陈振夏 - 华中农业大学 - 生物医学与健康学院

个人简介

教育经历 2006-2011 北京大学生命科学技术学院生物信息中心理学博士学位 2002-2006 华中农业大学生命科学技术学院国家生命科学与技术人才培养基地理学学士学位 2003-2006 武汉大学新闻传播学院学院新闻学文学学士学位工作经历 20016-至今华中农业大学教授、博士生导师 2011-2016 美国国立卫生研究院消化、糖尿病、肾脏病研究所博士后

研究领域

两性间的表型差异主要由差异表达基因（即性别偏爱性基因）引起。性别偏爱性基因中包含大量的长链非编码RNA（lncRNA）基因。虽然已经发现一些性别偏爱性lncRNA具有调控性腺发育等重要功能，但是大部分仍然功能未知。本实验室以往的研究证实利用高通量表达数据注释非编码功能元件的可靠性，并揭示性别相关驱动力对动物基因组中非编码序列演化的作用。然而，尽管已发现一些性别偏爱性lncRNA可以调控性别发育，但尚有许多仍然功能未知。

近期论文

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Shi MW#, Zhang NA#, Shi CP, Liu CJ, Luo ZH, Wang DY, Guo AY*, Chen ZX*. SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes. Nucleic Acids Research. 2019. Chen ZX*, Oliver B, Zhang YE, Gao G, Long M*. Expressed Structurally-stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements. Genome Biology and Evolution. 9(4):981–992 (2017). Lin Y, Chen ZX, Oliver B, Harbison ST*. Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster. G3-Genes Genomes Genetics. 6: 4197-4210 (2016). Lin Y, Golovnina K, Chen ZX, Lee HN, Negron YL, Sultana H, Oliver B, Harbison ST*. Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster. BMC Genomics 17: 28 (2016). Chen ZX & Oliver B*. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. G3-Genes Genomes Genetics. 5(6):1057-63 (2015). Clough E, Jimenez E, Kim YA, Whitworth C*, Neville MC, Hempel L, Pavlou H, Chen ZX, Sturgill D, Dale R, Smith HE, Przytycka TM*, Goodwin SF*, Doren MV*, Oliver B*. Sex- and Tissue-specific Functions of Drosophila Doublesex Transcription Factor Target Genes. Dev. Cell. 31(6):761-73 (2014). Chen ZX#, Sturgill D#, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B*, Richards S. Comparative analysis of the D.melanogaster modENCODE transcriptome annotation. Genome Research. 24:1209-23 (2014). Chen ZX*, Golovnina K, Sultana H, Kumar S, Oliver B. Transcriptional effects of gene dose reduction. Biology of Sex Differences, 5(1): 5 (2014). Chen ZX, Zhang YE, Vibranovski M, Luo J, Gao G*, Long M*. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol. 28:2823-2832 (2011). Golovnina K, Chen ZX, Lin Y, Sultana H, Oliver B, Harbison S, 2015. mRNA-Seq data of whole female/male individuals from 16 inbred Drosophila melanogaster DGRP lines. Gene Expression Omnibus GSE60314. Chen ZX, Oliver B. 2015. mRNA-Seq of female, male, and sex-transformed Drosophila melanogaster heads from flies heterozygous for deletions on chromosome X and 3L. Gene Expression Omnibus GSE60571. Chen ZX, Oliver B. 2015. CAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura. Gene Expression Omnibus GSE66284. Sturgill D, Chen ZX, Kopp A, Richards S, Oliver B. 2013. mRNA-Seq of whole adult females and males, and mixed sex embryos, from multiple Drosophila species. Gene Expression Omnibus GSE43321. Oliver B, Chen ZX, Sturgill. 2013. New Drosophila pseudoobscura RNA-Seq coverage data. FlyBase. http://flybase.org/cgi-bin/gbrowse/dpse/