个人简介

季乃云，男，1980年生。2008年毕业于中国科学院海洋研究所，获博士学位。中国海洋湖沼学会药物学分会理事。承担科研项目和课题包括国家自然科学基金(面上、青年)、山东省自然科学基金(青年)、中国科学院知识创新工程重要方向性项目等10余项。已在Chemical Reviews、Fungal Diversity、Organic Letters、Journal of Natural Products和Phytochemistry等SCI刊物上发表论文80篇，其中第一或通讯作者的71篇，以第一发明人获授权中国发明专利18项。 人才项目或称号： 中国科学院青年创新促进会“优秀会员” 山东省自然科学“杰出青年”基金 山东省有突出贡献的中青年专家 所获奖励： 中国科学院优秀导师奖 中国科学院院长特别奖 山东省自然科学二等奖 国家海洋局海洋科学技术二等奖 青岛市技术发明二等奖 荣誉奖励 “中国科学院院长特别奖” 专利 [1] 季乃云,王超之,苗凤萍. 一种从菊芋枝叶中提取甾醇的方法. 2014-06-16. [2] 季乃云,苗凤萍. 一种降二萜类化合物及其制备和应用. 2013-12-11. [3] 季乃云,苗凤萍. 一种多氧生物碱类化合物及其制备和应用. 2012-07-31. [4] 季乃云,苗凤萍. 一种氯代生物碱类化合物及其制备和应用. 2012-07-31. [5] 季乃云,苗凤萍. 一种四环二萜类化合物及其制备和应用. 2012-05-25. [6] 季乃云,李晓栋,苗凤萍. 一种海藻溴代倍半萜类化合物及其制备和应用. 2012-04-09. [7] 季乃云,李晓栋,苗凤萍. 一种海藻乙酰倍半萜类化合物及其制备和应用. 2012-04-09. [8] 季乃云,刘向红,苗凤萍. 一种蛇孢假壳素类二倍半萜化合物及其制备和应用. 2012-03-27. [9] 季乃云,刘向红,苗凤萍. 一种多氧二倍半萜类化合物及其制备和应用. 2012-03-27. [10] 季乃云,刘向红,苗凤萍. 一种海藻内生真菌倍半萜类化合物及其制备和应用. 2012-03-05. [11] 季乃云,乔明锋. 海藻内生真菌二萜生物碱类化合物及其制备和应用. 2010-03-19. [12] 季乃云,乔明锋. 一种天然海藻内生真菌二萜生物碱类化合物及其制备和应用. 2010-03-19. [13] 季乃云,乔明锋. 一种海藻内生真菌次生代谢产物二萜生物碱类化合物的应用. 2010-03-19. [14] 季乃云,乔明锋. 一种天然海藻内生真菌二萜生物碱类化合物的应用. 2010-03-19. [15] 季乃云,乔明锋. 一种海藻内生真菌二萜生物碱类化合物及其制备和应用. 2010-03-19.

研究领域

海洋化学 海洋植物化学，海洋真菌化学 研究领域为天然药物化学，以天然产物化学和生物合成研究为基础，重点开展海岸带耐盐植物及其共生微生物与海岸带特殊环境来源的非共生微生物次级代谢产物在农业、食品和医药方面的应用研究，以及海岸带微生物的诱导代谢与生物转化研究。 海洋生物学 海洋真菌适应性代谢 药物化学 海洋天然产物与药物化学

海洋天然产物与药物化学，在海洋植物与真菌天然产物结构与功能方面开展了一系列研究工作，丰富了海洋天然产物的结构多样性，并为海洋生态灾害和病害的绿色防治提供了指导作用。

近期论文

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[1] Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,&Ji, Nai-Yun.(2020).Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(52),15440-15448. [2] Liu, Xiang-Hong,Hou, Xu-Liang,Song, Yin-Ping,Wang, Bin-Gui,&Ji, Nai-Yun.(2020).Cyclonerane sesquiterpenes and an isocoumarin derivative from the marine-alga-endophytic fungus Trichoderma citrinoviride A-WH-20-3.FITOTERAPIA,141,104469. [3] Song, YP,Miao, FP,Yin, XL,&Ji, NY.(2019).Nitrogenous cyclonerane sesquiterpenes from an algicolous strain of Trichoderma asperellum.ORGANIC CHEMISTRY FRONTIERS,6(21),3698-3704. [4] Fang, ST,Wang, YJ,Ma, XY,Yin, XL,&Ji, NY.(2019).Two new sesquiterpenoids from the marine-sediment-derived fungus Trichoderma harzianum P1-4.NATURAL PRODUCT RESEARCH,33(21),3127-3133. [5] Song, YP,Miao, FP,Liang, XR,Yin, XL,&Ji, NY.(2019).Harziane and cadinane terpenoids from the alga-endophytic fungus Trichoderma asperellum A-YMD-9-2.PHYTOCHEMISTRY LETTERS,32,38-41. [6] Chen, Y.,Mi, YQ.,Sun, XQ.,Zhang, JJ.,Li, Q.,...&Guo, ZY.(2019).Novel Inulin Derivatives Modified with Schiff Bases: Synthesis, Characterization, and Antifungal Activity.POLYMERS,11(6),998. [7] Song, YP,Miao, FP,Liu, XH,Yin, XL,&Ji, NY.(2019).Seven chromanoid norbisabolane derivatives from the marine-alga-endophytic fungus Trichoderma asperellum A-YMD-9-2.FITOTERAPIA,135,107-113. [8] Song, YP,Miao, FP,Liu, XH,Yin, XL,&Ji, NY.(2019).Cyclonerane Derivatives from the Algicolous Endophytic Fungus Trichoderma asperellum A-YMD-9-2.MARINE DRUGS,17(5),252. [9] Shi, ZZ,Miao, FP,Fang, ST,Yin, XL,&Ji, NY.(2019).Trichobisabolins A-H, eight new bisabolane derivatives from the marine alga-epiphytic fungus Trichoderma asperellum Y6-2.FITOTERAPIA,134,372-377. [10] Song, YP,Miao, FP,Liu, XH,&Ji, NY.(2019).Responses of marine-derived Trichoderma fungi to seawater and their potential antagonistic behaviour.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(2),525-534. [11] 马新玥,赵业,梁小蕊,等. 海洋沉积物来源哈茨木霉R5-1萜类化合物的分离鉴定与抗弧菌活性研究[J]. 烟台大学学报(自然科学与工程版),2019,32(01):15-19. [12] Miao, FP,Zuo, JC,Liu, XH,&Ji, NY.(2019).Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(1),112-121. [13] Zou, JX,Song, YP,&Ji, NY.(2019).Deoxytrichodermaerin, a harziane lactone from the marine algicolous fungus Trichoderma longibrachiatum A-WH-20-2.NATURAL PRODUCT RESEARCH. [14] McAlpine, James B..,Chen, Shao-Nong.,Kutateladze, Andrei.,MacMillan, John B..,Appendino, Giovanni.,...&Pauli, Guido F..(2019).The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.NATURAL PRODUCT REPORTS,36(1),35-107. [15] McAlpine, James B..,Chen, Shao-Nong.,Kutateladze, Andrei.,MacMillan, John B..,Appendino, Giovanni.,...&Pauli, Guido F..(2019).The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research (vol 36, pg 35, 2018).NATURAL PRODUCT REPORTS,36(1),248-249. [16] Shi, Zhen-Zhen,Fang, Sheng-Tao,Miao, Feng-Ping,&Ji, Nai-Yun.(2018).Trichocarotins A-H and trichocadinin A, nine sesquiterpenes from the marine-alga-epiphytic fungus Trichoderma virens.BIOORGANIC CHEMISTRY,81,319-325. [17] Chen, Yuan.,Mi, Yingqi.,Zhang, Jingjing.,Dong, Fang.,Li, Qing.,...&Guo, Zhanyong.(2018).Radical Scavenging Activities of Novel Cationic Inulin Derivatives.POLYMERS,10(12),1295. [18] Shi, Zhen-Zhen,Fang, Sheng-Tao,Miao, Feng-Ping,&Ji, Nai-Yun.(2018).Two new tricycloalternarene esters from an alga-epiphytic isolate of Alternaria alternata.NATURAL PRODUCT RESEARCH,32(21),2523-2528. [19] Song, Yin-Ping,Fang, Sheng-Tao,Miao, Feng-Ping,Yin, Xiu-Li,&Ji, Nai-Yun.(2018).Diterpenes and Sesquiterpenes from the Marine Algicolous Fungus Trichoderma harzianum X-5.JOURNAL OF NATURAL PRODUCTS,81(11),2553-2559. [20] Song, Yin-Ping,Shi, Zhen-Zhen,Miao, Feng-Ping,Fang, Sheng-Tao,Yin, Xiu-Li,&Ji, Nai-Yun.(2018).Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum.ORGANIC LETTERS,20(19),6306-6309. [21] Shi, Zhen-Zhen,Miao, Feng-Ping,Fang, Sheng-Tao,Yin, Xiu-Li,&Ji, Nai-Yun.(2018).Sulfurated diketopiperazines from an algicolous isolate of Trichoderma virens.PHYTOCHEMISTRY LETTERS,27,101-104. [22] Song, Yin-Ping,Miao, Feng-Ping,Fang, Sheng-Tao,Yin, Xiu-Li,&Ji, Nai-Yun.(2018).Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2.MARINE DRUGS,16(8),266-. [23] Song, Yin-Ping,Liu, Xiang-Hong,Shi, Zhen-Zhen,Miao, Feng-Ping,Fang, Sheng-Tao,&Ji, Nai-Yun.(2018).Bisabolane, cyclonerane, and harziane derivatives from the marine-alga-endophytic fungus Trichoderma asperellum cf44-2.PHYTOCHEMISTRY,152,45-52. [24] Shi, Zhen-Zhen,Miao, Feng-Ping,Fang, Sheng-Tao,Yin, Xiu-Li,&Ji, Nai-Yun.(2018).Trichorenins A-C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3.JOURNAL OF NATURAL PRODUCTS,81(4),1121-1124. [25] Shi, Zhen-Zhen,Yin, Xiu-Li,Fang, Sheng-Tao,Miao, Feng-Ping,&Ji, Nai-Yun.(2018).Two new isomeric tricycloalternarenes from the marine alga-epiphytic fungus Alternaria alternata k23-3.MAGNETIC RESONANCE IN CHEMISTRY,56(3),210-215. [26] Fang, Sheng-Tao,Miao, Feng-Ping,Liu, Xiang-Hong,Song, Yin-Ping,Ji, Nai-Yun,&Ji, Nai-Yun.(2018).Two new tricycloalternarene acids from the marine-derived fungus Alternaria alternata ICD5-11.PHYTOCHEMISTRY LETTERS,23,185-188. [27] 马新玥,方圣涛,赵业,等. 海洋沉积物来源草酸青霉T4-6化学成分及其生物活性研究[J]. 化学与生物工程,2018,35(01):17-22. [28] Song, YP,Shi, ZZ,Miao, FP,Fang, ST,Yin, XL,&Ji, NY.(2018).Tricholumin A, a highly transformed ergosterol derivative from the alga-endophytic fungus Trichoderma asperellum.Organic Letters,20(19),6306–6309. [29] Fang, ST,Yan, BF,Yang, CY,Miao, FP,&Ji, NY.(2017).Hymerhabdrin A, a novel diterpenoid with antifouling activity from the intertidal sponge Hymerhabdia sp..JOURNAL OF ANTIBIOTICS,70(11),1043-1046. [30] Shi, Zhen-Zhen.,Miao, Feng-Ping.,Fang, Sheng-Tao.,Liu, Xiang-Hong.,Yin, Xiu-Li.,...&Ji, Nai-Yun.(2017).Sesteralterin and Tricycloalterfurenes A-D: Terpenes with Rarely Occurring Frameworks from the Marine-Alga-Epiphytic Fungus Alternaria alternata k21-1.JOURNAL OF NATURAL PRODUCTS,80(9),2524-2529. [31] 王超之,季乃云,苗凤萍,等. 耐盐菊芋块茎内生真菌次生代谢产物的分离与结构鉴定[J]. 中国科学:生命科学,2016,46(9):1101-1106. [32] 梁小蕊,苗凤萍,宋银平,等. 海藻内生真菌棘孢木霉dl-34中的二萜和甾体化合物[J]. 化学与生物工程,2016,33(5):32-36. [33] Yang, HB,Li, F,Ji, NY,Li, F ,Ji, NY ,&nyji@yic.ac.cn.(2016).Alkaloids from an algicolous strain of Talaromyces sp..CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),367-371. [34] Ji, NY.,Li, XM.,Ding, LP.,Wang, BG.,Wang, BG .,...&wangbg@ms.qdio.ac.cn.(2016).Halogenated eudesmane derivatives and other terpenes from the marine red alga Laurencia pinnata and their chemotaxonomic significance.BIOCHEMICAL SYSTEMATICS AND ECOLOGY,64,1-5. [35] Ji, NY,Song, YP,Miao, FP,Liang, XR,&Ji, NY .(2016).Three cadinane derivatives from the marine brown alga Dictyopteris divaricata.MAGNETIC RESONANCE IN CHEMISTRY,54(1),88-90. [36] Ji, Nai-Yun,&Wang, Bin-Gui.(2014).Nonhalogenated organic molecules from Laurencia algae.PHYTOCHEMISTRY REVIEWS,13(3),653-670. [37] Li, Xiao-Dong,Miao, Feng-Ping,Liang, Xiao-Rui,&Ji, Nai-Yun.(2014).Meroterpenes from an algicolous strain of Penicillium echinulatum.MAGNETIC RESONANCE IN CHEMISTRY,52(5),247-250. [38] Miao, Feng-Ping,Liang, Xiao-Rui,Liu, Xiang-Hong,Ji, Nai-Yun,&Ji, NY .(2014).Aspewentins A-C, Norditerpenes from a Cryptic Pathway in an Algicolous Strain of Aspergillus wentii.JOURNAL OF NATURAL PRODUCTS,77(2),429-432. [39] Ji, Nai-Yun,Liang, Xiao-Rui,Sun, Ran-Ran,Miao, Feng-Ping,&Ji, NY .(2014).A rule to distinguish diastereomeric bianthrones by H-1 NMR.RSC ADVANCES,4(15),7710-7715. [40] Liu, Xiang-Hong,Miao, Feng-Ping,Liang, Xiao-Rui,Ji, Nai-Yun,&Ji, NY .(2014).Ergosteroid derivatives from an algicolous strain of Aspergillus ustus.NATURAL PRODUCT RESEARCH,28(15),1182-1186. [41] Wang, Ming-Hui,Li, Xiao-Ming,Li, Chun-Shun,Ji, Nai-Yun,&Wang, Bin-Gui.(2013).Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus.MARINE DRUGS,11(6),2230-2238. [42] Ji, Nai-Yun,Liu, Xiang-Hong,Miao, Feng-Ping,&Qiao, Ming-Feng.(2013).Aspeverin, a New Alkaloid from an Algicolous Strain of Aspergillus versicolor.ORGANIC LETTERS,15(10),2327-2329. [43] Wang, Bin-Gui,Gloer, James B.,Ji, Nai-Yun,Zhao, Jian-Chun,&Wang, BG .(2013).Halogenated Organic Molecules of Rhodomelaceae Origin: Chemistry and Biology.CHEMICAL REVIEWS,113(5),3632-3685. [44] Liu, Xiang-Hong,Miao, Feng-Ping,Qiao, Ming-Feng,Cichewicz, Robert H.,&Ji, Nai-Yun.(2013).Terretonin, ophiobolin, and drimane terpenes with absolute configurations from an algicolous Aspergillus ustus.RSC ADVANCES,3(2),588-595. [45] Sun, Ran-Ran,Miao, Feng-Ping,Zhang, Jing,Wang, Gang,Yin, Xiu-Li,&Ji, Nai-Yun.(2013).Three new xanthone derivatives from an algicolous isolate of Aspergillus wentii.MAGNETIC RESONANCE IN CHEMISTRY,51(1),65-68. [46] Li, Xiao-Dong,Miao, Feng-Ping,Liang, Xiao-Rui,Wang, Bin-Gui,&Ji, Nai-Yun.(2013).Two halosesquiterpenes from Laurencia composita.RSC ADVANCES,3(6),1953-1956. [47] Zhang, Yi,Li, Xiao-Ming,Shang, Zhuo,Li, Chun-Shun,Ji, Nai-Yun,&Wang, Bin-Gui.(2012).Meroterpenoid and Diphenyl Ether Derivatives from Penicillium sp MA-37, a Fungus Isolated from Marine Mangrove Rhizospheric Soil.JOURNAL OF NATURAL PRODUCTS,75(11),1888-1895. [48] Li, Xiao-Dong,Miao, Feng-Ping,Yin, Xiu-Li,Liu, Jia-Lin,&Ji, Nai-Yun.(2012).Sesquiterpenes from the marine red alga Laurencia composita.FITOTERAPIA,83(7),1191-1195. [49] Miao, Feng-Ping,Liang, Xiao-Rui,Yin, Xiu-Li,Wang, Gang,&Ji, Nai-Yun.(2012).Absolute Configurations of Unique Harziane Diterpenes from Trichoderma Species.ORGANIC LETTERS,14(15),3815-3817. [50] Liu, Xiang-Hong,Miao, Feng-Ping,Li, Xiao-Dong,Yin, Xiu-Li,&Ji, Nai-Yun.(2012).A New Sesquiterpene from an Endophytic Aspergillus versicolor Strain.NATURAL PRODUCT COMMUNICATIONS,7(7),819-820. [51] Li, Xiao-Dong,Miao, Feng-Ping,Li, Ke,&Ji, Nai-Yun.(2012).Sesquiterpenes and acetogenins from the marine red alga Laurencia okamurai.FITOTERAPIA,83(3),518-522. [52] Xie, Zeping.,Liu, Bing.,Wang, Hongpeng.,Yang, Shengxiang.,Zhang, Hongyu.,...&Laatsch, Hartmut.(2012).Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp..MARINE DRUGS,10(3),551-558. [53] Li, Xiao-Dong,Ding, Wei,Miao, Feng-Ping,&Ji, Nai-Yun.(2012).Halogenated chamigrane sesquiterpenes from Laurencia okamurae.MAGNETIC RESONANCE IN CHEMISTRY,50(2),174-177. [54] Miao, Feng-Ping,Li, Xiao-Dong,Liu, Xiang-Hong,Cichewicz, Robert H.,&Ji, Nai-Yun.(2012).Secondary Metabolites from an Algicolous Aspergillus versicolor Strain.MARINE DRUGS,10(1),131-139. [55] Li, Xiao-Dong,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).Two New Epoxysteroids from Helianthus tuberosus.MOLECULES,16(10),8646-8653. [56] Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain.NATURAL PRODUCT COMMUNICATIONS,6(9),1243-1246. [57] Qiao, Ming-Feng,Ji, Nai-Yun,Miao, Feng-Ping,&Yin, Xiu-Li.(2011).Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus.MAGNETIC RESONANCE IN CHEMISTRY,49(6),366-369. [58] Li, Ke,Li, Qiao-Lian,Ji, Nai-Yun,Liu, Bo,Zhang, Wei,&Cao, Xu-Peng.(2011).Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus.MARINE DRUGS,9(5),690-695. [59] Qiao, Ming-Feng,Ji, Nai-Yun,Liu, Xiang-Hong,Li, Fang,&Xue, Qin-Zhao.(2010).Asporyergosterol, A New Steroid from an Algicolous Isolate of Aspergillus oryzae.NATURAL PRODUCT COMMUNICATIONS,5(10),1575-1578. [60] Qiao, Ming-Feng,Ji, Nai-Yun,Liu, Xiang-Hong,Li, Ke,Zhu, Qing-Mei,&Xue, Qin-Zhao.(2010).Indoloditerpenes from an algicolous isolate of Aspergillus oryzae.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(19),5677-5680. [61] Ji, Nai-Yun,Li, Xiao-Ming,&Wang, Bin-Gui.(2010).Sesquiterpenes and Other Metabolites from the Marine Red Alga Laurencia composita (Rhodomelaceae).HELVETICA CHIMICA ACTA,93(11),2281-2286. [62] Qiao, Yuan-Yuan,Ji, Nai-Yun,Wen, Wei,Yin, Xiu-Li,&Xue, Qin-Zhao.(2009).A New Epoxy-cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris divaricata.MARINE DRUGS,7(4),600-604. [63] Ji, Nai-Yun,Wen, Wei,Li, Xiao-Ming,Xue, Qin-Zhao,Xiao, Hua-Ling,&Wang, Bin-Gui.(2009).Brominated Selinane Sesquiterpenes from the Marine Brown Alga Dictyopteris divaricata.MARINE DRUGS,7(3),355-360. [64] Wen, Wei.,Li, Fang.,Ji, Nai-Yun.,Li, Xiao-Ming.,Cui, Chuan-Ming.,...&Wang, Bin-Gui.(2009).A New Cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris divaricata.MOLECULES,14(6),2273-2277. [65] Ji, Nai-Yun,Li, Xiao-Ming,&Wang, Bin-Gui.(2008).Halogenated Terpenes and a C(15)-Acetogenin from the Marine Red Alga Laurencia saitoi.MOLECULES,13(11),2894-2899.