Dai, Mingji - Emory University - Department of Chemistry

个人简介

2022-present: Asa Griggs Candler Professor of Chemistry, Emory University 2021-2022: University Faculty Scholar and Showalter Faculty Scholar, Purdue University 2020-2022: Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2018-2020: Associate Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2012-2018: Assistant Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2020-2022: Organic Division Head, Department of Chemistry, Purdue University 2020-2022: Program Co-Leader, the Purdue Center for Cancer Research 2020-2022: Equity Advisor, Department of Chemistry, Purdue University 2019-2022: Associate Director, the Purdue Drug Discovery NIH T32 Training Program

研究领域

We work on both natural and unnatural molecules with particular potential for the treatment of cancer, CNS disorders and infectious diseases. We view the completion of a synthesis as the beginning of a larger and deeper scholarly inquiry. It would enable us to profile the biology of the selected natural products and rationally designed small molecules, decipher their mechanism of actions, and optimize the lead compounds into biological probe and novel therapeutics development. We also use our new synthetic methodologies and strategies to create novel, diverse, complex and bio-functional small-molecule libraries to address the challenges in modulating the “undraggable” disease targets, such as protein-protein interactions and transcription factors. Total Synthesis via Catalytic Carbonylation Divergent Total Synthesis via Funtional Group Pairing Strategy Total Synthesis and Biological Study of Polycyclic Diterpenes (Hydroxy)Cyclopropanol Ring-Opening Chemistry Amphoteric Diamination to N- Heterocylces Medicinal Chemistry and Chemical Biology

近期论文

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Total Synthesis Ma, D.; Duran, P.; Al-Ahmad, R.; Hestehave, S.; Joa, M.; Alsbiei, O.; Rodríguez-Palma, E. J.; Li, Y.; Wang, S.; Khanna, R.;* Dai, M.* “C–H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of New Analogs in Osteoarthritis-related Pain Treatment” J. Am. Chem. Soc. 2024, 146, accepted. Total Synthesis Rivera, M. E.; Li, L.; Kolisetti, A. (UG); Chi, N. (UG); Dai, M.* “9-Step Synthesis of (–)-Larikaempferic Acid Methyl Ester Enabled by Skeletal Rarrangement" Chem. Commun. 2024, 60, accepted. (the ChemComm Pioneering Investigators Collection) ChemBio Li, X.; Wang, D.; Yin, X.; Dai, M.; Staiger, C. J.;* Zhang, C.* “A Chemical Genetic Screen with the EXO70 Inhibitor Endosidin2 to Uncover Potential Modulators of Exocytosis in Arabidopsis” Plant Direct, 2024, 8, accepted. ChemBio Imaging Chen, Z.; Chen, F.; Lee, H. J.; Zhang, M.; Yin, X.; Dai, M.; Cheng, J.-X.* “LIPA-Driven Hydrolysis of Cholesteryl Arachidonate Promotes Cancer Metastasis via NF-κB” bioRxiv (DOI: https://doi.org/10.1101/2022.03.11.484042). Natural Product Drug Discovery Liang, W.; Krabill, A. D.; Gallagher, K. S.; Muli, C.; Qu, Z.; Trader, D.; Zhang, Z.-Y.;* Dai, M.* “Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase” Tetrahedron, 2024, 155, accepted. (Invited contribution to the special issue in honor of Professor Thomas Maimone’s 2024 Tetrahedron Young Investigator Award in Organic Synthesis) Methodology Fang, W.; Luo, Z.-W.; Wang, Y.-C.; Zhou, W.; Li, L.; Chen, Y.; Zhang, X.; Dai, M.;* Dai, J.-J.* “An SN2 reaction at amide nitrogen enables hydrazide synthesis”. Angew. Chem. Int. Ed. 2024, 63, e202317570. Total Synthesis Jin, Y.; Hok, S.; Bacsa, J.; Dai, M.* “Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C-H Functionalizations” J. Am. Chem. Soc. 2024, 146, 1825-1831.. Total Synthesis Jiang, B.; Dai, M.* "Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products". J. Am. Chem. Soc. 2023, 145, 18731-18736. Total Synthesis Cui, C.; Dai, M.* "Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction". Chin. J. Chem. 2023, doi: 10.1002/cjoc.202300331. (Invited contribution dedicated to the Special Issue of C1 Chemistry). Total Synthesis Martin, B. S.†; Ma, D.†; Saito, T.; Gallagher, K. S.; Dai, M.* "Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing". Synthesis, 2023, accepted (DOI: 10.1055/a-2107-5159). Total Synthesis Cai, X.;† Li, L.;† Wang, Y.-C.; Zhou, J.; Dai, M.* "Total Syntheses of Phleghenrines A and C". Org. Lett. 2023, 25, 5258-5261. (†contributed equally) Previous deposit at ChemRxiv:ChemRxiv, May 26, 2023. DOI: 10.26434/chemrxiv-2023-8f4rz. Methodology Amination Dai, J.-J;† Yin, X.;† Li, L.;† Rivera, M. E.; Wang, Y.-C.;* Dai, M.* " Modular and practical diamination of Allenes". Nature Communications, 2023, 14, 1774. (†contributed equally) Perspective Sims, H. S.; Dai, M.* "Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments". J. Org. Chem. 2023, 88, 4925-4941. Spotlight Sims, H. S.*; Dai, M.* "Taming PRMT5-adaptor protein interactions" Trends Pharmacol. Sci. 2023, 44, 134-136. Total Synthesis Li, L.; Liang, W.; Rivera, M. E.; Wang, Y.-C.; Dai, M. "Concise Synthesis of (-)-GA18 Methyl Ester" J. Am. Chem. Soc. 2023, 145, 53-57. Total Synthesis Xu, B.;† Liu, C.;† Dai, M.;* “Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A” J. Am. Chem. Soc. 2022, 144, 19700-19703. (†contributed equally) Drug Discovery Cancer Asberry, A. M.†; Cai, X.†; Deng, X.†; Santiago, U.†; Liu, S.; Sims, H. S.; Liang, W.; Xu, X.; Wan, J.; Jiang, W.; Camacho, C.;* Dai, M.;* Hu, C.-D.* “Discovery and biological characterization of PRMT5:MEP50 protein-protein interaction inhibitors” J. Med. Chem. 2022, 65, 13793-13812. (†contributed equally) ChemBio Imaging Clark, M. G.; Gonzalez, G.; Luo, Y.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G.; Dai, M. Zhang, C.* "Real-Time Precision Opto-Control of Chemical Processes in Live Cells" Nature Communications, 2022, 13, 4343. Methodology Nickel Catalysis de Andrade Horn, P.; Sims, H. S. Dai, M.* "Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes" J. Org. Chem. 2022, 87, 8796-8801. Drug Discovery Cancer Peery, R.; Cui, Q.; Kyei-Baffour, K.; Josephraj, S.; Huang, C.; Dong, Z.; Dai, M.;* Zhang, J.-T.* Liu, J.-Y.;* “A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells” Bioorg. Med. Chem. 2022, 65, 116761. Book Chapter Carbonylation Luo, Y.; Li, L.; Dai, M.* “Complex Natural Products Total Syntheses Facilitated by Palladium-Catalyzed Carbonylative Cyclizations” in “The Chemical Transformations of C1 Compounds”, Volume 2, Chapter 18, 793-826, Book Editors: Kuling Ding, Xiao-Feng Wu, Buxing Han, Zhongmin Liu, Wiley. Total Synthesis Sims, H. S.; de Andrade Horn, P.; Isshiki, R.; Lim, M. (UG); Xu, Y.; Grubbs, R. H.; Dai, M* "Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester" Angew. Chem. Int. Ed., 2022, 61, e202115633. Total Synthesis Jiang, B.; Dai, M.* “11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C-H Functionalizations" J. Am. Chem. Soc. 2021, 143, 20084-20089. Total Synthesis Ma, D.†; Martin, B. S.†; Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine” J. Am. Chem. Soc. 2021, 143, 16383-16387. (†contributed equally) Total Synthesis Wang, Y.-C.†; Cui, C.†; Dai, M.* "Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A" Angew. Chem. Int. Ed. 2021, 60, 24828-24832. (†contributed equally) Drug Discovery Hypertension Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension” Science Advances, 2021, 7:eabh3794. Drug Discovery Antibiotic Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo” Sci. Rep. 2021, 11, 10913. Total Synthesis Target ID Cui, C.†; Dwyer, B. G.†; Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes " J. Am. Chem. Soc. 2021, 143, 4379-4386. (†contributed equally.) ChemBio Raffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118. Methodology Cyclopropanol Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311. Methodology Carbonylation Cyclopropanol Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682. Drug Discovery Antimalaria Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678. Total Synthesis Yin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004. Drug Discovery Cancer Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251. Total Synthesis Jiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179. ChemBio Huang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157.