杨光忠 - 中南民族大学

个人简介

1990年7月在中南民族学院化学系获理学学士 1993年7月在华中师范大学有机合成所获理学硕士学位 2001年在中国科学院上海药物研究所获理学博士学位 2001年-2003年在日本森林综合研究所从事JSPS博士后研究员 2003年回国后至今在中南民族大学任教。主要从事民族药物中新颖结构天然产物的发现、结构修饰及其生物活性的研究，系统研究了二十余种民族药物的化学成分和生物活性，从中分离鉴定了600余个化合物，涉及萜类，生物碱，黄酮，苯丙素，甾体皂苷等多种结构类型，其中新天然产物140个，7个化合物为新骨架。主持完成1项国家自然科学基金，2项省部级和1项国家重点实验室项目。获省部级奖励2项，在国内外重要学术期刊上发表学术论文100余篇，其中SCI收录50余篇。

研究领域

民族药物中新颖结构天然产物的发现、结构修饰及其生物活性的研究

近期论文

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[1]TangC.;ZhuL.H.;ChenY.;QinR.;MeiZ.N.;XuJ.*;YangG.Z.*,Synthesisandbiologicalevaluationofoleanolicacidderivative-chalconeconjugatesasa-glucosidaseinhibitors,RSCAdv.2014,4(21),10862-10874. [2]TangC.;LiangY.J.;BaiS.;HeH.W.;ChenY.;YangG.Z.*;FuL.W.*,Synthesisandanti- proliferativeevaluationofnoveltetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d] pyrimidinederivatives,RSCAdv.2014,4(55),29187-29192. [3]ChenY.;YangF.;WangS.;WangD.B.;XuJ.;YangG.Z.*,TriterpenoidsaponinsfromStauntoniachinensis,Bull.KoreanChem.Soc.2014,35(4),1212-1214. [5]ChenY.;HeH.W.;YangG.Z.*,LycopodiumalkaloidsfromLycopodiumobscurumL.Helv.Chim.Acta2014,97(4),519-523. [6]ZhangY.;YiP.;ChenY.;MeiZ.N.;HuX.*;YangG.Z.*,LycojaponicuminolA-F,Cytotoxic serratenetriterpenoidsfromLycopodiumjaponicum,Fitoterapia2014,96,519-523. [7]HuX.;WangS.;XuJ.;WangD.B.;ChenY.;YangG.Z.*,TriterpenoidsaponinsfromStauntoniachinensisameliorateInsulinResistanceviatheAMP-ActivatedProteinKinaseandIR/IRS-1/PI3K/AktPathwaysinInsulin-ResistantHepG2Cells,Int.J.Mol.Sci.2014,15(6),10446-10458. [8]YangH.;TianS.T.;WuR.Y.;ChenY.;MeiZ.N.;WangC.Y.*;YangG.Z.*,GlycoborinineinducesapoptosisthroughmitochondrialpathwayinHepG2cells,J.AsianNat.Prod.Res.2014,16(10),991-999. [9]GeY.B.;LiM.S.;MeiZ.N.;YangG.Z.*,TwonewflavonolglycosidesfromtheleavesofElaeagnuspungens,J.AsianNat.Prod.Res.2013,15(10),1073-1079. [10]LiY.F.,JiangY.;HuangJ.F.,YangG.Z.*,FournewlignansfromSchisandrasphenanthera,J.AsianNat.Prod.Res.2013,15(9),934-940. [11]TangC.;ChenY.;BaiS.;YangG.Z.*,Advancesinthestudyofstructuralmodificationandbiologicalactivitiesofoleanolicacid,Chin.J.Org.Chem.2013,33(1),46-65. [12]ChenY.;BaiS.;AiY.;FanH.;YangG.Z.*,Synthesisandantimicrobialevaluationofnovelpyrimidoquinolines,Chin.J.Org.Chem.2013，33(5),1074-1079. [13]ZhuD.R.;ZhuD.;ChenY.;MeiZ.N.;YangG.Z.*,TwonewphenylpropanoidsformZanthoxylumutileHuang,Chin.J.Org.Chem.2013,33(6),1345-1348. [14]ChenY.;YangB.;XuJ.;ZhengT.;FanH.;YangG.Z.*,Photo-activatedDNAbindingandantimicrobialactivitiesofalkaloidsfromGlycosmispentaphylla,ActaPharm.Sin.2012，47(12),1646-1652. [15]FanH.;ZhengT.;ChenY.;YangG.Z.*,Chemicalconstituentswithfree-radical-scavengingactivitiesfromthestemofFissistigmapolyanthum,PhcogMag2012,8(30)98-102. [16]WuY.;HuX,;YangG.Z.;MeiZ.N.;ChenY.*,TwonewflavanolsfromGlycosmispentaphylla,J.AsianNat.Prod.Res.2012,14(8),738-742. [17]YangG.Z.;WuY.;ChenY.*,AlkaloidsfromthestemsofGlycosmispentaphylla,Helv.Chim.Acta2012,95(8),1449-1454. [18]FuM.;FengHJ.;ChenY.;WangD.B.;YangG.Z.*,AntioxidantactivityofGarciniaxanthochymusleaf,rootandfruitextractsinvitro,Chin.J.Nat.Med.2012,10(2),129-134. [19]LiY.F.;YangG.Z.;MeiZ.N.,Spectroscopicanddynamiclightscatteringstudiesoftheinteractionbetweenpterodonticacidandbovineserumalbumin,ActaPharm.Sin.B2012,2(1),53-59. [20]TangC.;ZhuL.H.;LiJ.;QinR.;LiuC.;ChenY.;YangG.Z.*,Synthesisandstructureelucidationoffivenewconjugatesofoleanolicacidderivativesandchalconesusing1Dand2DNMRspectroscopy,Magn.Reson.Chem.2012,50,236-241. [21]AiY.;LiangY.J.;LiuJ.C.;HeH.W.;ChenY.;TangC.;YangG.Z.*;FuL.W.*,Synthesisandinvitroantiproliferativeevaluationofpyrimido[5,4-c]quinoline-4-(3H)-onederivatives,Eur.J.Med.Chem.2012,47(1),206-213. [22]ChenY.;FanH.;YangG.Z.*;JiangY.;ZhongF.F.;HeH.W.*,TwounusualxanthonesfromthebarkofGarciniaxanthochymus,Helv.Chim.Acta2011,94(4),662-668. [23]JiangY.;YangG.Z.*;ChenY.;LiaoM.C.;LiuX.M.;ChenS.;LiuL.;LeiX.X.*,TerpenesfromSchisandrasphenanthera,Helv.Chim.Acta2011,94(3),491-496. [24]DengJ.;ChengW.Y.;YangG.Z.*,Anovelantioxidantactivityindex(AAU)fornaturalproductsusingtheDPPHassay,FoodChem.2011,125(4),1430-1435. [25]ChenY.;FanH.;YangG.Z.*;JiangY.;ZhongF.F.;HeH.W.*,PrenylatedxanthonesfromthebarkofGarciniaxanthochymusandtheir1,1-diphenyl-2-picrylhydrazyl(DPPH)radicalscavengingactivities,Molecules2010,15(10),7438-7449. [26]ChenY.;YangG.Z.*;ZhongF.F.;HeH.W.*,TwonewprenylatedxanthonesfromthebarkofGarciniaxanthochymus,Bull.KoreanChem.Soc.2010,31(11),3418-3420. [27]ZhaoY.H.;DengT.Z.;ChenY.;LiuX.M.;YangG.Z.*,TwonewtriterpenoidsfromLycopodiumobscurumL.,J.AsianNat.Prod.Res.2010,12(8),666–671. [28]FanH.;YangG.Z.*;ZhengT.;MeiZ.N.;LiuX.M.;ChenY.;ChenS.,Chemicalconstituentswithfree-radical-scavengingactivitiesfromthestemofMicrocospaniculata,Molecules2010,15(8),5547-5560. [29]AiY.;YangG.Z.*;LiuJ.C.;ChenY.;LiuL.;LeiX.X.*,Synthesisandstructureelucidationoffivenewpyrimido[5,4-c]quinoline-4(3H)-onederivativesusing1Dand2DNMRspectroscopy,Magn.Reson.Chem.2010,48(12),955-959. [30]WuY.H.;YangG.Z.,InteractionbetweengarcigenrinandDNAbyspectrophotometryandfluorescencespectroscopy,Spectrosc.Lett.2010,43(1),28-35. [31]ChenY.;TianX.J.;LiY.F.;YangG.Z.*,TerpenoidsfromEuphorbiaantiquorumL.,ActaPharm.Sin.2009,44(10),1118-1122. [32]HuY.;ChenY.;ShangY.;YangG.Z.*,TwonewlignansfromthebarkofZanthoxylumplanispinum,Bull.KoreanChem.Soc.2009,30(8),1884-1886. [33]DengT.Z.;AiY.;ChenY.;YangG.Z.*,TriterpenoidfromLycopodiumobscurumL.,ActaPharm.Sin.2009,44(8),891-894. [34]ZhongF.F.;ChenY.;WangP.;FengH.J.YangG.Z.*,XanthonesfromthebarkofGarciniaxanthochymusandtheirDPPHradical-scavengingactivity,Chin.J.Chem.2009,27(1),74-80. [35]YangG.Z.*;HuY.;YangB.;ChenY.;LignansfromthebarkofZanthoxylumplanispinum,Helv.Chim.Acta2009,92(8),1657-1664. [36]YangG.Z.*;LiH.X.;SongF.J.;ChenY.,DiterpenoidandphenoliccompoundsfromJuncuseffususL.,Helv.Chim.Acta2007,90(7),1289-1295. [37]YangG.Z.;LiY.F.;YuX.;MeiZ.N.,TerpenoidsandflavonoidsfromLaggerapterodonta,ActaPharm.Sin.2007，42(5),511-515. [38]ZhongF.F.;ChenY.;MeiZ.N.;YangG.Z.*,XanthonefromthebarkofGarciniaxanthochymus,Chin.Chem.Lett.2007,18(7),849-851. [39]LiH.X.;DengT.Z.;ChenY.;FengH.J.;YangG.Z.*,IsolationandidentificationofphenolicconstituentsfromJuncuseffuses,ActaPharm.Sin.2007,42(2),174-178. [40]YangG.Z.;ChenY.,ProgressintotalsynthesisofCalanolideAanditsAnalogues,Chin.J.Org.Chem.2007,27(6),685-695.

学术兼职

现任药学院副院长,民族药学国家实验教学示范中心主任、全国药学教育研究会理事、湖北省药物化学和抗生素专业委员会委员、湖北省中药战略产业联盟理事和武汉市药学教育专业委员会副主任委员。为《FoodChemistry》、《MagneticResonanceinChemistry》、《NaturalProductResearch》、《EuropeanJournalofMedicinalChemistry》、《Bioorganic&MedicinalChemistry》、《药学学报》和《中国天然药物》等期刊的审稿专家，国家自然科学基金通讯评审专家，武汉市科技局专家库成员，国家民委分析化学重点实验室学术委员会委员。