of β-catenin Signaling Drives Glioma Tumorigenesis via USP1-mediated Stabilization of EZH2. Cancer Res, accepted, in press (*Co-corresponding).
2. Aidong Zhou. Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme: Linking Basic Studies to Clinical Applications. Curr Pharm Design. 2017, Nov 16;23(29):4290-4302. (corresponding，invited review)
3. Aidong Zhou1, Kangyu Lin1, Sicong Zhang1,2, Li Ma1,3, Jianfei Xue1, Saint-Aaron Morris1, Kenneth D Aldape4, and Suyun Huang1,2. Gli1-induced deubiquitinase USP48 promotes glioma tumorigenesis by deubiquitinating and stabilizing Gli1. EMBO Rep (2017) 18, 1318-1330.
4. Sicong Zhang, Boxuan Zhao, Aidong Zhou, Kangyu Lin, Shaoping Zheng, Zhike Lu, Yaohui Chen, Erik P. Sulman, Keping Xie, Oliver Bogler, Sadhan Majumder, Chuan He, Suyun Huang. M6A demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FoxM1 Expression and Cell Proliferation Program. Cancer Cell, 2017, 31, 591–606 (Previewed by Cancer Cell, Highlighted by Cancer Discovery)
Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett & Suyun Huang. High-level nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22. Nat Cell Biol. 2016 Sep;18(9):954-66. (Reported by BioCentury Innovation; highlighted and commented by Neuro-Oncology and Transl Can Res)
Jianfei Xue#, Aidong Zhou#, Yamei Wu#, Saint-Aaron Morris, Kangyu Lin, Samirkumar Amin, Roeland Verhaak, Gregory Fuller, Keping Xie, Amy B. Heimberger, and Suyun Huang. miR-182-5p induced by STAT3 activation promotes glioma tumorigenesis. Cancer Res, 2016 76(14); 4293–304. (#equal contribution).
7. Chen Y, Yu Li, Xue J, Gong A, Yu G, Zhou A, et al. Wnt-Induced Deubiquitination of FoxM1 Ensures Nucleus β-catenin Transactivation. EMBO J. 2016 Mar 15;35(6):668-84.
Xue J, Zhou A, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S. Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem. 2015 Jul 24;290(30):18662-70.
9. Lee HT, Xue J, Chou PC, Zhou A, Yang P, Conrad CA, Aldape KD, Priebe W, Patterson C, Sawaya R, Xie K, Huang S. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget. 2015 Apr 30;6(12):10016-29.
Yu G#, Zhou A#, Xue J, Huang C, Zhang X, Kang SH, Chiu WT, Tan C, Xie K, Wang J, Huang S. FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway. Oncotarget. 2015 May 10;6(13):11281-94. (#equal contribution)
Gong AH, Wei P, Zhang S, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Res. 2015 Jun 1;75(11):2337-48.
Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu & Suyun Huang. Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun. 2015 Feb, 2; 6:6156.
Zhang N, Wu X, Yang L, Xiao F, Zhang H, Zhou A, Huang Z, Huang S. FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51. Clin Cancer Res. 2012,18(21):5961-71
14. Aidong Zhou, Li-Ting Diao, Hui Xu, Zhen-Dong Xiao, Jun-Hao Li, Hui Zhou and Liang-Hu Qu*.β-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin signaling pathway. Oncogene. 2012 Jun 14;31(24):2968-78.
15. Lin K, Zhang X, Feng D, Zhang H, Zeng C, Han B, Zhou A, Qu L, Xu L, Chen Y. miR-125b, a target if CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. J Biol Chem, 2011 Nov 4; 286(44):38253-63.
Rushi Liu#, Aidong Zhou#, Daolong Ren, et.al. Transcription factor specificity protein 1(SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter. FEBS Journal, 276 (2009) 1114–1124. (#equal contribution)
Zhou A, Zhou J, Yang L, Liu M, Li H, Xu S, Han M, Zhang J. A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and suppresses the MAPK signal pathway. J Genet Genomics, 2008, 35(8): 467-72.
Zhou J, Fan C, Zhong Y, Liu Y, Liu M, Zhou A, Ren K, Zhang J. Genomic organization, promoter characterization and roles of Sp1 and AP-2 in the basal transcription of mouse PDIP1 gene. FEBS Lett. 2005 Mar 14; 579 (7):1715-22.
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