个人简介

李少钦，男，汉族，福建晋江人，山西大学生命科学院全职特聘教授、博导。曾任新加坡国立大学医学研究所首席研究员、博导，香港中文大学副研究员、研究助理教授、博导。在国外学习和工作25年（1989-2014），2014年回国任教。1997年获国际生物化学和分子生物学联盟所颁发的年轻科学家奖。所发表的文章影响因子累计99.7分，被他人引用485次，最高单篇影响因子11.5分，被他人引用109次。国际转化蛋白质组学研究杂志编委，十种国际学术期刊审稿，九次被选为国际学术会议专家组成员。 教育背景： 1983年获厦门大学理学（微生物学）学士 1986年获第一军医大学（现为南方医科大学）医学（免疫学）硕士 1999年获新西兰奥克兰大学哲学（生物科学）博士 工作经历: 1986-1989：第一军医大学（现为南方医科大学）助教 1989-1991：澳大利亚悉尼大学访问学者 1991-1992：澳大利亚昆士兰大学研究员 1997-2002：香港中文大学博士后、副研究员 2003-2010：新加坡国立大学首席研究员、博导 2011-2013：香港中文大学研究助理教授、博导 2014-现在:山西大学全职特聘教授、博导

研究领域

1.糖尿病人肿瘤易感性增高的生物悖掉理和分子机制 2.细胞中心体扩增的信号通路 3.天然化合物诱导的肿瘤细胞调山和分子途径 4.技术平台是功能蛋白质组学

代表性科研项目: 1.肿瘤细胞中心体扩增和凋亡的关系及其分子机制的研究。山西大学。1000000RMB。2014-2016 2.Characterizingtheresveratrol-evoked,Baxandp53independentapoptosissignalingcascades:inrelevancetothetherapeuticdevelopmentofresveratrolintreatingdrug-resistantcancers.NationalMedicalResearchCouncilofSingapore,201,550SGD,2008-2011 3.Proteomicdelineationofp53signalingpathways.NationalMedicalResearchCouncilofSingapore190,000SGD,2009-2011 4.Glucose-evokedcelldeathandunderlyingmolecularmechanisms:inrelevancetothedevelopmentofdiabeticnephropathy.NationalMedicalResearchCouncilofSingapore190,000SGD,2009-2011 5.EstablishmentofacatalogueofChinese-specificgeneticmarkersforobesity,diabetesanddiabetickidneydisease.HongKongInnovationTechnologyFund,4,473,000HKD,2000-2003 6.Screeningformutation/polymorphismsinobesity-relatedgenes,melanocortin-4receptor,uncouplingprotein2and3andtumornecrosisfactor-a,inChinesepatientswithearly-onsettype2diabetesandapositivefamilyhistory.ChineseUniversityofHongKong,110,000HKD,2000-2001 7.Roleofhyperglycemiaandoxidativestressongeneexpressionimplicatedincancerpathwaysintype2diabetes.Sanofi,832,600HKD,20120-2013 8.Genome-widesearchfordiabetes-associatedgenesinChinesepatientswithtype2diabetescharacterizedbyinsulindeficientornon-insulinresistanceinHongKong.HongKongResearchGantCouncil.580,000HKD,1999-2001 9.EstablishmentofacatalogueofChinese-specificgeneticmarkersforobesity,diabetesanddiabetickidneydisease.HongKongIndustrialFund.500000HKD,2000-2003 10.Mappinggenesforyoungonsetdiabetesobesityanddiabeticnephropathy.ChineseUniversityofHongKong.500000HKD.1999-2001.

近期论文

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1.LeeSC*,ChanJ,ProteomicidentificationofTCP-1gammaasp53responsiveprotein.CancerGenomicsandProteomics.9:101-108,2012 2.ChanJ,BennyTan,LeeSC*.Scutellarinsensitizesdrug-evokedcoloncancercellapoptosisthroughenhancedcaspase-6activation.AnticancerRes.29:3043-3047,2009 3.LeeSC*,ChanJ,PervaizS.Spontaneousand5-fluorouracil-evokedcentrosomeamplificationlowersthethresholdtoresveratrol-inducedapoptosisincoloncancercells.CancerLett.288:36-41,2009 4.ChanJ,PhooR,ClementM,PervaizS,LeeSC*.Resveratroldisplaysconversedose-relatedeffectson5-fluorouracil-evokedcoloncancercellapoptosis:therolesofcaspase-6andp53.CancerBio&Therapy.7:1-8,2008 5.LeeSC*,SimN,ClementM,YadavS,PervaizS.DominantnegativeRac1N17attenuateshumanmelanomaM14cellapoptosissensitivitybyupregulationofheatshockprotein27:afunctionalproteomicstudy.Proteomics.7:4112-4122,2007 6.LeeSC*,PervaizS.Apoptosisinthepathogenesisofdiabetesmellitusanditsmicrovascularcomplications.IntJBiochemCellBiol.39:497-504,2007 7.LeeSC,ChanJ,ClementM,PervaizS.Functionalproteomicanalysisofresveratrol-evokedcoloncancercellapoptosis:caspase-6cleavageoflaminAisamajorsignallingloop.Proteomics.6:2386-94,2006 8.WangY,NgMC,LeeSC,SoWY,TongPC,CockramCS,CritchleyJA,ChanJC.Phenotypicheterogeneityandassociationsoftwoaldosereductasegenepolymorphismswithnephropathyandretinopathyintype2diabetes.DiabetesCare.26:2410-2415,2003 9.KoGT,LeeSC,PuYB,NgMC,SoWY,ThomasN,ChanWB,CockramCS,ChanJC.Tumournecrosisfactor-alphapromotergenepolymorphismat-308(genotypeAA)inChinesesubjectswithType2diabetes.DiabetMed.20:167-168,2003 10.LeeSC*,CooperGJS.Amylinevokesproteinp20phosphorylationandinsulinresistanceinratskeletalmuscleextensordigitorumlongus.SciChina45:159-165,2002. 11.NgMC,LeeSC,KoGT,LiJK,SoWY,HashimY,BarnettAH,MackayIR,CritchleyJA,CockramCS,ChanJC.Familialearly-onsettype2diabetesinChinesepatients:obesityandgeneticshavemoresignificantrolesthanautoimmunity.DiabetesCare24:663-671,2001 12.LeeSC*,WangY,KoGTC,CritchleyJAJH,Cockram,CSandChanJCN.RisksfactorsforcataractinChinesepatientswithtype2diabetes:Evidencefortheinfluenceofthealdosereductasegene.ClinGenet59:356-359,2001 13.LeeSC*,KoGTC,LiJKY,ChowCC,YeungVTF,CritchleyJAJH,CockramCS,ChanJCN.Factorspredictingtheageatdiagnosisoftype2diabetesinHongKongChinese.DiabetesCare24:646-649,2001 14.ChanJCN,NgM,CritchleyJAJH,LeeSC,CockramCS.Diabetesmellitus-aspecialmedicalchallengefromaChineseperspective.DiabetesResClinPract54(Suppl1):19-27,2001 15.LeeSC*,Hashim,Y.LiJKY,KoGTC,CritchleyJAJH,CockramCSandChanJCN.Theisletamyloidpolypeptide(amylin)geneS20GmutationinChinesesubjects:EvidenceforassociationswithType2diabetesandcholesterollevelsClinEndocr54:541-546,2001 16.LeeSC*,PuYB,ChowCC,YeungVTF,KoGTC,SoWY,LiJKY,ChanWB,MaRCW,CritchleyJAJH,CockramCSandChanJCN.DiabetesinHongKongChinese:Familialclusteringandparentaleffects.DiabetesCare23:1365-1368,2000 17.LeeSC*,PuYB,ThomasNG,CritchleyJAJH,ThomlinsonB,CockramCSandChanJCN.Tumornecrosisfactor-?geneG-308Apolymorphisminthemetabolicsyndrom.Metab49:1021-1024,2000 18.JazwinskaEC,PyperWR,BurtMJ,FrancisJC,GoldwurmS,WebbSI,LeeSC,HallidayJWandPowellLW.HaplotypeanalysisinAustralianhemochromatosispatients:Evidenceforapredominantancestralhaplotypeexclusivelyassociatedwithhemochromatosis.AmJImpactfactor:11.1,citedfor74times(60timesexcludingselfcitation) 19.JazwinskaEC,LeeSC,WebbSI,HallidayJWandPowellLW.MappingofhemochromatosisgenetoclosetoD6S105andHLA-Abylinkageanalysis.AmJHumGenet53:347-352,1993