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(43) Dong R, Wang D, Wang X, Zhang K, Chen P, Yang CS, Zhang J# (#, corresponding author) . Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice. Redox Biol. 10:221-232, 2016.
(42) Zhang L, Cheng Q, Zhang L, Wang Y, Merrill GF, Ilani T, Fass D, Arnér ES, Zhang J#. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. Free Radic Biol Med. 99:426-435, 2016.
(41) Han M, Zhao G, Wang Y, Wang D, Sun F, Ning J, Wan X#, Zhang J#. Safety and anti-hyperglycemic efficacy of various tea types in mice. Sci Rep. 6:31703, 2016.
(40) Wei Y, Chen P, Ling T, Wang Y, Dong R, Zhang C, Zhang L, Han M, Wang D, Wan X, Zhang J#. Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG. Food Chem. 204:218-226, 2016.
(39) Zhang L, Ning M, Xu Y, Wang C, Zhao G, Cao Q, Zhang J#. Predicting the cytotoxic potency of cigarette smoke by assessing the thioredoxin reductase inhibitory capacity of cigarette smoke extract. Int J Environ Res Public Health. 13:348, 2016.
(38) Yang CS, Zhang J, Zhang L, Huang J, Wang Y. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res. 60:160-174, 2016.
(37) Wang D, Wei Y, Wang T, Wan X, Yang CS, Reiter RJ, Zhang J#. Melatonin attenuates (-)-epigallocatehin-3-gallate triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice. J Pineal Res. 59:497-507, 2015.
(36) Wang D, Wang Y, Wan X, Yang CS, Zhang J#. Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway. Toxicol Appl Pharmacol. 283:65-74, 2015.
(35) Wang Y, Chen P, Zhao G, Sun K, Li D, Wan X, Zhang J#. Inverse relationship between elemental selenium nanoparticle size and inhibition of cancer cell growth in vitro and in vivo. Food Chem Toxicol. 85:71-77, 2015.
(34) Wang X, Sun K, Tan Y, Wu S, Zhang J#. Efficacy and safety of selenium nanoparticles administered intraperitoneally for the prevention of growth of cancer cells in the peritoneal cavity. Free Radic Biol Med. 72C:1-10, 2014.
(33) Zhang Z, Zhang J#, Xiao J#. Selenoproteins and selenium status in bone physiology and pathology. Biochim Biophys Acta. 1840:3246-3256, 2014.
(32) Sun K, Eriksson SE, Tan Y, Zhang L, Arnér ES, Zhang J#. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury. Biochim Biophys Acta. 1840:2105-2111, 2014.
(31) Zhang L, Wei Y, Zhang J#. Novel mechanisms of anticancer activities of green tea component epigallocatechin-3-gallate. Anticancer Agents Med Chem. 14:779-786, 2014.
(30) Wu S, Sun K, Wang X, Wang D, Wan X, Zhang J#. Protonation of epigallocatechin-3-gallate (EGCG) results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles. J Agric Food Chem. 61:7268-7275. 2013.
(29) Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J#. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem Toxicol. 52:36-41, 2013.
(28) Huang J, Zhang Y, Zhou Y, Zhang Z, Xie Z, Zhang J, Wan X. Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression. J Agric Food Chem. 61:8565-8572, 2013.
(27) Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J#. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol Appl Pharmacol. 265:342-350, 2012.
(26) Wang D, Taylor EW, Wang Y, Wan X, Zhang J#. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int J Nanomedicine. 7:1711-1721, 2012.
(25) Li J, Sun K, Ni L, Wang X, Wang D, Zhang J#. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol Appl Pharmacol. 258:376-383, 2012.
(24) Zhang J#, Taylor EW, Wan X, Peng D#. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int J Nanomedicine. 7:815-825, 2012.
(23) Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.
(22) Li S, Zhang J#, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol Trace Elem Res. 136:294-301, 2010.
(21) Wang X, Zhang J#, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur J Heart Failure. 11:154-162, 2009.
(20) Zhang J#, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol Sci. 101:22-31, 2008.
(19) Zhang J#, Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol Appl Pharmacol. 226:251-259, 2008.
(18) Zhang J#, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.
(17) Wang X, Zhang J#, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur J Pharmacol. 579:66-73, 2008.
(16) Zhang J#, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol Lett. 176:223-229, 2008.
(15) Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat Toxicol 89:251-256, 2008.
(14) Zhang J#, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol Trace Elem Res. 125:13-21, 2008.
(13) Wang H, Zhang J#, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic Biol Med. 42:1524-1533, 2007.
(12) Zhang J#, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic Biol Med. 43:1574-1583, 2007.
(11) Wang X, Zhang J#, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol Appl Pharmacol. 218:88-95, 2007.
(10) Zhang J#, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol Appl Pharmacol. 224:81-88, 2007.
(9) Peng D, Zhang J#, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J Inorg Biochem. 101:1457-1463, 2007.
(8) Peng D, Zhang J#, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol Trace Elem Res. 117:77-88, 2007.
(7) Zhang J#, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol Interact. 162:24-30, 2006.
(6) Zhang J#, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.
(5) Zhang J#, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.
(4) Huang B, Zhang Jco-first, Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol Med. 35:805-813, 2003.
(3) Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 24:497-503, 2003.
(2) Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv Mater. 14:290-293, 2002.
(1) Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors. 15:27-38, 2001.
专著章节
(3) Zhang L, Wu S, Wang D, Wan X, Zhang J#. Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Sahu SC, Casciano D (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons, pp 131-144, 2014.
(2) Zhang J#, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.
(1) Zhang J#. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.
专利
Zhang J. Use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents, and a rapid process for preparing sodium selenosulfate. US 8,480,995 B2, 2013.
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