俞寿云 - 南京大学 - 化学化工学院

个人简介

Professional Experience 2016/01 – present Professor School of Chemistry & Chemical Engineering, Nanjing University 2010/09 – 2015/12 Associate Professor School of Chemistry & Chemical Engineering, Nanjing University 2010/04 – 2010/08 Associate Research Professor Shanghai Institute of Organic chemistry, CAS, Shanghai, China 2007/10 – 2010/04 Postdoctoral Fellow Department of Chemistry, University of Pennsylvania, USA Advisor: Prof. Jeffrey W. Bode 2006/07 – 2007/9 Assistant Research Professor Shanghai Institute of Organic chemistry, CAS, Shanghai, China Work with Prof. Dawei Ma Education 2001/08 – 2006/07 Ph. D. Shanghai Institute of Organic chemistry, CAS, Shanghai, China Advisor: Prof. Dawei Ma 1997/09 – 2001/07 B. S.School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

研究领域

In the 20th century the art and science of complex natural product total synthesis defined the frontiers of organic chemistry. In this century total synthesis of natural products is still the center of organic chemistry. Therefore the research interest of our group focuses on synthesis of biologically active complex natural products in concert with the discovery and the development of new reactions and strategies for organic synthesis. The research paradigm of our group can be described as the carton. Architecturally complex natural products are chosen not only for their sheer complexity, which drives us to develop new techniques and strategies to achieve their total synthesis, but also for their interesting biological activity, which provides us an opportunity to figure out biological mechanism behind these molecules. Another major task of our research group is training next generation chemists. Organic synthesis is an excellent training platform for young chemists. Creative students are one of major starting materials of research cycle. As they enter the cycle, they start to learn how to ask questions and then solve problems. At the end of the cycle, they will turn out to be qualified next generation chemists and be ready to start the cycles of their own.

近期论文

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Photoexcited Palladium-Initiated Remote Desaturation of N-Alkoxypyridinium Salts Weiwei Jin, and Shouyun Yu,* J. Org. Chem. 2022, 87, 14715. DOI: 10.1021/acs.joc.2c02036 Biocatalytic C14-Hydroxylation on Androstenedione Enabled Modular Synthesis of Cardiotonic Steroids Yang Zhao, Bo Zhang, Zi Qian Sun, Hao Zhang, Wen Wang, Zi Ru Wang, Zhi Kai Guo, Shouyun Yu,* Ren Xiang Tan,* and Hui Ming Ge,* ACS Catal. 2022,12, 9839. DOI: 10.1021/acscatal.2c02185 Photoexcited Chiral Copper Complex-Mediated Alkene E → Z Isomerization Enables Kinetic Resolution Hao Zhang, Congcong Huang, Xiang-Ai Yuan,* and Shouyun Yu,* J. Am. Chem. Soc. 2022, 144, in press. DOI: 10.1021/jacs.2c04040 In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation Jing Shi, Yang Shi, Jian Cheng Li, Wanqing Wei, Yu Chen, Ping Cheng, Cheng Li Liu, Hao Zhang, Rui Wu, Bo Zhang, Rui Hua Jiao, Shouyun Yu, Yong Liang,* Ren Xiang Tan* and Hui Ming Ge,* J. Am. Chem. Soc. 2022, 144, 7939. DOI: 10.1021/jacs.2c02855 Regio- and Enantioselective Decarboxylative Allylic Benzylation Enabled by Dual Palladium/Photoredox Catalysis Changhua Song, Hong-Hao Zhang,* and Shouyun Yu,* ACS Catal. 2022, 12, 1428. DOI: 10.1021/acscatal.1c05461 Synthesis of C-Alkynyl Glycosides by Photoredox-Catalyzed Reductive Coupling of Alkynyl Bromides with Glycosyl Bromides Liwen Xia, Maolu Jin, Yi Jiao, and Shouyun Yu,* Org. Lett. 2022, 24, 364. DOI: 10.1021/acs.orglett.1c04041 Transition-Metal-Catalyzed Synthesis of 6-Phenyl-5,6-dihydro-2H-pyran-2-one: A Comprehensive Organic Experiment for Undergraduate Students Zhitong Liu, Ziyi Zhao, Bo Peng, Yueming Qu, Songlin Tian, and Shouyun Yu,* Univ. Chem. 2022, 37, 2105004. (in Chinese) DOI: 10.3866/PKU.DXHX202105004 Enantioselective Radical SN2-Type Alkylation of Morita–Baylis–Hillman Adducts Using Dual Photoredox/Palladium Catalysis Xiangbin Bai, Linlin Qian, Hong-Hao Zhang, and Shouyun Yu,* Org. Lett. 2021, 23, 8322. DOI: 10.1021/acs.orglett.1c03064 Photoinduced and Palladium-Catalyzed Remote Desaturation of Amide Derivatives Weiwei Jin, and Shouyun Yu,* Org. Lett. 2021, 23, 6931. DOI: 10.1021/acs.orglett.1c02509 Synthesis of Chiral Unnatural α-Amino Acids Enabled by Photoredox/Brønsted Acid Cocatalysis (Highlights). Hong-Hao Zhang, and Shouyun Yu,* Chin. J. Org. Chem. 2021, 41, 1744–1745. (in Chinese). DOI: 10.6023/cjoc202100025 Enantioselective Reductive Homocoupling of Allylic Acetates Enabled by Dual Photoredox/ Palladium Catalysis: Access to C2-Symmetrical 1,5-Dienes Hong-Hao Zhang, Menghan Tang, Jia-Jia Zhao, Changhua Song, and Shouyun Yu,* J. Am. Chem. Soc. 2021, 143, 12836. DOI: 10.1021/jacs.1c06271 Photoredox-catalyzed Stereoselective Synthesis of C-Nucleoside Analogues from Glycosyl Bromides and Heteroarenes Liwen Xia, Wenjing Fan, Xiang-Ai Yuan,* and Shouyun Yu,* ACS Catal. 2021,11, 9397. DOI: 10.1021/acscatal.1c02088 Diastereoselective and Stereodivergent Synthesis of 2-Cinnamylpyrrolines Enabled by Photoredox-Catalyzed Iminoalkenylation of Alkenes. Xu Shen, Congcong Huang, Xiang-Ai Yuan,* and Shouyun Yu,* Angew. Chem. Int. Ed. 2021, 60, 9672. DOI: 10.1002/anie.202016941 Enantioselective Radical Functionalization of Imines and Iminium Intermediatesvia Visible Light Photoredox Catalysis. Jia-Jia Zhao, Hong-Hao Zhang,* and Shouyun Yu,* Synthesis 2021, 53, 1706. DOI: 10.1055/a-1343-6541 Synthesis of Chiral Fluorides by Sequential Organocatalyzed Desymmetrization of Glutaric Anhydrides and Photoredox-Catalyzed Decarboxylic Fluorination Jia-Jia Zhao, and Shouyun Yu,* Synlett 2021, 32, 391. DOI: 10.1055/s-0040-1707295 Access to Cyanoimines Enabled by Dual Photoredox/Copper-Catalyzed Cyanation of O-Acyl Oximes Hao Zhang, Ziyan Wei, Ai Hua Zhang*, and Shouyun Yu,* Org. Lett. 2020, 22, 7315. DOI: 10.1021/acs.orglett.0c02659 Role of Complexation in the Photochemical Reduction of Chromate by Acetylacetone Bingdang Wu, Shouyun Yu, Guoyang Zhang, Shujuan Zhang,* Pengfei Shen, and Paul G. Tratnyek, J. Hazard. Mater. 2020, 400, 123306. DOI: 10.1016/j.jhazmat.2020.123306 Enantioselective Remote C(sp3)–H Cyanation via Dual Photoredox and Copper Catalysis Hui Chen, Weiwei Jin, and Shouyun Yu,* Org. Lett. 2020, 22, 5910. DOI: 10.1021/acs.orglett.0c02008 Remote C–C Bond Formation via Visible Light Photoredox-Catalyzed Intramolecular Hydrogen Atom Transfer Hui Chen, and Shouyun Yu,* Org. Biomol. Chem. 2020, 18, 4519. DOI: 10.1039/D0OB00854K Generation and Application of Iminyl Radicals from Oxime Derivatives Enabled by Visible Light Photoredox Catalysis Changhua Song, Xu Shen, Fang Yu, Yu-Peng He,* and Shouyun Yu,* Chin. J. Org. Chem. 2020, 40, 3748. (in Chinese) DOI: 10.6023/cjoc202004008 Pedagogy Square and Live Video-Based Online Teaching Xinghua Li, Zhitong Liu, Menghan Tang, Chengjian Zhu, and Shouyun Yu,* Univ. Chem. 2020, 35, 24. (in Chinese) DOI: 10.3866/PKU.DXHX202002049 Photoredox/Palladium-Cocatalyzed Enantioselective Alkylation of Secondary Benzyl Carbonates with 4-Alkyl-1,4-dihydropyridines Xu Shen, Linlin Qian, and Shouyun Yu,* Sci. China Chem. 2020, 63, 687. DOI: 10.1007/s11426-019-9732-5 Asymmetric Synthesis of Atropisomeric Compounds with C-N Chiral Axis Zhaojie Li, and Shouyun Yu,* Sci. Sin. Chem. 2020, 50, 509. (in Chinese) DOI: 10.1360/SSC-2019-0168 Enantioselective α-Allylation of Anilines Enabled by a Combined Palladium and Photoredox Catalytic System Hong-Hao Zhang, Jia-Jia Zhao, and Shouyun Yu,* ACS Catal. 2020, 10, 4710. DOI: 10.1021/acscatal.0c00871 A Review of Enantioselective Dual Transition Metal/Photoredox Catalysis Hong-Hao Zhang, Hui Chen, Chengjian Zhu,* and Shouyun Yu,* Sci. China Chem. 2020, 63, 637. DOI: 10.1007/s11426-019-9701-5 Photocatalytic Isomerization of Styrenyl Halides: Stereodivergent Synthesis of Functionalized Alkenes Hao Zhang, Qing Xu,* Lei Yu,* and Shouyun Yu,* Eur. J. Org. Chem. 2020, 1472. DOI: 10.1002/ejoc.201901119 Atroposelective Haloamidation of Indoles with Amino Acid Derivatives and Hypohalides Zhaojie Li, Menghan Tang, Chenyang Hu, and Shouyun Yu,* Org. Lett. 2019, 21, 8819. DOI: 10.1021/acs.orglett.9b03456 Experimenting with a Suzuki−Miyaura Cross-Coupling Reaction That Demonstrates Tolerance toward Aldehyde Groups to Teach Undergraduate Students the Fundamentals of Transition-Metal-Catalyzed Reactions Jie Dai, Dadong Lu, Tao Ye, Shouyun Yu,* and Xu Cheng,* J. Chem. Educ. 2019, 96, 2672. DOI: 10.1021/acs.jchemed.9b00191 Site-Selective Remote C(sp3)–H Heteroarylation of Amides via Organic Photoredox Catalysis Hui Chen, Wenjing Fan, Xiang-Ai Yuan,* and Shouyun Yu,* Nature Commun. 2019, 10, 4743. DOI: 10.1038/s41467-019-12722-4 Advances on Transition Metals and Photoredox Cooperatively Catalyzed Allylic Substitutions Hong-Hao Zhang, and ShouyunYu,* Acta Chim. Sinica 2019, 77, 832. (in Chinese) DOI: 10.6023/A19050177 NaClO-Promoted Atroposelective Couplings of 3-Substituted Indoles with Amino Acid Derivatives Zhaojie Li, Hao Zhang, and Shouyun Yu,* Org. Lett. 2019,21, 4754. DOI: 10.1021/acs.orglett.9b01638 Visible-Light-Induced Radical Acylation of Imines with α-Ketoacids Enabled by Electron-Donor–Acceptor Complexes Hong-Hao Zhang, and Shouyun Yu,* Org. Lett. 2019,21, 3711. DOI: 10.1021/acs.orglett.9b01169 Enantioselective Radical Hydroacylation of Enals with α-Ketoacids Enabled by Photoredox/Amine Cocatalysis Jia-Jia Zhao, Hong-Hao Zhang, Xu Shen, and Shouyun Yu,* Org. Lett. 2019,21, 913. DOI: 10.1021/acs.orglett.8b0384 Visible Light-Promoted Isomerization of Alkenes Hao Zhang, and Shouyun Yu,* Chin. J. Org. Chem. 2019,39, 95. (in Chinese) DOI: 10.6023/cjoc201809010 Enantioselective Allylic Alkylation with 4‑Alkyl-1,4-dihydropyridines Enabled by Photoredox/Palladium Cocatalysis Hong-Hao Zhang, Jia-Jia Zhao, and Shouyun Yu,* J. Am. Chem. Soc. 2018, 140, 16914. DOI: 10.1021/jacs.8b10766 Primary, Secondary and Tertiary γ-C(sp3)–H Vinylation of Amides via Organic Photoredox Catalyzed-Hydrogen Atom Transfer Hui Chen, Liangliang Guo, and Shouyun Yu,* Org. Lett. 2018, 20, 6255. DOI: 10.1021/acs.orglett.8b02737 Stereodivergent Synthesis of α-Aminomethyl Cinnamyl Ethers via Photoredox-Catalyzed Radical Relay Reaction Xiao-De An,§ Hao Zhang,§ Qing Xu,* Lei Yu, and Shouyun Yu,* Chin. J. Chem. 2018, 36, 1147. (§ X.-D. A. and H. Z. contributed equally) DOI: 10.1002/cjoc.201800387 Photoredox-Catalyzed Intermolecular Remote C-H and C-C Vinylation via Iminyl Radicals Xu Shen, Jia-Jia Zhao and Shouyun Yu,* Org. Lett. 2018, 20, 5523. DOI: 10.1021/acs.orglett.8b02540 Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines Xiao-De An, and Shouyun Yu,* Synthesis 2018, 50, 3387. DOI: 10.1055/s-0037-1609844 Visible Light-Induced Aryltrifluoromethylation of Hydroxy Alkenes via Radical Trifluoromethylation-Triggered Aryl and Heteroaryl Migration Hao Wang, Qian Xu and Shouyun Yu,* Org. Chem. Front. 2018, 5, 2224. DOI: 10.1039/C8QO00430G Photoredox-Catalyzed C(sp2)–N Coupling Reactions Xiao-De An and Shouyun Yu,* Tetrahedron Lett. 2018, 59, 1605. DOI: 10.1016/j.tetlet.2018.03.050 Photoredox-Induced Radical Relay toward Functionalized β-Amino Alcohol Derivatives Xiao-De An, Yan-Yan Jiao, Hao Zhang, Yuxiang Gao and Shouyun Yu,* Org. Lett. 2018, 20, 401. DOI: 10.1021/acs.orglett.7b03693 Visible-Light-Induced Iminyl Radical Formation via Electron-Donor-Acceptor Complexes: A Photocatalyst-Free Approach to Phenanthridines and Quinolines Jingjing Sun,§ Yanyan He,§ Xiao-De An, Xu Zhang, Lei Yu* and Shouyun Yu,* Org. Chem. Front. 2018, 5, 977. (§ J. S. and Y. H. contributed equally) DOI: 10.1039/C7QO00992E Distal Radical Migration Strategy: An Emerging Synthetic Means Weipeng Li, Wentao Xu, Jin Xie,* Shouyun Yu,* and Chengjian Zhu,* Chem. Soc. Rev. 2018, 47, 654. DOI: 10.1039/C7CS00507E Halogen-Bond-Mediated Atom Transfer Radical Addition of Perfluoroalkyl Iodides to Alkynes under Visible Light Irradiation Xiaoyang Sun,§ Yanyan He,§ and Shouyun Yu,* J. Photochem. Photobiol. A Chem. 2018, 355, 326. DOI：10.1016/j.jphotochem.2017.08.026