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个人简介

女,1975年出生于四川泸县,教授,中国科学院研究员,博士生导师。曾获得云南省首届高端科技人才和云南省百名海外高层次人才引进计划;主持过国家自然科学基金、中科院知识创新工程领域前沿项目、云南省重点项目等多个项目的研究;共发表SCI论文70多篇,获得授权发明专利3项。研究结果发表在Clin Pharmacol Ther、J Gerontol A Biol Sci Med Sci、Br J Pharmacol、 Aging 、 J Proteomics 、Exp Gerontol等重要杂志上。现任中国老年保健医学研究会老年健康与转化医学分会青委会副主任委员、中国老年学和老年医学学会抗衰老分会委员、中国老年保健医学研究会老年健康与转化医学分会委员,云南省生物化学与分子生物学学会理事,云南省药理学会理事,云南省植物学会理事,昆明市实验动物行业协会常务理事。 1994-1998 兰州大学生物学系,生物化学,学士 1998-2003 中国科学院昆明动物研究所遗传资源与进化国家重点实验室,动物学专业(功能基因组方向),博士 2004-2007 美国堪萨斯大学医学中心博士后 2007-2008 美国迈阿密大学医学院博士后 2010.1-2010.3 美国哥伦比亚大学访问教授 2013.11-2014.3 美国德克萨斯大学休斯顿健康科学中心访问教授 2008-2016 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,研究员,博士生导师 2016-至今 西南医科大学药学院,教授,博士生导师

研究领域

衰老与老年医学,离子通道生理功能,衰老相关疾病药物筛选研究

近期论文

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Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR*. Chlorogenic acid extends the lifespan of Caenorhabditis elegans via insulin/IGF-1 signaling pathway. J Gerontol A Biol Sci Med Sci. 2017;72(4):464-472. Wan QL, Shi X, Liu J, Ding AJ, Pu YZ, Li Z, Wu GS*, Luo HR*. Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans. Aging-US. 2017; 9(2): 447-474. Pu YZ, Wan QL, Ding AJ, Luo HR*, Wu GS*. Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss. J Proteomics. 2017; 156: 85-93. Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR*. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017; 426(1-2): 101-109. Huang XB, Mu XH, Wan QL, He XM, Wu GS, Luo HR*. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One. 2017;12(9):e0184027. Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR*. Otophylloside B protects against Aβ toxicity in Caenorhabditis elegans models of Alzheimer's disease. Nat Prod Bioprospect. 2017;7(2):207-214. Ding AJ, Zheng SQ, Huang XB, Xing TK, Wu GS, Sun HY, Qi SH, Luo HR*. Current perspective in the discovery of anti-aging agents from natural products. Nat Prod Bioprospect. 2017; 7(5): 335-404. Tang H, Wu GS, Xie J, He X, Deng K, Wang H, Xu F*, Luo HR*. Brain-wide map of projections from mice ventral subiculum. Neurosci Lett. 2016; 629: 171-9. 姜方洁,付玉,吴桂生,杨丽萍,唐贺,邓科,林万华,罗怀容*。慢性应激诱导小鼠杏仁核基底外侧核theta波段下调介导焦虑反应。广西师范大学学报. 2016; 34(1):162-167。 Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR*. Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One. 2015; 10(8):e0136255. Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakura DP, Zhu J, Deng Z, Hu X, Wu M, McManus OB, Li M, Hong X*, Zhu MX*, Luo HR*. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015; 172(14):3495-509. Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR*. The lifespan-promoting effect of otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect. 2015; 5(4):177-83. Yuan XX, Yang LP, Yang ZL, Xiao WL*, Sun HD, Wu GS, Luo HR*. Effect of nigranoic acid on Ca2+ influx and its downstream signal mechanism in NGF-differentiated PC12 cells. J Ethnopharmacol. 2014; 153(3): 725-731. Wan QL, Zheng SQ, Wu GS, Luo HR*. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol. 2013; 48(5): 499-506. Zheng SQ, Ding AJ, Li GP, Wu GS, Luo HR*. Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One. 2013; 8(2): e56877. Zhu J, Wu CF, Li X, Wu GS, Xie S, Hu QN, Deng Z, Zhu MX*, Luo HR*, Hong X*. Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2013; 21(14):4218-24. Zhang SS, Ma QY, Zou XS, Dai HF, Huang SZ, Luo Y, Yu ZF, Luo HR*, Zhao YX*. Chemical constituents from the Fungus Amauroderma amoiensis and their in vitro acetylcholinesterase inhibitory activities. Planta Med. 2013; 79(1): 87-91. Wang WG, Wu ZY, Chen R, Li HZ, Li HM, Li YD, Li RT*, Luo HR*. Pierisformotoxins A–D, polyesterified grayanane diterpenoids from Pieris formosa and their cAMP-decreasing activities. Chem Biodivers. 2013; 10(6):1061-71. Luo HR, Wu GS, Pakstis AJ, Tong L, Oota H, Kidd KK, Zhang YP. Origin and dispersal of atypical aldehyde dehydrogenase ALDH2*487Lys. Gene. 2009; 435: 96–103. Luo HR, Wu GS, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, Wong ML. Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatr Dis Treat. 2009; 5: 163-70.

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