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个人简介

教授/博士生导师,重庆大学校长助理,理学部副主任,虎溪校区管委会常务副主任,1995年毕业于丹麦哥本哈根大学,获博士学位。教育部“跨世纪优秀人才”,教育部“高等学校青年教师奖”,国务院政府特殊津贴获得者。中国色谱学会常务理事,重庆市分析化学学科学术带头人,重庆市色谱学会理事长,重庆市分析测试学会副理事长,第十届、十一届全国人大代表,重庆市政协委员。《色谱》、《环境化学》等杂志编委。

研究领域

1. 活性天然产物:创新方法筛选中药中的活性成分;改进及应用现代制备技术从中药中获得活性单体成分;活性成分的分子、细胞及动物水平评价。 2. 药物分析化学:手性分离分析方法研究;药物亲和分析;功能化毛细管电泳分析方法的建立及应用。 3. 临床医药分析:现场、实时、便携的治疗药物监控方法开发,细胞内、活体的生物活性分子探测,手性分子识别及手性生物效应。 4. 微波化学与波谱:微波化学反应的机理、微波热与非热作用、微波在有机化学、分析化学、材料化学中的应用。

近期论文

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[1] D. Gao, D.D. Wang, Q. Zhang, F.Q. Yang,Z.N. Xia*, Q.H. Zhang, C.S. Yuan, In Vivo Selective Capture and Rapid Identification of Luteolin and Its Metabolites in Rat Livers by Molecularly Imprinted Solid-Phase Microextraction, Journal of Agricultural and Food Chemistry, 65 (2017) 1158-1166. [2] Q.H. Zhang, L. Zhou, H. Chen, C.Z. Wang, Z.N. Xia*, C.S. Yuan, Solid-phase microextraction technology for in vitro and in vivo metabolite analysis, Trends in Analytical Chemistry : TRAC, 80 (2016) 57-65. [3] L.J. Wang, W.L. Wei, Z.N. Xia*, X. Jie, Z.Z.L. Xia, Recent advances in materials for stationary phases of mixed-mode high-performance liquid chromatography, Trends in Analytical Chemistry : TRAC, 80 (2016) 495-506. [4] D. Gao, Y.L. Zhang, F.Q. Yang, F. Li, Q.H. Zhang, Z.N. Xia*, The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes, Journal of Ethnopharmacology, 191 (2016) 379-386. [5] D. Gao, F.Q. Yang, Z.N. Xia*, Q.H. Zhang, Molecularly imprinted polymer for the selective extraction of luteolin from Chrysanthemum morifolium Ramat, Journal of Separation Science, 39 (2016) 3002-3010. [6] K. Zhou, Y. Zhang, Z.N. Xia*, W.L. Wei, As-prepared MoS2 quantum dot as a facile fluorescent probe for long-term tracing of live cells, Nanotechnology, 27 (2016). [7] D. Gao, Y.L. Zhang, F.Q. Yang, Y.X. Lin, Q.H. Zhang, Z.N. Xia*, In vitro Screening and Evaluation of 37 Traditional Chinese Medicines for Their Potential to Activate Peroxisome Proliferator-activated Receptors-gamma, Pharmacognosy Magazine, 12 (2016) 120-127. [8] F.Q. Wang, Q. Zhang, C.H. Li, Y.Z. Wang, Y.J. Hu, Q.H. Zhang, Z.N. Xia, F.Q. Yang, Evaluation of affinity interaction between small molecules and platelets by open tubular affinity capillary electrochromatography, Electrophoresis, 37 (2016) 736-743. [9] Y. Pang, Y.K. Huang, F. Li, F.Q. Yang, Z.N. Xia*, Rapid screening and evaluation of antioxidants in alkaloid natural products by capillary electrophoresis with chemiluminescence detection, Analytical Methods, 8 (2016) 6545-6553. [10] L.J. Wang, D. Gao, Z.L. Xu, F.Q. Yang, Z.N. Xia*, Chemical Constituents of Pouzolzia zeylanica with PPAR gamma and PPAR beta Activities, Chemistry of Natural Compounds, 51 (2015) 1157-1159. [11] W. Xiao, C. Chen, Q. Zhang, Q.H. Zhang, Y.J. Hu, Z.N. Xia, F.Q. Yang, Separation Study of Eight Isoflavones by MEKC with Different Surfactants, Chromatographia, 78 (2015) 1385-1393. [12] Q.F. Fu, X.J. Li, Q.H. Zhang, F.Q. Yang, W.L. Wei, Z.N. Xia*, A facile and versatile approach for controlling electroosmotic flow in capillary electrophoresis via mussel inspired polydopamine/polyethyleneimine co-deposition, Journal of Chromatograpy A, 1416 (2015) 94-102. [13] L.X. Li,Z.N. Xia, J. Pawliszyn, Selective extraction and enrichment of glycoproteins based on boronate affinity SPME and determination by CIEF-WCID, Analytica chimica acta, 886 (2015) 83-90. [14] Y.H. Zhang, Z.N. Xia*, L. Yan, S.S. Liu, Prediction of Placental Barrier Permeability: A Model Based on Partial Least Squares Variable Selection Procedure, Molecules, 20 (2015) 8270-8286. [15] D. Gao, Y.L. Zhang, P. Xu, Y.X. Lin, F.Q. Yang, J.H. Liu, H.W. Zhu, Z.N. Xia*, In vitro evaluation of dual agonists for PPAR gamma/beta from the flower of Edgeworthia gardneri (wall.) Meisn, Journal of Ethnopharmacology, 162 (2015) 14-19. [16] X.J. Li, Q.F. Fu, Q.H. Zhang, X.M. Jiang, F.Q. Yang, W.L. Wei, Z.N. Xia*, Layer-by-layer self-assembly of polydopamine/gold nanoparticle/thiol coating as the stationary phase for open tubular capillary electrochromatography, Analytical Methods, 7 (2015) 8227-8234. [17] C. Chen, F.Q. Yang, Q. Zhang, F.Q. Wang, Y.J. Hu, Z.N. Xia, Natural Products for Antithrombosis,Evidence-based Complementary and Alternative Medcine, (2015). [18] Y.L. Zhang, Z.N. Xia*, J.H. Liu, F. Yin, Cell Signaling Mechanisms by which Geniposide Regulates Insulin-Degrading Enzyme Expression in Primary Cortical Neurons, CNS & Neurological Disorders-Drug Targets , 14 (2015) 370-377. [19] W. Xiao, F.Q. Wang, C.H. Li, Q. Zhang, Z.N. Xia, F.Q. Yang, Determination of eight isoflavones in Radix Puerariae by capillary zone electrophoresis with an ionic liquid as an additive, Analytical Methods, 7 (2015) 1098-1103. [20] Z.L. Xu, F.Q. Yang, L.J. Wang, J. Lu, D. Gao, W.H. Huang, Z.N. Xia*, A New gamma-Pyrone from Ampelocissus artemisiifolia, Chemistry of Natural Compounds, 50 (2014) 982-984.

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