张竹青 - 中国科学院大学

个人简介

招生专业 071023-计算生物学 071011-生物物理学招生方向生物大分子计算机模拟教育背景 2000-09--2005-06 中科院化学所博士工作经历 2005-2007 北京大学，化学与分子工程学院，理论生物中心，博士后 2008-2011 多伦多大学，医学院生物化学系，博士后 2011.6-现在中国科学院大学，生命科学学院，副教授、教授教授课程天然产物新药开发（助教）生物化学细胞的物理生物学纳米生物学高级生物化学（助教）计算生物学讨论课（助教）现代药物分析计算生物学生物单分子技术文献阅读课参与会议（1） LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro 第十七次中国暨国际生物物理大会 2019-08-02 （2）How Allostery Happens – An Example of N-terminal Domain of Calmodulin in Atomic Level Characterization Joint 12 EBSA 10 ICBP-IUPAP Biophysics Congress 2019-07-20 （3）从头设计蛋白质折叠的模拟研究中国化学会第30届学术年会 2016-07-01 （4）Influences of Native Energetic Heterogeneity and Many-body Interaction in  Value Analysis of Protein Folding IUPAB Congress 2014 2014-08-03 （5）Theoretical simulation study of transition paths and diffusive processe of protein folding 生物信息学和计算生物学的前沿研究 2013-09-23 （6）Nonnative interaction influences on folding kinetics for small proteins Top7 and Fyn SH3 domain from coarse-grained models 第17次国际生物物理大会暨第12次中国生物物理学术大会 2011-10-30

研究领域

生物大分子构象变化相关的计算机模拟工作，包括蛋白质折叠，别构机制，固有无序蛋白质的结构特征和功能关系。蛋白质体系相分离的机制。

近期论文

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1. Qian Li†, Xiaojun Peng†, Yuanqing Li, Wenqin Tang, Jia'an Zhu, Jing Huang, Yifei Qi and Zhuqing Zhang*. LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro. Nucleic Acids Res. 2020:48:D320-327 (†equal contribution) 2. Likun Zhao, Luhua Lai*, Zhuqing Zhang*. How calcium ion binding induces the conformational transition of the calmodulin N-terminal domain-an atomic level characterization. Phys Chem Chem Phys. 2019,21;19795-19804. 3. Yanhua Ouyang, Likun Zhao, Zhuqing Zhang*. Characterization of the structural ensembles of p53 TAD2 by molecular dynamics simulations with different force fields. Phys Chem Chem Phys. 2018,20:8676-8684. 4. Jie Hu, Tao Chen, Moye Wang, Hue Sun Chan*, Zhuqing Zhang*. A critical comparison of coarse-grained structure-based approaches and atomic models of protein folding. Phys Chem Chem Phys. 2017,19:13629-13639. 5. Zhuqing Zhang*, Yanhua Ouyang, Tao Chen. Influences of heterogeneous native contact energy and many-body interactions on the prediction of protein folding mechanisms. Phys Chem Chem Phys. 2016,18:31304-31311 6. Zhuqing Zhang, and Hue Sun Chan*. Transition paths, diffusive processes, and preequilibria of protein folding. Proc Natl Acad Sci U S A. 2012,109:20919-20924 7. Hue Sun Chan*, Zhuqing Zhang, Stefan Wallin and Zhirong Liu. Native Topology, Local-Nonlocal Coupling, and Nonnative Interactions: Principles of Protein Folding from Coarse-Grained Models. Annu Rew Phys Chem. 2011,62:301-332 8. Zhuqing Zhang, and Hue Sun Chan*. Competition between Native Topology and Nonnative Interactions in Simple and Complex Folding Kinetics of Natural and Designed Proteins. Proc Natl Acad Sci U S A. 2010,107:2920-2925 9. Zhuqing Zhang, Hao Chen, Luhua Lai*. Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential. Bioinformatics. 2007,23:2218-2225 10. Zhuqing Zhang, Hao Chen, Hongjun Bai, Luhua Lai*. Molecular dynamics simulations on the oligomer formation process of the GNNQQNY peptide from yeast prion protein Sup35. Biophys J. 2007,93;1484-1492