个人简介
1991-1995年就读南京大学基础学科教学强化部、获学士学位;1995-1998年为南京大学化学化工学院研究生、获博士学位;1998-2001年在纽约州立大学布法罗分校从事博士后研究;2001-2005年任纽约州立大学布法罗分校化学系研究助理教授;2005年2月到浙江大学化学系工作至今,2021年1月起担任浙江大学实验室与设备管理处处长。2006年入选教育部奖励计划教授,2011年获得中国青年科技奖,2016年获得国家杰出青年科学基金,2018年入选国家创新领军人才。是浙江大学求是高等研究院、硅材料国家重点实验室、附属邵逸夫医院浙江省骨骼肌肉退变与再生修复转化研究重点实验室成员。围绕生物矿化开展多学科交叉研究,内容包括:材料合成、生物材料、仿生修复以及材料调控生物等,涉及化学、材料、生物和医学等多个领域,主持国家重点研发计划项目及国家自然科学基金委重点项目等。
学术兼职
《无机化学学报》副主编、Nano Research 编委、Science China Materials 编委;《结构化学》编委;中国生物材料学会智能仿生生物材料分会副主任委员、生物陶瓷分会常务委员。
社会职务
浙江省人大常委会委员、浙江省人大环境与资源保护委员会委员、民盟浙江省委会副主委、民盟浙江大学委员会主委、浙江省欧美同学会副会长、浙江省留联会副会长、浙江大学侨联主席、浙江大学留联会会长、杭州市科协副主席。
研究领域
生物矿化 及 材料的仿生制备
生物材料 及 生物组织仿生修复
无机聚合 及 有机—无机共聚
生物—材料复合 及 基于材料开展生物调控
近期论文
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Biomimetic Mineralized Organic-Inorganic Hybrid Macrofiber with Spider Silk-Like Supertoughness, Adv Funct Mater 2020, 30(6),1908556.
Shape-preserving amorphous-to-crystalline transformation of CaCO3 revealed by in situ TEM, Proc Natl Acad Sci USA 2020, 117(7), 3397-3404.
Organic-Inorganic Copolymerization for a Homogenous Composite without an Interphase Boundary, Angew Chem Int Ed 2020, 59(5), 2071-2075.
Crosslinking ionic oligomers as conformable precursors to calcium carbonate, Nature 2019, 574(7778), 394-398.
Osteoporotic Bone Recovery by a Highly Bone-Inductive Calcium Phosphate Polymer-Induced Liquid-Precursor, Adv Sci 2019, 6(19), 1900683.
Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth, Sci Adv 2019, 5(8), eaaw9569.
Revealing the Cluster-Cloud and Its Role in Nanocrystallization, Adv Mater 2019, 31(16), 1808225.
Nanomaterial-Based Organelles Protect Normal Cells against Chemotherapy-Induced Cytotoxicity. Adv Mater 2018, 30 (7), 1801304.
In situ Liquid Cell TEM Reveals Bridge-induced Contact and Fusion of Au Nanocrystals in Aqueous Solution. Nano Lett 2018, 18(10), 6551-6556.
Citrate Improves Collagen Mineralization via Interface Wetting: A Physicochemical Understanding of Biomineralization Control. Adv Mater 2018, 30 (8), 1704876.
Mineralized State of the Avian Influenza Virus in the Environment. Angew Chem Int Ed 2017, 56 (42), 12908-12912.
Biomineralization: From Material Tactics to Biological Strategy. Adv Mater 2017, 29 (14), 1605903.
Prevention of Cyanobacterial Blooms Using Nanosilica: A Biomineralization-Inspired Strategy. Environ Sci Technol 2017, 51 (21), 12717-12726.
Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment. Theranostics 2017, 7 (17), 4301-4312.
Total morphosynthesis of biomimetic prismatic-type CaCO3 thin films. Nat Commun 2017, 8 (1), 1398.
Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection. Chem Sci 2017, 8 (12), 8240-8246.
Switchable Chiral Selection of Aspartic Acids by Dynamic States of Brushite. J Am Chem Soc 2017, 139 (25), 8562-8569.
Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity. Chem Commun 2016, 52 (38), 6447-6450.
A Drug-Free Tumor Therapy Strategy: Cancer-Cell-Targeting Calcification. Angew Chem Int Ed 2016, 55 (17), 5225-5229.
In vivo dual-targeted chemotherapy of drug resistant cancer by rationally designed nanocarrier. Biomaterials 2016,75, 71-81.
Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity. Adv Mater 2016, 28 (4), 694-700.
Biomineralized vaccine nanohybrid for needle-free intranasal immunization. Biomaterials 2016, 106, 286-294.
Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine-silica. Chem Sci 2016, 7 (3), 1753-1759.
Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection. Chem Commun 2016, 52 (9), 1879-1882.
Improvement of Biological Organisms Using Functional Material Shells. Adv Funct Mater 2016, 26 (12), 1862-1880.
Realignment of Nanocrystal Aggregates into Single Crystals as a Result of Inherent Surface Stress. Angew Chem Int Ed 2016, 55 (41), 12836-12840.
Cells Recognize and Prefer Bone-like Hydroxyapatite: Biochemical Understanding of Ultrathin Mineral Platelets in Bone. ACS Appl Mater Interfaces 2016, 8 (44), 29997-30004.
Silicification-Induced Cell Aggregation for the Sustainable Production of H2 under Aerobic Conditions. Angew Chem Int Ed 2015, 127 (41), 12129-12133.
The effect of amorphous calcium phosphate on protein protection against thermal denaturation. Chem Commun 2015, 51 (41), 8705-8707.
Hydrated silica exterior produced by biomimetic silicification confers viral vaccine heat-resistance. ACS Nano 2015, 9 (1), 799-808.
Virus Capture and Destruction by Label-Free Graphene Oxide for Detection and Disinfection Applications. Small 2015, 11 (9-10), 1171-1176.
Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier. Small 2015, 11 (2), 239-247.
Overcoming Multiple Drug Resistance by Spatial–Temporal Synchronization of Epirubicin and Pooled siRNAs. Small 2015, 11 (15), 1775-1781.
Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering. Chem Sci 2014, 5 (9), 3463-3468.
Nanomodification of living organisms by biomimetic mineralization. Nano Research 2014, 7 (10), 1404-1428.
Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls. Small 2014, 10 (18), 3644-3649
Spontaneously amplified homochiral organic–inorganic nano-helix complexes via self-proliferation. Nanoscale 2013, 5 (7), 3006-3012.
Alleviation of high light-induced photoinhibition in cyanobacteria by artificially conferred biosilica shells. Chem Commun 2013, 49 (68), 7525-7527.
Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions. Proc Natl Acad Sci USA 2013, 110 (19), 7619-7624.
Overcoming cisplatin resistance in chemotherapy by biomineralization. Chem Commun 2013, 49 (43), 4932-4934.
Biomineralization-Based Virus Shell-Engineering: Towards Neutralization Escape and Tropism Expansion. Adv Healthcare Mater 2012, 1 (4), 443-449.
Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration. Angew Chem Int Ed 2012, 51 (42), 10576-10579.
Bio-Inspired Enamel Repair via Glu-Directed Assembly of Apatite Nanoparticles: an Approach to Biomaterials with Optimal Characteristics. Adv Mater 2011, 23 (40), 4695-4701.
Self-Assembled Organic-Inorganic Hybrid Elastic Crystal via Biomimetic Mineralization. Adv Mater 2010, 22 (33), 3729-3734.
Mystery of the transformation from amorphous calcium phosphate to hydroxyapatite. Chem Commun 2010, 46 (39), 7415-7420.
Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean. Proc Natl Acad Sci USA 2009, 106 (52), 22096-22101.
Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralization. Angew Chem Int Ed 2008, 47 (19), 3560-3564.
Ultrasonic controlled morphology transformation of hollow calcium phosphate nanospheres: A smart and biocompatible drug release system. Chem Mater 2007, 19 (13), 3081-3083.