个人简介
朱斐,汉族,博士,浙江省中青年学科带头人,中国细胞生物学学会和中国海洋生物工程学会会员。主要从事经济甲壳动物先天性免疫机制和流行性病原的防治研究。主持国家自然科学基金面上项目和浙江省自然科学基金面上项目,作为主要成员参与科技部973项目、国家863项目、农业部公益性行业(农业)科研专项等项目。至今共发表SCI论文30余篇,其中25篇以第一作者或唯一通讯作者发表在FrontiersinImmunology、ScientificReports、FishShellfishImmunology、DevelopmentalComparativeImmunology、MarineBiotechnology、ExperimentalCellResearch和Aquaculture等专业权威SCI期刊上,获得国家发明专利一项。欢迎有志于海洋生物学和先天性免疫研究的同学加盟,欢迎生物相关专业的同学报考本试验室的研究生。
教育背景
1998.09-2002.07大连海洋大学水产养殖农学学士
2002.09-2005.05大连海洋大学水生生物理学硕士
2006.03-2009.03浙江大学动物营养与饲料农学博士
工作经历
2009.07-2011.06浙江大学生物学博士后(优秀)
2011—至今浙江农林大学2012年晋升浙江农林大学副研究员,2013年起任硕士研究生导师
课程教学
1.《动物病毒学》本科生
2.《水产动物疾病》本科生
科研项目
主持的项目
1.国家自然科学基金面上项目―细胞吞噬相关miRNA在对虾抗白斑综合征病毒中的作用(31370050)
2.国家自然科学基金青年项目―小G蛋白(Rab、Ran)在对虾抗病毒细胞吞噬中的作用(31001127)
3.浙江省自然科学基金面上项目―microRNA-125/133在拟穴青蟹感染白斑综合征病毒免疫反应中的作用机制(LY20C190001)
4.浙江省教育厅项目―葡聚糖包被siRNA抗对虾白斑综合征病毒研究(Y200908288)
参与的项目
1.国家高技术研究发展计划(863计划)2011AA10A216-3对虾抗病毒靶向药物研发。第三2011.1.1-2013.12.31
2.国家重点基础研究发展计划(973计划)2012CB114400-G“海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究”第三2012.1.1-2016.12.31
3.农业部公益性行业(农业)科研专项“养殖虾类病毒病快速诊断与生物防控技术的研究”研究课题。第三2011.1.1-2015.12.31
研究领域
研究方向
主要从事经济甲壳动物的病害与免疫学研究,探索无脊椎动物病毒感染与宿主细胞分子免疫相互作用的机制,借助先进的分子和细胞生物学研究方法,挖掘还未被揭示的先天性免疫机理,尤其是细胞吞噬机理的研究,同时以此为靶向来筛选一些提高先天性免疫力的分子制剂
近期论文
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发表论文
1.BaozhenSun,ZhiWang,ZiyanWang,XiongchaoMa,ZhuFei*.Aproteomicstudyofhemocyteproteinsfrommudcrab(Scyllaparamamosain)infectedwithwhitespotsyndromevirus(WSSV)orVibrioalginolyticus.FrontiersinImmunology,2017,8:468.
2.QianXiyi,LaiYongyong,ZhuFei.MolecularcharacterizationofcarboxypeptidaseB-like(CPB)inScyllaparamamosainanditsroleinwhitespotsyndromevirusandVibrioalginolyticusinfection.FishShellfishImmunology2019,94:434-446.
3.QianXiyi,ZhuFei.HesperetinprotectscrayfishProcambarusclarkiiagainstwhitespotsyndromevirusinfection.FishShellfishImmunology2019,93:116-123.
4.MaXiongchao,ZhuFei,JinQinri.Antibioticsandchemicaldisease-controlagentsreduceinnatediseaseresistanceincrayfish.FishShellfishImmunology2019,86:169-178.
5.ZhuFei,QianXiyi,MaXiongchao.ComparativetranscriptomicanalysisofcrabhemocytesinresponsetowhitespotsyndromevirusorVibrioalginolyticusinfection.FishShellfishImmunology2018,80:165-179.
6.WangZhi,SunBaozhen,ZhuFei.Molecularcharacterizationofglutaminyl-peptidecyclotransferase(QPCT)inScyllaparamamosainanditsroleinVibrioalginolyticusandwhitespotsyndromevirus(WSSV)infection.FishShellfishImmunology2018,78:299-309.
7.ZiyanWang,BaozhenSun,ZhuFei*.Molecularcharacterizationofdiphthamidebiosynthesisprotein7inMarsupenaeusjaponicusanditsroleinwhitespotsyndromevirusinfection.FishShellfishImmunology2018,75:8-16.
8.WangZhi,SunBaozhen,ZhuFei.Epigallocatechin-3-gallateprotectsKurumashrimpMarsupeneausjaponicusfromwhitespotsyndromevirusandVibrioalginolyticus.FishShellfishImmunology2018,78:1-9.
9.XiongchaoMa,BaozhenSun,ZhuFei*.MolecularcloningofKurumashrimpMarsupenaeusjaponicusendonuclease-reversetranscriptaseanditspositiveroleinwhitespotsyndromevirusandVibrioalginolyticusinfection.FishShellfishImmunology2018,73:297-308.
10.SunBaozhen,QianXiyi,ZhuFei.Molecularcharacterizationofshrimpharbingertransposasederived1(HARBI1)-likeanditsroleinwhitespotsyndromevirusandVibrioalginolyticusinfection.FishShellfishImmunology2018,78:222-232.
11.WangZhi,ZhuFei*.MicroRNA-100isinvolvedinshrimpimmuneresponsetowhitespotsyndromevirus(WSSV)andVibrioalginolyticusinfection.ScientificReports,2017,7:42334.
12.WangZhi,ZhuFei*.DifferentrolesofanovelshrimpmicroRNAinwhitespotsyndromevirus(WSSV)andVibrioalginolyticusinfection.DevelopmentalComparativeImmunology,2017,79:21-30.
13.ZhiWang,BaozhenSun,ZhuFei*.Epigallocatechin-3-gallateinhibitreplicationofwhitespotsyndromevirusinScyllaparamamosain.FishShellfishImmunology2017,67:612-619.
14.BaozhenSun,ZhiWang,ZhuFei*.Thecrustin-likepeptideplaysoppositeroleinshrimpimmuneresponsetoVibrioalginolyticusandwhitespotsyndromevirus(WSSV)infection.FishShellfishImmunology2017,66:487-496.
15.ZhiWang,BaozhenSun,ZhuFei*.Theshrimphormonereceptoractsasananti-apoptosisandanti-inflammatoryfactorininnateimmunity.FishShellfishImmunology2017,72:581-592.
16.WangZhi,ZhuFei*.Minichromosomemaintenanceprotein7regulatesphagocytosisinkurumashrimpMarsupenaeusjaponicasagainstwhitespotsyndromevirus.FishShellfishImmunology2016,55:293-303.
17.SunBaozhen,QuanH,ZhuFei*.DietarychitosannanoparticlesprotectcrayfishProcambarusclarkiiagainstwhitespotsyndromevirus(WSSV)infection.FishShellfishImmunology2016,54:241-246.
18.ZhuFei*,JinM.Theeffectsofathermophilemetabolite,tryptophol,uponprotectingshrimpagainstwhitespotsyndromevirus.FishShellfishImmunology2015,47(2):777-781.
19.ZhuFei*,WangZ,SunBZ.DifferentialexpressionofmicroRNAsinshrimpMarsupenaeusjaponicusinresponsetoVibrioalginolyticusinfection.DevelopmentalComparativeImmunology2015,55:76-79.
20.ZhuFei,ZhouY,JiangC,ZhangXiaobo*.RoleofJAK-STATsignalinginmaturationofphagosomescontainingStaphylococcusaureus.ScientificReports2015,5:14854.
21.ZhuFei*,WanfuYue,YongxiaWang.ThenuclearfactorkappaB(NF-κB)activationisrequiredforphagocytosisofStaphylococcusaureusbyRAW264.7cells.ExperimentalCellResearch2014,327(2):256-263.
22.SunBaozhen,ZhiWang,ZhuFei*.MolecularcloningofkurumashrimpMarsupenaeusjaponicusphosphopyruvatehydrataseanditsroleininfectionbywhitespotsyndromevirusandVibrioalginolyticus.Aquaculture2016,455:87-96.
23.ZhuFei,XiaoboZhang*.TheWntsignalingpathwayisinvolvedintheregulationofphagocytosisofvirusinDrosophila.ScientificReports2013,3:2069.
24.ZhuFei,XiaoboZhang*.ProtectionofPenaeusjaponicusagainstwhitespotsyndromevirus(WSSV)withβ-1,3-D-glucan-encapsulatedvp28-siRNAparticles(GeRPs).MarineBiotechnology2012,14:63-68.
25.ZhuFei,HuahuaDu,Zhi-GuoMiao,Hai-ZhiQuan,Zi-rongXu*.ProtectionofProcambarusclarkiiagainstwhitespotsyndromevirususinginactivatedWSSV.FishShellfishImmunology2009,26:685–690.
26.ZhuFei*,HaizhiQuan.Anewmethodforquantifyingwhitespotsyndromevirus:ExperimentalchallengedoseusingTaqManreal-timePCRassay.JournalofVirologicalMethods2012,184:121-124.
学术兼职
担任国家自然科学基金地区合作项目和青年基金项目评委及ReviewsinAquaculture、EmergingMicrobes&Infections、ScientificReports、FishShellfishImmunology和Aquaculture等SCI期刊的审稿人。