当前位置: X-MOL首页全球导师 国内导师 › 张建

个人简介

1988年获四川大学学士; 1996年获UniversityofMiami博士学位; 1997-1999年,UniversityofMiami和GenentechInc.博士后; 2002年入选中科院“百人计划”; 2004年获得国家杰出青年科学基金

研究领域

对发育生物学中的重要问题感兴趣,目前主要研究方向:1)早期胚胎发育的调控(如:原始生殖细胞发生);2)小鼠细胞谱系建立和维持。实验用模式动物包括斑马鱼,非洲爪蛙,和小鼠。我们在研究中广泛运用遗传学,细胞生物学,生物化学的方法。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

YuanY.,ZhangJ.*,ZhouQ.(2016)OverexpressionofJak1activatingmutantsinhepatocytesisinsufficienttogeneratehepatocellularcarcinomainzebrafish.JGenetGenomics.(inpress) MaWR,ZhangJ*.(2015)Jag1bisessentialforpatterninginnerearsensorycristaebyregulatinganteriormorphogenetictissueseparationandpreventingposteriorcelldeath.Development142(4):763-73. Zhu,G.,Li,Y.,Zhu,F.,Wang,T.,Jin,W.,Mu,W.,Lin,W.,Tan,W.,Li,W.,R.Street,C.,Peng,S.,Zhang,J.,Feng,Y.,Warren,S.,Sun,Q.*,Jin,P.*andChen,D.*(2014)CoordinationofEngineeredFactorswithTET1/2PromotesEarly-StageEpigeneticModificationduringSomaticCellReprogramming.StemCellReports2(3):253-61 SuW,FangJ,ChengF,LiuC,ZhouF,ZhangJ*.(2013)RNF2/Ring1bnegativelyregulatesp53expressioninselectivecancercelltypestopromotetumordevelopment.ProcNatlAcadSciUSA110(5):1720-5. LiuC,MaW,SuW,ZhangJ*.(2012)Prdm14actsupstreamofislet2transcriptiontoregulateaxongrowthofprimarymotoneuronsinzebrafish.Development139(24):4591-600. WangHW,FangJS,KuangX,MiaoLY,WangC,XiaGL,KingML,ZhangJ*.(2012)Activityoflong-chainacyl-CoAsynthetaseisrequiredformaintainingmeioticarrestinXenopuslaevis.Biol.Reprod.87(3):74. XuS,ChengF,LiangJ,WuW,ZhangJ*.(2012)MaternalxNorrin,aCanonicalWntSignalingAgonistandTGF-bAntagonist,ControlsEarlyNeuroectodermSpecificationinXenopus.PLOSBiol.10(3):e1001286.doi:10.1371/journal.pbio.1001286 ZhangL,KuangX,ZhangJ.*(2011)Nogoreceptor3,aparalogofNogo-66receptor1(NgR1),mayfunctionasaNgR1co-receptorforNogo-66.JGenetGenomics.38(11):515-23. WangY,ChenJ,HuJL,WeiXX,QinD,GaoJ,ZhangL,JiangJ,LiJS,LiuJ,LaiKY,KuangX,ZhangJ,PeiD,XuGL.(2011)programmingofmouseandhumansomaticcellsbyhigh-performanceengineeredfactors.EMBORep.12(4):373-8 GaoC,CaoW,BaoL,ZuoW,XieG,CaiT,FuW,ZhangJ,WuW,ZhangX,ChenYG.(2010)AutophagynegativelyregulatesWntsignallingbypromotingDishevelleddegradation.Nat.CellBiol.12(8):781-90. ZhangL,ZhengS,WuH,WuY,LiuS,FanM,ZhangJ*.(2009)IdentificationofBLyS(Blymphocytestimulator),anon-myelin-associatedprotein,asafunctionalligandforNogo-66receptor.J.Neurosci.29(19):6348-52.(HighlightedinNatureChinahttp://www.nature.com/nchina/2009/090527/full/nchina.2009.117.html;andinSciBXhttp://www.nature.com/scibx/journal/v2/n20/full/scibx.2009.845.html) ZhuD,FangJ,LiY,ZhangJ*.(2009)Mbd3,acomponentofNuRD/Mi-2complex,helpsmaintainpluripotencyofmouseembryonicstemcellsbyrepressingtrophectodermdifferentiation.PLOSOne.4(11):e7684. ZhangJ.*(2004)AnewtricktotunedownTGF-betasignal.CellResearch14(5):439-40. ZhouY.,ZhangJ.,KingM.L.(2004)PolarizeddistributionofmRNAsencodingaputativeLDLreceptoradaptorprotein,xARH(autosomalrecessivehypercholesterolemia)inXenopusoocytes.MechanismofDevelopment121:1249-58. MamidipudiV.,ZhangJ.,LeeK.,andCartwrightCA.(2004)RACK1regulatesG1/SprogressionbysuppressingSrckinaseactivity.Mol.Cell.Biol.24:6788-98. ZhouY.,ZhangJ.,KingM.L.(2003)XenopusARHcoupleslipoproteinreceptorswiththeAP-2complexinoocytesandembryosandisrequiredforvitellogenesis.J.Biol.Chem.278:44584-92 Zhang,J.,Rosenthal,A.,deSauvageF.J.,andShivdasani,R.A.(2001).DownregulationofHedgehogsignalingisrequiredfororganogenesisofthesmallintestineinXenopus.Dev.Biol.229:188-202. Zhang,J.,Houston,D.W.,King,M.L.,Payne,C.,Wylie,C.,andHeasman,J.(1998)TheroleofmaternalVegTinestablishingtheprimarygermlayersinXenopusembryos.Cell94,515-524. Houston,D.W.,Zhang,J.,Maines,J.Z.,Wasserman,S.A.,andKing,M.L.(1998)AXenopusDAZ-likegeneencodesanRNAcomponentofgermplasmandisafunctionalhomologuesofDrosophilaboule.Development125,171-180 Zhang,J.andKing,M.L.(1996)XenopusVegTRNAislocalizedtothevegetalcortexduringoogenesisandencodesanovelT-boxtranscriptionalfactorinvolvedindorsal/ventralpatterning.Development122,4119-4129

推荐链接
down
wechat
bug