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凌铁军,男,1999年6月毕业于安徽中医药大学中药专业,2005年6月毕业于中科院华南植物园,获理学博士学位,2004年在香港城市大学深圳研究院作为主要成员参与中华猕猴桃根中抗癌活性成分的研究,2005年7月至今于安徽农业大学茶与食品科技学院从事茶叶与其他食品中功能天然产物化学方面的教学和研究工作,2006年10月至2010年6月于本校园艺学博士后流动站从事茶及药用植物功能性次生代谢产物研究,2009年5月至7月于中国科学院昆明植物所张颖君课题组进行短期学术交流,2011年9月至12月赴比利时新鲁汶大学学术访问,2015年8月至2016年8月于加州大学圣地亚哥分校访学。 主讲课程: 《天然产物化学》 主持课题: (1)复合微生物菌群接力发酵结合二维液相色谱法探索茯砖茶中的黄烷-3-醇B环裂环内酯类物质(编号:31471720,国家自然科学基金面上项目,2015.01-2018.12,在研) (2)茯砖茶由发花而产生的特有次生代谢产物及其抗菌活性研究(编号31101335,国家自然科学青年基金项目,2012.01-2014.12,已结题) (3)茯砖茶中由发花而产生的特有高极性代谢产物研究(编号10040606Q19,安徽省自然科学青年基金项目,2011.01-2012.12,已结题) (4)茯砖茶中功能性次生代谢产物的研究(编号209058,教育部科学技术研究重点项目,2009.01.-2011.12.,已结题) 申请专利: (1)一种茶多酚或EGCG与β-CD包合物及其用于制备富含茶多酚或EGCG的适合真菌培养的通用固体培养基的方法(发明专利,申请日:2015年10月29日,申请号:201510734222.0) (2)一种名为茶山奈苷A的酰化黄酮糖苷及其制备方法和应用(发明专利,申请日:2015年09月24日,申请号:201510617767.3) (3)一种名为茶山奈苷B的黄酮氧苷类化合物及其制备方法和应用(发明专利,申请日:2015年09月24日,申请号:201510617679.3) (4)一种名为茯砖素B的儿茶素类衍生物及其制备方法和应用(发明专利,专利号:201310060914.2;申请日:2013年2月27日;授权日:2015年1月22日) 获奖情况: 获奖名称:第三届中国茶叶学会青年科技奖;奖励机构:中国茶叶学会;颁奖年份:2013年。

研究领域

茶与其他食品中的功能成分

近期论文

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1) Shan-Shan Xu, Jing-Jing Wang, Yu-Ming Wei, Wei-Wei Deng, Xiao-Chun Wan, Guan-Hu Bao, Zhong-Wen Xie, Tie-Jun Ling (co-corresponding author), Jing-Ming Ning. Metabolomics based on UHPLC-orbitrap-MS and Global Natural Products Social Molecular Networking reveals effects of time scale and environment of storage on the metabolites and taste quality of raw Pu-erh tea. J. Agric. Food Chem. 2019, 67: 12084–12093. 2) Hong-Juan Huang, Tie-Jun Ling (co-first author), Hui-Min Wang, Ao-Cheng Cao, Chao-Xian Zhang and Shou-Hui Wei. One new flavonoid from Solanum rostratum. Nat. Prod. Res. 2017, http://dx.doi.org/10.1080/14786419.2017.1290621 3) Shi-Gao Yang, Wen Liu, Shuai Lu, Yong-Zhen Tian, Wei-Yun Wang, Tie-Jun Ling (co-corresponding author), Rui-Tian Liu. A novel multifunctional compound camellikaempferoside B decreases Aβ production, interferes with Aβ aggregation, and prohibits Aβ-mediated neurotoxicity and neuroinflammation. ACS Chem. Neurosci. 2016, 7: 505-518. 4) Ya-Qing Wei, Ping-Ping Chen, Tie-Jun Ling (co-first author), Yi-Jun Wang, Rui-Xia Dong, Chen Zhang, Long-Jie Zhang, Man-Man Han, Dong-Xu Wang, Xiao-Chun Wan, Jin-Song Zhang. Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG. Food Chem. 2016, 204: 218-226. 5) Yong-Zhen Tian, Xiao Liu, Wen Liu, Wei-Yun Wang, Yan-Hua Long, Liang Zhang, Yan Xu, Guan-Hu Bao, Xiao-Chun Wan, Tie-Jun Ling (corresponding author). A new anti-proliferative acylated flavonol glycoside from Fuzhuan brick-tea. Nat. Prod. Res. 2016, 30: 2637-2641. DOI:10.1080/14786419.2015.1136911. 6) Lei Rong, Li-Juan Peng, Chi-Tang Ho, Shou-He Yan, Marc Meurens, Zheng-Zhu Zhang, Da-Xiang Li, Xiao-Chun Wan, Guan-Hu Bao, Xue-Ling Gao, Tie-Jun Ling (co-corresponding author). Brewing and volatiles analysis of three tea beers indicate a potential interaction between tea components and lager yeast. Food Chem. 2016, 197: 161-167. 7) Shao-Wei Wang, Shi-Gao Yang, Wen Liu, Yang-Xin Zhang, Peng-Xin Xu, Teng Wang, Tie-Jun Ling (co-corresponding author), Rui-Tian Liu. Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer’s disease. Behav. Brain. Res. 2016, 296: 109–117. 8) Dong-Yan Guo, Tie-Jun Ling (co-corresponding author), Xiang-Hai Cai. Chemical constituents of Nothapodytes pittosporoides (Icacinaceae). Biochem. System. Ecol. 2015, 61: 293–296. 8) Hong-Juan Huang, Tie-Jun Ling, Shou-Hui Wei, Chao-Xian Zhang. A new 4-oxazolidinone from Sorghum halepense (L.) Pers. Rec. Nat. Prod. 2015, 9: 247-250. 9) Jian-Fa Zong, Rui-Long Wang, Guan-Hu- Bao, Tie-Jun Ling, Liang Zhang, Xin-Fu Zhang, Ru-Yan Hou. Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. Show anti-proliferative activity against tumor cells. Fitoterapia 2015, 104: 7-13. 10) Zhen-Mei Luo, Hai-Xia Du, Li-Xiang Li, Mao-Qiang An, Zheng-Zhu Zhang, Xiao-Chun Wan, Guan-Hu Bao, Liang Zhang, and Tie-Jun Ling (corresponding author). Fuzhuanins A and B: the B-ring fission lactones of flavan-3-ols from Fuzhuan brick-tea. J. Agric. Food Chem. 2013, 61: 6982–6990. 11) Chun-Miao Li, Hui-Chun Geng, Ming-Ming Li, Gang Xu, Tie-Jun Ling (co-corresponding author), Hong-Bo Qin. Total synthesis of 1-oxomiltirone via Suzuki coupling. Nat. Prod. Bioprospect. 2013, 3 (3): 117–120. 12) Zhen-Mei Luo, Tie-Jun Ling (co-first author), Li-Xiang Li, Zheng-Zhu Zhang, Hong-Tao Zhu, Ying-Jun Zhang, Xiao-Chun Wan. A new norisoprenoid and other compounds from Fuzhuan brick tea. Molecules 2012, 17 (3): 3539–3546. 13) Yuan-Jun Chen, Chun-Miao Li, Wei-Wei Ling, Xiao-Chun Wan, Tao Xia, Xian-Feng Du, Zheng-Zhu Zhang, Tie-Jun Ling (co-corresponding author). A rearranged labdane-type diterpenoid and other constituents from Vitex negundo var. cannabifolia. Biochem. System. Ecol. 2012, 40 (2): 98–102. 14) Tie-Jun Ling, Wei-Wei Ling, Yuan-Jun Chen, Xiao-Chun- Wan, Tao Xia, Xian-Feng Du, Zheng-Zhu Zhang. Antiseptic activity and phenolic constituents of the aerial parts of Vitex negundo var. cannabifolia. Molecules 2010, 15 (11): 8469–8477. 15) Tie-Jun Ling, Xiao-Chun Wan, Wei-Wei Ling, Zheng-Zhu Zhang, Tao Xia, Da-Xiang Li, Ru-Yan Hou. New triterpenoids and other constituents from a special microbial-fermented tea—Fuzhuan brick tea. J. Agric. Food Chem. 2010, 58: 4945–4950. 16) Shi-gao Yang, Wei-yun Wang, Tie-jun Ling, Ying Feng, Xue-ting Du, Xi Zhang, Xiao-xia Sun, Min Zhao, Di Xue, Yang Yang and Rui-tian Liu. Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines. Neurochem. Int. 2010, 57 (8): 914–922. 17) Shi-Gao Yang, Xi Zhang, Xiao-Sia Sun, Tie-Jun Ling, Ying Feng, Xue-Ying Du, Min Zhao, Yang Yang, Di Xue, Li Wang, Rui-Tian Liu. Diverse ecdysterones show different effects on amyloid-β42 aggregation but all uniformly inhibit amyloid-β42-induced cytotoxicity. J. Alzheimers Dis. 2010, 22 (1): 107–117. 18) Tiejun Ling, Zhengzhu Zhang, Tao Xia, Weiwei Ling, Xiaochun Wan. Phytoecdysteroids and other constituents from the roots of Klaseopsis chinensis. Biochem. System. Ecol. 2009, 37 (1): 49–51. 19) 杜海霞, 戎磊, 肖凌, 李大祥, 凌铁军. 应用离线二维液相色谱(分子筛×反相)分析发花前和发花后的茯砖茶样品,第十六届中国科协年会12分会场:茶学青年科学家论坛会议论文集 2014. 20) 凌铁军, 宛晓春, 魏孝义, 凌玮玮, 魏志文. 麻花头属植物化学成分研究进展(综述). 安徽农业大学学报 2009, 36 (1): 26–32. 21) Tiejun Ling, Tao Xia, Xiaochun Wan, Daxiang Li, Xiaoyi Wei. Cerebrosides from the roots of Serratula chinensis. Molecules 2006, 11 (9): 677–683. 22) 凌铁军, 吴萍, 刘梅芳, 魏孝义. 华麻花头根中的神经酰胺成分. 热带亚热带植物学报2005, 13 (5): 403–407. 23) Tiejun Ling, Lidong Lin, Ping Wu, Wenhua Zhou, Huagu Ye, Meifang Liu, Xiaoyi Wei. Dihydrochalcones from Symplocos vacciniifolia. Chin. Chem. Lett. 2004, 15 (10): 1182–1184. 24) 凌铁军, 马文哲, 魏孝义. 华麻花头根中的蜕皮甾酮类化合物. 热带亚热带植物学报 2003, 11 (2): 143–147. 25) 宛晓春, 李大祥, 张正竹, 夏涛, 凌铁军, 陈琪. 茶叶生物化学研究进展. 茶叶科学 2015, 35 (1): 1-10. 26) 林丹, 李春苗, 鲜殊, 王玺, 宛晓春, 凌铁军 (co-corresponding author), 李大祥. 中压制备液相色谱快速分离制备儿茶素单体. 天然产物研究与开发 2013, 25 (1): 92–95, 100. 27) 凌玮玮, 张正竹, 凌铁军, 张应根. 牡荆挥发油的组成及其抑菌活性研究. 食品工业科技 2010, 31 (12): 75–79. 28) 徐燕, 李大祥, 凌铁军, 项威. 香附化学成分研究进展. 中国实验方剂学杂志 2010, 16 (11): 214–218. 29) 张雷, 王灼琛, 凌铁军, 张正竹. 香叶醇-β-D-葡萄糖苷的化学合成、纯化与表征. 食品与发酵工业 2009, 35 (4): 20–23. 30) 魏志文, 宛晓春, 李大祥, 凌铁军. 茶叶中槲皮素单体的分离与制备. 食品与发酵工业 2009, 35 (3): 187–190. 31) 魏志文, 李大祥, 宛晓春, 凌铁军. 儿茶素单体分离制备方法. 食品与发酵工业 2008, 34 (1): 141–146. 32) 王灼琛, 李英波, 凌铁军, 张雷, 宛晓春, 张正竹. 芳基烷醇-β-D-葡萄糖苷的化学合成与应用. 食品与发酵工业 2007, 33 (8): 21–24.

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