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招生专业 0710J3-生物信息学 071009-细胞生物学 086000-生物与医药 招生方向 蛋白质组学 细胞迁移 生物信息学 教育背景 1998-07--2003-07 Iowa State University 博士 1994-09--1997-08 中国科学院遗传研究所 硕士 1990-09--1994-06 兰州大学 学士 工作简历 1998-07~2003-07,Iowa State University, 博士 1994-09~1997-08,中国科学院遗传研究所, 硕士 1990-09~1994-06,兰州大学, 学士 教授课程 蛋白质组学 医学蛋白质组学 蛋白质组学系列讲座 信号转导 科研项目 ( 1 ) 干细胞三维培养与自我更新调控网络的研究, 参与, 国家级, 2011-01--2015-12 ( 2 ) 植物表观遗传调控及其在重要发育过程中的作用机制及结构基础研究, 主持, 国家级, 2012-01--2016-08 ( 3 ) 脊椎动物第四胚层发育的调控, 参与, 部委级, 2013-01--2015-12 ( 4 ) 诺和诺德长城教授奖, 主持, 研究所(学校), 2009-08--2012-08 ( 5 ) 集胞藻膜蛋白地图集的构建, 主持, 国家级, 2017-01--2021-12 ( 6 ) 以家犬为模型解析社交与情感的生物学基础, 参与, 国家级, 2020-01--2024-12 ( 7 ) 新型核糖核酸修饰鉴定和代谢及其对脑与胚胎发育的调控, 参与, 国家级, 2020-01--2024-12

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(1) Evaluation of the potential risk of advanced peak determination in distorting isobaric labeling-based single-shot proteome quantitation, Proteomics, 2020, 通讯作者 (2) Control of Grain Size and Weight by the GSK2-LARGE1/OML4 Pathway in Rice, The Plant Cell, 2020, 其他(合作组作者) (3) The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes, J Gerontol A Biol Sci Med Sci., 2020, 第 6 作者 (4) Integration of ovular signals and exocytosis of a Ca2+ channel by MLOs in pollen tube guidance, Nature Plants, 2020, 第 4 作者 (5) Nitration-Induced Ubiquitination and Degradation Control Quality of ERK1, Biochem J, 2019, 通讯作者 (6) Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection, Mol Cell, 2019, 第 8 作者 (7) Activation of the Oxidative Pentose Phosphate Pathway is Critical for Photomixotrophic Growth of a hik33-Deletion Mutant of Synechocystis sp. PCC 6803, Proteomics, 2018, 通讯作者 (8) Systematic identification of light-regulated cold-responsive proteome in a model cyanobacterium, J Proteomics, 2018, 通讯作者 (9) Translating Divergent Environmental Stresses into a Common Proteome Response through Hik33 in a Model Cyanobacterium, Mol Cell Proteomics, 2017, 通讯作者 (10) A receptor heteromer mediates the male perception of female attractants in plants., Nature, 2016, 第 4 作者 (11) SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana., Nature Communications, 2016, 第 4 作者 (12) Mea6 controls VLDL transport through the coordinated regulation of COPII assembly., Cell Research, 2016, 第 4 作者 (13) Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Protein, Mol Cell Proteomics, 2015, 通讯作者 (14) Toward the complete proteome of Synechocystis sp. PCC 6803, Photosynth Res, 2015, 通讯作者 (15) Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis sp. PCC6803, Mol Cell Proteomics, 2014, 通讯作者 (16) Evaluation of empirical rule of linearly correlated peptide selection (ERLPS) for proteotypic peptide-based quantitative proteomics, Proteomics, 2014, 第 4 作者 (17) Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans, PLos Genetics, 2013, 第 4 作者 (18) Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity, PLos Genetics, 2013, 第 4 作者 (19) KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer, Cancer research, 2012, 第 4 作者 (20) Proteomics method for identification of pseudopodium phosphotyrosine proteins, Methods Mol. Biol, 2012, 第 1 作者 (21) Mutational Analysis of Photosystem I of Synechocystis sp. PCC 6803: The Role of Four Conserved Aromatic Residues in the j-helix of PsaB, PloS One, 2011, 通讯作者 (22) Spatial Phosphoprotein Profiling Reveals a Compartmentalized ERK Switch Governing Neurite Growth and Retraction, J. Biol. Chem, 2011, 第 1 作者 (23) Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells , Proteomics, 2011, 第 4 作者 (24) Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation, PLos One, 2010, 第 4 作者 (25) Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression, Proc Natl Acad Sci U S A, 2010, 第 1 作者 (26) Structures of PHR Domains from Mus musculus Phr1 (Mycbp2) Explain the Loss-of-Function Mutation (Gly1092 → Glu) of the C. elegans Ortholog RPM-1, J Mol Biol, 2010, 第 4 作者 (27) Identification and bioinformatic analysis of the thylakoid membrane proteome of Synechocystis sp. PCC6803, Proteome Science, 2009, 通讯作者 (28) Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid induced chemotaxis using Dual-step 18O Labeling Coupled with Immobilized Metal Affinity Chromatography, J Proteome Res, 2008, 第 1 作者 (29) Spatial Mapping of the Neurite and Soma Proteomes Reveals a Functional Cdc42/Rac Regulatory Network, Proc Natl Acad Sci U S A, 2008, 第 2 作者 (30) PhosphoBlast: A Computational Tool for Comparing Phosphoprotein Signatures among Large Datasets, Mol Cell Proteomics, 2008, 第 1 作者 (31) Methods for Pseudopodia Purification and Proteomics Analysis, Sci STKE, 2007, 第 1 作者 (32) Profiling Signaling Polarity in Chemotactic Cells, Proc Natl Acad Sci U S A, 2007, 第 1 作者 (33) Biochemical Purification of Pseudopodia from Migratory Cells, Methods Mol Biol, 2007, 第 1 作者 (34) Computational methods for comparison of large genomic and proteomic datasets reveals protein markers of metastatic cancer, J Proteome Res, 2006, 第 1 作者 (35) Proteins of the cyanobacterial photosystem I, Biochimica Biophysica Acta, 2001, 第 3 作者 (36) Thermodynamics of electron transfer in oxygenic photosynthetic reaction center: a photoacoustic study revealed a similarity to bacterial reaction centers on electron transfer in photosystem I in both volume change and entropy, Biochemistry, 2001, 第 3 作者 (37) Proteomic study of the peripheral proteins from thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803, Electrophoresis, 2000, 第 1 作者

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