郑文杰 - 暨南大学 - 化学与材料学院

个人简介

学习经历 1994-1998，中山大学，博士研究生 1982-1985，中山大学，硕士研究生工作经历 1985- 现在，暨南大学硒化学生物学实验室负责人，历任暨南大学研究生院执行院长，生命科学技术学院副院长、书记、院长，研究生部主任等职。 1989-1990，作为访问学者在香港大学潘宗光教授、支志明教授实验室从事科研合作； 2005-2008，先后短期访学于澳大利亚、美国等多所大学。 1998-2000，博士后，华南师范大学生命科学院

研究领域

化学生物学、细胞通讯与药物设计。 (1) 有机硒及其金属配合物的分子设计、纳米硒的靶向性修饰及生物活性评价；(2) 硒/碲的生物有机化及生物活性研究

近期论文

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1.Li Y, Li X, Wong YS, Chen Tianfeng, Zhang H, Liu C, Wenjie Zheng*. (2011) The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials, 32, 9068-9076. 2.Fang Yang, Quanming Tang, Xueyun Zhong, Yan Bai, Tianfeng Chen, Yibo Zhang,Yinghua Li, Wenjie Zheng*. (2012) Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles. International Journal of Nanomedicine. 3.Zhang H, Chen Tianfeng, Jiang J, Wong YS, Yang F, Wenjie Zheng*. Selenium-containing allophycocyanin purified from selenium-enrich Spirulina platensis protects human erythrocytes from AAPH-induced oxidative damage through inhibition of ROS generation. Journal of Agricultural and Food Chemistry, 2011, 59, 8683-8690. 4.Linlin Li, Yum-Shing Wong, Tianfeng Chen, Cundong Fana and Wenjie Zheng*. (2011) Ruthenium Complexes Containing Bis-benzimidazole Derivatives as a New Class of Apoptosis Inducers. Dalton Transactions. DOI: 10.1039/C1DT11950H. 5.Ya-Nan Liu, Tianfeng Chen, Wen-Jie Mei, Xiao-Mei Huang, Shuo Wu, Yum-Shing Wong, Jie Liu*, Wenjie Zheng*. (2010) DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3’)TPP - Ru(phen)2Cl]Cl and its heterometallic derivatives. Chemico-Biological Interactions. 183, 349-356. 6.Chen Tianfeng, Yanan Liu, Wenjie Zheng*, Jie Liu, Yum-Shing Wong. 2010. Ruthenium polypyridyl complexes target mitochondria and induce cancer cell apoptosis. Inorganic Chemistry. 49, 6366-6368. 7.Chen Tianfeng, Yum-Shing Wong*, Wenjie Zheng*, Jie Liu. (2009) Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. Chemico-Biological Interactions. 180, 54-60. 8.Chen Tianfeng, Wenjie Zheng*, Wong Yum-Shing, Yan Fang. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine & Pharmacotherapy. 62, 77-84. 9.Chen Tianfeng, Yum-Shing Wong*, Wenjie Zheng*, Yan Bai, Liang Huang. (2008) Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 67, 26-31. 10.Chen Tianfeng, Wenjie Zheng*, Yang Fang，Bai Yan, Yum-Shing Wong. (2006) Accumulation of selenium in mixotrophic culture of Spirulina platensis on glucose. Bioresource Technology. 97, 2260-2265. 11.Qian Li, Tianfeng Chen*, Fang Yang, Jie Liu, Wenjie Zheng* (2010). Facile and controllable one-step fabrication of selenium nanoparticles assisted by L-cysteine. Materials Letters. 64, 614-617. 12.Chen Tianfeng, Wong Yum-Shing*, Wenjie Zheng* (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry. 67, 2424-2430. 13.Chen TianFeng, Wong Yum-Shing*, Wenjie Zheng* (2009) Induction of G1 Cell Cycle Arrest and Mitochondria-Mediated Apoptosis in MCF-7 Human Breast Carcinoma Cells by Selenium-Enriched Spirulina Extract, Biomedicine & Pharmacotherapy. 14.Chen Tianfeng, Wenjie Zheng*, Fang Yang, Yan Bai, Wong Yum-Shing*. (2006) Mixotrophic culture of high selenium-enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments. Enzyme and Microbial Technology. 39, 103-107. 15.Chen TianFeng, Wenjie Zheng*, Wong Yum-Shing. (2008) Selenium-induced changes in activities of antioxidant enzymes and content of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology. 50, 40-48. 16.Ya-Nan Liu, Shuo Shi, Wen-Jie Mei, Cai-Ping Tan, Lan-Mei Chen, Jie Liu*, Wenjie Zheng*, Liang-Nian Ji. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues. European Journal of Medicinal Chemistry. 2008, 1963-1970. 17.Chen Tianfeng, Wen-Jie Mei, Yum-Shing Wong, Jie Liu, Yanan Liu, Huang-Song Xie and Wen-Jie Zheng*. (2010) Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers. Medicinal Chemistry Communications. 1, 73-75. 18.Yi Luo, Xiaoling Li, Yum-Shing Wong, Tianfeng Chen, Yibo Zhang, Wenjie Zheng*. 1,4-diselenophene-1,4-diketone induces caspase-dependent apoptosis in human A375 melanoma cells with involvement of mitochondrial dysfunction. Chem. Pharm. Bull., 2011, 59 (10), 1227-1232.